So wunim nufu mu kokoram a wɔfrɛ no ER+ yi? (Estrogen Receptor-Positive Nufu mu Kokoram - ER +)

So woate nufu mu kokoram ho asɛm pɛn? Ebia wo nnamfo no mu biako ayɛ saa. Nufu mu kokoram ahorow pii wɔ hɔ. Ɛnnɛ yɛrebɛka wɔn mu baako ho asɛm. Ɛno ne ER+ (ER positive) nufu mu kokoram . Ɛwom sɛ ebia edin no bɛyɛ te sɛ nea ɛyɛ den kakra de, nanso momma yɛnkyerɛkyerɛ mu tiawa.

Dɛn ne ER+ nufu mu kokoram?

Sɛ yɛbɛka no tiawa a, ER+ nufu mu kokoram yɛ nufu mu kokoram bi. Kae sɛ mmea wɔ hormone bi a wɔfrɛ no estrogen wɔ wɔn nipadua mu. Saa hormone yi boa wɔ nneɛma pii mu. Nanso, ɛtɔ mmere bi a, saa estrogen hormone yi nso boa ma kokoram nkwammoaa nyin. Enti, nufu mu kokoram nkwammoaa a enyin esiane estrogen hormone nti no ne nea yɛfrɛ no ER+ nufu mu kokoram. ‘ER’ gyina hɔ ma Estrogen Receptor . Wei kyerɛ sɛ saa kokoram nkwammoaa yi wɔ mmeae a estrogen tumi ‘bata ho’. Nnuruyɛfo hwɛ sɛnea estrogen agyefo yi dodow te de yɛ ayaresa ho nhyehyɛe. Mpɛn pii no, wɔde oprehyɛn ne hormone ayaresa di dwuma sɛ eyi ho ayaresa. Nnipa binom nso frɛ eyi sɛ ‘nufu mu kokoram a estrogen wɔ mu’.

ER+ nufu mu kokoram abu so dɛn?

Eyi abu so kɛse ankasa sen sɛnea ebia wubesusuw. Nnipa dodow no ara a wonya nufu mu kokoram, bɛyɛ 100 biara mu 70 wɔ kokoram a wɔfrɛ no ER+ yi. Eyi ka mmarima ho, efisɛ mmarima nso betumi anya nufu mu kokoram, nanso ɛntaa nsi koraa. Enti eyi nyɛ nea wɔntee ho asɛm saa.

Dɛn ne ER+ nufu mu kokoram ho sɛnkyerɛnne?

Mpɛn pii no, obi a ɔwɔ ER+ nufu mu kokoram bɛda sɛnkyerɛnne koro no ara adi te sɛ obi a ɔwɔ nufu mu kokoram. Momma yɛnhwɛ nea wɔyɛ:

• Sɛ wuhu nsakrae a aba wo nufu biako kɛse, ne nsusuwii, anaa ne nsusuwii mu . Ebia nufu biako yɛ soronko wɔ foforo ho.
• Wɔkyere ade a ɛyɛ kurukuruwa anaasɛ ɛyɛ kurukuruwa wɔ nsa no mu. Eyi betumi ayɛ ketewaa te sɛ pea.
• Nkate a ɛne sɛ nufu anaa abasa no mu ayɛ den anaasɛ ayɛ den . Ɛsɛ sɛ wohaw wo ho titiriw sɛ eyi wɔ hɔ wɔ wo ɔsram biara brayɛ bere nyinaa mu a.
• Nsakrae a ɛba sɛnea nufu anaa nufu no honam ani hwɛbea te anaasɛ ɛte nka mu . Ebia honam ani yɛ te sɛ nea ɛyɛ nsensanee, ayɛ kurukuruwa, ayɛ mmerɛw, anaasɛ ɛho ayɛ hyew. Ebetumi nso ayɛ kɔkɔɔ anaa tuntum asen nufu no fã a aka no.
• Sɛ wote nka sɛ wowɔ baabi a ɛyɛ den wɔ wo honam ani, te sɛ marble asinasin .
• Mogya anaa nsu a emu da hɔ a efi nufu no mu ba.

Sɛ wususuw sɛ wowɔ saa sɛnkyerɛnne ahorow yi bi a, yɛsrɛ wo nsuro sɛ wobɛkɔ oduruyɛfo nkyɛn. Dodow a wuhu ntɛm no, dodow no ara na ɛyɛ mmerɛw sɛ wobɛsa.

Dɛn na ɛde ER+ nufu mu kokoram ba?

Okay, afei momma yɛnhwɛ sɛnea eyi ba ankasa. Wɔ yɛn nipadua mu nkwammoaa mu no, ɛwɔ hɔNneɛma bi wɔ hɔ a wɔfrɛ no hormone receptors. Eyinom te sɛ apon nketewa, protein bi. Hormone estrogen a ɛwɔ yɛn mogya mu no tumi kyekyere saa ntini ahorow yi. Wɔ nkwammoaa a ɛte apɔw mu no, estrogen boa nkwammoaa no ma ɛyɛ adwuma na enyin sɛnea ɛsɛ. Ɛno yɛ ade a ɛfata.

Nanso, wɔ ER+ nufu mu kokoram mu no, saa estrogen hormone yi kyekyere protein ahorow a ɛwɔ kokoram nkwammoaa no mu, na ɛma saa kokoram nkwammoaa no nyin kɛse mpo. Susuw ho te sɛ estrogen te sɛ ‘afã’ ma kokoram nkwammoaa. Ɛtɔ mmere bi a, ɛnyɛ estrogen nko, na mmom hormone foforo a wɔfrɛ no progesterone nso boa ma kokoram nkwammoaa yi nyin. Yɛfrɛ kokoram a ɛte saa a progesterone dodow dɔɔso wom no PR-positive (PR+) nufu mu kokoram. Kokoram ahorow bi betumi ayɛ ER+ ne PR+ nyinaa.

Dɛn ne asiane ahorow a ɛde eyi ba?

Asiane ahorow bi wɔ hɔ a ebetumi aka ER+ nufu mu kokoram a ɛba no. Momma yɛnhwɛ nea wɔyɛ.

Nneɛma a ɛde asiane ba mmea so:

Wɔ mmea fam no, asiane titiriw a ɛwɔ mu ne sɛ wɔde wɔn ho bɛhyɛ hormone estrogen mu bere tenten . Eyi kyerɛ sɛ estrogen dodow a ɛwɔ nipadua no mu no kɔ so yɛ kɛse bere tenten. Ma yɛnhwɛ sɛnea ɛba saa:

• Mmabunbere mfiase (brayɛ a efi ase ntɛm).
• Brayɛ a ɛkyɛ .
• Mmofra a wɔbɛwo akyiri anaasɛ wɔrenwo mma koraa.
• Hormone ayaresa (titiriw nea estrogen wom) a wɔnom de hwehwɛ sɛnkyerɛnne ahorow a ɛba bere a obi agyae brayɛ akyi.

Nneɛma a ɛde asiane ba mmarima so:

Wɔ mmarima fam no, asiane yi ne estrogen dodow a ɛkɔ soro sen sɛnea ɛte daa ne testosterone a ɛba fam wɔ wɔn nipadua mu no wɔ abusuabɔ. Wɔfrɛ eyi sɛ hormone a ɛnkari pɛ . Nhwɛso ahorow bi ne:

• Obolo .
• Asikreyare (Asikreyare) .
• Tebea horow te sɛ mmerɛbo mu akisikuru .

Ɔkwan bɛn so na wohu ER+ nufu mu kokoram pɛpɛɛpɛ?

Sɛ wususuw sɛ wowɔ nufu mu kokoram a, wo duruyɛfo bedi kan ayɛ nufu mu nhwehwɛmu . Nea ɛka eyi ho ne sɛ wobegye ntini ketewaa bi afi kokoram akisikuru no mu. Afei wɔde saa nhwɛsode yi kɔ lab. Ɛhɔ no, aduruyɛ mu ɔyare ho ɔbenfo , oduruyɛfo a ne ho akokwaw wɔ ntini mu nhwehwɛmu mu, bɛhwehwɛ ntini no mu ahwɛ sɛ ebia ɛwɔ hormone receptors anaa.

Sɛ nea efi sɔhwɛ no mu ba ne Hormone Receptor-Positive (HR+) , a, ɛkyerɛ sɛ estrogen, progesterone, anaa saa hormone abien yi nyinaa reboa ma kokoram nkwammoaa no anyin. ER+ nso yɛ HR + fã. Ɛkyerɛ sɛ estrogen agyefo wɔ hɔ. NtiSɛ nhwehwɛmu ahorow kyerɛ sɛ estrogen dodow nkɔ soro a, wobu nufu mu kokoram no sɛ estrogen receptor-negative (ER-negative) .

Dɛn ne ayaresa ahorow a wɔde sa ER+ nufu mu kokoram?

Nnuruyɛfo de akwan atitiriw pii di dwuma bere a wɔresa ER+ nufu mu kokoram no. Eyinom bi ne:

• Nufu mu kokoram oprehyɛn : Nea ɛka eyi ho ne sɛ woyi kokoram akisikuru fi hɔ.
• Mframa a wɔde sa yare : Wɔde mframa a ahoɔden wom kɛse di dwuma de sɛe kokoram nkwammoaa.
• Nnuru a wɔde sa yare : Wɔ saa ayaresa yi mu no, wɔde nnuru kum kokoram nkwammoaa anaasɛ wɔde siw wɔn nyin ano.
• Hormone ayaresa : Eyi ho hia yiye ma ER+ kokoram ahorow. Akwan abien na ɛwɔ hɔ a wɔfa so yɛ eyi:
• Aromatase inhibitors : Saa nnuru yi yɛ adwuma denam hormone estrogen a ɛba wo nipadua mu a ɛtew so, a ɛkyerɛ sɛ kokoram nkwammoaa no nnya aduan.
• Selective Estrogen Receptor Modulators (SERMs) : Saa nnuru yi yɛ adwuma denam estrogen hormone a esiw ano sɛ ɛnbata kokoram nkwammoaa ho no so. Wɔboa nso ma asiane a ɛwɔ hɔ sɛ kokoram no bɛsan aba no so tew.

Oduruyɛfo no bɛhwɛ wo tebea no na wasi ayaresa yi mu nea ɛfata ma wo ne sɛnea wɔde bɛma wo no ho gyinae.

Dɛn ne ayaresa no mu nsunsuanso bɔne?

Sɛnea ɛte wɔ ayaresa biara ho no, saa ayaresa ahorow yi betumi anya nsunsuanso bɔne bi. Mma ɛnhaw wo, nnuruyɛfo no bedi kan akyerɛkyerɛ eyinom nyinaa mu akyerɛ wo.

Nneɛma bɔne a ɛtaa ba wɔ nnuru a wɔde sa yare ne mframa a wɔde sa yare mu no bi ne:

• Ɔbrɛ kɛse a wɔte nka (Ɔbrɛ) .
• Akisikuru ne ɔfe

Wobetumi ahu nsunsuanso bɔne a edidi so yi bere a wɔde hormone resa yare no :

• Nkwaa mu yaw anaasɛ ɛyɛ den
• Ɔbrɛ
• Mu duru a ɛkɔ soro
• Ɔbarima ne ɔbea nna ho anigye a ɛba fam anaasɛ ɔhweree
• Hot flashes - ɔhyew ho atenka a efi nipadua no mu ba .
• Nufu a ɛyɛ mmerɛw anaasɛ ɛho ahonhon

Sɛ wɔresa wo yare wɔ ER+ nufu mu kokoram ho a, bisa wo duruyɛfo fa ayaresa a ɛma wo ho tɔ wo ho asɛm . Eyi betumi aboa wo ma woadi wo kokoram no ho sɛnkyerɛnne ne nea efi w’ayaresa no mu ba no ho dwuma.

Dɛn ne nkwa a wonya wɔ ER+ nufu mu kokoram mu?

Eyi yɛ asɛm a nnipa pii bisa. Sɛnea nsɛm a efi National Cancer Institute (NCI) , kyerɛ no, ne nyinaa mu no, mmea a wɔwɔ nufu mu kokoram wɔ mfe anum akyi a wɔahu sɛ wɔwɔ kokoram noNnipa bɛboro 90% na wɔte ase. Eyi yɛ asɛmpa ankasa. Nanso, NCI mfaa nsɛm a ɛsono emu biara mmae wɔ nkwa dodow a mmarima a wɔwɔ ER+ kokoram nya no ho.

Sɛ woresusuw nkwagye dodow ho a, ɛho hia sɛ wokae sɛ eyinom yɛ akontaabu a egyina nnipa kuw kɛse bi suahu so . Afei nso, ebia ɛbɛyɛ akontaabu a egyina tebea horow a na ɛwɔ hɔ mfe pii a atwam ni so. Ayaresa ahorow renya nkɔso da biara da. Enti, ɛbɛyɛ papa sɛ wo ne wo duruyɛfo bɛkasa afa wo tebea no ne nea wubetumi ahwɛ kwan ho.

So ER+ kokoram betumi asan aba bio bere a wɔasa no yare awie no?

Ɛwom sɛ wobu ER+ nufu mu kokoram sɛ ɛnyɛ nea ano yɛ den kɛse te sɛ kokoram ahorow afoforo bi de, nanso asiane wɔ hɔ sɛ ɛbɛsan aba bio bere a wɔasa no yare akyi. Saa asiane yi betumi aba sɛ wohu ER+ kokoram ntɛm mpo na wɔde ER+ kokoram a asiane nnim sa yare a. Sɛ ɛhaw wo sɛ ebia wo kokoram no bɛsan aba a, wo ne wo kokoram ho ɔyaresafo nka w’ankasa asiane ne nea wubetumi ayɛ de atew asiane a ɛwɔ hɔ no so.

Wobɛyɛ dɛn ahwɛ wo ho wɔ ER+ nufu mu kokoram ho?

Sɛ wo ne ER+ nufu mu kokoram te ase a, ɛho hia sɛ wohwɛ wo ho yiye. Nyansahyɛ ahorow bi a ebetumi aboa wo ni:

• Nya ahomegye a ɛdɔɔso. Nufu mu kokoram ne n’ayaresa betumi ayɛ ɔbrɛ kɛse. Kae sɛ wobɛhome bere biara a wobɛte nka sɛ woabrɛ, na ɛnyɛ bere a wote nka sɛ wopɛ kɛkɛ.
• Didi yiye. Ebia w’akɔnnɔ bɛsakra esiane ayaresa nti. Aduan a nnuaba, nhabannuru, protein a ɛnyɛ den, ne aburow a ahoɔden wom ka ho bɛboa wo ma woakɔ so ayɛ den bere a wɔreyɛ ayaresa no.
• Di adwennwen ho dwuma. Kokoram a wobedi ho dwuma no yɛ adwennwen kɛse. Apɔw-mu-teɛteɛ yɛ ɔkwan pa a wobɛfa so aboa wɔ eyi mu. Wubetumi ayɛ biribiara fi da biara da nantew so kosi apɔw-mu-teɛteɛ nhyehyɛe ahorow a wode wo ho bɛhyɛ mu so.
• Nya mmoa. Woyɛ obi a woanya nufu mu kokoram, na ɛno fi ase da a wobehu sɛ wowɔ wo no. Bisa wo duruyɛfo nhyehyɛe ahorow a wɔyɛ de nya kokoram no ho asɛm . Eyinom betumi aboa wo ma woadi nsɛnnennen a ɛwɔ nufu mu kokoram asetra mu no ho dwuma.

Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn ntɛm ara sɛnea wubetumi?

Sɛ wote nka sɛ wo yare no ho sɛnkyerɛnne no reyɛ kɛse, anaasɛ wunya sɛnkyerɛnne foforo te sɛ ɛyaw anaa mmerɛwyɛ wɔ wo nipadua mu baabi foforo a, kɔ wo duruyɛfo nkyɛn ntɛm ara.

Nsɛmmisa a ɛho hia bɛn na ɛsɛ sɛ wobisa oduruyɛfo no?

Sɛ wokɔ wo duruyɛfo nkyɛn a, nsuro sɛ wubebisa nsɛm biara a wowɔ. Nsɛmmisa bi a wubetumi abisa ni:

• Ayaresa bɛn na wokamfo kyerɛ me?
• So mihia nnuru a wɔde sa yare ne mframa a wɔde sa yare nyinaa, anaasɛ hormone ayaresa ara kwa bɛdɔɔso?
• So ɛsɛ sɛ menom hormone therapy me nkwa nna nyinaa?
• Dɛn ne ayaresa ahorow yi mu nsunsuanso bɔne? Dɛn na metumi ayɛ de atew wɔn so?
• Dɛn ne anidaso ahorow a ɛwɔ hɔ sɛ me ho bɛtɔ me?

Ɛhe na ER+ nufu mu kokoram betumi atrɛw?

Ɛtɔ mmere bi a, nufu mu kokoram tumi trɛw kɔ nipadua no afã afoforo. Nea ɛka eyi ho ne akwaa te sɛ ahurututu, amemene, nnompe, ne mmerɛbo . ER+ nufu mu kokoram yɛ nufu mu kokoram nyinaa mu bɛyɛ 70%, enti ɛho hia sɛ wohu saa ntrɛwmu yi nso.

Awiei koraa no, nneɛma kakraa bi a ɛsɛ sɛ wokae

Okay, enti momma yɛnsan nsusuw nsɛntitiriw a ɛho hia sen biara a yɛkaa ho asɛm nnɛ no ho asɛm.

ER+ nufu mu kokoram yɛ kokoram bi a enyin esiane hormone estrogen nti. Ɛwom sɛ mpɛn pii no, saa hormone yi boa ma nkwammoaa nyin de, nanso ɛma kokoram nkwammoaa ‘aduan’ nso.

Nnuruyɛfo sɔ estrogen dodow a ɛwɔ nufu mu kokoram nkwammoaa mu hwɛ na wɔyɛ ayaresa ho nhyehyɛe sɛnea ɛfata. Hormone ayaresa titiriw yɛ adwuma de tew nkɛntɛnso a saa hormone estrogen yi nya wɔ kokoram nkwammoaa so no so.

Sɛ wowɔ ER+ nufu mu kokoram a, nsuro sɛ wo ne wo duruyɛfo bɛkasa . Hwɛ hu sɛ wubetie na woate ayaresa a wubetumi apaw ne sɛnea ayaresa biara bɛboa wo no ase. Ɛnyɛ wo nkutoo na wowɔ hɔ, na nnuruyɛfo ne mmoa adwumayɛbea ahorow pii wɔ hɔ a wobetumi aboa wo.

Mma wo werɛ mmfi sɛ wobetumi adi tebea yi so yiye bere a wohu ntɛm na wɔasa no yiye no.

` ER+ Nufu mu Kokoram, Estrogen, Nufu mu Kokoram Nsɛnkyerɛnne, Hormone Ayaresa, Kokoram Ayaresa, Mmea Akwahosan, Estrogen Receptor-Positive Nufu mu Kokoram