Ake sifunde kabanzi nge-Leptin, ekusiza ngasese ukulawula isisindo sakho.

Sonke sikhathazeka ngesisindo sethu ngezinye izikhathi, akunjalo? Abanye abantu bafuna ukwehlisa isisindo, kanti abanye bafuna ukugcina isisindo esinempilo. Wake wacabanga ukuthi kukhona indlela encane emizimbeni yethu esisiza ukulawula isisindo sethu? I-Leptin ingenye yalezi zilawuli eziyimfihlo. Namuhla, ake sixoxe nge-leptin ngendlela elula ongayiqonda.

Kuyini iLeptin?

Kalula nje, i-leptin iyi-hormone ekhiqizwa amaseli amafutha omzimba wakho, noma izicubu zamafutha . Kufana nohlelo oluncane lokubonisa olukusiza ukulawula isisindo sakho isikhathi eside. Ikwenza kanjani lokho? I-Leptin ilawula indlala yakho futhi ikusiza uzizwe usuthi, noma usuthi .

Cabanga ngale ndlela: i-leptin ifana nesithunywa esitshela ubuchopho bakho ukuthi unamafutha angakanani emzimbeni wakho. Ososayensi bathole i-leptin muva nje ngo-1994. Ngakho-ke kusenocwaningo oluningi oluqhubekayo, ukuze baqonde kahle ukuthi isebenza kanjani. I-Leptin isivele ihlolwa ngendima yayo ekulawuleni isisindo, isifo i-Alzheimer's , impilo yokuzala, kanye nokungabi nabantwana .

Uma uzwa ukuthi i-leptin ilawula isisindo, ungase ucabange, "O... ngakho ngicabanga ukuthi kufanele ngithole indlela yokulawula i-leptin." Kodwa, uma ngikhuluma iqiniso, ukulawula le hormone akulula njengoba ucabanga.

Kwenzekani ngempela nge-leptin?

Umsebenzi oyinhloko we-Leptin ukukusiza ukuthi ugcine isisindo somzimba wakho. Okusho ukuthi, kusiza ukudala ibhalansi yesikhathi eside phakathi kwenani lokudla okudlayo kanye nenani lamandla umzimba wakho owasebenzisayo. I-Leptin ikuvimbela ukuthi uzizwe ulambile ngaso sonke isikhathi. Iphinde ilawule izimpawu zendlala ezifika lapho umzimba ungadingi amandla, noma ama-calories .

I-Leptin isebenza ngokuyinhloko ngokuthinta ingxenye yobuchopho bakho ebizwa ngokuthi i-hypothalamus . I-hypothalamus iyisikhungo esibalulekile sokulawula indlala nokusetshenziswa kwamandla. Kodwa-ke, kunezitho zokwamukela i-leptin kwezinye izingxenye zomzimba.

Into ebalulekile ukuthi i-leptin ayilawuli nje amazinga akho okulamba kusukela ekudleni okukodwa kuya kokulandelayo. Kunalokho, iyasiza ekushintsheni izindlela zakho zokudla ngokuhamba kwesikhathi, ilawule ukusetshenziswa kwamandla akho, futhi ikusize ugcine isisindo sakho.

Uma uzama ukwehlisa isisindo, amazinga e-leptin ayanda. Lokho kusebenza kanjani? Njengoba umzimba wakho ulahlekelwa amafutha, amazinga e-leptin ayancipha. Lokhu kuthumela isignali emzimbeni wakho, ethi, "O, angidli ngokwanele, ngilambile." Lokhu kukwenza uzizwe ulambile kakhulu futhi unezifiso. Lokhu kungaholela ekutheni udle okungaphezu kwalokho okufanele ukudle. Yingakho ngezinye izikhathi kungaba nzima ukugcina ukwehla kwesisindo.

Ososayensi basafunda i-leptin. Bakholelwa ukuthi ithinta futhi:

• I-metabolism yakho
• Uhlelo lwe-endocrine, okungukuthi, uhlelo lwe-hormone
• Isimiso somzimba sokuzivikela

Amazinga e-leptin alawulwa kanjani?

I-Leptin ikhiqizwa futhi ikhishwe yizicubu zamafutha ezimhlophe zomzimba wakho, noma amaseli amafutha amhlophe. Lawa maseli amafutha amhlophe ayilona uhlobo oluyinhloko lwamafutha emizimbeni yethu.

Ngenxa yokuthi i-leptin ivela kuma-fat cell, inani le-leptin egazini lakho lihlobene ngqo nenani lamafutha emzimbeni wakho. Kalula nje, uma unamafutha omzimba amancane, une-leptin encane. Uma unamafutha omzimba amaningi, une-leptin eningi.

Uma isisindo samafutha emzimbeni wakho sikhula ngokuhamba kwesikhathi, amazinga e-leptin ayanda. Ngokuphambene nalokho, uma isisindo samafutha emzimbeni wakho sincipha, amazinga e-leptin ayancipha.

Kwenzekani uma amazinga e-leptin enyuka?

Umuntu okhuluphele kakhulu angaba namazinga aphezulu kakhulu e-leptin emzimbeni wakhe. Lokhu kubizwa ngokuthi i-hyperleptinemia . Uma i-leptin ikhula ngale ndlela, kungavela isimo lapho umzimba ungasabeli ku-leptin. Lokhu kubizwa ngokuthi ukumelana ne-leptin .

Ezinye izimo ezingase zihlotshaniswe ne-hyperleptinemia zifaka:

• Ukucindezeleka
• Umlutha wokudla
• Izinkinga ze-Neurodegenerative
• Isifo sesibindi esinamafutha esingenalo utshwala ( NAFLD )
• I-Rabson-Mendenhall syndrome

Kuyini Ukumelana ne-Leptin?

Uma une-leptin resistance, ubuchopho bakho abuphenduli kahle ku-leptin. Ngisho noma i-leptin iqhubeka nokuthumela izimpawu ebuchosheni bakho, awutholi umuzwa "wokugcwala". Ngenxa yalokho, uyaqhubeka nokudla, noma ngabe unezitolo eziningi zamafutha emzimbeni wakho.

Ngenxa yalokhu kuntuleka okubonakalayo kwe-leptin, umzimba wakho ucabanga ukuthi "ulambile." Ukuze wonge amandla, ubuchopho bakho buyehlisa amazinga akho amandla futhi bunciphise inani lamakhalori owashisa ngenkathi uphumule. Lokhu kusho ukuthi i-Basal Metabolic Rate (BMR) yakho iyehla.

Ngakho-ke, ukumelana ne-leptin kukwenza uzizwe ulambile ngaso sonke isikhathi, kanti ne-BMR yakho nayo iyancipha. Lokhu kwenza ukukhuluphala kube kubi kakhulu.

Ososayensi okwamanje bazama ukuthuthukisa imithi engelapha ukumelana ne-leptin.

Izimpawu zokumelana ne-leptin

Izimpawu eziyinhloko zokumelana ne-leptin yindlala engapheli, noma i-hyperphagia , kanye nokudla ukudla okwengeziwe. Lezi zimpawu zenzeka uma unamafutha amaningi emzimbeni, mhlawumbe ngisho namafutha amaningi.

Kodwa-ke, lezi zimpawu zingase zibangelwe ezinye izici eziningi, hhayi nje ukumelana ne-leptin. Njengoba ososayensi besafunda nge-leptin, kungenzeka ukuthi izimpawu ezengeziwe zokumelana ne-leptin zizotholakala esikhathini esizayo.

Kwenzekani uma une-Leptin Deficiency?

Ukuntuleka kwe-Leptin, okwaziwa nangokuthi i-hypoleptinemia, kuyisimo esingavamile kakhulu. Isimo esiyinhloko esihambisana nalokhu ukuntuleka kwe-leptin yokuzalwa . Lesi yisimo sofuzo ozalwa naso. Lokhu kusho ukuthi izicubu zakho zamafutha azikwazi ukukhiqiza i-leptin.

Uma i-leptin ilahleka, umzimba wakho ucabanga ukuthi akukho mafutha emzimbeni. Lokhu kuphumela ekulambeni nasekufiseni okungalawuleki. Ngenxa yalesi sizathu, izingane ezincane ezizalwa nazo ezintula i-leptin ziba nokukhuluphala kwesigaba sesi-3 kanye nokuthomba okulibazisekile.

Lesi simo sihlotshaniswa nezinye izifo eziningana:

• I-Dyslipidemia (ukungalingani kwamafutha, njenge-cholesterol kanye ne-triglycerides)
• Isifo sesibindi esinamafutha
• Ukutheleleka njalo kwamagciwane
• I-Hyperinsulinemia (ukukhiqizwa kwe-insulin ngokweqile)
• I-hypogonadotropic hypogonadism (amazinga aphansi ama-hormone ocansi)

Ungahlola kanjani amazinga e-leptin?

Ukuhlolwa kwegazi kungahlola amazinga akho e-leptin. Kodwa-ke, odokotela abavamisile ukuhlola amazinga e-leptin awo wonke umuntu. Bacabanga kuphela ukwenza ukuhlolwa kwe-leptin kulezi zimo:

• Uma ingane yakho encane ikhuluphele kakhulu esigabeni sesi-3
• Uma ukhuluphele futhi uzizwa ulambile njalo

Ayini amazinga ajwayelekile e-leptin?

Ngokuvamile, amazinga e-leptin angahluka kusuka ku:

• Kwabesifazane: 0.5 kuya ku-15.2 nanograms nge-milliliter ( 0.5 kuya ku-15.2 ng/mL )
• Kwabesilisa: 0.5 kuya ku-12.5 nanograms nge-milliliter ( 0.5 kuya ku-12.5 ng/mL )

Noma kunjalo, la manani ajwayelekile angahluka kancane kusuka elabhorethri kuya kwelebhu. Ngakho-ke, qiniseka ukuthi uhlola ububanzi obujwayelekile embikweni wakho wokuhlolwa, noma ubuze udokotela wakho uma unemibuzo mayelana nemiphumela yakho.

Ngingawandisa kanjani amazinga ami e-leptin?

Eqinisweni, akukho okuningi ongakwenza ukwandisa amazinga akho e-leptin ukuze unciphise indlala noma isifiso sokudla. Lokho kungenxa yokuthi amazinga akho e-leptin ahlobene ngqo nenani lezicubu zamafutha onazo emzimbeni wakho.

Ucwaningo olulodwa luthole ukuthi abantu abangalali ngokwanele banamazinga aphezulu e-ghrelin (i-hormone yendlala) kanye namazinga aphansi e-leptin. Ngakho-ke, ukulala ngokwanele kungasiza ukugcina ama-hormone akho elinganisela.

Ososayensi baxhumanise i-leptin ne- triglycerides(Lolu futhi uhlobo lwamafutha olubizwa ngokuthi ama-lipid). Ezinye izifundo zibonise ukuthi uma amazinga e-triglyceride ephezulu, kuthinta indlela i-leptin esebenza ngayo. Kodwa kunemibono ehlukene ngalezi zifundo. Abanye ososayensi bacabanga ukuthi ukudla okuklanyelwe ukwehlisa ama-triglyceride kungasiza ekwandiseni amazinga e-leptin, kodwa abanye abavumelani.

Yikuphi ukudla okune-leptin eningi?

I-Leptin iyi-hormone ekhiqizwa ngumzimba wakho, hhayi isakhi esifana ne-vitamin C noma iphrotheni. Ngakho-ke, akukho ukudla okuqukethe i-leptin.

Ngenxa yokuthi i-leptin iyinto entsha sha, ososayensi basafunda kabanzi ngayo, ikakhulukazi ukuthi ithinta kanjani ukukhuluphala kanye nokwehla kwesisindo. Uma amafutha omzimba wakho ephansi, kungaba nzima ukunciphisa isisindo ngenxa yendima ye-leptin ekusebenziseni isignali "yendlala" yomzimba.

Umlayezo Wokuya Nawe Ekhaya

Kulungile, ngakho-ke kulokho esikhulume ngakho nge-leptin, ungakhumbula lokhu:

• I-Leptin iyi-hormone ekhiqizwa amaseli akho amafutha .
• Into eyinhloko ngalokhu ukuthi kukusiza ukulawula isisindo sakho ngokuhamba kwesikhathi futhi kukunikeza umuzwa "wokugcwala" .
• Uma amafutha omzimba wakho enyuka, amazinga e-leptin ayanda , futhi uma amafutha omzimba wakho ehla, amazinga e-leptin ayancipha.
• Ukumelana ne-leptin kwenzeka lapho umzimba une-leptin kodwa ubuchopho bungasabeli kahle kuyo. Lokhu kungaholela ekukhuluphaleni.
• Ukuntuleka kwe-Leptin akuvamile kakhulu .
• Akukho ukudla okuqukethe i-leptin, ngoba ikhiqizwa emzimbeni.
• Indlela yokuphila enempilo, ikakhulukazi ukulala kahle , ingasiza ekulinganiseni ama-hormone.

Uma ukhathazekile ngesisindo sakho noma udinga iseluleko sendlela yokwehlisa isisindo ngendlela enempilo, khuluma nodokotela wakho. Ungabona nodokotela ochwepheshe bama-hormone, isazi se -endocrinologist, ukuze nixoxe ngezinhlelo zokulawula isisindo. Into ebaluleke kakhulu ukunakekela impilo yakho kuqala.

I- Leptin, ukulawula isisindo, ama-hormone, ukukhuluphala, ukumelana ne-leptin, indlala, ukusutha