Momma yensua super cleaning service a ɛwɔ wo nipadua mu no ho ade! (Ahofadi a wɔde di dwuma)?

Ɛnnɛ yɛrebɛka adeyɛ bi a ɛyɛ nwonwa na ɛho hia paa a ɛkɔ so wɔ yɛn ankasa nipadua mu ho asɛm. Ɛte sɛ super cleaning service a ɛyɛ adwuma wɔ yɛn nipadua mu bere nyinaa. Ebia wontee ho asɛm da, nanso ɛyɛ biribi a enya yɛn akwahosan so nkɛntɛnso kɛse, titiriw bere a yɛrenyin no. Yɛfrɛ no ``Auto PH agy``. Asɛmfua no te sɛ nea ɛyɛ nwonwa kakra, ɛnte saa? Nanso momma yɛnkyerɛkyerɛ mu tiawa.

Dɛn ne ``Autophagy''? Sɛ yɛbɛka no tiawa a...

Fa no sɛ bere a wode wo fie redi dwuma no, dan mu nneɛma biara dedaw, ebi bubu, na ebi nso yɛ nea mfaso nni so. Ɛnde dɛn na yɛyɛ? Yeyi nneɛma a mfaso nni so fi hɔ, ɛtɔ da bi a yɛfa nneɛma dedaw no afã pa na yɛyɛ biribi foforo, anaasɛ yɛhohoro fie hɔ na yɛma ɛyɛ fɛ, ɛnte saa? Saa ara na ɛkɔ so wɔ nkwammoaa a ɛyɛ nneɛma nketenkete a ɛwɔ yɛn nipadua mu no mu.

Sɛ yɛbɛka no tiawa a, `(Autophagy)` yɛ adeyɛ a yɛn nipadua mu nkwammoaa yi nneɛma dedaw, asɛe, anaa mfaso nni so fi wɔn nipadua mu na wɔsan de di dwuma bio, a ɛkyerɛ sɛ wobetumi de adi dwuma bio. Ɛte sɛ nea yɛn nkwammoaa no rehohoro wɔn ho. Yebetumi nso aka sɛ eyi yɛ "quality control" nhyehyɛe a ɛwɔ yɛn nkwammoaa mu. Efisɛ sɛ nwura a ɛho nhia boaboa ano wɔ nkwammoaa bi mu a, saa nkwammoaa no ntumi nyɛ adwuma yiye. `(Autophagy)` yi saa nwura no fi hɔ na sɛ ɛho hia a, ɛyɛ nneɛma a mfaso wɔ so fi mu, na ɛboa nkwammoaa no ma ɛyɛ adwuma yiye.

Dɛn nti na ``Autophagy'' yi ho hia saa?

Afei ebia woresusuw sɛ, "Okay, ɛyɛ fɛ yiye sɛ nkwammoaa rehohoro wɔn ho, nanso dɛn ne asɛm kɛse no?" Autophagy ho hia ankasa na ama yɛn nkwammoaa no atumi atra ase na ayɛ adwuma yiye. Momma yɛnhwɛ nsɛntitiriw no bi:

• Wosiesie nkwammoaa afã horow a asɛe na wɔma ɛyɛ adwuma bio: Sɛnea wɔde nnua asinasin pa a woyi fi nkongua a abubu so na ɛyɛ pon foforo no, saa ara na nkwammoaa nso yɛ nneɛma foforo a mfaso wɔ so fi wɔn afã dedaw no mu.
• Yi afã horow a mfaso nni so a egye ahunmu: Sɛ nkwammoaa bi hyɛ nneɛma a ɛho nhia ma a, ɛnyɛ nea entumi nyɛ adwuma yiye. Autophagy yi adesoa a ɛho nhia yi fi hɔ, na ɛma tebea bi ba ma nkwammoaa no tumi yɛ adwuma wɔ ahofadi mu.
• Ɛsɛe nneɛma te sɛ mmoawa, mmoawa, ne mmoawa a wɔsɛe nkwammoaa: Saa adeyɛ yi tumi hu nneɛma bi a epira a ɛkɔ yɛn nkwammoaa mu mpo na ɛsɛe. Ɛne sɛ, eyi nso boa yɛn nipadua mu tumi a ɛko tia nyarewa no .

Nea ɛka eyi ho no, ``Autophagy'' wɔ abusuabɔ kɛse bi wɔ sɛnea yenyin ne bere tenten a yɛtra ase wɔ apɔwmuden mu no ho.Mpɛn pii no, bere a yɛrenyin no, saa ``Autophagy'' adeyɛ yi brɛ ase kakra. Nea ɛba ne sɛ nwura fi ase boaboa ano wɔ nkwammoaa no mu, na nkwammoaa no dwumadi so tew. Enti, saa adeyɛ yi a wobɛkɔ so akura mu yiye no betumi ayɛ nea ɛho hia ma apɔwmuden ne nkwa tenten.

Ɔkwan bɛn so na saa adeyɛ yi `(Autophagy)` kɔ so ankasa?

Okay, afei ma yɛnhwɛ sɛnea saa ahotew nhyehyɛe a ɛyɛ nwonwa yi yɛ adwuma wɔ nkwammoaa mu. Ebia eyi bɛyɛ te sɛ nea nyansahu mu de kakra, nanso ma menkyerɛkyerɛ mu tiawa.

Saa `(Autophagy)` adeyɛ yi yɛ mmerɛw denam protein soronko bi so . Wɔfrɛ eyinom `(Autophagy-related proteins)` anaa `(ATGs)`. Saa `(ATGs)` protein ahorow yi boaboa nwura a ɛwɔ nkwammoaa no mu ano, kyerɛ sɛ, afã horow dedaw ne nea asɛe, na ɛyɛ nhyehyɛe a ɛte sɛ ntini a ɛtwa ho hyia. Wɔfrɛ eyi `(Autophagosome)`. Fa no sɛ ɛte sɛ nwura kotoku.

Afei, saa ``Autophagosome'' yi, saa nwura kotoku no, kɔ nkwammoaa no fã titiriw foforo. Wɔfrɛ no ``Lysosome.'' Saa ``Lysosome'' yi te sɛ "nwura a wɔtow gu" wɔ nkwammoaa no mu. Nea ɛyɛ ne sɛ ɛyam nneɛma a ɛwɔ saa nwura kotoku no mu, kyerɛ sɛ, ɛpaapae mu nketenkete.

Asɛmfua "Autophagy" no fi Hela nsɛmfua abien mu ankasa. "Autos" kyerɛ "ankasa" na "Phagomai" kyerɛ "sɛ wobedi." Ɛkyerɛ sɛ "wodi wɔn ho." Ɛte sɛ nea nkwammoaa no "redi" n'ankasa afã horow a wɔmpɛ, ɛnte saa?

Enti bere a `(Lysosome)` no ayam nwura no akyi no, ɛma afã pa (te sɛ nneɛma a wɔde yɛ nneɛma) a wobetumi asan de adi dwuma no fi adi. Afei nkwammoaa no de saa nneɛma a wɔde yɛ nneɛma no yɛ nneɛma foforo a ehia. So ɛno nyɛ nwonwa?

Ɛhe na wɔkanyan saa ``Autophagy'' adeyɛ yi wɔ yɛn nipadua mu?

Saa ``Autophagy'' adeyɛ yi taa yɛ ntɛmntɛm bere a yɛn nkwammoaa no nni aduannuru anaa oxygen a wohia, anaasɛ bere a nkwammoaa no asɛe kakra no.

Susuw ho saa kwan yi so: `(Autophagy)` yɛ adeyɛ a wɔsan de di dwuma a ɛboa nkwammoaa ma ɛde n’ahode di dwuma yiye. Enti, sɛ nneɛma a nkwammoaa bi betumi anya afi abɔnten (te sɛ aduan, oxygen) sua a, ɛsɛ sɛ nkwammoaa no de nneɛma a ɛwɔ no di dwuma yiye. Ɛno na saa `(Autophagy)` nhyehyɛe yi bɛyɛ adwuma kɛse.

Sɛ yɛbɛka no tiawa a, ɛte sɛ nkwammoaa bi "redi" ne ho na ɛrebɔ mmɔden sɛ ɛbɛtra ase. Nanso adepa a ɛwɔ eyi ho ne sɛ nkwammoaa no fi ase yɛ adwuma yiye esiane mmɔden a wɔbɔ sɛ wɔbɛtra ase yi nti.

So yebetumi ahyɛ da akanyan saa adeyɛ a ɛne ``Autophagy'' yi?

Afei ebia woredwene sɛ, "Ah, enti yebetumi ahyɛ eyi ase sɛnea yɛpɛ? Ɛno bɛyɛ kɛse!" Wiɛ, akwan bi wɔ hɔ a yɛbɛfa so ama yɛn nkwammoaa no " stress " kakra na yɛaboa wɔn ma wɔafi ase saa adeyɛ yi a ɛne ``Autophagy''. Wɔne:

• Mmuadadi: Eyi kyerɛ sɛ worendidi bere bi. Eyi kyerɛ sɛ nipadua no gyae aduannuru a efi wiase a ɛwɔ akyi no mu na wɔhyɛ nkwammoaa no ma wɔsan de wɔn ankasa akwaa ahorow di dwuma bio ma ɛyɛ ahoɔden.
• Calorie anohyeto: Nea ɛka eyi ho ne sɛ wobɛtew calorie dodow a wudi da biara so a wunnyae adidi koraa, te sɛ mmuadadi. Eyi nso betumi akanyan ``Autophagy`` efisɛ nkwammoaa te nka sɛ wɔahwere aduannuru.
• Sɛ yɛdan kɔ aduan a srade pii wom, a carb nnim so: Eyi ne nea nnipa pii frɛ no ``Keto aduan.`` Nea ɛkɔ so wɔ eyi mu ne sɛ ɔkwan a nipadua no fa so de ahoɔden di dwuma no sesa. Sɛ́ anka ɛbɛyɛ carbohydrates (starch, asikre) no, efi ase hyew srade de hwehwɛ ahoɔden. Saa nsakrae yi nso betumi afi ase ayɛ ``Autophagy.``
• Apɔw-mu-teɛteɛ: Wɔ apɔw-mu-teɛteɛ mu, titiriw bere a yɛn ntini ahorow no wɔ adwennwen bi ase no, ``ATGs'' protein ahorow a yɛadi kan aka ho asɛm no dwumadi betumi akɔ soro na ``Autophagy'' betumi akanyan. Eyi betumi ayɛ soronko a egyina apɔw-mu-teɛteɛ ko a wɔyɛ ne sɛnea emu yɛ den so.

Nanso, biribi wɔ hɔ a ɛho hia paa sɛ yɛkae wɔ ha. Bere a akwan bi wɔ hɔ a wɔfa so kanyan `(Autophagy)` no, ɛnyɛ nea ɛfata obiara. Sɛ nhwɛso no, sɛ wonyinsɛn, worema nufu, anaasɛ wowɔ ayaresa tebea bi te sɛ `(Asikreyare)` a, mmuadadi, calories a wobɛbara, anaasɛ mpofirim ara wobɛdan akɔ `(Keto aduan)` so no betumi ayɛ asiane. Saa ara na ɛnyɛ papa sɛ wubefi apɔw-mu-teɛteɛ a emu yɛ den ase mpofirim a wo ne oduruyɛfo nkasa.

Bere tenten ahe na ɛsɛ sɛ wudi mmuada ansa na woafi ase `(Autophagy)`?

Mmoa ho nhwehwɛmu kyerɛ sɛ wobetumi akanyan autophagy denam mmuadadi a wobedi nnɔnhwerew 24 kosi 48 so. Nanso, wonnya nyɛɛ nhwehwɛmu a ɛdɔɔso wɔ bere tenten pɔtee a egye ansa na autophagy afi ase wɔ nnipa mu no ho.

Enti, sɛ woresusuw ho sɛ wobɛyɛ nsakrae kɛse wɔ w’aduan mu te sɛ mmuadadi a, hwɛ hu sɛ wo ne oduruyɛfo bɛkasa. Bere a mmuadadi betumi ayɛ papa ama nnipa binom de, nanso ebetumi apira afoforo akwahosan. Enti mfa wo ho nto asiane mu a ɛho nhia.

Abusuabɔ bɛn na ɛda `(Autophagy)` ne yareɛ ntam?

Bere bi a atwam no, nyansahufo susuwii sɛ ``Autophagy`` yɛ adeyɛ a ɛfata a wɔde tew nkwammoaa ho ara kwa, "ofiehwɛ" bi. Nanso nhwehwɛmu a wɔayɛ wɔ mfeɛ aduonu a atwam no mu ada no adi sɛ ``Autophagy`` betumi adi dwuma titiriw wɔ yareɛ a wɔsiw ano na wɔyɛ ho biribi .

Sɛ nhwɛso no, nhwehwɛmu ahorow ada no adi sɛ ɔhaw ahorow a ɛwɔ ``Autophagy'' nhyehyɛe no mu no betumi ne yare tebea horow a edidi so yi wɔ abusuabɔ:

• `(Crohn yareɛ)` (Crohn yareɛ) .
• `(Asikreyare)` (Asikreyare) .
• Koma mu yare
• `(Huntington yareɛ)` (Huntington yareɛ) .
• Asaabo mu yare
• Mmɛn mu yare
• `(Parkinson yareɛ)` (Parkinson yareɛ) .

Afei nso, wɔahu sɛ ɔhaw ahorow a ɛwɔ `(Autophagy)` adeyɛ no mu no ne kokoram wɔ abusuabɔ . Sɛ ``nwura`` boaboa ano wɔ nkwammoaa bi mu a, ebetumi ama asiane a ɛwɔ hɔ sɛ mfomso bɛba wɔ awosu mu nneɛma mu, kyerɛ sɛ, `(DNA)` no ayɛ kɛse. Saa nsakrae yi a ɛba `(DNA)` mu no betumi ama `(Genetic mutations)` aba, a ebetumi ama kokoram nkwammoaa ayɛ.

Nanso, ɛyɛ den sɛ yɛbɛka sɛ `(Autophagy)` ye anaasɛ enye ma yareɛ a wɔsiw ano. Sɛ nhwɛso no, nhwehwɛmu ahorow bi ada no adi sɛ `(Autophagy)` boa ma akisikuru ntumi nkɔ kokoram no mfiase. Nanso, nhwehwɛmu afoforo ada no adi sɛ `(Autophagy)` betumi ama kokoram nkwammoaa ayɛ adwuma yiye na mpo aboa kokoram akisikuru ma anyin.

Afei nso, nhwehwɛmu dodow no ara a wɔayɛ wɔ abusuabɔ a ɛda autophagy ne yare ntam no, wɔanyɛ wɔ nnipa so. Wɔayɛ no mpɛn pii wɔ mmoa te sɛ mpɔtorɔ so. Enti, bere a nyansahufo sua saa adeyɛ yi ho ade pii no, ebia yebetumi anya sɛnea ɛka nyarewa bi ne yɛn akwahosan a ɛtra hɔ kyɛ no ho mfonini a emu da hɔ.

Nea etwa to no, nneɛma a ɛsɛ sɛ wokae (Take-Home Message) .

Nnansa yi, bere a wɔaka `(Autophagy)` ho asɛm pii no, nnipa binom afrɛ no "akwahosan ho su" ara kwa - ɔkwan a wɔfa so kɔ so yɛ mmofra na wonya nkwammoaa a ɛte apɔw. Nanso, `(Autophagy)` nokwarem no ɛnyɛ mmerɛw saa.

Ɛyɛ nokware sɛ autophagy ho hia ma nkwammoaa a ɛwɔ apɔwmuden. Ɛyɛ nokware nso sɛ ɔhaw ahorow a ɛwɔ autophagy nhyehyɛe no mu no ne nyarewa bi wɔ abusuabɔ. Nanso, nhwehwɛmu a ɛdɔɔso nni hɔ a ɛbɛka sɛ autophagy a wɔkanyan no ye ma asetra a ahoɔden wom.

Ɛdenam w’akwahosan so no, mmuadadi, calories a wobɛtew so, nsakrae kɛse a wobɛyɛ wɔ w’aduan mu, anaa apɔw-mu-teɛteɛ a emu yɛ den a wubefi ase mpofirim no betumi ayɛ nea asiane wom. Enti, ɛho hia sɛ wo ne wo duruyɛfo kasa ansa na woayɛ asetra mu nsakrae biara a ebetumi aka wo nipadua no abɔde mu nneɛma. Ɛnyɛ adwene pa sɛ wobɛfa eyi sɛ ‘ade a ɛrekɔ so’ kɛkɛ na mpofirim ara woagyae adidi, atwitwa calories so, anaasɛ wubefi apɔw-mu-teɛteɛ nhyehyɛe a emu yɛ den ase. Wo duruyɛfo nkutoo na onim nea eye ma wo nipadua.

` Autophagy, nkwammoaa a wɔtew ho, mmuadadi, nkwammoaa akwahosan, onyin, nipadua dwumadi, asetra a ahoɔden wom