Isibindi sakho sisitho esimangalisayo. Senza ulwelo olubizwa ngokuba yi-'bile' olusinceda sitye ukutya okunamafutha esikutyayo. Kodwa kumntu onesifo esibizwa ngokuba yi-Primary Biliary Cholangitis (PBC), imibhobho ethambileyo ethwala le bile yonakele. Oku kubangela ukuba i-bile ingahambi kakuhle kwaye ivaleke ngaphakathi kwesibindi. Ekuhambeni kwexesha, le bile ivalekileyo inokuqina ibe ngamatye kwaye ibangele usulelo. Ekugqibeleni, le bile iyabuyela umva kwaye ibangele amanxeba ngaphakathi kwesibindi. Le yindlela esisiseko ye-PBC.
Kodwa ungakhathazeki. Kukho amayeza alungileyo anokunceda ukususa inyongo esibindini kwaye anciphise ukwakheka kwezi zilonda. Nangona kunjalo, ukuba awuyinyangi kakuhle i-PBC, okanye ukuba isifo siba sibi kakhulu, ezinye iingxaki zinokubakho. Namhlanje, siza kuthetha ngeengxaki eziqhelekileyo ze-PBC kunye nendlela yokuzilawula.
Isifo sofuba, imeko enzima
I-Cirrhosis kuxa iiseli eziphilileyo kwisibindi sakho zithathelwa indawo zizicwili zesilonda. Ngamafutshane, isibindi siyaqina kancinci sibe lilitye. Le meko yenzeka kwizigaba zokugqibela ze-PBC. Ngeli xesha, isibindi sele sonakele kakhulu.
I-Cirrhosis yimeko enzima ekufuneka siyiqaphele, kuba inokukhokelela kwiimeko ezinzima ezifana nokungasebenzi kakuhle kwesibindi kunye nomhlaza wesibindi.
Ngaphambili, i-PBC yayibizwa ngokuba yi-'primary biliary cirrhosis'. Oku kungenxa yokuba ingxaki ye-cirrhosis inxulumene ngokusondeleyo nesi sifo.
Iphathwa njani le nto?
Ugqirha wakho uza kukunika amayeza okulawula le meko.
- Amaxesha amaninzi, unyango lokuqala lunyango olubizwa ngokuba yi- ursodeoxycholic acid (Ursodiol) . Oku kusebenza ngokususa inyongo esibindini nokunciphisa umonakalo esibindini.
- Ukuba awuziva bhetele kakhulu ngale mithi yodwa, ugqirha wakho unokucebisa ukuba uthathe iyeza elibizwa ngokuba yi-obeticholic acid (Ocaliva) ukongeza kulo.
- Ukongeza, amayeza amatsha afana ne -elafibranor (Iqirvo) kunye ne-seladelpar (Livdelzi) ngoku avunyiwe ukuba asetyenziswe kunye ne-ursodeoxycholic acid.
- Olunye ukhetho ludidi lwamayeza abizwa ngokuba yi -fibrates . Nangona la mayeza evunyiweyo ukwehlisa amafutha egazini (i-lipids), kufunyenwe ukuba asebenza kakuhle kakhulu kwizigulane ze-PBC ezingaphenduli kakuhle kwi-ursodeoxycholic acid. Ngale ndlela, xa ugqirha esebenzisa iyeza kwimeko engeyiyo leyo livunyiweyo ngayo, silibiza ngokuba kukusetyenziswa 'okungekho kwileyibhile'.
Nangona kunjalo, kungakhathaliseki ukuba usebenzisa luphi unyango, ukuba izicubu zesilonda esibindini ziba zininzi kakhulu kwaye isibindi asikwazi ukusebenza, isisombululo kuphela kukufakelwa isibindi.Kuphela. Okwenziwayo apho kukususa isibindi sakho esonakeleyo size sifakwe kwisibindi esivela kumntu ophilileyo.
Uxinzelelo oluphezulu emthanjeni wesibindi (i-Portal Hypertension)
Le yenye ingxaki enkulu. Masiyiqonde le nto. Sinomthambo wegazi ophambili ozisa igazi esibindini sethu. Oku sikubiza ngokuba yi-'portal vein'.
Ngoku, xa izicubu zesilonda zikhula ngaphakathi kwesibindi ngenxa yemeko yesifo sesibindi esithethe ngaso ngaphambili, ukuhamba kwegazi kule 'portal vein' kuyathinteleka. Njengomxinano wezithuthi endleleni, igazi alikwazi ukuhamba kakuhle kwaye linamathela ngaphakathi kuloo vein. Njengoko igazi liqokelelana ngolu hlobo, uxinzelelo ngaphakathi kuloo vein luyanda kancinci kancinci. Oogqirha babiza le meko ngokuba yi-portal hypertension .
Kutheni oku kuyingozi? Olu xinzelelo luphezulu lunokubangela ukuba imithambo yegazi ebuthathaka emzimbeni iqhume, nto leyo ebangela ukopha ngaphakathi . Ngoko ke, kubaluleke kakhulu ukunyanga oku ngokukhawuleza.
Masiqonde nje ezi ngxaki zimbini kwitheyibhile engezantsi.
| Ingxaki | Kalula nje... | Umngcipheko Ophambili |
|---|---|---|
| Isifo sokuqina kwesibindi | Ukwakheka kwezicubu ezibomvu endaweni yezicubu zesibindi eziphilileyo (amatye esibindi). | Ukusilela Kwesibindi kunye noMhlaza Wesibindi. |
| Uxinzelelo lwegazi oluphezulu lwePortal | I-Cirrhosis ibangela ukuba imithambo ehambisa igazi esibindini ivaleke, nto leyo enyusa uxinzelelo apho. | Ukopha ngaphakathi. |
Zithini iindlela zonyango zoku?
Ugqirha wakho unokukunika amayeza, anjenge- beta-blockers, ukunciphisa uxinzelelo kule 'portal vein'. La mayeza anokulawula uxinzelelo lwegazi lakho okwethutyana.
Kodwa khumbula, unyango olupheleleyo noluhlala luhleli olunokuphelisa ngokupheleleyo uxinzelelo lwegazi oluphezulu lwe-portal kukufakelwa isibindi.Kuphela. Kuba unobangela woku kukonakala kwesibindi okubangelwa yi-cirrhosis. Ekubeni loo monakalo ungenakulungiswa, isigqibo sokugqibela kukususa isibindi esonakeleyo size sifakwe esitsha endaweni yaso.
I-PBC sisifo esinokulawulwa kakuhle ngonyango olufanelekileyo kunye neengcebiso. Ngoko ke, ukuba unesi sifo, ungoyiki, hlala unxibelelana rhoqo nogqirha wakho, kwaye ulandele unyango oluchaziweyo ngokuchanekileyo. Leyo yeyona ndlela ilungileyo yokuhlala ukhuselekile kwiingxaki ezinjalo.
Umyalezo Wokuya Ekhaya
- I-Primary Biliary Cholangitis (PBC) sisifo esonakalisa imibhobho ethambileyo yesibindi ethwala inyongo.
- Ukuba esi sifo asinyangwa ngokufanelekileyo, iingxaki ezinkulu ezifana ne-cirrhosis kunye ne-portal hypertension zinokwenzeka.
- I-Cirrhosis yimeko apho izicubu ezibomvu ziqokelelana esibindini, nto leyo ekhokelela ekungasebenzini kwesibindi kwanomhlaza.
- I-portal hypertension kukunyuka koxinzelelo kwimithambo yegazi ethwala igazi ukuya esibindini. Oku kunokubangela ukopha emzimbeni.
- Ukuba une-PBC, thetha nogqirha wakho ngayo nayiphi na into ekukhathazayo . Kubaluleke kakhulu ukuthatha amayeza akho njengoko kuyalelwe kwaye ulandele imiyalelo kagqirha wakho.
- Kwiimeko ezininzi, isisombululo sokugqibela sinokuba kukufakelwa isibindi.
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