Ingaba amathambo akho abuthathaka kwaye abuhlungu? Masifunde ngale nto (Osteitis Fibrosa Cystica - OFC)!

Ngaba ngamanye amaxesha uziva iintlungu emzimbeni wakho, ingakumbi emathanjeni akho? Okanye uziva ngathi amathambo akho ayaphuka nokuba yinto encinci? Mhlawumbi kukho imeko engasemva kwezi zinto esingathethi kakhulu ngayo, kodwa kubalulekile ukuyazi. Enye yeemeko ezinjalo yi-`(Osteitis Fibrosa Cystica - OFC)`. Nangona eli gama lisenokubonakala liyinkimbinkimbi kancinci, masilichaze ngokulula.

Yintoni i-Osteitis Fibrosa Cystica (OFC)?

Ngamafutshane, `(Osteitis Fibrosa Cystica - OFC)` sisifo esingaqhelekanga esichaphazela amathambo ethu. Sinxulumene ngokuthe ngqo namadlala e-parathyroid emzimbeni wethu. Ukhe weva ngedlala le-thyroid. Emva kwalo kukho la madlala mane e-parathyroid. La madlala avelisa i-parathyroid hormone (`Parathyroid Hormone - PTH`) .

Le hormone `(PTH)` ibalulekile ekugcineni amathambo ethu omelele kwaye esempilweni. Ikwanceda ekulawuleni inqanaba le-calcium egazini. Kodwa, khawucinge, kwenzeka ntoni ukuba le hormone `(PTH)` iveliswa kakhulu, oko kukuthi, ininzi kakhulu? Kulapho ingxaki iqala khona. Ngenxa yoko kugqithisileyo `(PTH)`, endaweni yokuqinisa amathambo, aqala ukuba buthathaka kancinci kancinci . Ngokuhamba kwexesha, imo yamathambo inokutshintsha, kwaye izinto ezifana nemingxunya (njengee-cysts ezizaliswe ngamanzi) nazo zinokuvela ngaphakathi.

Le PTH igqithisileyo inokubangela ukunyuka kwamanqanaba e-calcium egazini, nto leyo ekhokelela ekwakhekeni kwamatye ezintso, uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi), kunye nokusilela kwentliziyo.

Le meko ibizwa ngokuba yi-`(OFC)` ngamanye amagama aliqela. Usenokuba ukhe weva la magama:

• ``Isifo sethambo sikaVon Recklinghausen''
• `I-Osteitis fibrosa`
• `I-Cystica ngokubanzi`
• `I-Osteodystrophia fibrosa`
• Ithumba elimdaka lethambo . Musa ukothuka ngeli gama. Nangona lisithi `(ithumba)`, alikho ``umhlaza``. Eli gama lisetyenziswa kuba abantu abane `(OFC)` banamabala amdaka avela ngenxa yokopha kunye nezicubu ezine-fibrous emathanjeni abo. Kodwa ngokwenene asilo `(ithumba)` elinomhlaza.

Amagama athi "(Osteitis Fibrosa Cystica)" athetha into efana 'nokunyibilika kwamathambo kunye nokwakheka kwe-cyst'. Ngoko ke, xa inqanaba elithi `(PTH)` linyuka, amathambo angonakaliswa nangaliphi na ixesha. Nangona kunjalo, ukuba le meko ibizwa ngokuba yi `(Hyperparathyroidism)` (oko kukuthi, ukuveliswa kakhulu kwe `(PTH)`) iqatshelwa kwaye inyangwa kwangethuba, imeko ethi `(OFC)` inokunyangeka okanye ithintelwe ukuba ikhule.

Ixhaphake kangakanani le meko (ye-OFC)?

Ngoku usenokuba uzibuza ukuba esi sifo sixhaphake kangakanani. Enyanisweni, asixhaphakanga kakhulu kumazwe aneenkonzo zempilo ezilungileyo . Umzekelo, kwanase-United States, ngaphantsi kwe-5% yabantu abane-hyperparathyroidism baba ne-OFC. Sixhaphake kakhulu kubantu abane-hyperparathyroidism enzima abangakhange banyangwe ixesha elide.

Kodwa ngaphambili, oku kwakuxhaphake kakhulu. Kwiminyaka engamashumi amahlanu eyadlulayo, malunga nama-69% abantu abane-"Hyperparathyroidism" babenale ngxaki yamathambo. Kodwa ngokuhambela phambili kwesayensi yezonyango, ingakumbi ngokufika kwe-"Routine Blood Tests", ezi meko ziye zakwazi ukuchongwa nokunyangwa ngokukhawuleza. Ayisiyonto intle leyo?

Zithini iimpawu zale meko (ye-OFC)?

Kulungile, ngoku masibone ukuba zeziphi iimpawu ezinokubakho kwimeko ethi `(Osteitis Fibrosa Cystica)`.

Iimpawu eziphambili zezi:

• Intlungu yamathambo . Le yinto yokuqala abantu abaninzi abayivayo. Ngamanye amaxesha, kunokuba buhlungu nokuchukumisa ithambo.
• Ukuqhekeka kwamathambo . Amathambo, ingakumbi lawo asezingalweni, emilenzeni, okanye emqolo, anokwaphuka lula. Nokuba ukuwa okuncinci kunokwaphula ithambo.

Ekuqaleni kwale meko, ezi mpawu zilandelayo zinokwenzeka (ezi zisenokuba ziimpawu ze-"Hyperparathyroidism"):

• Ukuziva udiniwe ngalo lonke ixesha (`Ukudinwa`).
• Ubuthathaka.
• Isicaphucaphu nokuhlanza.
• Ukuqhinwa.
• Ukuchama kakhulu kunokuqhelekileyo (`iPolyuria`). Oku kuthetha ukuba kufuneka uye kwindlu yangasese rhoqo.

Ukuba unale mpawu, musa ukuzenzela isigqibo, "Owu, le yi-`(OFC)'." Kuba ezi mpawu zinokubakho nakwezinye izifo. Kodwa kubaluleke kakhulu ukuba uzazi ezi mpawu uze uxelele ugqirha.

Zithini izizathu ze-(OFC)?

Yintoni ebangela i-Osteitis Fibrosa Cystica? Njengoko benditshilo ngaphambili, unobangela oyintloko woku yi -Hyperparathyroidism enganyangwanga . Oko kukuthi, amadlala ethu e-Parathyroid avelisa i-PTH eninzi kakhulu. Oku kunokwenzeka ngeendlela ezimbini eziphambili:

1. I-Primary Hyperparathyroidism: Oku kubangelwa yingxaki yamadlala akho e-parathyroid. La madlala anokuba ngumhlaza (umhlaza) okanye abe nokukhula okungekho ngumhlaza (okufana ne-adenoma) okubangela ukuba avelise i-PTH eninzi kakhulu. Okanye onke amadlala amane anokwanda (hyperplasia) aze avelise i-hormone eninzi kakhulu.

2. I-Secondary Hyperparathyroidism: Oku kwenzeka ngenxa yesinye isifo sempilo. Umzekelo, ukuba umntu unesifo sezintso esingapheliyo, ibhalansi ye-calcium kunye ne-vitamin D emzimbeni wakhe iyaphazamiseka. Emva koko, ngenxa yoko, amadlala e-parathyroid aqala ukuvelisa i-PTH engaphezulu. Kwakhona, xa kukho ukungabikho okukhulu kwe-vitamin D, inqanaba le-calcium egazini liphantsi, ngoko ke amadlala e-parathyroid asebenza nzima ukwandisa inqanaba le-calcium. Ngelo xesha, i-hormone ye-PTH nayo iyanda, kwaye ngokuhamba kwexesha, i-Osteitis Fibrosa Cystica inokukhula.

Khawucinge nje, umakazi wethu uKamala ebeneengxaki zezintso ixesha elide. Akazange athathe amayeza afanelekileyo. Emva kwexesha elithile, amadlala akhe e-`(Parathyroid)`, ezama ukulawula i-calcium emzimbeni wakhe, aqala ukuvelisa i-`(PTH)` engaphezulu kunokuba kufanele. Ekugqibeleni, umakazi uKamala waba ne-`(OFC)` kunye nentlungu yamathambo. Ngaba uyayiqonda inxibelelwano?

Ziziphi iingxaki ezinokubakho ze-(OFC)?

Iingxaki eziphambili ze-hyperparathyroidism enganyangwanga kunye ne-OFC zinxulumene namathambo. Oku kuthetha iintlungu, ukukhubazeka kwamathambo (utshintsho kwimilo), kunye nokuqhekeka okulula . Ezi zizinto ezibonakala ngokukhawuleza. Umntu unokulahlekelwa bubude.

Nangona kunjalo, ukongeza koku, ezinye iingxaki zinokwenzeka. Nazi:

• Ukwakheka kwamatye ezintso.
• Ukungasebenzi kakuhle kwezintso.
• Amandla aphantsi, ukudinwa rhoqo.
• Intlungu zesisu.
• Iingxaki zengqondo ezifana nokudakumba.
• Iingxaki zenkumbulo kunye nokungakhathali.

Jonga ukuba ingxaki eqala kwindawo enye ingafikelela phi. Ingxaki kwenye inkqubo yomzimba wethu inokuchaphazela nezinye iinkqubo. Yiyo loo nto ukuxilongwa kwangoko kunye nonyango kubalulekile.

Ifunyaniswa njani i-OFC?

Kulungile, ngoku ugqirha uyixilonga njani le meko `(Osteitis Fibrosa Cystica)`?

Okokuqala, ugqirha wakho uza kubhala imbali epheleleyo yempilo yakho . Uza kukubuza ukuba unexesha elingakanani unale mpawu, nokuba unezinye iimeko zempilo (ezifana nesifo sezintso) ezinokuchaphazela amanqanaba akho e-PTH, kunye namayeza owasebenzisayo. Emva koko, baza kwenza uvavanyo lomzimba ukujonga iintlungu zamathambo, ukuthamba, okanye ukukhubazeka kwawo.

Ukuqinisekisa isifo, oogqirha banokusebenzisa iimvavanyo ezifana nezi:

• Uvavanyo lwegazi: Olu vavanyo lujonga ukungalingani kweehomoni kunye neeminerali. Ngokukodwa, lujonga amanqanaba ehomoni ye-parathyroid (PTH), amanqanaba e-calcium, amanqanaba e-phosphorus, amanqanaba e-vitamin D, kunye ne-alkaline phosphatase (i-enzyme ekhutshwa emathanjeni). Kwi-OFC, amanqanaba e-PTH kunye ne-alkaline phosphatase anokuba phezulu kakhulu.
• Uvavanyo lomchamo: Ungajonga nobungakanani bekhalsiyam kumchamo wakho.
• Uvavanyo lomfanekiso:
• Ii-X-reyi: Ezi zinokubonisa ukuba amathambo mancinci kangakanani, izinto ezifana nee-cysts, kunye nokuba kukho naziphi na iindawo ezincinci kakhulu zokuqhekeka (ii-microfractures) okanye utshintsho olubonakalayo emathanjeni (njengokutsalwa kwe-subperiosteal).
• Ii-CT Scans (`CT - Computed Tomography scans`) okanye ii-MRI Scans (`MRI - Magnetic Resonance Imaging scans`): Ezi zibonisa imeko yamathambo ngokweenkcukacha ezingaphezulu kunee-X-ray.

Ziziphi iindlela zonyango (OFC)?

Kulungile, ngoku masithethe ngonyango lwe-`(Osteitis Fibrosa Cystica)`. Unyango luxhomekeke kuhlobo kunye nobukhali be-`(Hyperparathyroidism)` ebangele i-`(OFC)`.

• Ukuba i-primary hyperparathyroidism ibangelwa yile:
• Kwiimeko ezininzi, ukuba imbangela yale meko `(OFC)` kukungasebenzi kakuhle kwendlala `(Parathyroid)` (njengethumba), unyango oluqhelekileyo kukususa indlala okanye inxalenye yendlala (`Parathyroidectomy`) . Olu tyando lunokuthintela ukubhitya kwamathambo kwaye lubuyisele umonakalo othile wethambo osele wenzeke (`remineralization`). Ngokwesiqhelo, sineendlala ezine `(Parathyroid)`. Ngoko ke, xa indlala enengxaki isusiwe, iindlala eziseleyo zinokuvelisa i-`(PTH)` hormone efunekayo emzimbeni.

• Kwabo bangakwaziyo utyando okanye abane-hyperparathyroidism yesibini:
• Ukunyanga unobangela oyintloko: Umzekelo, ukuba unobangela kukunqongophala kwevithamini D, kunikwa izongezo zevithamini D. Ukuba sisifo sezintso, sinyangwa ngokufanelekileyo.
• I-Calcimimetics: La mayeza alinganisa i-calcium egazini lakho. "Akhohlisa" i-parathyroid gland yakho ukuba ivelise i-PTH encinci. I-Cinacalcet yenye yezo ziyobisi.
• IiBisphosphonates: La mayeza asebenza ngokunciphisa izinga lokulahleka kwamathambo. Adla ngokunikwa abantu abane-osteoporosis. Nangona kunjalo, anokuba luncedo kwixesha elifutshane kubantu abane-OFC, ingakumbi ukuqinisa amathambo ngaphambi kotyando.
• I-Vitamin D kunye nezongezo ze-calcium: Ezi zinikwa xa kufuneka. Nangona kunjalo, ukuba inqanaba le-calcium egazini liphezulu, izongezo ze-calcium azinikwa.

Iyintoni imbonakalo yesimo (se-OFC)?

Lithini ithemba lale meko `(OFC)`? Enyanisweni, ngolawulo olufanelekileyo nonyango, iziphumo ezilungileyo zinokufumaneka . Unyango lunokuthintela ukubhitya kwamathambo kwaye luqinise amathambo (`remineralize`). Amathambo aphukileyo anokuphola kwaye anciphise iintlungu. Nangona kunjalo, ukuba amathambo akhubazekile kakhulu, asenokungaphindi aphile ngokupheleleyo.

Ngaba (i-OFC) ingathintelwa?

Ngaba kunokwenzeka ukuthintela ukwenzeka kwale meko `(Osteitis Fibrosa Cystica)`? Ewe, ngandlela ithile kunokwenzeka. Eyona nto iphambili kukubona nokunyanga le meko `(Hyperparathyroidism)` kwangethuba.

• Kubaluleke kakhulu ukuba wenze uvavanyo lwegazi rhoqo , ingakumbi ukuba unezinto ezinobungozi ezifana nesifo sezintso. Oku kuya kunceda ekufumaneni naluphi na utshintsho kumanqanaba e-calcium egazini lakho kunye ne-PTH ngaphambi kokuba kwenze umonakalo omkhulu.
• Kwakhona, thetha nogqirha wakho kwaye ugcine amanqanaba e-calcium kunye ne-vitamin D afanelekileyo.Yenza oko kufuneka ukwenze. Umzekelo, ukuba uhlala kwindawo apho ilanga lingafumaneki kangako ebusika, kunokufuneka uthathe izongezo zevithamini D. Ugqirha wakho uya kukuxelela nendlela yokufumana izondlo ozifunayo ekutyeni okutyayo.

Khumbula, okukhona imeko ethi `(Hyperparathyroidism)` iqatshelwa kwaye inyangwa ngokukhawuleza, kokukhona amathuba okuba i-`(Osteitis Fibrosa Cystica)` anciphe.

Ndifanele ndimbone nini ugqirha?

Ukuba unentlungu emathanjeni, ukuthamba, okanye ithambo elivakala ngathi liza kuphuka , bona ugqirha ngoko nangoko. Kwakhona, ukuba uneempawu zokuqala ze-hyperparathyroidism (ezifana nokudinwa, isicaphucaphu, kunye nokuchama rhoqo) endizikhankanyileyo ngaphambili, xelela ugqirha wakho ngazo. Ukuba sele une-hyperparathyroidism, licebo elihle ukuba igazi lakho livavanywe rhoqo ukuze kuhlolwe amanqanaba akho e-calcium kunye ne-PTH, njengoko ugqirha wakho ecebisa.

Ndingayibuza yiphi imibuzo ugqirha wam?

Ukuba ufunyaniswe une-`(Osteitis Fibrosa Cystica)`, kunokuba luncedo ukubuza ugqirha wakho le mibuzo:

• Imeko yam imbi kangakanani?
• Ziziphi iindlela zonyango endinazo? Zithini iingenelo kunye neengxaki zalo naluphi na unyango?
• Ingaba kulungile na ukuba ndithathe izongezo? Uhlobo luni?
• Ngaba ndiza kufuna utyando? Ukuba kunjalo, ndingayilindela ntoni emva koko?
• Zeziphi iinguqulelo endinokuzitshintsha kwindlela enditya ngayo eziya kundinceda?
• Le meko iza kuyichaphazela njani ubomi bam bemihla ngemihla?

Okokugqibela, amanqaku ambalwa abalulekileyo

Ngoko ke, kufuneka ndikuxelele oku. Amathambo abuthathaka kunye nentlungu zinokuba nefuthe elikhulu kubomi bethu bemihla ngemihla. Ukuba amathambo akho aphuka lula, usenokuziva ufuna ukungayisebenzisi eminye imisebenzi. Ukuba uneempawu ezifana nokudinwa, ubuthathaka, isicaphucaphu, kunye nokuchama rhoqo, isenokuba yi-"Hyperparathyroidism" okanye ingxaki yayo ethi "OFC".

Ukuba unayo nayiphi na kwezi mpawu, nceda ubone ugqirha ngokukhawuleza. Okukhona uqaphela kwaye unyanga esi sifo ngokukhawuleza, kokukhona ungenza umonakalo omncinci emathanjeni akho. Impilo yakho ibaluleke kakhulu kuwe. Ngoko ke yinyamekele.

I- Osteitis Fibrosa Cystica, i-OFC, Isifo Samathambo, i-Parathyroid, i-PTH Hormone, i-Hyperparathyroidism, Intlungu Yamathambo