Ingabe ngezinye izikhathi uzwa ukuvuvukala okungazelelwe emzimbeni wakho? Kungaba yi-angioedema!

Wake waphawula ukuthi izindebe zakho ziyavuvukala ngokuzumayo, noma ukuthi amehlo akho azizwa evuvukile? Ngezinye izikhathi ubuso bakho bonke, ngisho nezandla nezinyawo zakho, kuyavuvukala. Kuvamile ukuzizwa wesaba kancane uma kwenzeka into efana nale. Isikhathi esiningi, lokhu kubangelwa yisimo esibizwa ngokuthi i-angioedema . Ake sixoxe ngalokhu ngokuningiliziwe, kalula nje, kulungile?

Kuyini i-Angioedema? Masiyiqonde kalula!

Kalula nje, i-Angioedema ukuvuvukala kwezicubu ezingaphansi kwesikhumba sethu, ikakhulukazi i-dermis, ungqimba lwangaphakathi lwesikhumba, noma izingqimba ezingaphansi kolwelwesi lwamafinyila. Lokhu kwenzeka njengokusabela kokuthile. Kungenzeka ukuthi uke wezwa ngesimo esibizwa ngokuthi i-urticaria , noma ama-hives . I-Angioedema nama-hives kuvame ukwenzeka ndawonye, ​​futhi izimbangela zifana kakhulu. Kuzo zombili izimo, uketshezi luvuza emithanjeni yethu yegazi emincane luye ezicutshini, okubangela ukuthi izindawo zivuvuke.

I-Angioedema ivame ukuqala ngokuzumayo bese iphela phakathi nosuku olulodwa noma ezimbili. Ithinta kakhulu izindebe kanye namehlo azungezile . Kodwa, ake ucabange, uma lokhu kuvuvukala kuthinta imigudu yethu yokuphefumula, kungaba yingozi kakhulu, ngisho nokufa . Ngakho-ke kudingeka siqaphele nalokho futhi.

Yiziphi izinhlobo eziyinhloko ze-angioedema?

Kunezinhlobo eziningana ze-angioedema. Izinhlangano ezahlukene zezempilo zingazihlukanisa ngezindlela ezahlukene, kodwa ngokuvamile, singabona izinhlobo eziningana eziyinhloko.

1. I-angioedema ebukhali yokungezwani komzimba

Cishe lolu uhlobo oye wezwa ngalo futhi waluzwa kakhulu. Luyenzeka uma ubhekene nento ethile onayo i-allergy kuyo . Lokhu kungaba yinto oyidlile (ukudla, isiphuzo), uphuze umuthi, noma uyithinte (isibonelo, into eyenziwe nge-latex yerabha yemvelo). Lungenzeka futhi ngemva kokulunywa yisinambuzane noma isicabucabu.

I-angioedema ebukhali yokungezwani komzimba ivele ngokushesha kakhulu , ngokuvamile phakathi kwemizuzu embalwa kuya ehoreni elilodwa noma amabili, ngemva kokuchayeka ku-allergen. Lokhu kuvuvukala kuvame ukuhambisana nama-hives.

2. I-Angioedema ebangelwa ukusabela kwemithi okungeyona i-allergy

Lolu hlobo lwe-angioedema aluveli ngokushesha ngemva kokuthatha umuthi. Uhlobo oluyinhloko lwemithi ebangela lokhu kusabela okungenalo i-allergy yi- angiotensin-converting enzyme inhibitors , noma i-ACE inhibitors noma i-ACEIs ngamafuphi.Le mithi ivame ukusetshenziselwa ukwandisa imithambo yegazi, ukwelapha izifo zenhliziyo, kanye nokwehlisa umfutho wegazi ophakeme. Imithi elwa nokuvuvukala engeyona eye-steroidal (ama-NSAID) , njenge- ibuprofen kanye ne-naproxen, nayo ingabangela lolu hlobo lwe-angioedema.

3. I-Angioedema yembangela engaziwa (i-Idiopathic angioedema)

Igama elithi " idiopathic" lisho ukuthi "imbangela engaziwa." Ngakho-ke kunzima ukuthola imbangela ethile yalolu hlobo lwe-angioedema. Ukuvuvukala kuvame ukwenzeka ebusweni, ezingalweni, esiqwini nasemilenzeni. Abanye abantu bangase babe nezinkinga zesimiso somzimba sokuzivikela kanye nokucindezeleka.

4. I-angioedema yefa (HAE)

Lokhu kuyi -angioedema edluliselwa ngefa , eyaziwa nangokuthi i-HAE ngamafuphi. Lokhu kuyinto oyithola kubazali bakho ngezakhi zofuzo zakho. Izingane zingayithola ngisho noma umzali oyedwa kuphela onezakhi zofuzo, noma noma ngabe zinalesi sifo. Abanye abantu bangaphinde babe nalolu hlobo lwe-angioedema ngenxa yokuguquka kwezakhi zofuzo okuzenzakalelayo. Kulinganiselwa ukuthi cishe umuntu oyedwa kwabangu-50,000 angaba nalolu hlobo lwe-angioedema edluliselwa ngefa (HAE). Kunezinhlobo ezintathu eziyinhloko zalokhu, ngayinye yazo ihlobene ngandlela thile namazinga e -C1 protein kanye/noma i-C1 esterase inhibitor egazini lethu.

5. Ukuntuleka kwe-C1 inhibitor angioedema

Lokhu futhi kubangela i-angioedema, kodwa akuyona into ezuzwe njengefa. I-Acquired isho ukuthi awuzalwanga une-deficiency, kodwa uyihlakulela kamuva ekuphileni. Njengezinye izinhlobo, lolu hlobo lwe-angioedema lungathinta i-larynx yakho, noma i-windpipe, futhi lungabangela ukuminyana. Uma unesimo esifana ne -B-cell lymphoma, lesi simo sibizwa ngokuthi i-Acquired C1 inhibitor deficiency.

6. I-Angioedema ebangelwa ukudlidliza (i-Vibratory angioedema)

Kulesi simo, ukuvuvukala kubangelwa ukudlidliza okuqhubekayo. Isibonelo, lokhu kungenzeka uma ugibela isithuthuthu, ugijima, ugijima, uthola ukubhucungwa okunamandla, noma wenza eminye imisebenzi efanayo. I-vibratory angioedema ingenye indlela yesimo esingavamile esibizwa ngokuthi i-chronic inducible urticaria . Kuyo, kuvela ama-hives ngenxa yezinto zangaphandle ezifana nokubanda, ukushisa, amanzi, ingcindezi, noma ukudlidliza. Ama-welts alumayo ayaqhubeka futhi ahlala cishe amasonto ayisithupha.

Ubani onamathuba amaningi okuthuthukisa i-angioedema?

Eqinisweni, noma ubani angaba ne-angioedema. Kulinganiselwa ukuthi phakathi kuka-20% no-25% wabantu baseMelika bazobhekana ne-angioedema kanye/noma i-urticaria okungenani kanye empilweni yabo. Ngakho-ke lesi simo sivamile naseSri Lanka.

Ziyini izimpawu ze-angioedema? Uzibona kanjani?

Izimpawu eziyinhloko ze-angioedema yilezi:

• Ukuvuvukala noma ukuvuvuka kobuso , ikakhulukazi eduze kwamehlo nomlomo, okuhlanganisa nezindebe nolimi. Cabanga uvuka ekuseni bese ngokuzumayo izindebe zakho zivuvuka kangangokuthi uzizwa sengathi kunzima ukukhuluma.
• Uma amathumbu akho evuvukala, ungase ube nezinkinga zokugaya ukudla . Lokhu kufaka phakathi ubuhlungu besisu, uhudo, isicanucanu kanye nokuhlanza.
• Ukuvuvukala kwezandla, izinyawo, noma izindawo zobulili.
• Izinguquko ekucindezelekeni kwegazi zingabangela izinto ezifana nesiyezi noma ukuquleka .
• Ukuvuvukala komlomo, umphimbo, noma imigudu yomoya kungenza kube nzima ukuphefumula nokukhuluma. Lena yinto eyingozi kakhulu. Uma kwenzeka into efana nale, kuyisimo esiphuthumayo sezokwelapha. Udinga ukuya esibhedlela ngokushesha!

Okubaluleke kakhulu: Uma umphimbo wakho uvuvukala futhi uzizwa sengathi unenkinga yokuphefumula, akulona ihlaya. Funa iseluleko sezokwelapha ngokushesha.

Kungani kwenzeka i-angioedema? Ziyini izimbangela?

Izimbangela ze-angioedema ziyahlukahluka kuye ngohlobo lwe-angioedema onayo. Kodwa-ke, imbangela evame kakhulu ukungezwani komzimba . Kunezinhlobo eziningi zokungezwani komzimba ezingayibangela:

• Ukungezwani nokudla: Ngokuyinhloko ubisi, amaqanda, amantongomane afana nama-cashew, kanye nokudla kwasolwandle okufana ne-shellfish yikona okubangela lokhu.
• Ukungezwani nemithi: Ama-antibiotic afana nemithi ye-penicillin kanye ne-sulfa, imithi engeyona i-steroidal anti-inflammatory (NSAIDs), kanye ne-contrast media esetshenziswa kwezinye izivivinyo zezithombe kungabangela lokhu. Lezi zinhlobo zokungezwani nemithi zingabangela ama-hives.
• I-Venom: Ubuthi obukhishwa ukulunywa yizinambuzane, futhi akuvamile ukuthi bukhiqizwe yizilwane ezifana nesicabucabu esinsundu esihlala sisodwa.
• I-latex yerabha yemvelo: I-Latex iyinto esetshenziselwa ukwenza izinto ezifana namagilavu, amabhaluni, amakhondomu, kanye nama-catheter ezokwelapha. Udokotela wakho kungenzeka ukuthi ukubuzile ukuthi une-allergy yini ne-latex.

Ezinye izimbangela zifaka phakathi izinkinga zofuzo kanye nezinkinga zakamuva ngeprotheni ye-C1 inhibitor, ukusabela kwemithi okwenzeka ngaphandle kokulunywa noma ukuqubuka (lokhu akuzona izinto ezivamile zokungezwani komzimba), kanye nokunyakaza kokudlidliza.

Ingabe i-Angioedema iyathelelana?

Cha, akunjalo nhlobo.Awukwazi ukuthola i-angioedema komunye umuntu, futhi awukwazi ukuyidlulisela komunye umuntu. Akusona isifo esithelelanayo.

Uyixilonga kanjani i-angioedema? Odokotela bafunani?

Kungaba nzima ukusho ukuthi hlobo luni lwe-angioedema onayo. Udokotela wakho uzoqala akuhlole ngokomzimba, kodwa isikhathi esiningi ukuvuvukala kubonakala kalula. Ngemuva kwalokho bazokubuza imibuzo embalwa:

• Kwaqala nini ukuvuvukala?
• Ingabe udlile, waphuza, wathatha, noma wathinta noma yini ocabanga ukuthi ibangele ukusabela?
• Yimiphi imithi kanye nezithasiselo ozisebenzisayo njengamanje?
• Ingabe kwake kwaba khona ukusabela okunje ngaphambili?
• Ingabe ukhona omunye emndenini wakho oke waba nokuvuvukala okunje?

Ngaphezu kokubuza le mibuzo, udokotela wakho angase acele ukuhlolwa kwegazi noma ukuhlolwa kwesikhumba ukuze kuhlolwe ukungezwani komzimba , noma ukuhlolwa kwegazi ukuze kuhlolwe i-angioedema ehlobene neprotheni ye-C1 inhibitor.

Yiziphi izindlela zokwelapha i-Angioedema?

Ukwelashwa kwe-angioedema kuyahlukahluka kuye ngohlobo onalo.

• Uma kwenzeka ukusabela kabi komzimba , udokotela wakho angakunika umjovo we-epinephrine ojovayo ongawugcina nawe ngaso sonke isikhathi. Kufanele uzinike lo mjovo uma ushayela ku-911 (1990 eSri Lanka) esimweni esiphuthumayo.
• Uma une -allergy angioedema , udokotela wakho angase akunike ama-antihistamine noma ama-steroid . Lawa angathathwa njengamaphilisi, njengoketshezi (ngomlomo), noma anikezwe ngemithambo yegazi.
• Uma une -reaction yemithi engeyona i-allergy , udokotela wakho uzothola enye indlela efanelekile esikhundleni semithi ebangela ukuvuvukala. Ungalokothi uyeke ukuthatha imithi yakho ngaphandle kweseluleko sikadokotela wakho.

Izindlela zokwelapha zasekhaya zifaka phakathi ukufaka iqhwa ukunciphisa ukuvuvukala, ukugeza ngamanzi abandayo, kanye nokufaka indwangu epholile nemanzi endaweni evuvukele. Lokhu kungasebenza kahle ekuvuvukeni kwendawo, ukuvuvukala kuyo yonke izindebe, noma kwamehlo avuvukele.

Uma une -angioedema yokuntuleka kwe-C1 inhibitor, idiopathic, noma i-acquired , cishe uzothunyelwa kuchwepheshe. Eminye yemithi esetshenziselwa ukwelapha noma ukuvimbela i-angioedema ye-hereditary (HAE) ifaka:

• I-C1 esterase inhibitor (i-recombinant) (i-Ruconest®)
• Isithiyo se-C1 (somuntu) (iBerinert®, iCinryze®, iHaegarda®)
• I-Ecallantide (Kalbitor®)
• I-Icatibant (Firazyr®)
• I-Lanadelumab (Takhzyro®)
• I-Berotralstat (Orladeyo®)

Ingabe zikhona izindlela zokuvimbela i-angioedema?

Yebo, kunezindlela ezithile.

• Uma une -angioedema ehlobene nokungezwani komzimba , ungayivimbela ngokugwema ukudla, imithi, noma ezinye izinto (izinto ezibangela ukusabela kokungezwani komzimba) ezibangela ukusabela kokungezwani komzimba.
• Uma uba ne-angioedema engabangelwa ukungezwani komzimba ngenkathi uthatha imithi ye-ACEI (ACE inhibitors) , kufanele ukhulume nodokotela wakho mayelana nokushintshela komunye umuthi.

Yini umuntu one-angioedema angayilindela?

Iningi lamacala e-angioedema awahlali isikhathi eside . Ngokuvamile ayazixazulula ngokwawo. Kodwa-ke, ezimweni ezimbi kakhulu, ukwelashwa kuyadingeka ukuze kugcinwe indlela yokuphefumula ivulekile.

Ingabe i-Angioedema ingabulala? Ingabe lokhu kuyingozi?

Kwabanye abantu, i-angioedema yokungezwani komzimba ingaholela esimweni esibizwa ngokuthi i-anaphylaxis - ukuvuvukala okukhulu kwemigudu yomoya namaphaphu. Lokhu kungaba yingozi empilweni . Odokotela beluleka abantu abanalesi simo ukuthi baphathe i-epinephrine ejovwayo (i-EpiPen®, i-Auvi-Q®, i-Adrenaclick® kanye neminye imikhiqizo) ukuze baphathe ukusabela okukhulu kokungezwani komzimba.

Kungakhathaliseki ukuthi imbangela iyini, i-angioedema ethinta umgudu womoya ihlala iyisimo esiphuthumayo sezokwelapha. Ngakho-ke, kudingeka ukwelashwa okusheshayo. Ngezinye izikhathi, inqubo yokuhlinzwa ebizwa ngokuthi i-tracheostomy (ukudala imbobo epayipini lomoya) ingadingeka ukuze kusizwe ekuphefumuleni.

Uma ngine-angioedema, ngingazinakekela kanjani?

Uma une-angioedema, kufanele ugweme izinto ezibangela ukungezwani komzimba . Uma udokotela wakho ekunike imithi yokuvimbela ezinye izigameko, yiphuze njengoba kuyalelwe. Uma utshelwe ukuthi uphathe i-epinephrine ejovwayo , qiniseka ukuthi uhlala unayo. Fundisa umndeni wakho nabangani ukuthi bayisebenzise kanjani.

Kufanele ngimbone nini udokotela?

Uma une-allergy enkulu futhi ukuvuvukala kuthinta imigudu yakho yomoya, shayela u-1990 (isevisi ye-ambulensi ephuthumayo) ngokushesha.

Ezimweni ezingezimbi kangako, uma uqhubeka nokuba ne-angioedema, bona udokotela wakho. Bangaxoxa ngezinketho zokuvimbela. Ezinye izindlela zokwelapha zifaka phakathi ama-antihistamine omlomo nama-steroid. Idiopathic, okunzima ukwelaphaAbanye odokotela basebenzise i-antibody ye-monoclonal ebizwa ngokuthi i-Omalizumab (Xolair®) ye-angioedema (i-idiopathic angioedema).

Okokugcina, izinto ezibaluleke kakhulu okufanele uzikhumbule

Uma amehlo akho, izindebe, noma izandla zakho zizizwa zivuvukele, kungaba ukusabela kwesikhumba okubizwa ngokuthi i-angioedema. Lokhu kungenzeka kakhulu uma unesifo sokungezwani komzimba. Gcina irekhodi lokuthi lokhu kwenzeka nini futhi ngasiphi isikhathi, futhi ufunde ukugwema izinto ozizwa ungezwani komzimba nazo. Uma wazi ukuthi abanye abantu emndenini wakho bake baba nalezi zimpawu, tshela udokotela wakho. Angase aphakamise ukuhlolwa ukuze abone ukuthi lesi simo siyenzeka yini emndenini wakho. Uma une-angioedema ngenxa yokungezwani komzimba, kubaluleke kakhulu ukugcina i-epinephrine ejovwayo eduze, njengoba ukuvuvukala emigudwini yakho yomoya kungabangela ukuthi uyeke ukuphefumula. Ungesabi, kodwa kuwukuhlakanipha ukuqaphela lokhu futhi uthathe izinyathelo ezidingekayo.

I- Angioedema, ukuvuvukala, ukungezwani komzimba, izifo zesikhumba, ukunakekelwa okuphuthumayo, i-epinephrine, i-urticaria