Ingabe untula i-vitamin B12? Thola ulwazi ngalolu vivinyo lwe-Methylmalonic Acid (MMA)!

Namuhla sizokhuluma ngokuhlolwa okunegama elithile lezokwelapha, kodwa okubaluleke kakhulu empilweni yomzimba wethu. Kuwukuhlolwa kwe-Methylmalonic Acid ( MMA ), noma njengoba sikubiza ngamafuphi. Kungenzeka ukuthi awukaze uzwe ngaleli gama ngaphambili. Kodwa cabanga ngakho, lokhu kuhlolwa kwe-MMA kuwusizo kakhulu ekutholeni ukuthi une-vitamin B12 eyanele yini (elinye igama le-vitamin B12 yi-cobalamin) emzimbeni wakho, noma ukuthi umzimba wakho ungamunca kahle yini. Ngakho-ke, ake sixoxe ngalokhu ngemininingwane ethe xaxa, akunjalo?

Kuyini lokhu kuhlolwa kwe-MMA?

Kalula nje, ukuhlolwa kwe-methylmalonic acid (MMA) kuyindlela yokuthola ukuthi unesifo se-vitamin B12 . Udokotela wakho uzothatha isampula yegazi noma umchamo wakho bese ehlola izinga le-methylmalonic acid (MMA).

Cabanga ngale ndlela. Uma amazinga ethu e-vitamin B12 ephansi, noma uma singamunci kahle i-B12 esiyidlayo, imizimba yethu iqala ukukhiqiza ikhemikhali ebizwa ngokuthi i-MMA. Uma sikhuluma iqiniso, i-MMA ingumkhiqizo wenqubo ye-metabolic ye-vitamin B12. Uma i-B12 iphansi, le nqubo ayenzeki kahle, ngakho-ke i-MMA iyanqwabelana. Ngakho-ke, uma amazinga akho e-MMA ephezulu, kusho ukuthi kungaba nenkinga nge-B12.

Kungani ufuna ukwenza isivivinyo se-MMA?

Manje ungase ucabange, "Kungani ngithatha lolu vivinyo lwe-MMA?" Kungaba nezizathu ezimbalwa:

• Uma unezimpawu zokuntuleka kwe-vitamin B12:
• Ingabe uhlala uzizwa ukhathele futhi ungenampilo ?
• Ingabe zikhona izinkinga zesistimu yokugaya ukudla, njengohudo noma ubuhlungu besisu?
• Ingabe uzwa ubuhlungu noma ukuqaqamba emilenzeni yakho?
• Unesifiso sokudla?

Uma unalezi zimpawu, udokotela wakho angase akuncome ukuthi uhlolwe i-MMA, njengoba lokhu kungaba izimpawu zokuntuleka kwe-B12.

• Ukuhlola izinsana ezisanda kuzalwa: Ngezinye izikhathi, umntwana unikezwa ukuhlolwa kwe-MMA ngokushesha nje ngemva kokuzalwa ukuze kuhlolwe isimo esingavamile sofuzo esibizwa ngokuthi i-methylmalonic acidemia noma i-methylmalonic aciduria . Lokhu kuvame ukwenziwa njengokuhlolwa kwe-MMA komchamo ukuze kuqashwe isimo.

Kubalulekile ukuhlonza ngokunembile ukuntuleka kwe-vitamin B12, njengoba kungaba uphawu lwezimo eziningana zempilo ezimbi ezingalimaza imizwa . Izibonelo zifaka phakathi i-anemia eyingozi (uhlobo lwe-anemia olubangelwa ukungakwazi ukumunca i-B12) kanye ne-neuropathy ehlobene nesifo sikashukela .

Kungani ubheka i-MMA esikhundleni sokubheka amazinga e-B12 ngqo?

Lona umbuzo omuhle. Ungase ucabange ukuthi ukubheka nje izinga le-B12 egazini kungaxazulula inkinga. Kodwa-ke, kunezinzuzo ezikhethekile zokuhlola izinga le-B12 kanye nezinga le-MMA. Ukuhlola izinga le-MMA kunikeza udokotela ulwazi olwengeziwe futhi kuvumela ukuxilongwa okunembile .

Cabanga ngalokhu. Amazinga akho e-B12 egazini angase abe ajwayelekile uma uwahlola. Kodwa umzimba wakho ungase ungakwazi ukusebenzisa i-B12 kahle. Lokhu kubizwa ngokuthi i-bioavailability ephansi. Khumbula, i-MMA yakheka lapho amazinga e-B12 ephansi. Ngakho-ke, noma amazinga akho e-B12 egazini ejwayelekile, uma amazinga akho e-MMA ephezulu, ingatshela udokotela wakho ukuthi umzimba wakho awusebenzisi i-B12 kahle, nokuthi kukhona okungahambi kahle. Futhi, amazinga aphezulu e-MMA angasiza ekuxilongeni nasekuphatheni izimo ezithile zempilo kusenesikhathi .

Ungenza kanjani ukuhlolwa kwe-MMA?

Ukuze wenze isivivinyo se-MMA, udokotela wakho uvame ukukucela ukuthi uthathe isampula yegazi (ukuthatha igazi) noma isampula yomchamo (ukuhlolwa komchamo).

• Isampula yegazi ingathathwa elabhorethri, esibhedlela, noma ehhovisi likadokotela.
• Uma kuyisampula yomchamo , ungase ucelwe ukuthi uyilande ekhaya bese uyiyisa elabhorethri, noma ungase ucelwe ukuthi uyinike ehhovisi likadokotela.

Izinga le-MMA kulesi sampula lihlolwa elabhorethri yezifo, okuyindawo lapho kuhlolwa khona uketshezi lomzimba nezicubu.

Ngezinye izikhathi, udokotela wakho angase acele nokuhlolwa kwe-homocysteine . Ngemuva kwalokho, ukuxilongwa kwenziwa ngokusekelwe kulowo mbiko kanye nombiko we-MMA.

Ulungiselela kanjani lolu vivinyo?

Inqubo yokulungiselela ingahluka kancane kuye ngokuthi ngabe ukuhlolwa kwakho kwe-MMA kwenziwa ngegazi noma ngomchamo. Ngakho-ke, buza udokotela wakho njalo uma kukhona imiyalelo ekhethekile.

• Ngokuvamile, uma kuwukuhlolwa kwegazi , uzocelwa ukuba uzile ukudla , okusho ukuthi ungadli noma uphuze lutho, amahora ambalwa ngaphambi kokuhlolwa.
• Uma kuqoqwa isampula yomchamo emahoreni angama-24 , ungase ucelwe ukuthi uyeke ukudla okuthile kanye nemithi ngosuku olwandulela ukuhlolwa.

Kwenzekani ngesikhathi sokuhlolwa?

Lokhu kuyahlukahluka kuye ngokuthi isampula ofuna ukuyinikeza.

• Ukuhlolwa kwegazi: Uhlala esihlalweni bese welula ingalo eyodwa. Ngemuva kwalokho, udokotela we-phlebotomist, umuntu oqeqeshwe ukukhipha igazi, ufaka inaliti emthanjeni ongalweni yakho eduze kwengqiniba yakho bese ekhipha igazi elincane. Uma inaliti isusiwe, uzocelwa ukuba ubambe indawo endaweni yayo nge-gauze. Ngemuva kwalokho, kufakwa ibhandishi elincane. Ungakhathazeki, uzozwa ubuhlungu obuncane, kodwa buzophela ngokushesha.

• Ukuhlolwa komchamo kwamahora angama-24: Uqoqa umchamo wakho esikhathini samahora angama-24 ebhodleleni elihlanzekile elikhethekile. Udokotela wakho noma umhlengikazi uzokukhombisa ngqo ukuthi ungakwenza kanjani lokhu. Uma isikhathi sesiphelile, udinga ukuyisa ibhodlela elabhorethri.

• Isampula yomchamo ejwayelekile (ukuhlolwa komchamo): Lokhu kuhilela ukuthi uqoqe inani elincane lomchamo endebeni ehlanzekile, kungaba ekhaya noma ehhovisi likadokotela wakho. Uzofundiswa ukuthi ungakwenza kanjani lokhu.

• Ukuhlolwa kosana olusanda kuzalwa kuwukuhlolwa okubandakanya umhlinzeki wezempilo ukuthatha amaconsi ambalwa egazi endaweni encane esithendeni somntwana wakho ngenaliti. Lokhu kuvame ukwenziwa esibhedlela, kungakapheli usuku noma ezimbili zokuzalwa.

Kwenzekani ngemva kokuhlolwa?

Ngemva kokuhlolwa kwegazi noma komchamo, akukho lutho olukhethekile ongakwenza. Ilabhorethri izohlola isampula bese ithumela umbiko kudokotela wakho. Kungase kubonakale nakumarekhodi akho ezokwelapha e-elekthronikhi.

Ingabe zikhona izingozi ngalolu vivinyo?

Njenganoma yikuphi ukuhlolwa kwegazi, kunengozi encane yokutheleleka endaweni yokufaka inaliti, kodwa iphansi kakhulu.

Izingozi zokuhlolwa komchamo ukuthi isampula ingase ingaqoqwa kahle (ikakhulukazi lapho kuqoqwa umchamo amahora angama-24) nokuthi isampula ingase ingcoliswe - isibonelo, uma into efana namagciwane avela endle ingena emchameni - okungaholela emiphumeleni engalungile embikweni.

Linjani izinga elijwayelekile le-MMA?

Amazinga ajwayelekile e-MMA egazini nasemchameni angahluka kancane kuye ngelebhu.

• Izinga le-MMA elijwayelekile le-serum lingu- 0.40 µmol/L (i-micromole ngelitha) , ngezinye izikhathi libhalwa ngokuthi i-umol/L noma i-mcmol/L, futhi kufanele libe ngaphansi kwalelo zinga.
• Amazinga e-MMA emchameni angaba ajwayelekile, noma ngabe aphezulu njengo- 4.0 mmol/mol crt (i-millimole nge-mole ye-creatinine) . Lapha i-crt ibhekisela kumakhemikhali abizwa ngokuthi i-creatinine.

Ngakho-ke, kufanele nakanjani uhlole ububanzi bezinkomba ezinikezwe embikweni wakho.

Kuthatha isikhathi esingakanani ukuthi umbiko ufike?

Kungathatha noma yikuphi kusukela osukwini olulodwa kuya esontweni elilodwa noma amabili ukuthi umbiko ubuye ekuhlolweni kwe-MMA. Kuyahlukahluka kuye ngelebhu. Ungabuza udokotela wakho ukuthi ungalindela nini umbiko.

Kwenzekani uma izinga le-MMA liphezulu kakhulu?

Uma umbiko wakho we-MMA ubonisa ukuthi amazinga akho aphezulu, ungadinga ukuhlolwa okwengeziwe noma ukwelashwa kokuntuleka kwe-vitamin B12. Udokotela wakho cishe uzoqhathanisa umbiko wakho we-MMA neminye imiphumela yokuhlolwa, njengombiko wakho we-B12 kanye nombiko wakho we-homocysteine , ukuze enze isinqumo.

• Uma umntwana osanda kuzalwa enamazinga aphezulu e-MMA, angase abe ne-methylmalonic acidemia.Kungase kube khona. Udokotela cishe uzoyala ukuhlolwa okwengeziwe ukuqinisekisa ukuxilongwa. Ukwelashwa kwalesi simo kuhlanganisa izithako zamavithamini, ukudla okunamaphrotheni aphansi, kanye nokunciphisa ukudla okuqukethe ama-amino acid athile.

Kuthiwani uma i-B12 ijwayelekile kodwa i-MMA iphezulu?

Isibonelo, amazinga akho e-B12 ajwayelekile, kodwa amazinga akho e-MMA aphezulu. Noma kunjalo, ungase ube nokuntuleka kwe-B12 - ikakhulukazi uma unezimpawu. Kungaba ukuntuleka kwasekuqaleni noma ukuntuleka okuncane . Lokhu akusho ukuthi uzoba mubi kakhulu. Udokotela wakho uzonquma ukuthi udinga ukwelashwa noma cha.

Kufanele ngimbone nini udokotela?

Uma unezimpawu zokuntuleka kwe-vitamin B12, noma uma unemibuzo mayelana nemiphumela yokuhlolwa kwakho, qiniseka ukuthi ubona udokotela. Ungesabi, udokotela uzokuchazela konke.

Okokugcina, izinto okufanele uzikhumbule

Uyabona, ngezinye izikhathi ukuhlolwa okwenziwa engxenyeni ethile yomzimba wethu kungasitshela ukuthi enye ingxenye isebenza kanjani. Lokhu kuhlolwa kwe-MMA kufana nalokho. Izinga le-MMA eliphakeme lingatshela udokotela wakho ukuthi amazinga akho e-B12 aphansi, noma ukuthi umzimba wakho awumunci kahle.

Lokhu kungaba ulwazi olubaluleke kakhulu, ikakhulukazi ukuhlonza izimo ezilimaza izinzwa zethu bese siqala ukwelashwa ngokushesha okukhulu.

Ngakho-ke, uma unemibuzo noma ukukhathazeka mayelana nalolu vivinyo lwe-MMA noma umbiko walo, ungangabazi ukukhuluma nodokotela wakho ngakho. Uzokunikeza zonke izincazelo ozidingayo. Hlala uphilile!

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