Wake wazizwa sengathi indandatho oyigqoka njalo isinamathele emunweni wakho? Noma ukuthi usayizi wesicathulo sakho, ikakhulukazi ububanzi, usukhulu kunokujwayelekile? Ngezinguquko ezincane kangaka, uzizwa sengathi ukuma kobuso bakho nakho kuyashintsha kancane kancane? Ungase ungazinaki kakhulu lezi. Kodwa lezi kungaba izimpawu zesimo esingavamile kodwa esikhathazayo esibizwa ngokuthi i-Acromegaly. Ake sixoxe ngalokhu namuhla.

Kalula nje, iyini i-Acromegaly?

I-Acromegaly yisimo esingavamile kodwa esibucayi esenzeka lapho umzimba wakho une -hormone yokukhula (GH) eningi kakhulu. Le hormone ivame ukukhiqizwa yi-pituitary gland, i-gland engangophizi etholakala phansi kobuchopho bakho. Kodwa-ke, ku-acromegaly, le hormone ikhiqizwa kakhulu ngenxa yesimila esise-pituitary gland noma kwenye indawo emzimbeni.

I-Growth Hormone ibalulekile ukuze izingane zikhule zinde futhi zikhule. Kodwa uma sesibadala, ngemva kokuba amapuleti okukhula emathanjeni ethu evaliwe, le hormone ayisakhulisi ukuphakama kwethu. Kodwa imizimba yethu yabantu abadala nayo iyayidinga le hormone. Iwukugcina isakhiwo esinempilo samathambo ethu, i-cartilage, kanye nezitho zomzimba, ukwenza i-metabolism ngendlela efanele, nokugcina amazinga kashukela egazini esezingeni elifanele.

Kodwa-ke, uma i-hormone yokukhula emzimbeni womuntu omdala ikhula kakhulu, kungavela izinkinga eziningi, njengokushintsha okungajwayelekile esimweni samathambo, ukwandiswa kwezitho zomzimba, kanye nokwanda koshukela egazini (i-hyperglycemia).

Uyini umehluko phakathi kwe-Acromegaly ne-Gigantism?

Zombili lezi zimo zibangelwa ukwanda kwe-Growth Hormone (GH). Umehluko useqenjini leminyaka elithintekile.

• I-Gigantism: Lokhu kwenzeka ezinganeni. Lokhu kusho ukuthi uma i-GH hormone ikhula ngaphambi kokuthomba, ngaphambi kokuba ama-growth plates amathambo avaleke, lezo zingane zikhula zibe zinde ngendlela engavamile. Lesi yisimo esingavamile kakhulu kune-acromegaly.
• I-Acromegaly: Lokhu kwenzeka kubantu abadala. Njengoba kushiwo ngaphambili, ngemva kokuvala ama-growth plate, i-GH iyanda, kodwa esikhundleni salokho isimo samathambo ezandleni, ezinyaweni nasebusweni siyashintsha futhi siba sikhulu.

Ubani othola i-acromegaly? Kuvamile kangakanani lokhu?

I-Acromegaly yisifo esingavamile kakhulu. Ngokwezibalo, abantu abaphakathi kuka-3 no-14 kwabangu-100,000 batholakale benalesi sifo. Nakuba singakhula kunoma yimuphi ubudala ngemva kokuthomba, lesi sifo sivame ukutholakala kakhulu eminyakeni ephakathi, okungukuthi, phakathi kweminyaka engu-40 no-50.

Lesi simo sithinta kanjani umzimba?

Uma i-Growth Hormone (GH) ikhula, itshela isibindi sethu ukuthi sikhiqize enye i-hormone. Ibizwa ngokuthi `I-Insulin-like Growth Factor 1 (IGF-1)`. Le hormone ebizwa ngokuthi i-IGF-1 empeleni yenza amathambo nezicubu zethu zikhule, futhi ilawula noshukela wegazi kanye nama-lipid. Ngakho-ke, lapho i-GH ikhula, i-IGF-1 nayo iyanda kakhulu. Ngenxa yalokho, izimo ezibucayi ezifana nesifo sikashukela sohlobo lwesibili, umfutho wegazi ophezulu, kanye nesifo senhliziyo zingavela.

Ziyini izimpawu ze-acromegaly?

Izimpawu ze-acromegaly zivela kancane kakhulu, eminyakeni eminingi. Ngakho-ke kungaba nzima ukuzibona ezigabeni zokuqala. Ungase ukwazi ukubona izinguquko ebusweni bakho kuphela uma ubheka isithombe sakho esidala.

Ithebula elingezansi libonisa ngokucacile ukuthi lezi zimpawu ziyini.

Uma unesinye noma ngaphezulu salezi zimpawu, kubaluleke kakhulu ukubona udokotela wakho ngokushesha bese ukhuluma ngalokhu.

I-acromegaly ihlolwa kanjani?

Uma ubona udokotela, uzolalela ngokucophelela izimpawu zakho, ahlole umzimba, bese eyala ukuhlolwa okuningana ukuqinisekisa ukuxilongwa.

• Ukuhlolwa kwegazi: Lokhu kubaluleke kakhulu. Kulinganisa amazinga e-GH kanye ne-IGF-1 egazini lakho.
• Ukuhlolwa Kwezithombe: Uma ukuhlolwa kwegazi kuqinisekisa ukuthi amazinga e-GH aphezulu, kungacelwa ukuthi kwenziwe i -MRI scan ukuze kuhlolwe isimila se-pituitary.

Uma lesi sifo siqinisekiswa, kungenziwa ukuhlolwa okwengeziwe ukuze kubonakale ukuthi ngabe sithinte ezinye izingxenye zomzimba.

• I- echocardiogram yokuhlola ukusebenza kwenhliziyo.
• Ucwaningo lokulala ukuze kubonakale ukuthi uyacinana yini ngenkathi ulele.
• I-Colonoscopy ukuhlola impilo ye-colon.
• I- X-ray noma i-DEXA scan ukuhlola impilo yamathambo.

Yiziphi izindlela zokwelapha i-acromegaly?

Kunezindlela eziningana zokwelapha i-acromegaly. Udokotela wakho uzonquma ukuthi yikuphi ukwelashwa okungcono kakhulu kuwe ngokusekelwe esimweni sakho, ubukhulu kanye nendawo yesimila.

1. Ukuhlinzwa: Lena yindlela yokwelapha eyinhloko kubantu abaningi. Inqubo evame kakhulu ibizwa ngokuthi i-Transsphenoidal Surgery . Lokhu kuhilela ukususa isimila se-pituitary gland ngekhala. Uma isimila sisusiwe ngokuphelele, kunethuba elihle lokwelashwa okuphelele.

2. Imithi: Uma ukuhlinzwa kungakwazi ukususa ngokuphelele isimila, noma uma kudingeka ukunciphisa isimila ngaphambi kokuhlinzwa, kusetshenziswa imithi. Le mithi ilawula amazinga e-GH emzimbeni. Abanye abantu kungadingeka bathathe imithi isikhathi eside.

3. Ukwelashwa Ngemisebe: Lokhu kwelashwa kusetshenziselwa ukubhubhisa noma yiziphi izingxenye ezisele zesimila lapho ukuhlinzwa kanye nemithi kungakwazi ukulawula lesi sifo.

Yiziphi izinkinga ezingaba khona uma zingelashwa?

Uma ingelashwa, i-acromegaly ingaholela ezinkingeni zempilo ezinkulu ngokuhamba kwesikhathi. Lesi yisici esiyingozi kakhulu salesi sifo.

• Isifo Sikashukela Sohlobo 2
• Umfutho wegazi ophezulu (i-Hypertension)
• Isifo senhliziyo, ikakhulukazi i-cardiomyopathy
• Isifo samathambo
• Ama-polyp ekholoni - Lawa angaphenduka umdlavuza kamuva.
• Ukwehluleka Kwezitho Zomzimba

Ngakho-ke, kubaluleke kakhulu ukubonana nodokotela ngokushesha okukhulu uma unezimpawu futhi ulandele ukwelashwa okunqunyiwe uma isifo sitholakala. Uma amazinga e-GH elawulwa ngokwelashwa, ingozi yalezi zinkinga ingancishiswa kakhulu.