Ingabe ngezinye izikhathi uzizwa sengathi awunawo amandla, uhlala ukhathele, futhi uhlala ugula? Ngezinye izikhathi, lezi zimpawu ezibonakala zingahlobene zingabangelwa inkinga kwenye yezingxenye ezincane kakhulu zomzimba wethu. Namuhla, sizokhuluma ngesimo esiyinkimbinkimbi kancane, kodwa okubaluleke kakhulu ukwazi ngaso. Leso yizifo ze-Mitochondrial.
Okokuqala, ake sibone, iyini i-mitochondria?
Kalula nje, i-mitochondria "izindawo zamandla" ezincane ngaphakathi kweseli ngalinye emzimbeni wethu. Njengoba nje sinesiteshi samandla sokunika amandla emakhaya ethu, amangqamuzana ethu asebenzisa lawa ma-mitochondria ukukhiqiza amandla adingayo ukuze asebenze. Sisebenzisa ukudla esikudlayo nomoya-mpilo esiwuphefumulayo, la mafektri amancane akhiqiza cishe u-90% wamandla adingwa yimizimba yethu. Ngakho cabanga ukuthi yiziphi izinkinga ezingavela ukube lawa mafektri kagesi abengasebenzi kahle.
Izifo ze-Mitochondrial azisona isifo esisodwa. Ziyigama elijwayelekile leqembu lezimo ezibangelwa ukungasebenzi kahle kwalezi zikhungo ezinamandla.
Uma lezi zitshalo zikagesi zingasebenzi kahle, amaseli awatholi amandla awadingayo. Khona-ke izitho eziqukethe lawo maseli ziba zingasebenzi kahle. Lokhu kungathinta noma iyiphi ingxenye yomzimba wethu.
- Ubuchopho
- Uhlelo lwezinzwa
- Imisipha
- Izinso
- Inhliziyo
- Isibindi
- Amehlo
- Izindlebe
- I-Pancreas
Lokhu kungathinta noma yini.
Yiziphi izinhlobo eziyinhloko zezifo ze-mitochondrial?
Kunezinhlobo eziningi zalesi sifo, kodwa ezinye ezivame kakhulu yilezi:
- I-MELAS syndrome (i-Mitochondrial encephalopathy, i-lactic acidosis kanye neziqephu ezifana nohlangothi)
- I-Leber hereditary optic neuropathy (LHON)
- I-Leigh syndrome
- I-Kearns-Sayre syndrome (KSS)
- Isifo sokuwa esibangelwa yi-myoclonic kanye nesifo se-ragged-red fiber (MERRF)
Lokhu kungase kuzwakale kuyinkimbinkimbi kancane, kodwa khumbula ukuthi lezi yizimo ezibangela izimpawu ezahlukene futhi zibangelwa izinguquko ekusebenzeni kwe-mitochondrial.
Yiziphi izimpawu zalezi zifo?
Lena yingxenye eyinkimbinkimbi kakhulu yalesi sifo. Ngoba izimpawu zingahluka kakhulu kumuntu nomuntu, kuye ngohlobo lwamaseli athintekile nokuthi akuphi emzimbeni. Abanye abantu bangase babe nezimpawu ezincane kakhulu , kanti abanye bangase babe nezimpawu ezinzima kakhulu. Izimpawu zingahluka ngisho nangaphakathi komndeni ofanayo.
Ithebula elingezansi libonisa ezinye zezimpawu ezivamile ezibonakala kulezi zifo.
| Isigaba sezimpawu | Izimpawu ezibonakalayo |
|---|---|
| Okuhlobene nokukhula namandla | Ukuntuleka kokukhula ngokweminyaka, ubuthakathaka bemisipha, ubuhlungu bemisipha, kanye nomzimba ongenampilo. |
| Okuhlobene nokuqonda nokufunda | Ukukhubazeka kokubona kanye/noma ukuzwa, ukukhubazeka kokufunda, noma ukubambezeleka kokukhula. |
| Okuhlobene nohlelo lokugaya ukudla | Ukuhlanza okungachazeki, uhudo noma ukuqunjelwa, ubunzima bokuchama, i-acid reflux. |
| Okuhlobene nesistimu yezinzwa | Ukuquleka, i-migraines, ukuquleka. |
| Ezinye izici | Ubunzima bokuphefumula, ijwabu leso eligobile (i-ptosis). |
Lezi zimpawu zingaqala ekuzalweni noma zivele kunoma yimuphi ubudala empilweni. Udokotela uvame ukusola lokhu uma izimpawu zivela ngesikhathi esisodwa ezithweni eziningana ezingahlobene.
Kungani lolu hlobo lwesifo luvela?
Isizathu esiyinhloko salokhu ukukhubazeka kofuzo .
Kalula nje, i-mitochondria engaphakathi kwamaseli ethu ithola imiyalelo yayo yokwenza amandla nge-DNA yethu. Uma kukhona ushintsho noma ukuguquka kwezakhi zofuzo kule DNA, i-mitochondria ayitholi imiyalelo efanele. Khona-ke ayikwazi ukwenza amandla ngendlela efanele. Lokhu kungalimaza amaseli noma kubangele ukuba afe ngaphambi kwesikhathi.
Umuntu uyithola kanjani lesi sifo njengefa?
Lezi yizifo zofuzo, okusho ukuthi zingadluliselwa kusuka kubazali ziye ezinganeni. Ngezinye izikhathi, noma kungekho muntu emndenini onalesi sifo, othile angasithola lesi sifo ngenxa yokuguquka kwezakhi zofuzo okungahleliwe.
Iqiniso elikhethekile ukuthi i-mitochondria ine-DNA yayo ehlukile. Izifo ezibangelwa ukukhubazeka kule DNA ye-mitochondrial zizuzwa kuphela kumama kuya ezinganeni.
Ingabe ezinye izifo zingaphazamisa ukusebenza kwe-mitochondrial?
Yebo. Kubizwa ngokuthi ukungasebenzi kahle kwe-mitochondrial yesibili. Lokho kusho ukuthi awunaso isifo se-mitochondrial esibangelwa ufuzo, kodwa esinye isimo sezokwelapha sibangela ukuthi i-mitochondria yakho ingasebenzi kahle. Isibonelo:
- Isifo sika-Alzheimer
- Ukuwohloka kwemisipha
- Isifo sikashukela sohlobo 1
- I-Multiple sclerosis (MS)
- Ezinye izinhlobo zomdlavuza
I-Mitochondria ingathinteka yizifo ezifana nalezi:
Ungasithola kanjani lesi sifo?
Ukuxilonga lesi sifo kungaba nzima kancane ngoba izimpawu ziyahlukahluka kakhulu. Akunakutholwa ngokuhlolwa okukodwa nje. Udokotela wakho angase enze uchungechunge lwezivivinyo.
- Ukubuyekezwa okuningiliziwe komlando wezokwelapha wakho nowomndeni wakho .
- Ukwenza ukuhlolwa okuphelele komzimba .
- Ukuhlolwa okuhlobene nesimiso sezinzwa .
- Ukuhlolwa kwegazi nomchamo . Ngezinye izikhathi kungenziwa nompompi womgogodla.
- Ukuhlolwa kwe-DNA .
- Kuye ngezimpawu, kungenziwa izivivinyo ezifana ne-MRI scan, i-EKG noma i-Echocardiogram yenhliziyo, ukuhlolwa kwamehlo, ukuhlolwa kokuzwa, kanye nokuhlolwa kwe-EEG ukuze kuqashwe ukusebenza kobuchopho .
- Ngezinye izikhathi kungadingeka ukuthatha ucezu oluncane lwesikhumba noma imisipha (i-biopsy) bese uluhlola ngaphansi kwe-microscope.
Ngakho-ke, kubaluleke kakhulu ukubonana nodokotela noma isibhedlela esingochwepheshe kulezi zinhlobo zezifo ukuze kutholakale ukuthi ziyini.
Yiziphi izindlela zokwelapha?
Ngeshwa, alikho ikhambi lesifo se-mitochondrial okwamanje. Kodwa-ke, kunezindlela zokwelapha ezahlukahlukene ezitholakalayo zokusiza ukulawula izimpawu nokuvimbela izinkinga ezisongela ukuphila .
- Imithi enciphisa izimpawu:Isibonelo, imithi yokulwa nesifo sokuwa.
- Amavithamini kanye nezithasiselo: Izinto ezifana ne-riboflavin, i-coenzyme Q10, kanye ne-carnitine zingaba usizo kwabanye abantu.
- Izinguquko ekudleni nasekuzivocavoceni: Udokotela wakho uzokutusa lokhu kuye ngesimo sakho.
- Ukwelashwa ngokomzimba, ukwelashwa ngokomsebenzi, noma ukwelashwa ngokwelashwa ngenkulumo .
- Ukugqoka izinto zokusiza njengezinsiza zokuzwa .
Okusebenza komunye umuntu kungase kungasebenzi komunye, ngakho-ke kungcono ukukhuluma nodokotela wakho bese uqhamuka nohlelo lokwelashwa olufanele wena.
Ingabe lesi sifo singavinjelwa ukuthi singabi sibi kakhulu?
Nakuba kungekho ndlela yokuvimbela lesi sifo ukuthi singabi khona, ungagwema ezinye izinto ezenza izimpawu zibe zimbi kakhulu.
- Gwema ukuchayeka emakhazeni amakhulu noma ekushiseni okukhulu .
- Ungayeki ukudla.
- Lala kahle ebusuku.
- Hlala kude nokucindezeleka ngangokunokwenzeka.
Udokotela wakho angase akucebise ukuthi wonge amandla kunokuba usebenzise wonke amandla omzimba wakho ngesikhathi esisodwa.
Kufanele ngimbone nini udokotela?
Uma unezimpawu zesifo se-mitochondrial futhi unenkinga yokwenza imisebenzi yakho yansuku zonke, qiniseka ukuthi ubona udokotela.
Uma uhlangabezana nokuquleka noma ubunzima obukhulu bokuphefumula, hamba uye eMnyangweni Wezimo Eziphuthumayo (ETU) wesibhedlela ngokushesha.
Ukwazi ukuthi wena noma othandekayo wakho unalesi simo kungaba nzima. Kodwa khumbula, umndeni wakho, abangani, kanye nethimba lezokwelapha, okuhlanganisa nodokotela, bakhona ukukusiza ukuthi uphile ngempumelelo nalezi zimpawu.
Umlayezo Wokuya Nawe Ekhaya
- Izifo ze-Mitochondrial ziyiqembu lezifo zofuzo ezibangelwa ukungasebenzi kahle "kwezitshalo zamandla" ezikhiqiza amandla amangqamuzana ethu.
- Izimpawu zihlukahlukene kakhulu futhi zingafaka phakathi ubuthakathaka bemisipha, ukukhubazeka kokubona/ukuzwa, ukukhubazeka kokufunda, kanye nesifo sokuwa.
- Ukuxilonga lesi sifo kuyinkimbinkimbi futhi kudinga uchungechunge lwezivivinyo zezokwelapha. Kubalulekile ukubona uchwepheshe walokhu.
- Nakuba lesi sifo singelapheki ngokuphelele, kunezindlela zokwelapha ezahlukahlukene ezitholakalayo zokulawula izimpawu nokuthuthukisa ikhwalithi yokuphila.
- Ukwanda kwezimpawu kungalawulwa ngokugwema izinto ezifana nokucindezeleka, ukungalali kahle, kanye nokushisa okuphezulu.
- Uma wena noma othile omaziyo enalezi zimpawu, ungangabazi ukufuna iseluleko sezokwelapha.
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