Ubuwazi ukuthi igazi eligeleza emithanjeni yakho ngezinye izikhathi lingagoba ngokungadingekile? Uma i-blood clot enjalo iya ebuchosheni, ingabangela isifo sohlangothi, futhi uma iya enhliziyweni, ingabangela ukuhlaselwa yinhliziyo. Ngakho-ke namuhla sizokhuluma ngohlobo olukhethekile lwemithi esetshenziswa odokotela ukuvimbela lezi zimo eziyingozi. Lezi zibizwa ngokuthi ama-Direct Thrombin Inhibitors.
Kalula nje, ziyini lezi Zithibithi Ze-Direct Thrombin?
Lezi yizinhlobo zemithi evimbela ukujiya kwegazi. Yilokho esivame ukukubiza ngokuthi "imithi yokunciphisa igazi." Kodwa indlela esebenza ngayo ihlukile kancane. Umqondo wokwenza le mithi usekelwe kuphrotheni etholakala ematheni ezimpungushe. Kungenzeka ukuthi wake wezwa ukuthi izimpungushe zazisetshenziswa nasekwelapheni esikhathini esidlule.
Iningi labantu emhlabeni liyafa ngenxa yesifo senhliziyo. Isizathu esiyinhloko salokho ukuqhekeka kwegazi. Ngakho odokotela banikeza imithi efana nale ukuze basindise abantu kule ngozi.
Lo muthi usetshenziselwa ziphi izimo?
Lolu hlobo lwemithi, olubizwa ngokuthi ama-direct thrombin inhibitors, luvame ukusetshenziselwa ukuvimbela noma ukwelapha amahlule egazi abangelwa izimo zezokwelapha ezahlukahlukene. Ake sibheke ukuthi ayini.
| Isimo sesifo | Incazelo elula |
|---|---|
| I-acute coronary syndrome (ukuphazamiseka kokugeleza kwegazi enhliziyweni) | Ukuvaleka kwemithambo yegazi ehambisa igazi enhliziyweni noma ukuhamba kwegazi kancane. |
| I-thrombocytopenia ebangelwa yi-heparin (HIT) | Inkinga ebangelwa esinye isinciphisi segazi esibizwa ngokuthi i-heparin. |
| I-VTE (i-Vnous thromboembolism) | Ihlule legazi emthanjeni emzimbeni. |
| I-Atrial Fibrillation (Afib) | Ingozi yokuqhekeka kwegazi kanye nesifo sohlangothi ngenxa yokushaya kwenhliziyo okungajwayelekile. |
| Ngemva kokuhlinzwa kokufakelwa inqulu | Nciphisa ingozi yokuqhekeka kwegazi ngemva kokuhlinzwa. |
| Ukuqhekeka kwegazi emthanjeni ojulile emlenzeni (i-Deep vein thrombosis - DVT) | Amahlule egazi, ikakhulukazi emithanjeni ejulile yemilenze. |
| Ukuqhekeka kwegazi emaphashini (i-pulmonary embolism) | Ihlule legazi elakheka kwenye indawo emzimbeni liya emaphashini bese lihlala. |
Ngaphezu kwalokho, unganikezwa lo muthi ngesikhathi sokwelashwa okufana ne-angioplasty, okuvula imithambo yegazi enhliziyweni yakho.
Yimiphi imithi engaphansi kwalesi sigaba?
Kunezinhlobo eziningana zemithi yokuvimbela i-thrombin eqondile esetshenziswa kakhulu eSri Lanka nasemhlabeni jikelele.
- I-Argatroban (lokhu kunikezwa njengomjovo we-IV)
- I-Bivalirudin (lokhu kunikezwa futhi njengomjovo we-intravenous - umjovo we-IV)
- I-Dabigatran (yilokhu okuthatha njengephilisi)
Lo muthi usebenza kanjani emzimbeni?
Kulula kakhulu. Njengoba igama lisho, lo muthi uya ngqo ku -enzyme ebizwa ngokuthi i-Thrombin futhi uyayiqeda.
Manje ungase uzibuze ukuthi iyini le Thrombin. Kalula nje, iThrombin iyisici esibalulekile enkambisweni yokujiya kwegazi emzimbeni wethu. Kufana nompheki oyinhloko olungisa ukudla. Lokho okwenziwa yilomuthi ukugcina lowo mpheki eceleni. Khona-ke inqubo yokujiya kwegazi ayenzeki kahle. Ngakho ukwakheka kwamaqhubu egazi angadingekile kuyayeka. Uyaqonda?
Kodwa ngezinye izikhathi lo muthi ungabangela ukopha okukhulu. Kukhona umjovo okhethekile ongaguqula imiphumela yephilisi i-Dabigatran. Ubizwa ngokuthi 'i-Idarucizumab'. Kodwa-ke, ayikho ikhambi elikhethekile lomuthi wokufakwa emthanjeni. Kodwa-ke, uma umuthi usuyekiwe, imiphumela yawo izophela ngemva kwesikhashana.
Ngidinga ukuthatha lo muthi isikhathi esingakanani?
Kuhlukahluka kuye ngomuntu nomuntu. Abanye abantu badinga ukukuthatha isikhathi esifushane kuphela, njengenyanga ngemva kokuhlinzwa kokufakelwa inqulu. Kodwa umuntu osengozini enkulu kakhulu yokuqhekeka kwegazi kungadingeka athathe lo muthi impilo yakhe yonke . Udokotela wakho uzonquma ukuthi yini okufanele ayenze.
Yiziphi izinzuzo zalolu hlobo lomuthi?
Lolu hlobo olusha lwemithi lunezinzuzo eziningana kunemithi emidala.
- Imiphumela iyafana: Njengoba lokhu kuthinta i-Thrombin ngqo kuphela, ungalindela imiphumela efanayo kumthamo ofanayo njalo.
- Akukho ukwehla kwama-platelet: Ngokungafani neminye imithi emidala, le mithi ayinciphisi izinga lama-platelet, okusiza ukujiya kwegazi.
- Akudingeki ukuthi igazi lakho lihlolwe njalo: Eminye imithi, njenge-Warfarin, idinga ukuhlolwa kwegazi njalo ukuze kuhlolwe ukuthi igazi lakho liqina ngokushesha kangakanani. Kodwa lo muthi awudingi lokho.
- Imiphumela emibi embalwa: I-Dabigatran, ethathwa njengephilisi, inengozi ephansi yokopha kanye nokusebenzisana neminye imithi uma iqhathaniswa ne-Warfarin.
- Kulula ukuyisebenzisa: Kulula kakhulu ukuyisebenzisa njengoba kufanele uphuze iphilisi kanye noma kabili ngosuku.
- Enye indlela: Lezi ziyindlela enhle kulabo abangakwazi ukusebenzisa imithi efana ne-Heparin.
Isebenza kangakanani le mithi? Futhi yiziphi izingozi zayo?
Ucwaningo luthole ukuthi lo muthi uphephile futhi usebenza kahle njengeWarfarin noma iHeparin. Kodwa-ke, awufaneleki kubantu abanezifo ezithile ze-valve yenhliziyo.
Kodwa into ebaluleke kakhulu lapha ukuthi isikhathi lo muthi ohlala ngaso emzimbeni siyancipha. Isibonelo, uma uthatha umthamo we-Warfarin, cishe u-50% wawo ungaba semzimbeni amahora angu-20-60. Kodwa uma uthatha i-Dabigatran, u-50% wawo ukhishwa emzimbeni zingakapheli amahora angu-12-14.
Kusho ukuthini lokhu? Awukwazi ukuphuthelwa usuku olulodwa lokuphuza lo muthi. Uma uphuthelwa usuku olulodwa lokuphuza, ingozi yakho yokuba nehlule legazi iyanda kakhulu.
Imiphumela emibi engaba khona
Njenganoma yimuphi umuthi, lo ungaba nemiphumela emibi, eminye yayo ingaba mibi kakhulu.
| Umphumela ongemuhle | Incazelo |
|---|---|
| Ukopha ngokweqile | Ukopha okuvela ezinsinini, ukopha ekhaleni, noma inxeba elingayeki ukopha. |
| Ukungagayeki kahle kokudla (i-Dyspepsia) | Ubuhlungu besisu, ukungakhululeki. |
| Ushintsho kumbala womchamo | Umchamo uba nsundu noma upinki. |
| Ikhanda elibuhlungu, isiyezi | Ikhanda elijwayelekile noma isiyezi. |
| Ubuhlungu besifuba, ubunzima bokuphefumula | Lezi kungaba izimpawu ezinkulu. |
| Umkhuhlane, ukutheleleka (i-Sepsis) | Izimo ezimbi kakhulu ezibangelwa ukutheleleka. |
Kufanele ngimbone nini udokotela?
Uma uhlangabezana nanoma yimiphi imiphumela emibi ngenkathi usebenzisa lo muthi, yazisa udokotela wakho ngokushesha.
Ikakhulukazi, uma uphuma igazi ngokweqile (isibonelo, uma ungakwazi ukuyeka ukuphuma kwegazi esilondeni, uma unegazi esitulweni sakho, uma unomopho obangela ukuba ube nokuphazamiseka kwengqondo) noma uma unezinye izimpawu ezinkulu (ubuhlungu obukhulu besifuba, ubunzima bokuphefumula), iya eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela esiseduze ngokushesha.
Okokugcina, asikho isidingo sokwesaba ukwakheka kwehlule legazi. Imithi yesimanje efana nemithi yokuvimbela i-thrombin eqondile ingalawula leyo ngozi ngezinga elikhulu. Kodwa udokotela wakho uzonquma ukuthi yimuphi umuthi okulungele wena nokuthi kufanele uwuthathe isikhathi esingakanani. Ngakho-ke landela njalo iseluleko sikadokotela wakho.
Umlayezo Wokuya Nawe Ekhaya
- Ama-Direct Thrombin Inhibitors ayiqembu elisha lemithi evimbela ukujiya kwegazi.
- Lokhu kusebenza ngokuvimbela ngqo i-thrombin, i-enzyme ebalulekile enqubweni yokujiya kwegazi.
- Uma usebenzisa lo muthiUngalokothi weqe umthamo wemithi. Ukwenza kanjalo ngokushesha kwandisa ingozi yokuqhekeka kwegazi.
- Uma ubona ukopha ngokweqile noma ezinye izimpawu ezingavamile, xhumana nodokotela wakho ngokushesha.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho