Namhlanje, ingxaki yempilo abantu abaninzi kwilizwe lethu banayo yiType 2 Diabetes. Ngoko ke, njengonyango loku, sidla ngokusebenzisa iipilisi kunye neenaliti ze-insulin. Kodwa kutshanje, kuye kwaveliswa amayeza amatsha athethwayo awenze umahluko omkhulu kwiindlela zonyango lwesifo seswekile. Namhlanje, siza kuthetha ngaloo mayeza, iRybelsus. Ugqirha wakho usenokuba ukucebisile oku, okanye usenokuba uvile ngako. Masizame ukuqonda yonke into malunga nale mayeza ngendlela elula.
Luhlobo luni lonyango iRybelsus?
Ngamafutshane, iRybelsus sisiyobisi esikudidi lwamayeza abizwa ngokuba yi-“Glucagon-like peptide-1 (GLP-1) agonists.” Isithako esisebenzayo kuyo yi-semaglutide. Nangona igama lisenokuvakala liyinkimbinkimbi kancinci, indlela esebenza ngayo ilula kakhulu.
Khawucinge nje, imizimba yethu ivelisa ihomoni ebizwa ngokuba yi-GLP-1 ngokwendalo. Le homoni inceda ekulawuleni amanqanaba eswekile egazini emva kokutya. Into eyenziwa yiRybelsus kukuba isebenza njengehomoni yendalo. Oko kukuthi, ibopha kwii-receptors ze-GLP-1 emizimbeni yethu kwaye isebenza njengehomoni yethu.
Ngaphambili, olu hlobo lwamayeza e-GLP-1 lwalufumaneka kuphela njengeenaliti. Kodwa iRybelsus liyeza lokuqala nelokuphela kweGLP-1 eliza ngohlobo lwepilisi enokuselwa ngomlomo . Eli linyathelo elikhulu kunyango lwesifo seswekile.
Eli yeza lilawula njani amanqanaba eswekile egazini?
I-Rybelsus yehlisa amanqanaba eswekile egazini lakho, okanye i-glucose, ngeendlela ezintathu eziphambili.
- Ukukhuthaza ukuveliswa kwe-insulin yi-pancreas: Emva kokutya, eli yeza libonisa i-pancreas yakho ukuba ivelise isixa esifunekayo se-insulin. I-insulin yi-hormone enceda iswekile egazini ukuba ingene kwiiseli, nto leyo ehlisa amanqanaba eswekile egazini.
- Ithintela ukukhululwa kweswekile esibindini: Isibindi sethu sigcina iswekile. Ngamanye amaxesha le swekile igciniweyo ikhutshwa ngokungeyomfuneko egazini. I-Rybelsus ilawula le nkqubo.
- Ukucothisa ukuhamba kokutya: Eli yeza licothisa isantya sokuhamba kokutya okutyayo esiswini nasemathunjini. Oku kuthetha ukuba iswekile ekutyeni ayifunxwa egazini lakho ngaxeshanye, kodwa kancinci kancinci. Oku kunceda ukulawula ukunyuka ngequbuliso kweswekile egazini emva kokutya.
Uyisebenzisa njani kanye kanye ipilisi yeRybelsus?
Le yeyona nto ibalulekileyo nebalulekileyo ekufuneka uyilumkele xa usebenzisa eli yeza. Le miyalelo mayilandelwe ngokuchanekileyo, kungenjalo ukusebenza kakuhle kweli yeza kunokuncipha.
I-Rybelsus ifanele ithathwe qho kusasa, isisu singenanto. Oku kuthetha ukuba ubuncinane imizuzu engama-30 ngaphambi kokutya kokuqala, isiselo (ngaphandle kwamanzi), okanye naluphi na olunye unyango losuku.
Le pilisi kufuneka ithathwe ngamanzi angaphantsi kwe-4 ounces (malunga ne-120 milliliters) . Ginya ipilisi yonke . Musa ukuyiqhekeza, ukuyityumza, okanye ukuyihlafuna .
Ukuba ulinda ngaphantsi kwemizuzu engama-30, okanye ukuba uyithatha kunye nokutya, isiselo esingengawo amanzi, okanye amanye amayeza, ubungakanani beRybelsus efunxwa ngumzimba bunokuncipha, kwaye iyeza lisenokungabi nasiphumo esifunekayo.
Ugqirha wakho uhlala ekuqalisela i-3 milligrams (mg) ye-insulin kwiintsuku ezingama-30 zokuqala ukunceda umzimba wakho uqhelane namayeza. Emva koko, idosi iya kwandiswa iye kwi-7mg. Ugqirha wakho unokunyusa idosi iye kwi-14mg ukuba kuyimfuneko, kuxhomekeke kumanqanaba eswekile egazini lakho kunye neziphumo zovavanyo lwe -HbA1c .
Yintoni i-HbA1c?
I-HbA1c luvavanyo lwegazi olubonisa amanqanaba akho aqhelekileyo eswekile egazini kwiinyanga ezi-2-3 ezidlulileyo . Kufana 'nekhadi lengxelo' yokulawula iswekile yakho egazini. Ukulawula eli xabiso kunokunceda ukunciphisa umngcipheko wakho wokuba neengxaki ezinxulumene nesifo seswekile (ezifana nesifo sentliziyo kunye nesifo sezintso).
Ziziphi iingenelo zeRybelsus?
Izifundo zeklinikhi kwiRybelsus zibonise ukuba eli yeza, nokuba lisetyenziswa lodwa okanye kunye namanye amayeza eswekile, linceda ekunciphiseni amanqanaba e-HbA1c kunye nobunzima bomzimba.
Ezi theyibhile zingasezantsi zibonisa nje iziphumo zezi zifundo. Kodwa khumbula, ezi ziziphumo eziqhelekileyo kwaye iziphumo zakho zinokwahluka .
| Uthelekiso phakathi kweRybelsus kunye nezinye iziyobisi | ||
|---|---|---|
| Iyeza elithelekiswayo | Ixabiso le-HbA1c elinciphileyo | Ukuhla ukusinda |
| I-Rybelsus 14mg xa ithelekiswa ne- Jardiance (empagliflozin) 25mg | I-Rybelsus yehlise amanqanaba e-HbA1c ngakumbi . | Ukunciphisa umzimba bekufana kuzo zombini. |
| I-Rybelsus 7mg okanye i-14mg xa ithelekiswa ne -Januvia (sitagliptin) 100mg | I-Rybelsus yehlise amanqanaba e-HbA1c ngakumbi . | I-Rybelsus yabangela ukwehla kobunzima ngakumbi . |
| I-Rybelsus 14mg xa ithelekiswa ne- Victoza (liraglutide) 1.8mg inaliti | Ukwehla kwe-HbA1c bekufana . | I-Rybelsus yabangela ukwehla kobunzima ngakumbi . |
Ezi ziphumo zibonisa ukuba iRybelsus liyeza elinokunceda ekulawuleni iswekile egazini nasekunciphiseni ubunzima bomzimba ngandlela ithile.
Zithini iziphumo ebezingalindelekanga zeRybelsus kwaye ziphathwa njani?
Njengayo nayiphi na iyeza, iRybelsus inokuba nemiphumo emibi. Ezona zixhaphakileyo zezi:
- Isicaphucaphu
- Isisu esibuhlungu
- Urhudo
- Umnqweno wokutya
- Ukuhlanza
- Ukuqhinwa
Ezi ziquka isicaphucaphu, ukuhlanza, kunye norhudo, izinto eziqhelekileyo xa uqala ukuthatha amayeza. Ukuba ufumana naziphi na kwezi mpawu, sela amanzi amaninzi ukuze uthintele ukuphelelwa ngamanzi emzimbeni . Ukuba ezi mpawu ziyaqhubeka okanye ziba nzima, thetha nogqirha wakho.
Iingcebiso zokulawula iziphumo ebezingalindelekanga
- Kuphephe ukutya okunamafutha, okunencasa egqithisileyo, kunye nokutya okuneziqholo.
- Endaweni yokutya kakhulu ngexesha elinye, yitya izidlo ezincinci ezininzi.
- Mamonki, yityani ukutya kwenu ngononophelo.
- Musa ukulala phantsi kwangoko emva kokutya.
- Yitya ukutya okulula (umz. isuphu, iyogathi, itoast, irayisi).
- Ziphephe iivumba ezibukhali (ivumba legadi, ivumba leziqholo, ivumba lomsi).
Zeziphi iimeko ezikhethekileyo ekufuneka uzilumkele?
I-Pancreatitis
Ukuba ufumana iintlungu eziqatha zesisu ezinganyamezelekiyo nezisasazeka emqolo, kunye nokuhlanza, yeka ukuthatha iRybelsus ngoko nangoko kwaye uxelele ugqirha wakho. Oku kungaba luphawu lwesifo esibi esibizwa ngokuba yi-pancreatitis.
Iswekile ephantsi egazini (iHypoglycemia)
Ukuba uthatha iRybelsus kunye ne-insulin okanye amanye amayeza eswekile (afana ne-sulfonylureas), inqanaba leswekile yakho egazini linokuba phantsi kakhulu (i-hypoglycemia). Buza ugqirha wakho ukuba inqanaba leswekile yakho egazini liphantsi kangakanani.
Ukuba iswekile yakho egazini iphantsi, yitya iswekile. Umzekelo, ungathatha iipilisi zeglucose, ijusi yeziqhamo, iswekile, okanye ithisipuni yobusi. Ukuba unezinye zezi mpawu zilandelayo okanye ukuba iswekile yakho egazini iphantsi, thetha nogqirha wakho.
| Iimpawu zeswekile ephantsi egazini (iHypoglycemia) | |
|---|---|
| - Isiyezi | - Indlala enkulu |
| - Uloyiko | - Ukubetha kwentliziyo ngokukhawuleza |
| - Ukubila | - Ukulala kakhulu |
| - Ukungazoli, ukucaphuka | - Intloko ebuhlungu |
Amanye amanqaku
- Ukukhulelwa: Xelela ugqirha wakho ukuba uceba ukukhulelwa. Ufanele uyeke ukuthatha iRybelsus ubuncinane iinyanga ezimbini ngaphambi kokuba ukhulelwe.
- Amanye amayeza: I-Rybelsus ingayichaphazela indlela umzimba wakho ofunxa ngayo amanye amayeza owasela ngomlomo. Ngoko ke ukuba ubona utshintsho kwindlela amanye amayeza owasela ngayo, thetha nogqirha wakho ngaloo nto.
I-Rybelsus liyeza elinikwa ngugqirha elifanele lithathwe kuphela ngomyalelo kagqirha. Ugqirha wakho uya kugqiba ukuba eli yeza likulungele na ngokwemeko yakho yempilo, amanqanaba eswekile egazini, kunye nezinye izinto.
Umyalezo Wokuya Ekhaya
- I-Rybelsus liyeza elitsha elithathwa ngomlomo lesifo seswekile sohlobo lwesibini.
- Oku kufanele kuthathwe rhoqo kusasa ungenanto esiswini, imizuzu engama-30 ngaphambi kwayo nayiphi na enye into, ngamanzi amancinci. Musa ukuphula, ukutyumza, okanye ukuhlafuna ipilisi.
- Oku kunciphisa amanqanaba eswekile egazini (i-HbA1c) kwaye kunokunceda ekunciphiseni ubunzima.
- Kuqhelekile ukuba neziphumo ebezingalindelekanga ezifana nokucaphuka, ukuhlanza, kunye norhudo xa uqala amayeza.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana iintlungu eziqatha zesisu (uphawu lwe-pancreatitis) okanye iimpawu zeswekile ephantsi egazini (i-hypoglycemia).
- Landela imiyalelo kagqirha wakho ngokuchanekileyo rhoqo. Kuphephe ukuzinyanga.
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