Ngaba nawe unesifo esibuhlungu esiswini? Masifunde nge-VIPoma (i-Vasoactive Intestinal Peptide Secreting) tumor!

Ngaba ngamanye amaxesha unesifo sorhudo esinzima esihlala iintsuku ezininzi, sihamba neentlungu zesisu kunye nokuqaqamba? Usenokuba awutyi okanye awuseli nto, kodwa usaziva ngolu hlobo. Ukuba uneempawu ezinje, unobangela usenokuba unqabile, kodwa usenokuba yimeko ekufuneka sithethe ngayo ngokuqinisekileyo. Namhlanje sithetha ngenye yeemeko ezinjalo ezibizwa ngokuba yi -VIPoma , okanye i-'Vasoactive Intestinal Peptide Secreting' tumor . Nangona igama lisenokuvakala liyinkimbinkimbi kancinci, masiligcine lilula.

Yintoni i-VIPoma tumor?

Ngamafutshane, i-VIPoma luhlobo olungaqhelekanga kakhulu lwethumba olukhula kwi-pancreas . Ngokukodwa, ezi ziithumba ezikhula kwiiseli ze-pancreas ezivelisa iihomoni, ezibizwa ngokuba ziiseli ze-endocrine . Oogqirha ngamanye amaxesha babiza le meko ngokuthi 'yi-Verner-Morrison syndrome' .

Ii-tumor ze-VIPoma zinqabile kakhulu . Kwanakwilizwe elifana neMelika, le meko kuthiwa iyenzeka kumntu omnye kwizigidi ezilishumi. Ngoko ke ungacinga ukuba inqabile kangakanani. Ukuphila nesifo esingaqhelekanga kangaka kunokuba ngumceli mngeni wokwenene, kuba sinempembelelo enkulu kubomi bakho bemihla ngemihla. Kodwa, ungakhathazeki . Ngoku kukho unyango olunokuthi ngamanye amaxesha lunyange ngokupheleleyo esi sifo se-VIPoma, okanye ubuncinane lulawule iimpawu.

Zithini iimpawu zethumba le-VIPoma?

Uphawu oluphambili nolubalulekileyo olubonakala kule meko kurhudo olunzima, olunamanzi . Oku kukhulu kangangokuba unokuba nalo rhudo nokuba awutyi (uzilile). Alupheli kwiintsuku ezimbalwa. Olu lolona phawu lubalaseleyo lwesi sifo.

Ngaphandle koko, kunokubakho nezinye iimpawu ezininzi:

• Ukuqaqamba kwesisu okanye intlungu: Isisu sakho sisenokuvakala ngathi siyajika okanye sinokuba buhlungu xa usichukumisa.
• Ukudinwa: Ukuziva udiniwe kwaye ungenabomi ngalo lonke ixesha.
• Ukuhlambuluka: Ukubomvu ngequbuliso kobuso nesifuba. Oku kunokwenzeka ngaphandle kwesizathu esicacileyo.
• Ubuthathaka bemisipha: Usenokuziva ngathi amalungu akho ayaphelelwa ngamandla, kwaye kunokuba nzima ukuphakamisa iintsimbi.

Khawucinge ukuba ubuya kuziva njani ukuba ubunokupha iibhotile ezimbini okanye ezintathu zamanzi njengendle ngosuku. Oku kunokuba nzima kangangokuba awukwazi nokwenza imisebenzi yakho yemihla ngemihla.

Yintoni ebangela ukuba i-VIPoma ikhule?

Iingcali azikayazi kakuhle into ebangela ii-tumor ze-VIPoma, kodwa ziyaqonda ngokucacileyo indlela ezi mpawu ezenzeka ngayo.

Umzimba wethu unehomoni ebizwa ngokuba yi-'Vasoactive Intestinal Peptide' (VIP) . Le homoni ye-VIP inoxanduva lokulawula inkqubo yethu yokugaya ukutya.Inceda kakhulu. Oko kukuthi, le hormone ilawula ukukhutshwa kwamanzi, iityuwa, ii-enzymes, kunye ne-asidi yesisu kwindlela yokugaya ukutya. Ikwanceda ukukhulula ezinye zezihlunu kwindlela yokugaya ukutya.

Xa kuvela ithumba le-VIPoma, likhupha inani elikhulu kakhulu le-VIP hormone emzimbeni. Xa le hormone ye-VIP engaphezulu ingena emzimbeni, iimpawu ezikhankanyiweyo ngaphambili, ezinje ngorhudo olunzima kunye nokuqaqamba kwesisu, ziyavela. Ngamafutshane, eli thumba libangela ukuba i-VIP hormone isebenze kakhulu.

Ziziphi iingxaki ezinokubakho ngenxa ye-VIPoma?

Ingxaki ephambili nge-VIPoma kurhudo olugqithisileyo. Abanye abantu banokukhupha ilitha enye ukuya kwezintathu (iilitha ezi-1-3) zendle enamanzi ngosuku. Xa olu rhudo luqhubeka, umzimba ulahlekelwa ngamanzi amaninzi kunye neeminerali ezibalulekileyo, ngakumbi i-potassium.

Oku kunokukhokelela ekuphelelweni ngamanzi emzimbeni kunye nokuncipha kwe-kalemia ekuhambeni kwexesha. Zombini ezi meko ziyingozi kuba zinokukhokelela kwiingxaki zempilo ezinzulu. Umzekelo:

• Ukuphazamiseka kwentliziyo (`Arrhythmia`): Ukubetha kwentliziyo okungaqhelekanga.
• Uxinzelelo lwe-Hypovolemic: Imeko ebangelwa kukuncipha kobuninzi bolwelo emzimbeni.
• Ubuthathaka bemisipha (`Myopathy`): Ukusebenza kwemisipha okungasebenzi kakuhle.
• I-Tetany: Ukushwabana okubuhlungu kwemisipha.

Ngenxa yezi ngxaki, kubaluleke kakhulu ukufuna iingcebiso zonyango ngokukhawuleza ukuba uneempawu ze-VIPoma.

Oogqirha bayixilonga njani i-VIPoma?

Ukuba uneempawu ezifana norhudo olunzima okanye iintlungu zesisu ebeziqhubeka kangangeentsuku ezininzi, ugqirha uza kukwenza uvavanyo lomzimba aze akubuze ngeempawu zakho.

Uvavanyo lwesitulo lunokwenziwa ukuze kuthintelwe ezinye iimeko eziqhelekileyo ezibangela urhudo (umz., usulelo). Ukongeza, ezi vavanyo zilandelayo zinokwenziwa:

• Uvavanyo lwegazi: Olu vavanyo lujonga ikakhulu inqanaba le-hormone ye-VIP egazini. Kwi-VIPoma, eli nqanaba liphezulu kakhulu. Banokujonga nezinto ezinje ngokuphelelwa ngamanzi emzimbeni kunye nokungabikho kwe-potassium.
• Uvavanyo lokujonga imifanekiso: Olu vavanyo luthatha imifanekiso yangaphakathi yomzimba ukuze lubone ukuba kukho ithumba, ukuba likho, apho likhoyo, kwaye likhulu kangakanani. Oku kungabandakanya uvavanyo lwe-`Computed Tomography (CT)` okanye uvavanyo lwe-`Magnetic Resonance Imaging (MRI)` .

Oogqirha bayaqinisekisa imeko ye-VIPoma emva kokwenza zonke ezi vavanyo.

Iphathwa njani iVIPoma?

Unyango lwe-VIPoma ludla ngokubandakanya indibaniselwano yamayeza kunye notyando. Ugqirha wakho unokucebisa oku kulandelayo:

• Ulwelo olufakwa emthanjeni (`ulwelo lwe-IV`):Ezi zinikwa ukuze zithathe indawo yolwelo kunye neeminerali ezilahlekayo emzimbeni ngenxa yorhudo olungapheliyo. Oku kunokunceda ekulawuleni ukuphelelwa ngamanzi emzimbeni.
• Amayeza:
• Urhudo lunokulawulwa ngamayeza anjenge- "Octreotide (Sandostatin LAR®)`` . La mayeza anciphisa ukukhululwa kwehomoni ye-VIP.

Emva kokulawula iimpawu zakho ngale ndlela, ugqirha wakho unokucebisa ezinye iindlela zokususa okanye zokulawula ithumba:

• Utyando: Ukuba ithumba alikasasazekanga kwamanye amalungu omzimba (lisasazeke) , utyando lungasetyenziswa ukususa ithumba. Oku kungenziwa ngotyando olubizwa ngokuba yi-distal pancreatectomy, olususa umsila nomzimba wepancreas. Ukuba ithumba lisusiwe ngokupheleleyo, isifo sinokunyangeka.
• Unyango lweKhemotherapy: Ukuba ithumba lisasazekile okanye alinakususwa ngokupheleleyo ngotyando, ikhemotherapy inikwa ukutshabalalisa iiseli zomhlaza.
• Unyango olujoliswe ekujoliswe kulo: La ngamayeza ajoliswe kwiindawo ezithile zeeseli zomhlaza.

Iqela lakho lezonyango liza kugqiba unyango olufanelekileyo kuwe emva kokuyihlola ngononophelo imeko yakho.

Yintoni enokulindelwa ngumntu one-VIPoma?

Oku kuyahluka ngokwenene kumntu nomntu. Utyando lunokuyinyanga ngokupheleleyo i-VIPoma. Amayeza anokulawula iimpawu kakhulu.

Nangona kunjalo, ayingomntu wonke ofana naye . Amava akho asenokuhluka kakhulu kunalawo omnye umntu one-VIPoma. Ugqirha wakho kunye neqela lezonyango ngabona banokukunika ulwazi olungcono kunye nesikhokelo. Bakwazi kakuhle wena kunye nemeko yakho, ngoko ke babuze nantoni na ofuna ukuyazi.

Ndifanele ndimbone nini ugqirha?

Ukuba sele ufumana unyango lwe-VIPoma, fowunela ugqirha wakho ngokukhawuleza ukuba iimpawu zakho aziphucuki okanye azibi mandundu.

Kwakhona, yiya kwigumbi likaxakeka ukuba unezinye zezi mpawu:

• Ukuba unentlungu ebuhlungu esiswini .
• Ukuba ubunesisu esimanzi kangangeentsuku ezininzi .
• Ukuba ubonisa iimpawu zokuphelelwa ngamanzi emzimbeni , njengokuziva unesizungu, ukuba nesiyezi, okanye ukuba nomchamo otyheli okanye omdaka.

Urhudo olungapheliyo olubangelwa yi-VIPoma lunokuphazamisa imisebenzi yakho yemihla ngemihla kwanokulala kwakho ebusuku. Ukwazi ukuba yintoni ebangela ezi mpawu kunokuba luncedo. Nangona kunjalo, kuba i-VIPoma sisifo esingaqhelekanga, bambalwa abantu abaziyo ngaso. Oku kunokukwenza uzive unesizungu kwaye udanile. Usenokuziva uneentloni ngeempawu ze-VIPoma.

Iqela lakho lezonyango liyaziqonda kakuhle ezi mvakalelo, ngoko ungathandabuzi ukubacela uncedo olufunayo, nokuba lumalunga nokulawula iimpawu zakho okanye ukuphila nesifo esingaqhelekanga.

Izinto ezibalulekileyo ekufuneka sizikhumbule (Umyalezo Wokuya Ekhaya)

I-VIPoma sisimila esingaqhelekanga esikhula kwi-pancreas. Sibangela ukukhutshwa kakhulu kwehomoni ebizwa ngokuba yi-VIP, ebangela iimpawu ezifana norhudo olunzima kunye nokuqaqamba kwesisu. Ukuba ezi mpawu ziyaqhubeka, kubalulekile ukufuna ingcebiso kagqirha. Unyango olukhawulezileyo lubalulekile njengoko iingxaki ezifana nokuphelelwa ngamanzi emzimbeni kunye nokungabikho kwe-potassium zinokwenzeka. Kukho unyango olufana notyando, amayeza, kunye ne-chemotherapy. Nangona esi sisifo esingaqhelekanga, awuwedwa. Fumana inkxaso kwiqela lakho lezonyango.

I- VIPoma, i-Vasoactive Intestinal Peptide, umhlaza we-pancreatic, isifo sohudo, i-Verner-Morrison syndrome, ukungalingani kwamaHormonal, izifo ezingaqhelekanga