Uyazi ngempela ngale hormone "eyingozi" ebizwa ngokuthi i-Adiponectin?

Sonke sizwile ngezinhlobo ezahlukene zama-hormone emizimbeni yethu. Sikhuluma ngamanye awo ngaso sonke isikhathi, ngisho nodokotela bakhuluma ngawo. Kodwa uke wezwa nge-hormone ebizwa ngokuthi i-Adiponectin ? Mhlawumbe awukaze wezwa. Kodwa idlala indima ebaluleke kakhulu emizimbeni yethu, ikakhulukazi ezintweni ezifana nesisindo sethu kanye namazinga kashukela egazini. Ngakho-ke, namuhla, ake sixoxe nge-Adiponectin ngendlela elula neqondile.

Kuyini i-Adiponectin? Kulula kakhulu!

Kalula nje, i-adiponectin iyi-hormone yamaprotheni ekhiqizwa kakhulu ngamaseli amafutha, noma izicubu zamafutha, emizimbeni yethu. Ibizwa nangokuthi i-adipokine , ngoba ikhiqizwa ngokuhambisana namafutha. Kodwa-ke, ayikhiqizwa ngamaseli amafutha kuphela, kodwa nakwezinye izingxenye zomzimba wethu.

Lo mfana obizwa ngokuthi i-Adiponectin watholakala ngawo-1990. Lokho kusho ukuthi ososayensi basafunda okuningi ngayo. Mhlawumbe kunezinye izinto ezenziwa yile hormone esingazazi okwamanje. Ngokwazi kwethu, kusiza kakhulu ukwandisa ukuzwela kwemizimba yethu ku-insulin nokunciphisa ukuvuvukala emzimbeni .

Yiziphi izinzuzo ze-Adiponectin emzimbeni wethu?

Lo mngane obizwa ngokuthi i-Adiponectin uhilelekile ezinqubweni eziningi ezibalulekile emzimbeni wethu. Ake sibheke ezimbili ezibaluleke kakhulu.

1. Indlela yokuzwela imizimba yethu ku-insulin

Uyazi ukuthi iyini i-insulin? Kalula nje, i-insulin ifana nesihluthulelo esivula umnyango wokuvumela ushukela (i-glucose) ungene emangqamuzaneni emizimba yethu. Ukuzwela i-insulin kusho ukuthi lesi sihluthulelo singavula umnyango ngendlela efanele. Khona-ke umzimba ungawusebenzisa kalula ushukela futhi ugcine amazinga kashukela egazini esezingeni elifanele.

Ngakho-ke, nansi indlela i-Adiponectin esiza ngayo:

• Imisipha yakho yamathambo nesibindi kusiza umzimba wakho ukuthi usabele kahle ku-insulin.
• Kwandisa ukukhishwa kwe-insulin kusuka ku-pancreas.
• Kuvimba ukugcinwa okungadingekile koshukela okuthiwa i-glycogen esibindini.
• Kuyasiza ekuqhekekeni kwama-fatty acid futhi kudale amandla.

Cabanga ngakho, amangqamuzana omzimba wakho afana nezindlu. I-insulin yiyo ethwala ukudla okubizwa ngokuthi ushukela kulezo zindlu. I-Adiponectin iyasiza ekungeniseni lokhu kudla ngomnyango. Bese indlu ithola ukudla, akunjalo?

2. Indlela yokunciphisa ukuvuvukala emzimbeni

Ukuvuvukala yilapho amasosha omzimba ethu ethumela amaseli ukulwa nento efana namagciwane noma ukwelapha isilonda. Ngezinye izikhathi lokhu kuyadingeka. Kodwa ukuvuvukala okungapheli, Lokho kusho ukuthi akulungile ukuthi umzimba uhlale unokuvuvukala okuncane ngaphakathi. Cabanga ukuthi uhlala unomlilo omncane emzimbeni wakho... Yilokho okubizwa ngakho ukuvuvukala okungapheli.

I-Adiponectin isiza ekunciphiseni ukuvuvukala ezindaweni ezilandelayo:

• Ama-Macrophage (uhlobo lweseli elimhlophe legazi eligwinya futhi libulale izinto ezifana namagciwane namagciwane)
• Izicubu ze-endothelial (lezi ngamaseli akha ulwelwesi oluncane oluhlanganisa ingaphakathi lenhliziyo nemithambo yegazi)
• Amaseli emisipha
• Amaseli e-Epithelial (lawa amaseli amboza zonke izindawo ngaphakathi nangaphandle komzimba)

Ngokunciphisa ukuvuvukala ngale ndlela, i-Adiponectin ivikela lezi zitho:

• Uhlelo lwemithambo yegazi
• Inhliziyo
• Amaphaphu
• Ikholoni

I-Adiponectin ikhiqizwa kuphi emizimbeni yethu?

I-Adiponectin yenziwa futhi ikhishwe ngokuyinhloko ngamaseli abizwa ngokuthi ama-adipocytes, agcina amandla ezicutshini zethu ezimhlophe zamafutha . Izicubu ezimhlophe zamafutha ziwuhlobo oluyinhloko lwamafutha emizimbeni yethu. Itholakala ku:

• Amafutha angaphansi kwesikhumba - okungukuthi, ungqimba lwamafutha esiluzwayo uma siluthinta.
• Amafutha angaphakathi esiswini - Lawa amafutha angaphakathi esiswini angaba yingozi kancane.
• Umnkantsha wamathambo (amafutha omnkantsha)

I-Adiponectin ingakhiqizwa futhi ngezinye izinhlobo zamaseli:

• Amaseli emisipha yamathambo
• Amaseli emisipha yenhliziyo
• Amaseli e-Endothelial

Alawulwa kanjani amazinga e-adiponectin?

Njengoba ngishilo ngaphambili, i-adiponectin iyinto entsha kakhulu. Ngakho ososayensi basacwaninga ngayo. Kuze kube manje, kutholakale ama-hormone amaningana ukusiza ukulawula amazinga e-adiponectin.

Nakuba i-hormone i-insulin ibonakala ihilelekile kulokhu, akubona bonke abavumelanayo ngokuthi kwenzeka kanjani ngempela.

I-insulin-like growth factor (IGF-1) kanye ne-growth hormone (GH) zilawula ukukhishwa kwe-adiponectin ezicutshini zamafutha. I-Leptin (elinye i-hormone elikhiqizwa amaseli amafutha) nayo ingase ihileleke.

Ungawahlola kanjani amazinga e-Adiponectin?

Ungahlola amazinga akho e-Adiponectin ngokuhlolwa kwegazi .

Odokotela ngezinye izikhathi badidanisa isifo sikashukela sohlobo lwesibili nesifo se-metabolic syndrome.Ukuhlolwa kwegazi kwe-adiponectin kungasetshenziswa ukusiza ekuxilongeni izimo ezifana nalezi:

Amazinga ajwayelekile e-adiponectin kufanele abe njani?

Amazinga ajwayelekile e-adiponectin ayahlukahluka kuye ngobulili bakho kanye ne -Body Mass Index (BMI) , okuyisisindo sakho ngobude bakho.

Izinhlobo ezijwayelekile ze-Adiponectin zamadoda yilezi ezilandelayo:

• Uma i-BMI ingaphansi kwama-25: ama-microgram angu-5 kuya kwangu-37/millilitha (5 kuya ku-37 ug/mL)
• Uma i-BMI iphakathi kuka-25 no-30: 5 kuya ku-28 ug/mL
• Uma i-BMI ingaphezu kuka-30: 2 kuya ku-20 ug/mL

Izinhlobo ezijwayelekile ze-Adiponectin kwabesifazane yilezi ezilandelayo:

• Uma i-BMI ingaphansi kuka-25: 5 kuya ku-37 ug/mL
• Uma i-BMI iphakathi kuka-25 no-30: 4 kuya ku-20 ug/mL
• Uma i-BMI ingaphezu kuka-30: 4 kuya ku-22 ug/mL

Into ebalulekile ukuthi lezi zinombolo zingahluka kancane kumuntu nomuntu kanye naselabhorethri nelabhorethri. Ngakho-ke, hlola ububanzi obujwayelekile embikweni wakho wezabhorethri. Uma unemibuzo mayelana nemiphumela yakho, qiniseka ukuthi ubuza udokotela wakho noma umhlengikazi.

Yiziphi izifo ezingavela uma amazinga e-adiponectin engajwayelekile?

Kunezimo eziningana zempilo ezihlotshaniswa namazinga angajwayelekile e-adiponectin. Lezi zifaka:

• Ukukhuluphala ngokweqile kanye nokukhuluphala ngokweqile
• Ukumelana ne-insulin
• I-atherosclerosis
• I-Lipodystrophy

Eziningi zalezi zimo zihlotshaniswa namazinga aphansi e-adiponectin .

I-Adiponectin kanye nokukhuluphala ngokweqile

Abantu abakhuluphele kakhulu banamazinga aphansi e-adiponectin. Ngakolunye uhlangothi, abantu abancane kakhulu, kungaba ngenxa yezimo ezifana ne -anorexia nervosa noma ukungondleki kahle, banamazinga aphezulu e-adiponectin.

Kalula nje, njengoba amafutha omzimba womuntu ekhula, amazinga e-adiponectin akhe ayancipha. Ngokufanayo, njengoba amafutha omzimba ehla, amazinga e-adiponectin akhe ayanda. Lapho umuntu okhuluphele ehla isisindo, amazinga e-adiponectin akhe ayanda.

I-Adiponectin kanye nokumelana ne-insulin

Ngenxa yokuthi i-adiponectin isiza ekwandiseni ukuzwela kwe-insulin, abantu abanokumelana ne-insulin bavame ukuba namazinga aphansi e-adiponectin. Ukumelana ne-insulin kwenzeka lapho amangqamuzana omzimba wakho engasabeli kahle ku-insulin, okubangela ukuthi umzimba wakho ukhiphe i-insulin eningi kakhulu (i-hyperinsulinemia).

Ngenxa yokumelana ne-insulinIsifo sikashukela sangaphambi kwesifo sikashukela, isifo sikashukela sohlobo 2 , kanye nesifo sikashukela sokukhulelwa singakhula. Lokhu kuvame ukuhlotshaniswa nokukhuluphala. Kodwa-ke, abantu abangakhuluphele kakhulu nabo bangaba nokumelana ne-insulin. Ngokumangazayo, abantu abamelana ne-insulin ngaphandle kokukhuluphala nabo banamazinga aphansi e-adiponectin. Lokhu kusikisela ukuthi kukhona isici sofuzo esihilelekile ekumelaneni ne-insulin kanye ne-adiponectin.

I-Adiponectin kanye ne-Atherosclerosis

I-atherosclerosis yisimo lapho i-plaque inqwabelana khona ngaphakathi kwemithambo yakho, iyivimbe. Kufana nokugqwala okwakheka ngaphakathi kwepayipi lamanzi.

I-Adiponectin inezakhiwo zokulwa nokuvuvukala, ezivikela inhliziyo nemithambo yegazi. Ngakho-ke, lapho amazinga e-adiponectin ephansi, ingozi yokuthola izifo zenhliziyo ezifana ne-atherosclerosis kanye nokuhlaselwa yinhliziyo inganda.

I-Adiponectin kanye ne-Lipodystrophy

I -Lipodystrophy yisifo esingavamile kakhulu esibangela ukulahleka kwamafutha kwezinye izindawo zomzimba kanye nokuqongelela kwamafutha ngokweqile kwezinye.

I-lipodystrophy ingaba khona kusukela ekuzalweni, noma ingakhula kamuva ekuphileni. Amazinga e-Adiponectin aphansi ku-lipodystrophy yokuzalwa kanye ne-HIV ehlobene nayo. Lokhu kungenzeka ngoba i-adiponectin ihilelekile endleleni amafutha omzimba agcinwa ngayo.

Ingabe kukhona ukwelashwa kwamazinga angavamile e-adiponectin?

Eqinisweni, kunezindlela zokwelapha zemvelo ezingasiza ekuthuthukiseni amazinga e-adiponectin. Lokhu kuhlanganisa ukuvivinya umzimba njalo kanye nokwehlisa isisindo okunempilo. Kodwa-ke, kufanele ukhulume nodokotela wakho njalo ngaphambi kokwenza noma yiziphi izinguquko ezinkulu ekudleni kwakho noma ohlelweni lwakho lokuzivocavoca.

Imithi yesifo sikashukela efana ne -metformin kanye ne -thiazolidinediones itholakale ukuthi inyusa amazinga e-adiponectin.

Ososayensi okwamanje bacwaninga ngemithi esebenza ngendlela efanayo ne-Adiponectin yokwelapha izimo zokuvuvukala ezingamahlalakhona. Lokho kungaba izindaba ezinhle kithi maduze nje!

Uyini umehluko phakathi kwe-Adiponectin ne-Leptin?

I-Leptin kanye ne-Adiponectin kokubili ama-hormone enziwa futhi akhishwe yizicubu zakho zamafutha, uhlobo lwama-adipokines. I-Leptin isebenza ngokukhulisa i-metabolism kanye nokunciphisa isifiso sokudla.

Njenge-adiponectin, amazinga angajwayelekile e-leptin nawo ahlotshaniswa nokukhuluphala ngokweqile - kodwa ngendlela ehlukile. Amazinga e-leptin ayanda njengoba amafutha omzimba enyuka. Kodwa-ke, amazinga e-adiponectin ayancipha njengoba amafutha omzimba enyuka. Kulula ukukhumbula, akunjalo?

Okokugcina, into ebaluleke kakhulu

Cishe usuyaqonda manje ukuthi i-adiponectin ibaluleke kangakanani emizimbeni yethu. Njengoba kuyinto entsha etholakele, ososayensi basafunda okwengeziwe ngayo.

Uma unesifo se-metabolic esifana nokukhuluphala ngokweqile noma isifo sikashukela sohlobo 2, kungenzeka ukuthi uke wezwa udokotela wakho ekhuluma nge-adiponectin. Uma wake waba nombuzo mayelana nezwi udokotela wakho alishoyo, ungesabi ukubuza. Balapha ukuzokusiza.

Akukho okufanele ukhathazeke ngakho uma kukhulunywa ngamazinga akho e-adiponectin. Imikhuba emihle yezempilo, ukudla okulinganiselayo, kanye nendlela yokuphila esebenzayo ngokuvamile kuyizindlela ezinhle kakhulu zokugcina la mazinga ama-hormone elawulwa. Ngakho-ke, nakekela umzimba wakho, ngoba impilo iyona nto ebaluleke kakhulu!

I- Adiponectin, i-Adiponectin, i-Hormone, i-Insulin, isifo sikashukela, ukukhuluphala ngokweqile, ukuvuvukala, i-Metabolism, amaseli amafutha