Iihormone zifana nezithunywa ezincinci eziququzelela imisebenzi eyahlukeneyo emzimbeni wethu. Khawucinge nje, ezi hormone zongezwa egazini lethu ngamadlala emzimbeni wethu. Emva koko, ezi hormone zihamba egazini zize zinike imiyalezo kwisitho ngasinye, njengokuthi "yenza oku" kunye "yeka oku". Enyanisweni, imizimba yethu ayinakusebenza kakuhle ngaphandle kweehormone. Kodwa ngamanye amaxesha, ezi zithunywa zilungileyo zikwanceda ezinye iiseli ezinomhlaza "zikhule kakuhle kwaye zahlukane ngokukhawuleza". Kulapho unyango lweehormone luba lubalulekile kuthi.
Ngoko ke olu nyango lwe-hormone lusebenza njani?
Ngamafutshane, unyango lweehomoni lusebenza ngokuthintela indlela iiseli zomhlaza ezifumana ngayo iihomoni ezizidingayo ukuze zikhule. Oku kungenziwa ngeendlela ezahlukeneyo. Ugqirha wakho uya kugqiba ukuba yeyiphi indlela omawuyisebenzise ngokwemeko yakho.
- Ukuyeka ukuveliswa kweehomoni: Ezinye iiseli zomhlaza ziyakwazi ukuyeka ukuvelisa iihomoni ezizinceda zikhule. Kwezinye iimeko, iindlala ezivelisa ezi homoni zisenokufuna ukususwa ngotyando.
- Ukuthintela ukusebenza kweehomoni: Kule ndlela, nangona umzimba uvelisa iihomoni, iiseli zomhlaza ziyathintelwa 'ekusebenziseni' ezo homoni. Cinga ngeseli yomhlaza njengendlu, kwaye ihomoni njengesitshixo. Olu nyango lufana nokuvala umngxuma wesitshixo ohambelana nesitshixo. Emva koko, nokuba isitshixo sikhona, ucango alunakuvulwa.
- Unyango lokutshintshwa kweehomoni: Ngamanye amaxesha, endaweni yeehomoni zendalo emizimbeni yethu, sinika imizimba yethu uhlobo lwehomoni yokwenziwa eyenziwe kwilebhu (iihomoni zeBioidentical). Ezi homoni zokwenziwa azinakusetyenziswa ziiseli zomhlaza ukuze zikhule. Ngamanye amazwi, endaweni yehomoni efunekayo ziiseli zomhlaza, zinika ihomoni 'yobuxoki' ezingenakuyisebenzisa, kodwa ibukeka ifana.
Into ebalulekileyo kukuba unyango lweehomoni lusebenze ngokunqanda ukunikezelwa 'kwepetroli' kwiiseli zomhlaza. Oku kungenziwa wedwa okanye kudityaniswe nezinye iindlela zonyango ezifana notyando, i-chemotherapy, okanye unyango lwemitha.
Lolu nyango lusetyenziselwa ziphi iintlobo zomhlaza?
Unyango lwehomoni alusetyenziswa kuzo zonke iintlobo zomhlaza. Lusetyenziswa kakhulu kumhlaza oxhomekeke kwiihomoni. Ezinye zazo ziquka:
- Umhlaza weprostate
- Umhlaza webele
- Umhlaza we-Ovarian
- Umhlaza wesibeleko
Makhe sijonge indlela unyango lweehomoni oluchaphazela ngayo uhlobo ngalunye lomhlaza ngokwahlukeneyo.
Unyango lweHormone kumhlaza weprostate
Iiseli zomhlaza weprostate zihlala zifuna iihomoni zamadoda, ingakumbi i-testosterone, ukuze zikhule. Ngoko ke injongo ephambili yolu nyango kukunciphisa amanqanaba ezi homoni okanye ukuziyekisa ukusebenza. Kwezinye iimeko, ukususwa ngotyando kwethambo elinye okanye omabini, avelisa i-testosterone, (orchiectomy) kwenziwa njengenxalenye yolu nyango.
Ukuba kusetyenziswa amayeza, la mayeza alandelayo angasetyenziswa ikakhulu.
| Uhlobo lweziyobisi | Ingaba isebenza kanjani |
|---|---|
| I-abiraterone acetate | Eli yeza lithintela ukuveliswa kweehomoni zamadoda (androgens) kwiiseli zomhlaza weprostate. Lidla ngokunikwa amadoda angaphenduliyo kwezinye iindlela zonyango lweehomoni. |
| Ii-agonists ze-LHRH | La mayeza abonisa i-pituitary gland engqondweni yethu ukuba iyeke ukukhupha i-hormone exelela amasende ukuba avelise i-testosterone. Ke ngoko, xa ukunikezelwa kwe-testosterone kuyeka, iiseli zomhlaza ziyayeka ukukhula. |
| Ii-antiandrogens | Ezi zisebenza ngokuthintela i-testosterone eveliswa emzimbeni ekubeni inamathele kwiiseli zomhlaza. Oku kuthetha ukuba nokuba i-hormone ikhona, iseli yomhlaza ayinakungenelwa kuyo. |
Iziphumo ebezingalindelekanga ezinokubakho
Ezinye iziphumo ebezingalindelekanga zinokwenzeka xa usebenzisa olu nyango. Nangona kunjalo, ezi azenzeki kuye wonke umntu kwaye abanye abantu basenokungabi nazo naziphi na iziphumo ebezingalindelekanga. Kungcono ukuthetha nogqirha wakho ngale nto.
- Ukutyeba kwakho.
- Ukuncipha okanye ukuphelelwa ngumnqweno wesondo.
- Ukungasebenzi kakuhle kwe-erectile.
- Ukuncipha koxinano lwamathambo (i-Osteoporosis).
Unyango lweHormone kumhlaza webele
Malunga nesibhozo kwishumi leemidla zomhlaza wamabele zixhomekeke kwiihomoni. Ngamafutshane, i-estrogen, ihomoni yabasetyhini, inceda ezi seli zomhlaza zikhule. Cinga ngeeseli zomhlaza njengezine-'antenna' ezincinci kumphezulu wazo ezinokunamathela kwiihomoni. Sizibiza ezi receptor zehomoni. Xa i-estrogen ibopha kwezi antenna, iseli yomhlaza ifumana isignali yokukhula. Sizibiza ezi 'cancers-positive receptor-positive' .
Unyango lwehomoni lusebenza ngokunciphisa amanqanaba e-estrogen emzimbeni okanye ukuthintela i-hormone estrogen ekubopheni kwiiseli zomhlaza. Olu nyango luhlala lunikwa emva kotyando ukunciphisa umngcipheko wokubuya komhlaza.
| Uhlobo lweziyobisi | Ingaba isebenza kanjani |
|---|---|
| Izithinteli zeAromatase | La mayeza anciphisa amanqanaba e-estrogen emzimbeni ngokuthintela i-enzyme ebizwa ngokuba yi-aromatase, eguqula ezinye iihomoni zibe yi-estrogen. Adla ngokunikwa abafazi abaye bafikelela kwixesha lokuya exesheni. |
| Ii-SERM (ii-modulators ze-estrogen receptor ezikhethiweyo) | La mayeza athintela i-hormone estrogen ekubopheleleni kwii-receptors kwiiseli zomhlaza webele, ukuze iiseli zomhlaza zingafumani signal yokukhula. |
| Ii-ERD (abalawuli be-estrogen receptor down) | Ezi zinto zithintela ukusebenza kwe-estrogen kwaye zinciphisa inani lee-receptor ze-estrogen kwiiseli zomhlaza, nto leyo ezenza zingabi nathuba lokuzibophelela kwi-estrogen. |
Iziphumo ebezingalindelekanga ezinokubakho
- Intlungu okanye ukuqina kwamalungu.
- Ukudinwa.
- Isicaphucaphu nokuhlanza.
- Ukutyeba kwakho.
- Ukuncipha komnqweno wesondo.
- Ubushushu obugqithisileyo.
- Intlungu yebele okanye ukudumba.
Unyango lweHormonal kumhlaza we-ovarian kunye nomhlaza wesibeleko
Unyango lweehomoni lusetyenziswa kwiintlobo ezithile ezingaqhelekanga zomhlaza wesibeleko kunye nomhlaza wesibeleko. Kumhlaza wesibeleko, iyeza elibizwa ngokuba yi-progestin, elisebenza njengehomoni ye-progesterone, lisetyenziswa kakhulu. Oku kucothisa ukukhula kweeseli zomhlaza.
Amayeza afana ne-LHRH agonists, i-tamoxifen, kunye ne-aromatase inhibitors nawo angasetyenziswa ukunyanga zombini iintlobo zomhlaza.
Iziphumo ebezingalindelekanga ezinokubakho
- Ubushushu obugqithisileyo.
- Ukoma kwesisu.
- Ukuncipha koxinano lwamathambo (i-Osteoporosis).
- Intlungu yamalungu kunye nemisipha.
- Ukutyeba kwakho.
- Ukubila ebusuku.
Ziziphi iindlela zonyango kunye neengozi?
Unyango lwehomoni lunikezelwa ngeendlela ezimbini eziphambili. Enye kukuthatha iipilisi okanye iikhaphu ngomlomo (amayeza omlomo) . Enye kukusebenzisa inaliti . Le ndlela iyahluka ngokuxhomekeke kuhlobo lonyango olunikiweyo.
Njengalo naluphi na unyango lomhlaza, unyango lweehomoni lunengozi yeziphumo ebezingalindelekanga. Nangona kunjalo, ezi zahluka kakhulu kumntu nomntu. Zininzi izinto ezichaphazela oku, kubandakanya impilo yakho iyonke kunye nohlobo lonyango lweehomoni olufumanayo.
Eyona nto ibalulekileyo kukuthetha ngokukhululekileyo nogqirha wakho malunga nemiphumo emibi enokubakho kunye nendlela yokuyilawula ngaphambi kokuba uqale unyango. Uza kukuchazela yonke into.
Zithini iingenelo kunye namazinga empumelelo onyango lweehomoni?
Eyona nzuzo iphambili yonyango lweehomoni kukuba inceda ekumiseni okanye ekucothiseni ukukhula komhlaza. Isebenza ngakumbi xa isetyenziswa kunye nezinye iindlela zonyango. Ngamanye amaxesha, ingasetyenziselwa ukunciphisa ithumba ngaphambi kotyando kunye nokuthintela umhlaza ukuba ungabuyi emva kotyando.
Kunzima ukutsho ukuba olu nyango lusebenza kangakanani na. Luxhomekeke kwizinto ezininzi, kuquka uhlobo lomhlaza onalo, ukuba usasazeke kangakanani, ubudala bakho, kunye nempilo yakho iyonke. Ulwazi olungcono malunga nemeko yakho lunokufumaneka kuphela kugqirha wakho onyangayo. Ngoko ke ungoyiki ukumbuza ngale nto.
Ukuba ufumana unyango lwehomoni, kubaluleke kakhulu ukuya kwiikliniki kwaye wenze uvavanyo ngexesha njengoko ugqirha wakho eyalele.
Umyalezo Wokuya Ekhaya
- Iihormone ziikhemikhali ezilawula imisebenzi eyahlukeneyo emizimbeni yethu.
- Ezinye iintlobo zomhlaza, ezifana ne-prostate kunye nebele, zixhomekeke kwiihomoni ukuze zikhule.
- Unyango lwehomoni lusebenza ngokunciphisa ukunikezelwa kweehomoni ezifunekayo kwiiseli zomhlaza okanye ukuthintela ukusebenza kwazo.
- Olu nyango lunikwa njengeepilisi okanye iinaliti.
- Iziphumo ebezingalindelekanga zinokwenzeka, kodwa ziyahluka kumntu nomntu kwaye zinokulawulwa.
- Kubaluleke kakhulu ukuthetha ngokukhululekileyo nogqirha wakho ngayo nayiphi na imibuzo okanye izinto ezikuxhalabisayo.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho