Dɛn ne Systemic Mastocytosis (SM) a ɛwɔ nipadua no mu? Momma yensua aduru Ayvakit no ho ade.

So wo duruyɛfo aka akyerɛ wo sɛ wowɔ tebea bi a ɛntaa nsi a wɔfrɛ no Systemic Mastocytosis ? Ebia wobɛte ehu kakra nka na woahaw wo ho bere a wote saa asɛm no. Ɛyɛ ade a ɛyɛ daa yiye. Nanso mma ɛnhaw wo. Mprempren ayaresa a eye paa na etu mpɔn wɔ hɔ ma tebea horow a ɛtete saa. Ɛnnɛ yɛrebɛka aduru Ayvakit (avapritinib) a wɔkyerɛw maa wo no ho asɛm. Momma yɛnte yare yi ne aduru no ho biribiara ase mmerɛw na emu nna hɔ.

Dɛn ankasa ne Systemic Mastocytosis (SM)?

Sɛ yɛbɛka no tiawa a, Systemic Mastocytosis yɛ tebea a ɛntaa nsi a nkwammoaa bi a wɔfrɛ no ‘mast cells’ a ɛwɔ yɛn nipadua mu nyin dodo. Saa mast cells yi yɛ yɛn nipadua mu ahoɔden a ɛko tia nyarewa no fã. Te sɛ yɛn man no asraafo a wɔbɔ wɔn ho ban no. Sɛ biribi a ɛyɛ ahɔhoɔ hyɛn nipadua no mu a, saa nkwammoaa yi yɛ adwuma na ɛma nnuru te sɛ ‘histamine’ fi adi.

Fa no sɛ sɛ nwansena bi ka wo a, baabi a ɛhɔ yɛ hyew na ɛyɛ kɔkɔɔ, ɛnte saa? Saa na ɛba esiane histamine yi nti. Nanso wɔ obi a ɔwɔ Systemic Mastocytosis mu no, saa mast cells yi boaboa ano wɔ ɔkwan a wontumi nni so wɔ nipadua no mu. Wɔboaboa ano wɔ honam ani, nnompe mu ntini, anaa emu akwaa te sɛ mmerɛbo ne akyi berɛmo mu. Esiane eyi nti, nipadua no tumi nya akisikuru ho sɛnkyerɛnne te sɛ ɛyaw, honam ani kɔkɔɔ, yafunu mu yaw, ne adwenemhaw, a ntease biara nnim.

Asɛmfua "systemic" kyerɛ sɛ ebetumi aka nipadua no nyinaa, ɛnyɛ beae biako pɛ. Saa yare yi ahorow pii wɔ hɔ, efi nea emu nyɛ den a enyin brɛoo (a ɛyɛ mmerɛw) so kosi nea ɛkɔ akyiri a ɛyɛ kokoram so.

Mɛyɛ dɛn ahu sɛ Ayvakit fata me anaa?

Wo duruyɛfo bɛyɛ nhwehwɛmu ahorow a ɛtoatoa so de ahu Systemic Mastocytosis ko a wowɔ ankasa. Nea ebefi saa nhwehwɛmu ahorow no mu aba ne wo sɛnkyerɛnne ahorow no na ɛbɛkyerɛ sɛ ebia Ayvakit fata wo anaa. Mprempren wɔapene Ayvakit so sɛ wɔmfa nsa Systemic Mastocytosis ahorow pii wɔ mpanyimfo mu.

Ɔkwan bɛn so na Ayvakit aduru yi yɛ adwuma wɔ nipadua no so?

Ayvakit yɛ aduru a ɛka nnuru kuw bi a wɔfrɛ no ‘kinase inhibitors’ ho. Kinases yɛ enzyme protein bi a ɛboa ma nsɛnkyerɛnne kɔ nkwammoaa a ɛwɔ yɛn nipadua mu no ntam. Saa nsɛnkyerɛnne yi ho hia yiye ma nneɛma te sɛ nkwammoaa nyin ne mpaapaemu.

Nnipa pii a wɔwɔ Systemic Mastocytosis no wɔ protein bi a wɔfrɛ no KIT a ɛwɔ mast cells mu no mu nsakrae . Saa nkwaadɔm mu nsakrae yi ma KIT protein no yɛ adwuma boro so, na ɛma mast nkwammoaa no nyin a wontumi nni so.

Ayvakit aduru no de n’ani si saa KIT protein a wɔayɛ no foforo no so pɛpɛɛpɛ na egyae ne dwumadi.. Te sɛ abantenten bi a ɛrema sɛnkyerɛnne a ɛnteɛ a wɔreyɛ komm. Eyi ma mast cells a ɛdɔɔso dodo no gyae, ɛtew sɛnkyerɛnne ahorow so, na esiw akwaa ahorow a ɛsɛe no so.

Ɔkwan bɛn so na ɛsɛ sɛ mede Ayvakit nnuru di dwuma?

Ayvakit yɛ aduru a wɔde yɛ aduru. Ade a ɛho hia sen biara bere a worenom ne sɛ wobɛfa no yafunu a hwee nni mu . Ɛno kyerɛ sɛ, anyɛ yiye koraa no, ɛsɛ sɛ wonom dɔnhwerew biako ansa na woadi, anaa nnɔnhwerew abien wɔ adidi akyi. Ɛno ne bere a nipadua no twetwe aduru no yiye.

Nnuru dodow a wɔtaa kyerɛw ma no ne nea edidi so yi:

• Sɛ wopɛ Advanced Systemic Mastitis TOS (AdvSM): 200mg pɛnkoro da biara.
• Wɔ Indolent Systemic Mastocytosis (ISM) ho no: 25mg pɛnkoro da biara.

Mpɛn pii no, eyi yɛ ayaresa a ɛkyɛ. Wo duruyɛfo bɛka akyerɛ wo sɛ kɔ so nom aduru no kosi sɛ wubenya nea eye afi mu na worennya ɔhaw biara a emu yɛ den. Sɛ wowɔ ɔhaw biara a, ebia wo duruyɛfo besi gyinae sɛ ɔbɛtew dodow a wode ma no so, obegyae bere tiaa bi, anaasɛ obegyae koraa.

Dɛn na nhwehwɛmu ka fa Ayvakit nkonimdi ho?

Nsɛm wɔ hɔ a ɛfa nnuruyɛ mu sɔhwɛ abiɛsa a wɔyɛe de hwehwɛɛ sɛnea Ayvakit aduru no yɛ adwuma yiye ne ahobammɔ ho.

Wɔ AdvSM (a emu yɛ den): Wɔ nhwehwɛmu abien no mu no, EXPLORER ne PATHFINDER no, nnipa a wɔnom Ayvakit, anaa bɛboro fã no mu 57%, nyaa yare no ho sɛnkyerɛnne so tew na wɔn dwumadi san bae kakra wɔ akwaa a ɛkaa wɔn no mu. Wɔn a wɔdaa nea efii mu bae adi no mu fã kuraa saa nkɔso no mu asram 38, anaa bɛboro mfe 3.

Wɔ ISM (a ɛyɛ mmerɛw) fam no, Wɔ PIONEER nhwehwɛmu no mu no, wɔn a wɔnom Ayvakit no nyaa yare no ho sɛnkyerɛnne kakraa bi koraa (te sɛ ɛyaw, yafunu mu yaw, ne ɔbrɛ) sen wɔn a wɔnom placebo no. Eyi kyerɛ sɛ saa aduru yi ama ahotɔ kɛse wɔ asetra pa a wɔbɛma atu mpɔn no mu.

Saa nhwehwɛmu ahorow yi kyerɛ sɛ Ayvakit yɛ ayaresa a etu mpɔn yiye a wɔde sa Systemic Mastocytosis. Nanso, ma ɛntra w’adwenem sɛ ɛnsa yare no koraa, na nea ebefi mu aba no renyɛ pɛ mma obiara.

So ɔhaw ahorow betumi aba wɔ nnuru afoforo ho? (Nnuru a Wɔde Di Dwuma) .

Yiw, Ayvakit betumi ne nnuru bi adi nkitaho. Titiriw nea ɛka enzyme CYP3A a ɛwɔ yɛn mmerɛbo mu no. Nnuru bi betumi ama Ayvakit dodow akɔ soro wɔ nipadua no mu na ama nea efi mu ba no akɔ soro, bere a nnuru afoforo betumi ama Ayvakit dodow so atew na atew ne mmɔdenbɔ so.

Enti, hwɛ hu sɛ wobɛbɔ wo duruyɛfo amanneɛ wɔ nnuru a worenom nyinaa ho (nnuru a wɔde sa nyarewa afoforo, vitamin, aduru a wɔde di dwuma wɔ amanne kwan so, nnuru a wɔde ka ho). Afei obetumi ahwɛ sɛ ɔhaw biara wɔ hɔ anaa, na sɛ ɛho hia a, asesa wo nnuru afoforo no anaasɛ ɔsesa Ayvakit dodow.

Afei nso, sɛ worenom nnuru a ɛma mogya tu te sɛ warfarin (Coumadin, Jantoven) , asiane a ɛwɔ hɔ sɛ mogya bɛtɔ amemene no mu afi Ayvakit mu no betumi ayɛ kɛse kakra. Enti, sɛ worenom nnuru a ɛte saa a, wo duruyɛfo bɛhwɛ wo yiye.

Ɔkwan bɛn so na wobetumi anya Ayvakit aduru?

Ayvakit yɛ aduru a wɔkyerɛw ma obi nkutoo, na mpɛn pii no mogya ho ɔbenfo anaa kokoram ho ɔbenfo na ɔkyerɛw ma.

Eyi nyɛ aduru a wubetumi anya wɔ nnurutɔnbea a wɔyɛ no daa . Wobetumi anya bi wɔ ‘nnurutɔnbea titiriw’. Sɛ wo duruyɛfo no de nnuru a wɔakyerɛw ama wo no kɔma saa nnurutɔnbea titiriw no wie a, wobetumi de aduru no akɔ wo fie anaa wo duruyɛfo adwumayɛbea.