Ingabe udokotela wakho ukutshelile wena noma othile emndenini wakho ukuthi niqale ukuthatha i-aromatase inhibitor? Kuvamile ukuzizwa wesaba futhi unelukuluku uma uzwa lokho. "Uhlobo luni lomuthi?", "Kungani nginikwa lokhu?", "Kuzokwenzekani kimi?", "Ingabe kuzoba nemiphumela emibi?" Cishe unemibuzo eminingi engqondweni yakho. Ngakho ungesabi. Namuhla, sizoxoxa ngalomuthi obizwa ngokuthi i-aromatase inhibitor ngolimi olulula kakhulu ongaluqonda, njengokungathi ukhuluma nomngane.
Kuyini i-Aromatase Inhibitor (AI) ngamagama alula?
Kalula nje, i-Aromatase Inhibitor uhlobo lokwelashwa kwama-hormone olusetshenziselwa umdlavuza. Zivame ukusetshenziswa kakhulu ukwelapha uhlobo lomdlavuza webele olubizwa nge -Estrogen Receptor-Positive (ER+) .
Manje cishe uyazibuza, "Kusho ukuthini lokhu okuthi 'ER+`?" Kusho into efana nale. Amanye amangqamuzana omdlavuza webele asizwa ukuba akhule futhi asakazeke yi-hormone ebizwa ngokuthi i-estrogen emizimbeni yethu. Njengoba nje isitshalo sidinga amanzi nomanyolo ukuze sikhule, lawa maseli omdlavuza asebenzisa i-hormone i-estrogen "njengokudla" kwawo. Ngakho-ke, umdlavuza okhuthazwa yi-hormone i-estrogen yilokho esikubiza ngokuthi umdlavuza we-`ER+`.
Lokho okwenziwa yi-Aromatase Inhibitor ukuvimba amangqamuzana omdlavuza ekutholeni lokho "kudla". Lokhu kwenza lokhu ngokuthi: Umzimba wethu une-enzyme ebizwa ngokuthi i-Aromatase . Le enzyme iguqula amanye ama-hormone emzimbeni abe yi-estrogen. Ngakho-ke lokho okwenziwa yilo muthi ukuthi uvimba isenzo se-enzyme ye-Aromatase. Ngemuva kwalokho ukukhiqizwa kwe-estrogen emzimbeni kwehla kakhulu. Lapho i-estrogen isiphelile, amangqamuzana omdlavuza alahlekelwa "ukudla" akudingayo ukuze akhule, futhi kancane kancane ayafa.
Kalula nje, i-Aromatase Inhibitor ibulala amangqamuzana omdlavuza futhi imise ukukhula kwawo.
Lokhu kwelashwa kusebenza kahle kakhulu kwabesifazane abaneminyaka engaphezu kwengu-50 asebedlule esikhathini sokunqamuka kokuya esikhathini , ngoba ngemva kokunqamuka kokuya esikhathini, i-estrogen emzimbeni wowesifazane ikhiqizwa kakhulu ngale enzyme ye-aromatase.
Kukuziphi izimo lapho lokhu kwelashwa kunikezwa khona?
Kunezimo eziningana lapho odokotela bangase batuse khona ukwelashwa nge-Aromatase Inhibitor. Ake sibheke ukuthi ziyini.
- Ngemva kokuhlinzwa komdlavuza webele we-ER+: Lo muthi unikezwa ukuvimbela umdlavuza ukuthi ungabuyi, okungukuthi, ukunciphisa ingozi yokuphinda ubuye.
- Uma umdlavuza ususakazekele kuma-lymph node aseduze: Lokhu kwelashwa kusiza ukulawula ukusabalala okuqhubekayo komdlavuza.
- Uma umdlavuza ususakazeke (usakazeke kakhulu) kwezinye izitho zomzimba:Umdlavuza webele ngezinye izikhathi ungasakazekela ezithweni ezikude njengamaphaphu, amathambo, ubuchopho, noma isibindi. Lokhu kwelashwa kuyasetshenziswa nasezimweni ezinjalo.
- Uma uba nomdlavuza webele we-ER+ ngaphambi kokunqamuka kokuya esikhathini: Njengoba ama-ovari esakhiqiza i-estrogen kule minyaka, kuzodingeka uthathe i-aromatase inhibitor kanye nezinye izindlela zokwelapha ezivimba ama-ovari ekukhiqizeni i-estrogen.
- Uma unengozi enkulu yokuba nomdlavuza webele we-`ER+`: Ezinye izifundo zibonise ukuthi le mithi inciphisa ingozi yomdlavuza webele. Kodwa-ke, ayikavunyelwa ngokusemthethweni ngale njongo.
- Uma indoda iba nomdlavuza webele we-`ER+`: Yebo, amadoda angaba nomdlavuza webele. Futhi anamazinga aphansi e-hormone i-estrogen emizimbeni yawo. Ngakho-ke, kunezikhathi lapho amadoda anganikezwa khona lokwelashwa.
Yiziphi izinhlobo ezivame ukusetshenziswa kakhulu ze-Aromatase Inhibitors?
Kunezinhlobo eziningana zale mithi emakethe. Udokotela wakho uzoncoma leyo ekufanele kakhulu. Lezi yizinhlobo ezintathu ezivame ukusetshenziswa kakhulu.
| Igama Elijwayelekile Lomuthi |
|---|
| I-Letrozole |
| I-Anastrozole |
| I-Exemestane |
Ngingawusebenzisa kanjani lo muthi? Kufanele ngiwuthathe isikhathi esingakanani?
Ama-Aromatase inhibitors uhlobo lwephilisi oliphuza nsuku zonke . Ungase unikezwe lo muthi lapho uqala ukwelashwa. Noma, kwezinye izimo, udokotela wakho angase akunike olunye ukwelashwa kwe-hormone okuthiwa i-tamoxifen iminyaka embalwa bese ekushintshela ku-aromatase inhibitors.
Ngokuvamile, lokhu kwelashwa kuqhubeka iminyaka engaba mihlanu . Ekupheleni kweminyaka emihlanu, uma ungenazo izimpawu zomdlavuza futhi ukuhlolwa kukhombisa ukuthi awukho umdlavuza, kubhekwa njengomuntu osesimweni esihle.
Kodwa kukhona okubalulekile okufanele ukukhumbule. Ezinye izifundo zikhombisile ukuthi umdlavuza webele ungabuya uma nje uneminyaka engama-20 ngemuva kokwelashwa. Lokhu kubizwa ngokuthi ukuphinda kwesifo sekwephuzile . Ngakho-ke kubalulekile ukukhuluma nodokotela wakho ngale ngozi, ngokusekelwe esimweni sakho.
Yiziphi izinzuzo nezingozi zalokhu kwelashwa?
Njenganoma yikuphi ukwelashwa, kunezinzuzo kanye nezingozi zemiphumela ethile emibi.
Inzuzo eyinhloko
Inzuzo enkulu nebaluleke kakhulu yalokhu kwelashwa yithuba lokuqeda ngokuphelele umdlavuza webele i-'ER+'. Izifundo zibonisa ukuthi abantu abangu-95% abathola lokhu kwelashwa ngemva kokuhlinzwa ngeke babe nezimpawu zomdlavuza nhlobo ngemva kweminyaka emihlanu. Leli izinga lempumelelo eliphezulu ngempela.
Imiphumela emibi engaba khona (izingozi)
Njengoba sixoxile ngaphambili, lo muthi usebenza ngokunciphisa amazinga e-estrogen emzimbeni. I-estrogen iyi-hormone ebalulekile empilweni yokuzala kanye nempilo yamathambo nenhliziyo . Ngakho-ke lapho amazinga e-estrogen ehla, kungaba nemiphumela emibi ehambisana nayo.
| Umphumela Ongemuhle | Incazelo elula |
|---|---|
| I-Osteoporosis kanye nokuqhekeka kwamathambo | Njengoba amazinga e-estrogen ehla, amathambo aya ngokuya eba mancane futhi aqale ukuba mancane, okwandisa ingozi yokuqhekeka ngisho noma umuntu ewa kancane. |
| Ubuhlungu bemisipha (i-Myalgia) kanye nobuhlungu bamalunga | Lona umphumela ovame kakhulu. Ungase ube nobuhlungu bamalunga kanye nokudikiza kwemisipha ezindaweni ezifana nezingalo, imilenze kanye nomhlane. |
| Ukushisa okukhulu | Ungase uzizwe ushisa futhi ujuluka ebusweni, entanyeni, nasesifubeni. Lokhu kufana nophawu lokunqamuka kokuya esikhathini. |
| Ukoma kwesitho sangasese sowesifazane | Ukwehla kwamazinga e-estrogen kungabangela ukwehla komswakama wesitho sangasese sowesifazane, ukoma, kanye nokungakhululeki. |
| Isifo senhliziyo | Ngenxa yokuthi i-estrogen iphinde ivikele impilo yenhliziyo, ukwehla kwayo kungandisa kancane ingozi yesifo senhliziyo ngokuhamba kwesikhathi. |
Yini ongayenza uma unenkinga ngemiphumela emibi?
Le miphumela emibi, ikakhulukazi ubuhlungu bamalunga, ingaba nzima kakhulu kangangokuthi abanye abantu abakwazi ukwenza imisebenzi yansuku zonke. Kodwa akudingeki uhlupheke buthule . Kunezixazululo. Into ebaluleke kakhulu ukukhuluma ngokukhululekile nodokotela wakho nganoma yikuphi ukungakhululeki okuzwayo. Angakusiza.
Udokotela wakho angase ancome izinto ezifana nalezi:
- Imithi yokulwa nokuvuvukala: Imithi engeyona i-steroidal anti-inflammatory (NSAIDs) efana ne-ibuprofen inganikezwa ukunciphisa ubuhlungu. Kodwa-ke, le mithi kufanele ithathwe kuphela ngaphansi kweseluleko sikadokotela.
- Ukushintshela ku-Aromatase Inhibitor ehlukile: Ngezinye izikhathi imiphumela emibi yohlobo olulodwa lwe-AI ayiveli kolunye uhlobo. Ngakho udokotela wakho angakutshela ukuthi uzame iphilisi le-AI elihlukile.
- Ukushintshela ku-Tamoxifen: Uma imiphumela emibi ingabekezeleleki, kungase kube khona inketho yokushintshela kolunye ukwelashwa kwama-hormone okuthiwa i-Tamoxifen.
Kufanele umshayele nini udokotela ucingo?
Qiniseka ukuthi ukhuluma nodokotela wakho ezimweni ezilandelayo:
- Uma imiphumela emibi inzima kakhulu kunalokho obekulindele futhi kunzima ukuyibekezelela.
- Uma umuthi onikezwe udokotela ungasizi ngemiphumela emibi.
- Uma ubona noma yiziphi izinguquko emzimbeni wakho osola ukuthi kungaba izimpawu zomdlavuza obuyayo (isib. iqhubu elisha, ubuhlungu obungavamile). (Buza udokotela wakho ukuthi yiziphi izimpawu okufanele uziqaphele).
Kubaluleke kangakanani lokhu kwelashwa?
Ukwelashwa nge-Aromatase inhibitor kunciphisa kakhulu ingozi yokubuya komdlavuza webele one-hormone. Ucwaningo luthole ukuthi abesifazane abathatha i-aromatase inhibitor therapy ngemuva kokuhlinzwa banengozi ephansi engu-40% yokufa ngenxa yomdlavuza webele ngemva kweminyaka eyi-10, uma kuqhathaniswa nalabo abangathathi noma yiluphi uhlobo lokwelashwa ngama-hormone.
Olunye ucwaningo lukhombisile ukuthi ukuthatha umuthi i-'Letrozole' kunganciphisa ingozi yokufa ngenxa yomdlavuza ngo- 24% kuya ku-35% .
Lezi zibalo zibonisa ukuthi lokhu kwelashwa kubaluleke kangakanani ekusindiseni impilo yakho. Ungase ufune ukuyeka lokhu kwelashwa ngenxa yemiphumela emibi. Kodwa ngaphambi kokuba wenze kanjalo, kungcono ukukhuluma nodokotela wakho ngalezi zinkinga, uziphathe, bese uzama ukuqeda lokhu kwelashwa okusindisa impilo.
Umlayezo Wokuya Nawe Ekhaya
- Ama-Aromatase Inhibitors (AI) ayindlela yokwelapha esebenza kahle kakhulu yama-hormone yomdlavuza webele we-ER+, ikakhulukazi ngemva kokunqamuka kokuya esikhathini.
- Lokhu kunciphisa izinga le-hormone ye-estrogen emzimbeni, kumise ukukhula kwamangqamuzana omdlavuza, futhi kunciphisa kakhulu ingozi yokuphinda umdlavuza.
- Imiphumela emibi efana nobuhlungu bamalunga kanye nobuthakathaka bamathambo ingavela, kodwa kunezindlela zokuyilawula. Ungalokothi uhlupheke buthule; khuluma nodokotela wakho njalo.
- Ukuze uthole imiphumela emihle kakhulu futhi uvimbele umdlavuza ukuthi ungabuyi, kubaluleke kakhulu ukuthatha imithi njengoba uyalelwe, ngokuvamile iminyaka emihlanu.
- Yazisa udokotela wakho ngokushesha nganoma yiziphi izimpawu ezintsha noma eziya ziba zimbi emzimbeni wakho.
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