Masifunde ngeepilisi zeTofacitinib. Zibalulekile kuwe!

Ngaba ugqirha ukunike iyeza elibizwa ngokuba yiTofacitinib okanye umntu omaziyo? Kuqhelekile ukuba kuvele imibuzo engqondweni, akunjalo? "Lithini eli yeza? Kuza kwenzeka ntoni ngalo? Ndifanele ndilumkele ntoni?" Izinto ezinjalo. Ngoko ke namhlanje, masithethe ngeli yeza iTofacitinib ngendlela elula onokuyiqonda. Njengokuthetha nomhlobo.

Luhlobo luni lweyeza iTofacitinib? Isetyenziselwa ntoni?

Ngamafutshane, iTofacitinib liyeza elisetyenziselwa ukunyanga iintlobo ezithile ze-arthritis kunye nezinye izifo ezinxulumene nenkqubo yomzimba yokuzikhusela. Usenokuba ukhe weva nge-rheumatoid arthritis kunye ne-psoriatic arthritis, ezizifo ezivuthayo nezibuhlungu zamalungu. Eli yeza lisetyenziselwa ukunyanga ezo ntlobo zezifo. Likwasetyenziselwa ukunyanga imeko ebizwa ngokuba yi-polyarticular juvenile idiopathic arthritis, i-ankylosing spondylitis, kunye ne-ulcerative colitis, echaphazela amathumbu.

Eli yeza lisebenza ngokuchaphazela inkqubo yomzimba yethu yokuzikhusela . Sinenkqubo emizimbeni yethu esikhusela kwizifo, akunjalo? Yiloo nto siyibiza ngokuba yinkqubo yokuzikhusela. Ngamanye amaxesha le nkqubo iyasebenza kakhulu ize iqale ukuhlasela iiseli zomzimba wethu. Kulapho ke ezi zifo zikhankanyiweyo apha ngasentla zenzeka khona. Iyeza elibizwa ngokuba yiTofacitinib likwiqela lamayeza abizwa ngokuba yiJAK inhibitors. La mayeza asebenza ngokulawula eminye yemisebenzi engafunekiyo yenkqubo yomzimba yokuzikhusela. Emva koko ezo mpawu ziyancitshiswa, kwaye ufumana isiqabu.

Ungalifumana eli yeza kwikhemesti phantsi kwegama lophawu `(Xeljanz)`. Nalo ke liyeza elifanayo.

Zeziphi izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba usebenzise eli yeza?

Oku kubaluleke kakhulu . Ngaphambi kokuba uqale ukusebenzisa eli yeza, kufuneka uxelele ugqirha wakho inkcazo epheleleyo yempilo yakho. Musa ukufihla nezona nkcukacha zincinci. Kuba, kufuneka ulumke kakhulu xa unika eli yeza kubantu abaneengxaki ezithile zempilo.

Ukuba unayo nayiphi na kwezi zinto, qiniseka ukuba uxelela ugqirha wakho:

• Iingxaki zokunqanda igazi: Ngaba wakha waba namahlwili egazi ngaphambili? Okanye kukho umntu kusapho lwakho owakha wanawo?
• Umhlaza: Ngaba unawo umhlaza okwangoku, okanye ukhe wanayo ngaphambili waza wanyangwa?
• Isifo seswekile: Ngaba unesifo seswekile?
• Isifo sentliziyo: Ngaba unesifo sentliziyo?
• Uxinzelelo lwegazi oluphezulu: Ngaba uxinzelelo luphezulu kakhulu?
• I-cholesterol ephezulu: Ngaba i-cholesterol iphezulu?
• I-HIV okanye i-AIDS: Ngaba une-HIV okanye i-AIDS?
• Ubuthathaka bomzimba: Ubusazi na ukuba amandla omzimba wakho okumelana nezifo aphantsi?
• Iintsholongwane eziqhelekileyo:Ngaba uhlala ugula ngumkhuhlane kunye nomkhuhlane? Ingakumbi izifo ezibangelwa ziintsholongwane ezifana ne-chickenpox kunye ne-herpes, izifo ezibangelwa ziintsholongwane ezifana nesifo sephepha, kunye nosulelo lwefungus.
• Isifo Sezintso: Ngaba unengxaki yezintso?
• Isifo sesibindi: Ngaba unengxaki yesibindi?
• Ukunqongophala kwegazi: Ngaba kukho iingxelo zokuba iiseli ezimhlophe zegazi, iiseli ezibomvu zegazi, okanye iiplatelets azikho ngokwaneleyo?
• Izifo zemiphunga okanye zokuphefumla: Ngaba uneengxaki zokuphefumla ezifana ne-asthma okanye i-COPD?
• Ukufakelwa amalungu omzimba: Ngaba wakha wafakelwa amalungu omzimba?
• Ukutshaya: Ngaba uyatshaya icuba?
• Iingxaki zesisu okanye zamathumbu: Izinto ezifana nezilonda zesisu kunye ne-gastritis.
• Ii-Allergies: Ngaba une-allergy kwi-Tofacitinib, amanye amayeza, ukutya, okanye iidayi?
• Ukuba uzama ukukhulelwa okanye ukhulelwe: Oku kubaluleke kakhulu.
• Ukuba ungumama oncancisayo.

Olu luhlu lude kancinci, kodwa konke kungenxa yokhuseleko lwakho.

Ndingayisebenzisa njani le yeza?

Eli yeza liza likwimo yeepilisi. Kufuneka ulisele neglasi yamanzi. Lumka kakhulu ukuba usele umlinganiselo ofanelekileyo, ngexesha elifanelekileyo, njengoko ugqirha wakho ekuxelela.

• Ungayithatha le nto ngaphambi okanye emva kokutya. Nangona kunjalo, ukuba uziva isisu sibuhlungu, yithathe kunye nokutya.
• Qhubeka usela eli yeza de ugqirha wakho akuxelele ukuba uyeke. Musa ukuyeka ukulisebenzisa ngequbuliso, nokuba uzive ungcono.
• Xa ufumana eli yeza kwikhemesti, uza kunikwa incwadana yemiyalelo ekhethekileyo ebizwa ngokuba yi-"MedGuide". Lifunde ngononophelo rhoqo. Liqulethe ulwazi olubalulekileyo.

Ukuba unika abantwana eli yeza: Eli yeza linokunikwa abantwana abaneminyaka emi-2 ubudala kwiimeko ezithile ezikhethekileyo. Nangona kunjalo, kufuneka uthethe nogqirha wakho ngalo mba kwaye ulandele imiyalelo yakhe ngokuchanekileyo.

Ukugqithisa amayeza: Ukuba ucinga ukuba uthathe amayeza amaninzi kakhulu, kufuneka uye kwigumbi likaxakeka esibhedlele ngoko nangoko okanye utsalele umnxeba kwiziko lokulawula ityhefu.

Kubalulekile: Eli yeza limiselwe wena wedwa. Ungaze wabelane ngalo nabanye abantu. Linokubalimaza.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Oko kunokwenzeka, akunjalo? Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Kodwa ukuba sele kusondele ixesha lomthamo wakho olandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye.

Ngawaphi amanye amayeza anokusebenza kunye nale mithi? (Ukusebenzisana kwamayeza)

Oku nako yinto ekufuneka uyilumkele kakhulu. Kukho amayeza anokubangela iingxaki xa esetyenziswa kunye neTofacitinib.

Amayeza angafanele asetyenziswe kunye nale yeza:

• I-Upadacitinib

Amanye amayeza anokusebenzisana nalo mayeza:

• Amayeza okulwa ne-hepatitis, i-HIV, okanye i-AIDS.
• I-Azathioprine.
• Amayeza ebhayoloji aquka amayeza afana ne-Abatacept, i-Adalimumab, kunye ne-Tocilizumab. (Zininzi ezinye, ugqirha wakho uya kwazi ngazo.)
• Amanye amayeza osulelo lwefungus, njengeFluconazole kunye neKetoconazole.
• Amanye amayeza asetyenziswa kwisifo sokuwa, njenge-phenobarbital kunye ne-phenytoin.
• I-Cyclosporine.
• Iigonyo eziphilayo.
• Amanye amayeza anciphisa amandla omzimba okuzikhusela.
• I-Rifampin.
• Izongezo ezifana ne-St. John's wort.
• I-Tacrolimus.

Olu luhlu aluphelelanga. Ngoko ke, xelela ugqirha wakho ngawo onke amayeza owathathayo (amiselwe ngugqirha wakho, athengwe kwikhemesti, amayeza esintu, imifuno, iivithamini, izongezo zesondlo). Kwakhona, xelela ugqirha wakho ukuba utshaya icuba, usela utywala, okanye usela ezinye iziyobisi. Ezi zinto zinokudibana namayeza.

Yintoni endifanele ndiyiqaphele xa ndisebenzisa eli yeza?

Ngelixa usela eli yeza, ugqirha wakho uza kujonga impilo yakho rhoqo. Yiya kugqirha ngeentsuku ezimiselweyo .

• Ukuba iimpawu zakho aziphucuki okanye azibi mandundu, xelela ugqirha wakho.
• Kuya kufuneka wenze uvavanyo lwegazi ngelixa usebenzisa eli yeza. Lisebenzise kakuhle.
• Eli yeza linokunyusa kancinci umngcipheko wakho wokufumana usulelo . Ke ngoko, ukuba ufumana iimpawu ezinje ngomkhuhlane, ukubanda, umphimbo obuhlungu, okanye umkhuhlane, musa ukuzinyanga kwaye ufune iingcebiso zonyango. Zama ukuhlala kude nabantu abagulayo.
• Musa ukuthatha amayeza okudambisa iintlungu kunye namayeza okunciphisa umkhuhlane afana ne-aspirin, i-acetaminophen, kunye ne-ibuprofen ngaphandle kwengcebiso kagqirha wakho, kuba anokufihla ukubakho komkhuhlane.
• Thetha nogqirha wakho malunga nomngcipheko wakho womhlaza. Ukusela eli yeza kunokunyusa kancinci umngcipheko wakho wokuba neentlobo ezithile zomhlaza.
• Kuphephe ukukhulelwa: Musa ukukhulelwa ngelixa usebenzisa eli yeza. Ukuba uzama ukukhulelwa, okanye ucinga ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko. Eli yeza linokulimaza kakhulu usana olungekazalwa.
• Kuphephe ukuncancisa: Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza okanye ubuncinane iiyure ezili-18 emva kokuba uyekile ukusebenzisa eli yeza.

Zeziphi iziphumo ebezingalindelekanga endinokuzifumana kweli yeza?

Njengayo nayiphi na iyeza, iTofacitinib inokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa kulungile ukuzazi.

Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha ngoko nangoko:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kwemilebe, ulwimi, nobuso.
• Ukuqhekeka kwegazi: Intlungu yesifuba, ukuphefumla kancinci, intlungu yemilenze, ukudumba, okanye ukufudumala.
• Ukuhlaselwa yintliziyo: Ubunzima bokuphefumla, ukuqina okanye iintlungu esifubeni, entanyeni, emqolo, okanye ezingalweni, ukudinwa kakhulu.
• Usulelo: Umkhuhlane, ukubanda, ukukhohlela, umphimbo obuhlungu, iintlungu okanye ubunzima bokuchama.
• Izitulo ezinombala okhanyayo.
• Ukulimala kwesibindi: Umchamo otyheli okanye omdaka omnyama, ukudinwa, umkhuhlane, ukungabi namdla wokutya, iintlungu kwicala eliphezulu lasekunene lesisu, ukutyheli kwamehlo okanye ulusu.
• Iiseli ezibomvu zegazi ezisezantsi: Ukuphefumla nzima, ukuquleka, isiyezi, ukuquleka, ukudinwa kakhulu.
• Istroke: Ukutshintsha kombono, ukudideka, ubunzima bokuthetha okanye ukuqonda, intloko ebuhlungu kakhulu, ukudinwa okanye ubuthathaka ngequbuliso ebusweni, engalweni, okanye emlenzeni, ubunzima bokuhamba, isiyezi, ukulahlekelwa yibhalansi.
• Iinyembezi esiswini okanye emathunjini: Umkhuhlane, iintlungu zesisu, utshintsho olukhawulezileyo kwindlela odla ngayo amathumbu.

Iziphumo ebezingalindelekanga ezingezizo ezinzulu, kodwa ekufuneka zixelwe kugqirha wakho ukuba ziyaqhubeka okanye ziyakhathaza:

• Urhudo (intlungu yesisu)
• Intloko ebuhlungu
• Intlungu yemisipha
• Ukuxinana kwempumlo okanye impumlo egobhozayo

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga ukongeza kwezi, xelela ugqirha wakho ngayo.

Ndingawagcina njani amayeza am?

• Gcina eli yeza kude nabantwana kunye nezilwanyana zasekhaya .
• Gcina kubushushu begumbi (phakathi kwama-20 nama-25 degrees Celsius).
• Musa ukusebenzisa amayeza aphelelwe lixesha. Walahle.

Ndingawalahla njani amayeza angasetyenziswanga okanye aphelelwe lixesha?

• Eyona nto ingcono onokuyenza kukuya kwindawo enenkqubo yokuthatha olu hlobo lwamayeza (ubuncinane cela kwikhemesti) uze uwanike wona.
• Ukuba akunjalo, jonga ibhotile yeyeza okanye ilebheli ukuze ubone ukuba inemiyalelo yokuba ungayilahla njani enkunkuma okanye kwindlu yangasese. Ukuba awuqinisekanga, buza ugqirha wakho okanye ikhemisti.
• Ukuba ungayilahla enkunkuma, khupha iyeza ebhotileni, ulixube nento efana nenkunkuma yekati, umhlaba, okanye ikofu, uyifake kwibhegi okanye kwisikhongozeli esivalwe kakuhle, uze uyilahle enkunkuma.

Okokugqibela, kufuneka ndikuxelele... (Umyalezo Wokuya Ekhaya)

I-Tofacitinib liyeza elibalulekileyo elinokukunceda ulawule imeko yakho. Kodwa khumbula ezi zinto xa uyisebenzisa:

• Thetha nogqirha wakho ngayo yonke into: ezinye izifo zakho, nawaphi na amayeza owasebenzisayo, kunye nazo naziphi na iziphumo ebezingalindelekanga ozifumanayo.
• Landela imiyalelo ngokuchanekileyo: thatha idosi emiselweyo, ngexesha elimiselweyo. Musa ukuyeka ukuyithatha ngequbuliso.
• Lumka: Qaphela iimpawu ezintsha kunye nemiphumo emibi. Ukuba unenkxalabo, xelela ugqirha wakho.
• Musa ukwabelana ngamayeza: Eli lelakho kuphela.
• Lumka ngokukodwa ngexesha lokukhulelwa nokuncancisa.

Ukuba unemibuzo engaphezulu malunga nale yeza, ungathandabuzi ukubuza ugqirha wakho, ikhemisti, okanye umboneleli wezempilo. Baya kukwazi ukukunceda.

I- Tofacitinib, i-Tofacitinib, isifo samathambo, inkqubo yomzimba yokuzikhusela, i-JAK inhibitor, i-Xeljanz, isifo samalungu