Uma iningi lethu lizwa igama elithi isifo sikashukela, silicabanga njengesifo esithinta amazinga kashukela emzimbeni, inhliziyo, izinso, namehlo. Kuyiqiniso lokho. Kodwa bewazi, ucwaningo lwamuva luthole ukuthi isifo sikashukela singathinta ngqo ubuchopho bethu kanye nenkumbulo yethu. Abanye odokotela basebenzisa ngisho negama elisha lalesi simo, elithi 'Isifo Sikashukela Sohlobo 3'. Ngakho-ke namuhla, ake sixoxe ngalokhu.
Siyini ngempela isifo sikashukela 'sohlobo 3'?
Kalula nje, igama elithi 'uhlobo lwesithathu lwesifo sikashukela' liyigama abanye ochwepheshe abaliphakamisile ngesifo i-Alzheimer's. Isizathu ukuthi bakholelwa ukuthi imbangela eyinhloko yezinye izinhlobo zesifo i-Alzheimer's umonakalo ongenziwa yisifo sikashukela ebuchosheni ngokuhamba kwesikhathi.
Isikhathi eside, ososayensi babecabanga ukuthi i-hormone i-insulin ayihlobene nokusebenza kobuchopho. Kodwa manje sesiyazi ukuthi akunjalo. I-insulin iyahamba iye emangqamuzaneni ethu obuchopho. Futhi le insulin ibaluleke kakhulu ekucabangeni nasekukhumbuleni kwethu.
Ngakho-ke, uma ubuchopho bakho bungatholi i-insulin eyanele, noma uma bungakwazi ukusebenzisa i-insulin, buthola kahle (lokhu sikubiza ngokuthi ukumelana ne-insulin), ukusebenza kwansuku zonke kwamangqamuzana obuchopho kuqala ukuwohloka. Yilokhu okwenzekayo esifweni i-Alzheimer's.
Kodwa into eyodwa ebalulekile ukuyikhumbula. 'Isifo sikashukela sohlobo lwesithathu' asikabi yisifo esamukelekayo sezokwelapha. Sisesesigabeni socwaningo. Ngakho-ke, akekho udokotela ozokutshela ngokusemthethweni ukuthi unesifo 'sesifo sikashukela sohlobo lwesithathu'.
Kungani lokhu kwenzeka? Yiziphi izizathu?
Ucwaningo lubonise ngokusobala ukuthi abantu abanesifo sikashukela sangaphambi kwesifo sikashukela noma isifo sikashukela sohlobo 2 basengozini enkulu yokuthola isifo i-Alzheimer's kanye nezinye izifo zokulahlekelwa yingqondo kamuva ekuphileni. Lokhu kungenxa yezici eziningana.
1. Ukulimala nokuvuvukala kwemithambo yegazi (Ukuvuvukala)
Isifo sikashukela sandisa ingozi yesifo senhliziyo kanye nesifo sohlangothi. Futhi, lapho amazinga kashukela egazini ekhuphuka, ukuvuvukala kwenzeka emzimbeni. Lokhu akukuhle emithanjeni yethu yegazi. Lapho imithambo yegazi ebucayi ebuchosheni yonakele ngale ndlela, kungavula indlela yesifo i-Alzheimer's.
2. Ukuphazamiseka kokuxhumana phakathi kwamangqamuzana ezinzwa
Uma amazinga kashukela egazini ekhuphuka, amaqoqo amaprotheni abizwa ngokuthi i-beta-amyloid ayakhelana ebuchosheni. La maqoqo ayahlangana futhi abambeke phakathi kwamaseli ezinzwa ebuchosheni. Njengemijaho yezimoto emgwaqweni, la maqoqo amaprotheni avimbela amaseli ezinzwa ukuthi axhumane. Lesi yisici esibalulekile sesifo i-Alzheimer's.
3. Ukugoba kweprotheni ye-Tau
Cabanga ukuthi ubuchopho bethu bunesimiso samapayipi amancane (ama-microtubules) athutha izakhamzimba emuva naphambili ngaphakathi kwamangqamuzana ezinzwa. Iphrotheni ebizwa ngokuthi i-tau isebenza 'njengomqaphi' wokugcina lesi simiso samapayipi sihlelekile futhi singaduki. Ebuchosheni bomuntu onesifo i-Alzheimer's, le phrotheni ye-tau iyaxakaxaka. Ngemuva kwalokho uhlelo lwamapayipi luyavaleka, amangqamuzana awakwazi ukuthutha lokho akudingayo, futhi amangqamuzana ayafa. Ezinye izifundo zithole ukuthi kunezinye zalezi protein ze-tau ezixakaxaka ebuchosheni babantu abanesifo sikashukela.
4. Ukumelana ne-insulin
Lena yinhliziyo yomqondo 'wesifo sikashukela sohlobo 3'. Njengamaseli emzimbeni, lapho amaseli obuchopho engasabeli kahle ku-insulin, lawo maseli awatholi amandla (uphethiloli) awadingayo. Khona-ke ukusebenza kobuchopho kuyaphazamiseka. Futhi, ukumelana ne-insulin ebuchosheni kwandisa isimo esiyingozi esibizwa ngokuthi ukucindezeleka kwe-oxidative.
| Ezinye izinto ezandisa ingozi | |
|---|---|
| Izici Zofuzo | Iziguli ezingaphezu kwengxenye ezine-Alzheimer's zine-gene ebizwa ngokuthi i-APOE4. Le gene itholakale yenza kube nzima ngobuchopho ukusebenzisa i-insulin. |
| Indlela Yokuphila | - Ukucindezeleka Okungapheli - Ukuntuleka kokuzilolonga - Ukudla okunama-calories amaningi, ushukela namafutha, kanye ne-fiber ephansi |
Yiziphi izimpawu zalesi simo?
Izimpawu ezihlobene nomqondo 'wesifo sikashukela sohlobo 3' zifana nezesifo i-Alzheimer's. Lezi zingabonakala ezigabeni zokuqala.
| Isigaba sezimpawu | Izibonelo |
|---|---|
| Izinkinga ngenkumbulo nokucabanga | - Ukukhohlwa izinsuku noma imicimbi ebalulekile. - Ukubuza umbuzo ofanayo ngokuphindaphindiwe. - Ubunzima bokulandela into enezinyathelo eziningana, njengeresiphi. - Ukukhohlwa lokho obufuna ukukusho ngenkathi ukhuluma. |
| Izinguquko emisebenzini yansuku zonke | - Ukukhohlwa ukusebenzisa idivayisi esisetshenziswe isikhathi eside (isb. i-remote ye-TV). - Ukushiya izimpahla ezindaweni ezingajwayelekile. - Ukulahlekelwa isithakazelo ekuhlanzekeni. - Ukwenza izinqumo ezimbi mayelana nemali. |
| Ukushintsha kokuziphatha kanye nemizwa | - Kancane kancane uzihlukanise nabangani nomndeni. - Ukungathandi ukuphuma 'endaweni yakho yokunethezeka'. - Ukuthukuthela noma ukukhathazeka kalula. |
Uma wena noma othandekayo wakho enanoma yiziphi zalezi zimpawu, ikakhulukazi uma nawe unesifo sikashukela, sicela ukhulume nodokotela wakho ngazo. Ungazinaki.
Ake sifunde ngokuxilongwa kanye nokwelashwa.
Njengoba sishilo ngaphambili, akukho ukuxilongwa okusemthethweni kwesifo sikashukela sohlobo lwesithathu, ngakho udokotela akanakwenza ukuhlolwa ukuze akuqinisekise. Kodwa-ke, uma unezinkinga ngenkumbulo yakho, udokotela wakho uzokuhlolela i-dementia.
Lokhu kungafaka phakathi imibuzo yesimo sengqondo, ukuskena kobuchopho (i-MRI noma i-CT scans), kanye nokuhlolwa koketshezi lomgogodla ngezinye izikhathi.
Uma kukhulunywa ngokwelashwa, akukho ukwelashwa okuqondile 'kwesifo sikashukela sohlobo 3'. Kodwa kunezinto ezimbili ezibaluleke kakhulu ongazenza:
1. Uma unesifo sikashukela, silawule kahle. Kubalulekile ukusebenzisa imithi oyinikezwe udokotela wakho ngqo futhi ulawule amazinga kashukela egazini lakho.
2. Thola ukwelashwa kwamanje kwesifo i-Alzheimer's. Nakuba lokhu kwelashwa kungeke kuphulukise lesi sifo ngokuphelele, kungasiza ekunciphiseni izinga lapho izimpawu ziba zimbi khona.
Ucwaningo oluthile luye lwaphakamisa nokuthi eminye imithi yesifo sikashukela, njenge-metformin kanye ne-pioglitazone, inganciphisa ingozi yokuba nesifo sengqondo esishintshashintshayo kamuva ekuphileni. Ucwaningo olwengeziwe luyaqhubeka.
Ungayivikela kanjani impilo yobuchopho bakho futhi unciphise le ngozi?
Ukuze sihlale siphephile kule ngozi, kunezinto ezibaluleke kakhulu esingazifaka endleleni yethu yokuphila. Lezi zinhle kakhulu empilweni yobuchopho bakho, kanye nomzimba wakho wonke.
- Hlala umatasa: Vivinya umzimba imizuzu engama-30 ngosuku, okungenani izinsuku ezi-5 ngesonto. Khetha into oyithandayo. Kungaba yinoma yini, njengokuhamba, ukudansa, noma ukugibela ibhayisikili.
- Gwema ukubhema: Uma ubhema, cela usizo kudokotela wakho ukuze uyeke.
- Gcina isisindo esinempilo: Yidla izithelo eziningi, imifino, okusanhlamvu okuphelele (njengelayisi elinsundu), inyama engenamafutha amaningi, kanye nemikhiqizo yobisi enamafutha aphansi. Yehlisa ushukela namafutha agcwele.
- Nakekela umfutho wegazi lakho: Uma udokotela wakho ekunike imithi, yithathe njengoba uyalelwe.
- Lala kahle: Zama ukulala kahle amahora angu-7-8 nsuku zonke.
- Yiba nobudlelwano nabantu: Chitha isikhathi nabangani nomndeni. Isizungu kanye nokuzihlukanisa akukuhle ebuchosheni.
- Funda izinto ezintsha: Izinto ezifana nokufunda ulimi olusha, insimbi yomculo, noma ukuxazulula amaphazili zakha ukuxhumana okusha phakathi kwamangqamuzana obuchopho.
Umlayezo Wokuya Nawe Ekhaya
- Igama elithi 'isifo sikashukela sohlobo 3' lisetshenziswa ukuchaza umonakalo wobuchopho obangelwa isifo sikashukela ongaholela esifweni i-Alzheimer's. Kodwa-ke, lokhu akukabi ukuxilongwa okusemthethweni okwamanje.
- Amazinga aphezulu kashukela egazini kanye nokumelana ne-insulin kungalimaza kakhulu amangqamuzana obuchopho bakho futhi kuphazamise inkumbulo.
- Uma unesifo sikashukela, ukugcina amazinga kashukela egazini lakho elawulwa kahle kubaluleke kakhulu empilweni yomzimba wakho kanye nengqondo.
- Uma ubona noma yikuphi ukulahlekelwa noma ushintsho enkumbulo yakho, ikakhulukazi uma unesifo sikashukela, ungakushayi indiva bese ukhuluma nodokotela wakho ngokushesha.
- Ngokulandela indlela yokuphila enempilo (ukudla okuhle, ukuvivinya umzimba, ukuxhumana nabantu) ungavikela umzimba wakho kanye nobuchopho bakho.
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