Kuvamile ukuzizwa wesaba kancane futhi ukhathazekile uma usuzoqala ukwelashwa komdlavuza. Kodwa uma usuwazi kahle umuthi owuthathayo nokuthi uwuthinta kanjani umzimba wakho, lokho kwesaba kungancishiswa kakhulu. Namuhla sikhuluma ngomuthi obizwa ngokuthi i-Dacarbazine, osetshenziselwa ukwelashwa komdlavuza okunjalo. Ake sixoxe ngalokhu ngendlela elula ukuze uqonde.
Uhlobo luni lomuthi iDacarbazine?
Kalula nje, i-dacarbazine uhlobo lomuthi we-chemotherapy . Ukwelashwa ngamakhemikhali uhlobo lomuthi onamandla onikezwa ukuvimba ukukhula kwamangqamuzana omdlavuza noma ukuwabulala.
Lomuthi usetshenziswa kakhulu ukwelapha:
- Ngomdlavuza wesikhumba
- Kuhlanganiswe neminye imithi yokwelapha isifo sikaHodgkin
Lo muthi awunikezwa ekhaya. Unikezwa esibhedlela noma emtholampilo ngudokotela noma umhlengikazi oqeqeshwe ngokukhethekile ukuwunikeza. Umuthi unikezwa emzimbeni ngokujova emithanjeni noma ngokuwufaka emithanjeni, njenge-saline .
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuqala ukwelashwa
Kubaluleke kakhulu ukuthi udokotela wakho azi kahle isimo sakho sempilo ngaphambi kokuqala lokhu kwelashwa. Ngakho-ke, uma unanoma yikuphi kwalokhu okulandelayo, qiniseka ukuthi uyamtshela udokotela wakho .
| Isimo okudingeka usibike | Kungani lokho kubalulekile? |
|---|---|
| Ukutheleleka kwamanje (isb., ukutheleleka ngegciwane njenge-chickenpox, i-herpes) | Ngenxa yokuthi lo muthi wehlisa amasosha omzimba, izifo ezikhona zingase zibe zimbi kakhulu. |
| Isifo sezinso noma sesibindi | Ngenxa yokuthi lezi zitho zihilelekile enqubweni yokukhipha izidakamizwa emzimbeni, kubalulekile ukwazi umsebenzi wazo. |
| Izimo ezifana namaseli abomvu aphansi, amaseli amhlophe egazi, noma ama-platelet | I-Dacarbazine inganciphisa kakhulu inani lala maseli, ngakho-ke kubalulekile ukuqaphela isimo samanje. |
| Uma usanda kuthola ukwelashwa ngemisebe | Njengoba kokubili ukwelashwa ngemisebe kanye ne-chemotherapy kuthinta umzimba, udokotela kufanele aqaphele lokhu. |
| Uma une-allergies kulo muthi noma eminye imithi noma ukudla | Lokhu kubaluleke kakhulu ukuvimbela ukusabela okukhulu kwe-allergy. |
| Uma ukhulelwe noma uzama ukukhulelwa | Lokhu kubaluleke kakhulu. Lo muthi ungalimaza kakhulu ingane engakazalwa. |
| Uma ungumama oncelisayo | Ukuncelisa kufanele kugwenywe ngesikhathi kuthathwa ukwelashwa, njengoba umuthi ungadlula ubisi lwebele futhi ulimaze ingane. |
Izinto okufanele siziqaphele ngokukhethekile lapho sithatha lo muthi:
Udinga ukunakekela umzimba wakho kancane phakathi nesikhathi sokwelashwa.
Ukuhlolwa kwegazi okuvamile
Ngesikhathi uthatha lo muthi, udokotela wakho uzoyala ukuhlolwa kwegazi okuvamile. Lokhu kwenzelwa ukuqapha ukuthi umuthi uthinta kanjani umzimba wakho kanye namaseli akho egazi. Ungaweqi lawa mavivinyo.
Ukungakhululeki
Kuvamile ukuzizwa ungakhululekile futhi ukhathele lapho uthatha i-chemotherapy. Lokhu kungenxa yokuthi le mithi ithinta amangqamuzana omdlavuza kanye namaseli anempilo ngezinga elithile. Ngakho-ke, ungayeki ukwelashwa ngoba nje ungazizwa kahle. Kubalulekile ukuqedela umjikelezo wokwelashwa onqunyiwe ngaphandle kokuthi udokotela wakho akutshele ukuthi uyeke .
Qaphela izifo.
Lo muthi unganciphisa inani lamaseli amhlophe egazi emzimbeni alwa nezifo, okwandisa ingozi yokuthola izifo .
Uma uba nezimpawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, ukukhwehlela, noma ikhala eligobhozayo, ungaziniki imithi bese ushayela udokotela wakho ucingo ngokushesha.Phakathi nalesi sikhathi, nciphisa ukuya ezindaweni lapho abantu abagulayo kanye nezindawo ezinabantu abaningi ngangokunokwenzeka.
Ukopha kanye nokudumba
Inani lama-platelet, asiza ekuqhekekeni kwegazi, lingancipha. Lokhu kungandisa ingozi yokopha nokuklwebheka . Tshela udokotela wakho uma ubona noma yikuphi ukopha okungajwayelekile, njengokuklwebheka okungachazeki, amabala amancane abomvu esikhumbeni, igazi esithweni sakho, noma igazi emchameni wakho.
Gwema ukukhulelwa!
Into ebaluleke kakhulu ukugwema ukukhulelwa ngokuphelele ngesikhathi sokwelashwa nangemva kwalokhu isikhathi eside njengoba udokotela wakho ekutshelile. Lo muthi ungalimaza kakhulu ingane engakazalwa. Futhi, omama abancelisayo kufanele bagweme ukuncelisa ingane yabo ngenkathi bethatha lokhu kwelashwa. Uma unemibuzo ngalokhu, khuluma nodokotela wakho ngokukhululekile.
Yimiphi imiphumela emibi engaba khona?
Njenganoma yimuphi umuthi, i-dacarbazine ingabangela imiphumela emibi. Kodwa-ke, akuwona wonke umuntu oyitholayo. Ithebula elingezansi linikeza isithombe esicacile salokhu.
| Imiphumela emibi engaba khona ye-Dacarbazine | |
|---|---|
| 🚨 Izinto okufanele uzibike kudokotela wakho ngokushesha | |
| Ukusabela Kokungezwani Nomzimba | Ukuqubuka kwesikhumba, ukulunywa, ukuvuvukala kwezindebe/ulimi/ubuso, ubunzima bokuphefumula. |
| Izimpawu zokutheleleka | Umkhuhlane, ukubanda, ukukhwehlela, umphimbo obuhlungu, ubuhlungu lapho uchama. |
| Ama-platelet aphansi noma izimpawu zokuphuma kwegazi | Ukuphuka okungachazeki emzimbeni, obomvu, amabala amancane esikhumbeni, indle emnyama, kanye negazi emchameni. |
| Inani lamaseli abomvu egazi eliphansi (i-anemia) | Ukuzizwa ukhathele ngendlela engavamile, ungenampilo, ubuthakathaka, namehlo aluhlaza okwesibhakabhaka. |
| Ezinye izimpawu ezinkulu | Ubunzima bokuphefumula, ubuhlungu bemisipha, ubuhlungu lapho umuthi ujovwe khona, ukuhlanza, ukuphuzi kwamehlo noma isikhumba, ushintsho enanini lomchamo owukhiqizayo. |
| 🙂 Izinto ezivamile, kodwa okufanele zibikwe kudokotela uma ziqhubeka | |
| Izinkinga zesistimu yokugaya ukudla | Isicanucanu, ukucasuka kwesisu, uhudo, ukuphelelwa yisifiso sokudla. |
| Eminye imiphumela emincane | Ukulahlekelwa izinwele, ukuzwela kwesikhumba elangeni. |
Uma uhlangabezana nanoma yiziphi ezinye izimpawu ezingavamile ezingashiwongo kulolu hlu, sicela wazise udokotela wakho ngazo.
Kuthiwani uma ngiphuthelwa umthamo bese ngithatha umuthi omningi kakhulu?
Kubaluleke kakhulu ukuphuza imithi yakho ye-chemotherapy ngosuku oluhleliwe nangesikhathi esihleliwe. Ukwehluleka ukwenza kanjalo kungathinta impumelelo yokwelashwa. Uma ungakwazi ukuya ngosuku oluhleliwe, shayela udokotela wakho ngokushesha .
Njengoba lo muthi ungasetshenziswa ekhaya, ingozi yokudlula ngokweqile iphansi. Kodwa-ke, uma ucabanga ukuthi uke wabhekana nawo nganoma iyiphi indlela, kufanele ushayele ucingo ngokushesha iNational Poisons Information Centre eColombo National Hospital , noma uye e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze.
Umlayezo Wokuya Nawe Ekhaya
- I-Dacarbazine iwumuthi onamandla wokulwa nomdlavuza onikezwa ngemithambo yegazi ngabasebenzi abaqeqeshwe ngokukhethekile esibhedlela.
- Ngaphambi kokuqala ukwelashwa, tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha, imithi oyiphuzayo, kanye nokungezwani komzimba.
- Hlala uqaphile izimpawu ezifana nomkhuhlane, ukopha okungajwayelekile, kanye nokushaqeka. Uma ubona noma yikuphi kwalokhu, xhumana nodokotela ngokushesha.
- Gwema ukukhulelwa nokuncelisa ngokuphelele ngesikhathi sokwelashwa.
- Nakuba kuvamile ukuzizwa ungakhululekile, yazisa udokotela wakho nganoma yimiphi imiphumela emibi enzima noma eqhubekayo.
- Ukulandela imiyalelo kadokotela ngqo kubalulekile ukuze ukwelashwa kuphumelele.
👩🏽⚕️ Imibuzo eyengeziwe (ama-FAQ)
💬 Isetshenziselwani i-Dacarbazine (DTIC-Dome)?
Leli akulona iphilisi elivamile! Leli iphilisi elinamandla kakhulu elisetshenziswa njenge-chemotherapy (i-Alkylating agent) elifakwa ngqo emthanjeni wesiguli (IV Injection) esibhedlela somdlavuza ukuze kubhujiswe i-'Hodgkin's Lymphoma' embi futhi kusakazwe kakhulu umdlavuza wesikhumba (i-Metastatic Melanoma)!
💬 Lo muthi wokugomela wamakhemikhali (i-Dacarbazine / i-Chemo) uwabhubhisa kanjani ngokuphelele amangqamuzana omdlavuza uma engena emizimbeni yethu?
Ukuze iseli lomdlavuza lihlukane/lizalane, kudingeka lenze i-'DNA' entsha. Lo muthi ungena egazini lethu, bese isibindi sivuselela ingxenye yawo (i-Active metabolite - MTIC). Bese ungena ngqo emaseli omdlavuza, uzungeze uchungechunge olwenza i-DNA (GC base pairs) bese uluvala (Alkylation / Cross-linking). Lapho i-DNA ishaywa/ihlakazeka, iseli lomdlavuza liyaqhuma bese lifa khona lapho sengathi lidutshuliwe.
💬 Ukufa Komdlavuza Yiziphi izingozi eziyingozi kakhulu (Izexwayiso Zebhokisi Elimnyama) isiguli esibhekana nazo lapho sinikezwa lo muthi wokugomela?
Ingozi ebulalayo kakhulu esigulini ukuthi lokhu kubangela ukubhujiswa okungu-100% komnkantsha owakha igazi (Bone Marrow Suppression)! Lapho amangqamuzana egazi elahleka, ngisho nomkhuhlane omncane ungaholela e-pneumonia/ekuhlanzeni igazi futhi isiguli singafa. Enye ingozi enkulu ukuthi lokhu kubangela ukuthi imithambo yegazi esibindini ivaleke (Hepatic Necrosis / VOD) nesibindi sibole. Futhi, ukuhlanza/isicanucanu esingabekezeleleki kuzokwenzeka nakanjani ngosuku lokufakwa kwalo mjovo.
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