Ngezinye izikhathi ngemva kokudla, isisu sethu sizizwa sigcwele futhi sivuvukele, akunjalo? Kuzwakala sengathi ukudla akwehli esiswini sethu. Noma sizwa ukungakhululeki njengokubhodla njalo, isilungulela, nokuhlanza. Esinye sezizathu zalezi zinto kungaba ukuthi uhlelo lwakho lokugaya ukudla, okungukuthi, amathumbu akho, luhamba kancane. Namuhla, sikhuluma ngeklasi elikhethekile lemithi elisiza ngezikhathi ezinjalo.
Kalula nje, ayini lawa ma-Prokinetic Agents?
Ama-prokinetic agents uhlobo lomuthi ovuselela imisipha yomgudu wakho wokugaya ukudla ukuthi ifinyele, noma "icindezele," futhi isize ukuhambisa ukudla kalula.
Cabanga nje, lapho sigwinya ukudla, imisipha esuka emhubheni wethu iye esiswini nasemathunjini ethu ivele ifinyele futhi iphumule njengegagasi, isunduza ukudla phambili. Lokhu sikubiza ngokuthi inqubo ezenzakalelayo i-peristalsis . Kufana nokucindezela nokucindezela into ngaphakathi kwepayipi bese uyithumela phambili. Ngenxa yokuthi le nqubo yenzeka kahle, umzimba wethu uyakwazi ukumunca izakhamzimba ozidingayo ekudleni.
Kodwa-ke, uma ngesizathu esithile le nqubo yokunyakaza ibuthakathaka, ukudla kungahlala esiswini isikhathi eside. Lokhu kungabangela ukungakhululeki njengokuqunjelwa, ukuqunjelwa, kanye nesilungulela. Yilapho imithi ebizwa ngokuthi ama-Prokinetic Agents isiza khona ukunika amathumbu ethu "ukusunduza" kancane nokubuyisela leyo nqubo.
Lo muthi usebenza kanjani emzimbeni?
Ama-prokinetic agents asebenza ngokuvuselela imizwa emathunjini ethu, okwenza imisipha ifinyele. Lokhu kwenza izinto ezimbalwa ezibalulekile:
- Kwandisa ukufinyela komphimbo: Lokhu kubangela ukuthi ukudla kungene ngokushesha esiswini.
- Qinisa i-Lower Esophageal Sphincter (LES): Leli "sango" eliphakathi komhubhe wethu nesisu. Uma libuthakathaka, i-asidi yesisu ingageleza iphindele emhubheni. Yilokhu esikubiza ngokuthi isilungulela, noma i-GERD . Imithi ye-prokinetic iqinisa leli sango futhi ivimbele i-asidi ukuthi igeleze iphindele phezulu.
- Kwandisa ukufinyela kwesisu: Lokhu kuvumela ukudla esiswini ukuthi kuhambe ngokushesha kungene emathunjini amancane. Uma isisu siphuma ngokushesha, mancane amathuba okuthi siphinde sikhuphuke.
- Kunciphisa isikhathi esithathayo ukuze isisu siphume: Lokhu kusiza kakhulu ekulawuleni izimo ezifana ne-GERD okukhulunywe ngayo ngenhla.
Yiziphi izimo ezisetshenziswa ama-prokinetic agents?
Lolu hlobo lomuthi luvame ukunconywa odokotela ezimweni lapho ezinye izindlela zokwelapha zingazange zilethe impumuzo, njengoba lokhu kungaba nemiphumela emibi ethile.
| Isimo sezokwelapha | Kalula nje... | Lomuthi usiza kanjani? |
|---|---|---|
| I-Gastroparesis | Ukugaya ukudla kuyabambezeleka ngoba imisipha yesisu ayisebenzi kahle. Lesi simo sivame kakhulu kubantu abanesifo sikashukela. | Kwandisa ukufinyela kwesisu, okusisiza ukuthi sikhiphe isisu ngokushesha. I-Metoclopramide umuthi omkhulu ovunyelwe ukwenza lokhu. |
| I-GERD (isicanucanu/ubuhlungu besifuba) | Isimo sesikhathi eside esibangelwa yi-asidi yesisu egeleza njalo emphinjeni. | Le mithi ayilona ikhambi le-GERD ngokwayo. Kodwa-ke, uma ukuphuma kwesisu okuphuzile nakho kuyimbangela ye-GERD, udokotela wakho angase ayinikeze kanye neminye imithi. |
| I-Dyspepsia esebenzayo | Izimpawu eziqhubekayo zokungagayi kahle ukudla ngemva kokudla, kodwa akukho sizathu esicacile esingatholakala. | Kuyasiza ekunciphiseni izimpawu ngokwandisa ukuminyana kwesisu, kuqede ngokushesha. |
| Isicanucanu nokuhlanza | Ukuhlanza okuqhubekayo kanye nesicanucanu okunzima ukukulawula ngezinye izindlela zokwelapha. Kuphinde kusetshenziswe ekwelapheni ukuhlanza okubangelwa yi-chemotherapy enikezwa iziguli ezinomdlavuza. | Lezi zimpawu zilawulwa ngokuthinta izikhungo zokuhlanza ebuchosheni kanye nokusheshisa ukuphuma kwesisu. |
Yiziphi izinhlobo eziyinhloko zama-prokinetic agents?
Le mithi ingahlukaniswa ngamaqembu amabili amakhulu ngokusekelwe endleleni esebenza ngayo: Ama-Agonists kanye nama-Antagonists .
- Ama-Agonists: Lawa asebenza njengama-neurotransmitter emizimbeni yethu futhi enza into efanayo naleyo ayenzayo. Okusho ukuthi, athumela umyalezo emisipheni emathunjini ukuze ifinyele.
- Abaphikisi: Laba basebenza ngokuvimba ikhemikhali ephethe imiyalezo yezinzwa enciphisa ukusebenza kwamathumbu ekufinyeleleni emthanjeni. Okusho ukuthi, bavimba umyalezo owenza amathumbu "anciphise ijubane."
Kunezinhlobo eziningana zemithi ngaphansi kwalokhu:
- Izithasiselo ze-Dopamine: I-Dopamine, ikhemikhali etholakala ebuchosheni nasemathunjini, yehlisa ukusebenza kwamathumbu. Le mithi isebenza ngokuvimbela isenzo se-dopamine. Izibonelo: I-Metoclopramide, i-Domperidone .
- Ama-agonist e-Serotonin: Asebenza njengekhemikhali ebizwa ngokuthi i-serotonin futhi avuselela ukufinyela kwamathumbu. Izibonelo: I-Prucalopride .
- Ama-agonist e-Motilin: I-Motilin iyikhemikhali elawula ukufinyela kwamathumbu ethu amancane. Le mithi isebenza kanje. Ngokumangalisayo, leli qembu lihlanganisa ama-antibiotic afana ne -Erythromycin .
- Ama-agonist e-Cholinergic: Sebenza njenge-neurotransmitter acetylcholine futhi babangele ukuthi imisipha emathunjini ifinyele. Izibonelo: I-Bethanechol, i-Neostigmine .
Okubaluleke Kakhulu: Imiphumela emibi yalo muthi
Lena yingxenye ebaluleke kakhulu yalesi sihloko. Ama-Prokinetic Ejenti awawona umuthi ofana nePanadol wekhanda elivamile. Angaba nemiphumela emibi kakhulu futhi akufanele athathwe nganoma yisiphi isizathu ngaphandle kweseluleko sikadokotela.
Odokotela banikeza le mithi kuphela uma ezinye izindlela zokwelapha zehlulekile, futhi zivame ukunikezwa ngemithamo ephansi futhi isikhathi esifushane.
Imiphumela emibi evame ukubonwa:
- Isisu esibuhlungu
- Isicanucanu nokuhlanza
- Uhudo
- Umbono ofiphele
- Ikhanda elibuhlungu
- Ukukhathala okukhulu, ukozela
- Ukucindezeleka Nokukhathazeka
Imiphumela emibi kakhulu okufanele uyiqaphele:
Lezi zimpawu zibaluleke kakhulu. Uma uhlangabezana nanoma yiziphi zalezi zimpawu ngenkathi uthatha umuthi we-prokinetic, kufanele wazise udokotela wakho ngokushesha.
- I-Dystonia: Lesi yisimo lapho imisipha emzimbeni ifinyela khona ngendlela engalawuleki, njengokudonswa kwentamo ohlangothini olulodwa, amehlo ephenduka phezulu, noma ulimi luphuma ngaphandle.
- Ukunyakaza okungahleliwe kwezingxenye zobuso (i-Tardive Dyskinesia): Lesi yisimo esingaba khona ngemva kokuthatha umuthi isikhathi eside. Izingxenye zobuso, njengomlomo, ulimi, nomhlathi, ziyanyakaza ngokungazikhetheli. Lesi simo ngezinye izikhathi asithuthuki ngisho nangemva kokuyeka umuthi.
- Izinkinga zenhliziyo: Eminye imithi, ikakhulukazi i-Domperidone , ingabangela ukushaya kwenhliziyo okungajwayelekile (i-arrhythmias) kanye nokuhlaselwa yinhliziyo. Ngenxa yalesi sizathu, ukusetshenziswa kwale mithi kuye kwavinjelwa kwamanye amazwe.
Ngenxa yalezi zingozi, uma udokotela wakho ekunike lo muthi, khuluma naye ngokucophelela ngezinzuzo nezingozi. Qiniseka ukuthi utshela udokotela wakho nganoma yiziphi ezinye izimo zezokwelapha onazo kanye nanoma yimiphi eminye imithi oyiphuzayo.
Umlayezo Wokuya Nawe Ekhaya
- Ama-prokinetic agents uhlobo lomuthi olunikeza "ukusunduza" ohlelweni lokugaya ukudla "oluhamba kancane", okwenza ukudla kuhambe kalula.
- Lezi zisetshenziselwa ukwelapha izimo ezifana ne-gastroparesis (ukungasebenzi kahle kwesisu) kanye ne-GERD enzima.
- Lokhu akuvamile ukusetshenziswa njengokwelashwa kokuqala ngenxa yengozi yemiphumela emibi kakhulu.
- Ungalokothi usebenzise le mithi ngaphandle kweseluleko sikadokotela.
- Uma uhlangabezana nanoma yiziphi izimpawu ezingavamile ngenkathi uthatha lo muthi, ikakhulukazi ukudikiza kwemisipha ebusweni noma emzimbeni, tshela udokotela wakho ngokushesha.
- Uma udokotela wakho ekunike lo muthi, kungenxa yokuthi unqume ukuthi izinzuzo zinkulu kunezingozi ezingaba khona. Ngakho-ke, landela imiyalelo kadokotela wakho ngqo.
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