Ngaba ngamanye amaxesha ukhe ube nesisu esibuhlungu? Okanye uzive udiniwe ngendlela engaqhelekanga ngaphandle kwesizathu esithile? Mhlawumbi ucinga ukuba yinto enxulumene noko ukutyayo kule mihla, okanye mhlawumbi yimeko ye-gastritis. Yiloo nto inokuba yiyo kwiimeko ezininzi. Kodwa, nangona ingaqhelekanga, ezi mpawu zinokuba luphawu lomhlaza ongaqhelekanga nongaqhelekanga. Yiloo nto siza kuthetha ngayo namhlanje. Yiyo leyo i-GIST, okanye i-Gastrointestinal Stromal Tumor. Musa ukoyika xa usiva igama, siza kuthetha ngayo yonke into ngokulula nangokucacileyo.
Kalula nje, yintoni le GIST?
I-GIST imele iGastrointestinal Stromal Tumor . Masiwahlalutye la magama.
- Isisu: Oku kubhekisa kwinkqubo yethu yokwetyisa. Oko kukuthi, indlela ehamba ngayo ukutya esikutyayo - umlomo, umphimbo, isisu, amathumbu amancinci, kunye namathumbu amakhulu.
- I-Stromal: Oku kubhekisa kuhlobo oluthile lwezicubu ezifumaneka eludongeni lwamalungu ethu kwaye kusebenza njengenkxaso yalawo malungu.
- Ithumba: Mhlawumbi ukhe weva ngalo. Oku kuthetha ithumba.
Ngamafutshane, i-GIST sisimila esinomhlaza esiqala kuhlobo oluthile lweseli eludongeni lwesitho kwinkqubo yethu yokugaya ukutya (idla ngokuba sisisu okanye amathumbu amancinci).
Olu luhlobo olungaqhelekanga lomhlaza olukwiqela lee-sarcomas zezicubu ezithambileyo. Kwiindonga zamathumbu ethu, kukho iiseli ezikhethekileyo ezibizwa ngokuba yi-"interstitial cells of Cajal." Cinga ngezi seli njenge-pacemaker yamathumbu ethu. Ezi seli zinceda ukulawula ukuxinana kwe-rhythmic okufunekayo ukutyhala ukutya emathunjini. Ii-GIST tumors zenzeka xa kukho isiphene kwezi seli, nto leyo ebangela ukuba zahlukane ngokungalawulekiyo.
Ezi cysts ngamanye amaxesha zinokuba ncinci njenge-pensile eraser. Xa zincinci, zinokuhlala iminyaka emininzi zingabonakalisi zimpawu. Nangona kunjalo, ezinye cysts ziyakhula kancinci kancinci zize ziqale ukubangela iimpawu ezisibangela ukungakhululeki.
Ziziphi iimpawu ezinokubakho ze-GIST?
Uninzi lwexesha, la mathumba afunyanwa ngengozi ngexesha lokuskena okanye utyando olwenziwe ngesinye isizathu, ngaphandle kweempawu. Kodwa ukuba iimpawu ziyabonakala, zinokubonakala ngolu hlobo. Masizibeke kwitheyibhile elula ukuyiqonda.
| Uphawu | Indlela onokuziva ngayo |
|---|---|
| Intlungu yesisu okanye ukungakhululeki | Kusenokuba yintlungu yesisu, ukuziva ugcwele, okanye ukuziva ngathi kukho into ebambeke kwindawo enye. |
| Ukopha xa usiya kwindlu yangasese | Oku kungaba bomvu, njengegazi. Okanye kungaba mnyama, kube mdaka, kuze kunamathele. Oku kungenxa yokopha kwinxalenye ephezulu yesisu. |
| Ukuhlanza igazi | Xa uhlanza, ungabona igazi elibomvu okanye into emnyama efana nekofu egayiweyo. |
| Ukudinwa | Oku akukokudinwa nje kuphela. Yimvakalelo yokudinwa imini yonke engapheliyo nokuba ulele kamnandi ebusuku. Le meko inokubangelwa yi-anemia, imeko ebangelwa kukopha ngaphakathi emzimbeni. |
| Ukunciphisa umzimba ngaphandle kokuzama | Ukuba ngequbuliso wehla ubunzima ngaphandle kokunciphisa ukutya okanye ukwenza umthambo, nangona utya ngendlela eqhelekileyo, yinto ekufuneka uyixhalabele. |
| Ukulahlekelwa ngumdla kunye nokuqhina kwesisu | Usenokungaziva unqwenela ukutya, uzive uhluthi nasemva kokutya kancinci, okanye ube nobunzima bokuya kwindlu yangasese. |
Khumbula, ayinguye wonke umntu onezi mpawu one-GIST. Ezi ziqhelekile kwezinye izifo ezininzi. Kodwa ukuba ezi mpawu ziyaqhubeka, kungcono ukubona ugqirha ukuze ahlolwe.
Kutheni le GIST iphuhla? Yintoni unobangela?
Kwiimeko ezininzi, imbangela ephambili ye-GIST kukutshintsha kwenye yezakhi zofuzo zethu. Cinga ngezakhi zofuzo emzimbeni wethu njengencwadi yemiyalelo yokukhula nokusebenza kwemizimba yethu. Kukho iphepha kule ncwadi yemiyalelo elibizwa ngokuba yi-`(KIT gene)`. Ngokwemiyalelo ekweli phepha, iiseli ezibizwa ngokuba yi-`(interstitial cells of Cajal)` esithethe ngazo ngaphambili zenziwe kwaye zilawulwa.
Kodwa ngamanye amaxesha, unobumba okanye igama libhalwa ngendlela engafanelekanga kweli phepha elithi `(KIT gene)`. Kufana nempazamo yokubhala. Kwizonyango, oku kubizwa ngokuba yi `(mutation)`. Ngenxa yale mpazamo, i-KIT gene inika imiyalelo engalunganga yokuvelisa iproteni ekhethekileyo ebizwa ngokuba yi `(KIT CD117)`. Ngenxa yale proteni engalunganga, ezo seli zihlala zifumana umqondiso wokuba "ziqhubeke zahlula, ziqhubeke zahlula." Kulapho ezo seli zikhula ngokungalawulekiyo kwaye zenze ithumba.
Olu tshintsho lwemfuza ludla ngokwenzeka ngokungacwangciswanga ngexesha lobomi bethu. Oko kukuthi, asinto esizalwa nayo.
Nangona kunjalo, kunqabile kakhulu, le meko inokunxulunyaniswa neemeko zemfuza ezidluliselwa kwizizukulwana ngezizukulwana. Ezinye zezi meko ziquka:
- Isifo se-GIST seentsapho: Esi sisifo esingaqhelekanga kakhulu. Kwimeko enjalo, umntwana ufumana i-gene ye-KIT enesiphene kumzali omnye. Kwimeko enjalo, iithumba ze-GIST zinokukhula esemncinci, okanye iithumba ezingaphezulu kwesinye zinokukhula.
- Uhlobo lwe-Neurofibromatosis 1: Olu lukwayimeko yemfuza. Lubangela ukuba iithumba zivele kwizicubu zemithambo-luvo yomzimba. Abantu abanale meko banomngcipheko ophezulu kancinci wokufumana i-GIST kunabantu ngokubanzi.
- I-Carney-Stratakis syndrome: Le yimeko engaqhelekanga kakhulu, efunyanwa njengelifa. Abantu abanale meko nabo basengozini enkulu yokuba ne-GIST.
Oogqirha bayixilonga njani i-GIST?
Xa usiya kugqirha oneempawu ezikhankanyiweyo apha ngasentla, uza kuqala akubuze ngeempawu zakho. Ukuba zikho ixesha elide kangakanani, zivakalelwa njani, njl. Emva koko uza kukuhlola. Ukongeza, uza kucebisa iimvavanyo ezininzi ukuze afumanise unobangela wesifo.
Uvavanyo oluphambili olwenziweyo
- I-Upper endoscopy: Olu luvavanyo lokuqala oluqhutywayo. Kalula nje, ityhubhu enekhamera encinci eqhotyoshelweyo ifakwa ngomlomo kwaye i-esophagus, isisu, kunye nenxalenye yokuqala yamathumbu amancinci ziyahlolwa. Oku kunokujonga ngokuthe ngqo ukuba akukho zithumba kunye nokopha.
- I-CT scan: Oku kuthatha imifanekiso enqamlezileyo yangaphakathi lomzimba wethu. Kufana nokusika isilayi sesonka. Oku kungabonisa ngokucacileyo ubungakanani bethumba, indawo elikuyo, kunye nokuba lisasazeke na kwamanye amalungu omzimba, njengesibindi.
- Uvavanyo lwebhayoloji:Olu lolona vavanyo lubalulekileyo lokuqinisekisa isifo i-100% yexesha. Ngexesha le-endoscopy okanye enye indlela, kuthathwa iqhekeza elincinci kakhulu lesicubu kwithumba elirhanelekayo. Emva koko, isicubu sihlolwa phantsi kwe-microscope kwilebhu ukuze kubonwe ukuba ziiseli ze-GIST na.
- I-PET scan: Kwezinye iimeko, ingakumbi ukuba kukho ukurhanelwa kokuba umhlaza usasazeke kwamanye amalungu omzimba, olu vavanyo lunokwenziwa.
Ziziphi iindlela zonyango ze-GIST?
Unyango lwe-GIST luxhomekeke kubukhulu bethumba, indawo elikuyo, nokuba lisasazeke na kwezinye iindawo. Kukho iintlobo ezimbini eziphambili zonyango.
1. Utyando:
Kwiimeko ezininzi, unyango olungcono lwe-GIST tumors kukususa i-tumor ngokupheleleyo ngotyando. Ukuba i-tumor incinci kwaye ayikasasazekanga kwezinye iindawo, utyando lodwa lunokunyanga ngokupheleleyo isifo.
2. Unyango olujoliswe kulo:
Le yeyona nto itshintsha kakhulu ngonyango lwe-GIST. Ngokungafaniyo ne-chemotherapy eqhelekileyo, la mayeza afana "neebhombu ezikrelekrele." Ajolise ngqo kwiproteni ye-KIT enesiphene esithethe ngayo ngaphambili. Ke ngoko, akukho monakalo mkhulu kwiiseli ezisempilweni.
- Ngaphambi kotyando: Ukuba ithumba likhulu kakhulu kwaye kunzima ukulityanda, olu nyango lujoliswe kulo lunikwa kuqala, emva koko utyando lwenziwa emva kokuba ithumba linciphile.
- Emva kotyando: Ukuba kukho umngcipheko wokuba isifo siphinde sibuye emva kotyando, la mayeza anikwa ukunciphisa loo mngcipheko.
- Ukuba umhlaza usasazekile: Ukuba ithumba lisasazeke kakhulu ukuba lingasuswa, kunokufuneka usebenzise la mayeza ubomi bakho bonke ukulawula isifo nokunciphisa iimpawu.
Yintoni onokuyilindela xa uphila nesifo se-GIST?
Emva konyango, iimpawu zinokuphucula, kwaye ngamanye amaxesha isifo sinokunyangeka ngokupheleleyo. Nangona kunjalo, i-GIST yimeko enethuba lokubuyela umva. Ke ngoko, kubaluleke kakhulu ukuhlala unxibelelana nogqirha wakho womhlaza oza kukunyamekela nasemva konyango.
Uza kuba nentlanganiso yokulandelelana nogqirha wakho rhoqo emva kweenyanga ezi-3 ukuya kwezi-6. Ngeli xesha, kuya kwenziwa uvavanyo lokujonga iimpawu zokubuyela kwimeko yesiqhelo.
- `Ii-CT scans`
- `Iiskeni ze-MRI`
- `Iiskeni zezilwanyana zasekhaya`
Senza uvavanyo olufana nolu ukuqinisekisa ukuba yonke into ilungile.
Xa uthetha ngomhlaza, usenokuba ukhe weva ngamanani anje "ngezinga lokusinda". Kwi-GIST, ngokubanzi, idatha ibonisa ukuba ama-85% abantu bayaphila emva kweminyaka emi-5 bexilongiwe. Kodwa ungoyiki ngamanani anjalo. La ngamanani asekelwe kwidatha evela kumawaka ezigulane. Imeko yakho isenokuba yahlukile kakhulu. Ngoko ke, thetha ngokukhululekileyo nogqirha wakho malunga nemeko yakho, impumelelo yonyango lwakho, kunye noko unokukulindela. Uya kukunika ulwazi olukhethekileyo kuwe.
Ngenxa yokuba i-GIST yimeko engaqhelekanga, kuyinto eqhelekileyo ukuziva wothukile kwaye usoyika xa ufumanisa ngayo. Kodwa khumbula, ngoku kukho unyango olusebenzayo kakhulu lwesi sifo. Awuwedwa. Iqela lakho lezonyango, usapho, kunye nabahlobo bakho bonke bakhona ukukunceda. Funda ngesi sifo, ubuze imibuzo, kwaye ujongane nonyango oluhle.
Umyalezo Wokuya Ekhaya
- I-GIST (Gastrointestinal Stromal Tumor) luhlobo olungaqhelekanga lwethumba elinomhlaza oluvela eludongeni lwenkqubo yethu yokugaya ukutya.
- Amaxesha amaninzi akukho zimpawu, kodwa iimpawu ezifana neentlungu zesisu, ukudinwa, igazi esitulweni, kunye nokwehla kobunzima zinokubakho.
- Ukuba unale mpawu, ungoyiki kwaye ubone ugqirha ngokukhawuleza.
- Eyona nto ibangela i-GIST lutshintsho (utshintsho) kwiijini.
- Esi sifo sinokulawulwa kwaye sinyangeke ngotyando kunye nonyango olujoliswe kulo olusebenzayo kakhulu.
- Kwanasemva konyango, kubaluleke kakhulu ukulandelelwa ngexesha elicwangcisiweyo.
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