So wote nka sɛ wo ho yɛ wo yaw? So wo akwaa reyɛ ayɛ mmerɛw? Eyi betumi ayɛ Inclusion Body Myositis (IBM)!

So ɛtɔ mmere bi a wote nka sɛ ɛyɛ den ma wo sɛ wubekura nneɛma mu, wobɛbɔ bɔtn bi, anaasɛ wobɛnantew mpo? Ebia wobɛdwene sɛ, "Oo, eyi yɛ biribi a ɛba bere a woanyin no ara kwa." Nanso ɛtɔ da bi a, saa nneɛma yi nyɛ mmerɛw saa. Ɛnnɛ, yɛrebɛka tebea bi a ɛntaa nsi nanso ɛho hia yiye a ɛsɛ sɛ yɛma yɛn ani da hɔ ho asɛm. Ɛno na wɔfrɛ no `Inclusion Body Myositis`, a wɔsan frɛ no `(IBM)` tiawa.

Dɛn ne `Inclusion Body Myositis (IBM)`? Momma yɛnte ase kɛkɛ!

Sɛ yɛbɛka no tiawa a, `Inclusion Body Myositis` yɛ tebea a ɛma wo ntini yɛ mmerɛw nkakrankakra, nanso ɛmma ɛyaw pii mma. Ɛtaa fi ase bere a woadi mfe 50. Susuw ho hwɛ, ebia ɛbɛyɛ den ama wo sɛ `bɛbɔ` biribi ketewaa bi, ɛbɛyɛ den ama wo sɛ `wobɛkyere` biribi, anaasɛ mpo wobɛhwe ase na woahwe ase bere a wonam kɛkɛ no. Eyinom ne nsɛnkyerɛnne a edi kan a ebia wubehu.

Saa tebea yi a wɔfrɛ no `IBM` no kɔ so nkakrankakra wɔ mfe pii mu. Ɛnyɛ tebea a ɛde nkwa to asiane mu. Wei kyerɛ sɛ ɛrenkum wo. Nanso, bere kɔ so no, ebetumi ama ayɛ den sɛ wɔbɛyɛ da biara da dwumadi ahorow, na ebetumi ama obi adi dɛm kodu baabi. Ɛtɔ mmere bi a, wo nipadua no fã biako pɛ na ɛka kɛse. Nnipa a wɔwɔ saa tebea yi mu bɛyɛ fã nso betumi anya ɔhaw wɔ menewa mu.

Awerɛhosɛm ne sɛ, wonnya nnyaa aduru biara mma IBM. Nanso mma ɛnhaw wo! Apɔw-mu-teɛteɛ betumi aboa wo ma woakura wo ntini ahoɔden mu bere tenten biara a wubetumi.

Saa `IBM` tebea yi abu so dɛn?

Nea Wɔde Ka Ho Nipadua mu Myositis yɛ tebea a ɛka nyarewa kuw bi a ɛma ntini yɛ mmerɛw a wɔfrɛ no myopathies ho. Myopathies yɛ nyarewa a ɛtow hyɛ wo ntini mu nhama so na ɛma ɛyɛ mmerɛw. Nhwehwɛmu kyerɛ sɛ IBM ka mpanyimfo ɔpepem biara mu 5 kosi 9. Ɛsan nso dɔɔso bɛyɛ mpɛn abiɛsa wɔ mmarima mu sen mmea (3:1).

Dɛn ne `Inclusion Body Myositis (IBM)` ho sɛnkyerɛnne? Momma yɛnhwehwɛ mu pɛpɛɛpɛ!

Ntini mu mmerɛwyɛ a IBM de ba no ba nkakrankakra. Ɛtaa fi ase wɔ akwaa no mu. Ebia wubedi kan ahu mmerɛwyɛ wɔ wo nan, w’asen, anaa wo nsa, wo nsateaa, anaa wo nsateaa mu. Susuw ho saa kwan yi so: ɛyɛ den ma nnipa binom sɛ wɔbɛbɔ atade bi bɔton, anaasɛ wɔn kyerɛwdua nkyerɛw yiye. Afoforo nso yɛ den sɛ wɔbɛforo antweri, anaasɛ wɔto hintidua na wɔhwe ase bere a wɔnantew no.

Bere a yare no ho sɛnkyerɛnne no mu yɛ den nkakrankakra no, ebia wubehu nneɛma te sɛ:

• Ntini a ɛwɔ nsa, nan, mmati, asen, nsateaa, ne nsateaa mu no yɛ mmerɛw nkakrankakra. Fa no sɛ, wuntumi mma nneɛma a kan no na wotumi ma so ntɛm no so, na ɛyɛ den ma wo sɛ wobɛsɔre afi akongua so.
• Ntini a ɛwɔ kɔn anaa aduan mu a ɛyɛ mmerɛw. Eyi betumi ama ayɛ den sɛ wobɛma ne ti agyina hɔ, ama ayɛ den sɛ ɔbɛmene aduan, na ebetumi mpo ama aduan akyeakyea.
• Ntini a ɛyɛ mmerɛw no da adi pefee. Eyi kyerɛ sɛ ntini no atew na ayɛ teateaa paa.
• Ntini mu ɛyaw a emu nyɛ den, ɛtaa ba (`myalgia`). Nanso, ɛyaw yi mma obiara, na sɛ ɛba mpo a, ɛnyɛ den koraa.

Sɛ nhwɛso no, fa no sɛ wowɔ adamfo bi a wɔfrɛ no Sunil. Ɔntumi nkura ne tii kuruwa no yiye bere tenten ni, ɛkɔ so hwirew fi ne nsam. Sɛ ɔkɔkenkan atesɛm krataa no a, ne nsa te sɛ nea ɛrewosow. Mfiase no, osusuwii sɛ ɛyɛ ɔbrɛ ara kwa. Nanso akyiri yi, ohui sɛ eyi betumi ayɛ `IBM` ho sɛnkyerɛnne a edi kan.

Dɛn nti na saa `Inclusion Body Myositis (IBM)` yi ba? Dɛn na ɛde ba?

Nokwarem no, saa tebea a wɔfrɛ no `Inclusion Body Myositis` yi yɛ `idiopathic`. Ɛne sɛ, ɛte sɛ nea ɛba a ɛnyɛ nea ɛde ba pɔtee biara. Te sɛ `myositis` ahorow afoforo no, wɔ eyi mu no, ɔfe a ɛtra hɔ kyɛ wɔ ntini no mu (`ɔfe a enni sabea`) ne ade titiriw a ɛde ntini no mmerɛwyɛ ba. Nanso, nhwehwɛmufo da so ara nnim nea enti a ɔfe yi ba ankasa. Wosusuw sɛ ebia efi ɔhaw bi a ɛwɔ nipadua no mu tumi a ɛko tia nyarewa no mu (`autoimmune disease`) . Ɛne sɛ, nkwammoaa a ɛbɔ yɛn nipadua ho ban no di mfomso tow hyɛ yɛn ankasa ntini mu nkwammoaa so.

`Inclusion bodies` nso ne `IBM` wɔ abusuabɔ. Eyinom yɛ protein akuwakuw a ɛnyɛ ne kwan so a wɔde gu ntini mu nkwammoaa mu. Ebetumi afi ɔyare mmoawa bi, nkwammoaa a ɛsɛe, anaa awosu mu nsakrae mu aba . Saa `inclusion bodies` yi nso wohu wɔ neurodegenerative nyarewa te sɛ `ALS` mu. Wobetumi asiw nkwammoaa no dwumadi kwan sɛnea ɛsɛ.

Nsonsonoe a ɛda `Inclusion Body Myopathy` ne `Inclusion Body Myositis` ntam

Ɛtɔ da bi a wɔsan frɛ `Inclusion Body Myositis` `sporadic inclusion body myositis (sIBM)`. `Sporadic` kyerɛ sɛ ɛba kwa, anaasɛ ɛnyɛ nea ɛde ba pɔtee bi. Eyi yɛ nea wɔde kyerɛ nsonsonoe a ɛda tebea horow a ɛte saa ara a efi awosu mu no ntam. Wɔfrɛ wɔn a wonya fi awo mu no `hereditary inclusion body myopathies (hIMB)`. Sɛ yɛka sɛ `inclusion body myopathies` a, saa ahorow abien yi nyinaa yɛ ne dea. Seesei yɛreka `sIBM` a ɛba randomly no ho asɛm.

Ɔkwan bɛn so na wohu `Inclusion Body Myositis`? Sɔhwɛ ahorow bɛn na wɔyɛ?

Sɛnea ɛbɛyɛ na oduruyɛfo bi ahu sɛ wowɔ IBM anaa no, obedi kan abisa wo wo yare no ho sɛnkyerɛnne na wahwɛ wo ntini mu. Nsɛnkyerɛnne a ɛwɔ nipadua mu myositis a wɔde ka ho no betumi ayɛ te sɛ nea ɛwɔ tebea afoforo te sɛ polymyositis ne myasthenia gravis mu. Wo duruyɛfo bɛhwehwɛ nneɛma pɔtee bi te sɛ:

• Ntini bɛn na ɛka? (e.g., wɔ nsateaa anaa asen mu?)
• So nipadua no fã biako pɛ na ɛka kɛse?
• So ntini a ɛyɛ mmerɛw no da adi pefee?
• Ná woadi mfe ahe bere a yare no ho sɛnkyerɛnne fii ase no? (Mpɛn pii no, bere a wɔadi mfe 50 akyi) .

Afei, wobetumi ayɛ sɔhwɛ ahorow pii de ``apow`` tebea afoforo te sɛ:

• Creatine Kinase (CK) nhwehwɛmu: Eyi na ɛkyerɛ sɛnea enzyme titiriw bi a ɛwɔ mogya no mu no te. Saa `CK` dodow yi betumi akɔ soro bere a ntini no asɛe no.
• Mogya mu nhwehwɛmu a wɔyɛ de hu mmoawa ne nyarewa ahorow a nipadua no tumi ko tia nyarewa.
• Electromyogram (EMG): Eyi kyerɛ anyinam ahoɔden dwumadi a ɛwɔ wo ntini mu. Wɔnam nnade nketenkete a wɔde hyɛ ntini no mu so na ɛyɛ.
• Ntini a Ɛfa Ntini Ho Nhwehwɛmu (NCS): Eyi kyerɛ ahoɔhare a anyinam ahoɔden bi fa ntini (motor nerves) a ɛhwɛ wo ntini so no mu.

Ntini mu nkwaadɔm mu nhwehwɛmu

Ɔkwan a eye sen biara a wobɛfa so asi so dua sɛ ebia wowɔ inclusion-body myositis ne sɛ wubegye ntini ketewaa bi (biopsy) afi ntini a ɛka wo no mu. Ɔyare ho ɔbenfo bi bɛhwɛ ntini a wɔde yɛ nhwɛso yi wɔ afiri a wɔde hwɛ nneɛma nketenkete mu. Sɛ wowɔ IBM a, obetumi ahu nipadua a wɔde ka ho (protein akuwakuw, ahurututu, anaa vacuoles a ɛnyɛ ne kwan so) wɔ nhwɛsode no mu.

So ayaresa bi wɔ hɔ a etu mpɔn a wɔde sa `Inclusion Body Myositis`?

Nea ɛyɛ awerɛhow no, ayaresa biara nni hɔ a etu mpɔn a wɔde sa inclusion body myositis. Nea ɛnte sɛ tebea afoforo a ɛma obi ho hyehye no ne nyarewa a nipadua no tumi ko tia nyarewa no, ɛnyɛ nea ɛyɛ adwuma wɔ corticosteroids anaa nnuru a ɛma nipadua no tumi ko tia nyarewa ho.

Nanso mma anidasoɔ nnyae! Apɔw-mu-teɛteɛ ne apɔw-mu-teɛteɛ daa ho hia na ama wo ntini ahoɔden akɔ so atra hɔ bere tenten biara a wubetumi. Apɔw-mu-teɛteɛ betumi aboa ma wɔasiw ntini ahorow a ɛyɛ mmerɛw bio ano.

Bere a yare no kɔ so yɛ den na ɛyɛ den sɛ wobɛyɛ da biara da dwumadi ahorow no, ebia ebehia sɛ wusua akwan foforo a wobɛfa so ayɛ nneɛma. Eyi ne baabi a adwuma mu ayaresa betumi aboa. Sɛ nhwɛso no, ebia wɔbɛkyerɛ wo sɛnea wode mfiri ahorow bedi dwuma de aboa wo ma woasiesie wo ho, adidi, na woakyerɛw. Ebia ɛho behia nso sɛ nnipa binom sua sɛnea wɔde mmubuafo akongua di dwuma. Sɛ ɛyɛ den sɛ wobɛmene ade a, Speech-Language Pathologist (SLP) betumi aboa wo. Wobetumi akyerɛ wo sɛnea wobɛmene wo dwoodwoo na woayɛ apɔw-mu-teɛteɛ a wode bɛmene.

Sɛ mewɔ `Inclusion Body Myositis` a, dɛn na ɛsɛ sɛ mehwɛ kwan?

Sɛ wowɔ `IBM` a, ɛbɛkɔ soro nkakrankakra. Sɛnea madi kan aka no, .Eyi renka wo nkwa nna. Nanso, ebetumi anya w’asetra pa so nkɛntɛnso. Ebia ebehia sɛ wode wo ho to afoforo so anaa wusua akwan foforo a wobɛfa so ayɛ nneɛma. Nnipa dodow no ara nhwere wɔn nantew koraa, nanso ebia ebinom behia mmubuafo akongua wɔ mfe 10-15 akyi.

Mɛyɛ dɛn ahwɛ me ho bere a mete ase wɔ inclusion-body myositis ho no?

Ɛsɛ sɛ wo ne `Inclusion body myositis` tra ase bere tenten, na ebetumi abɛyɛ den kakra bere a bere kɔ so no. Ɔkwan a eye sen biara a wobɛfa so agyina eyi ano ne sɛ wobɛyɛ nhyehyɛe a ɛbɛkyɛ de ahwɛ wo nipadua ne w’adwene mu akwahosan so. Ɛno kyerɛ sɛ wobɛkɔ so de suban nketenkete a ɛboa wo ma wo ho atɔ wo no adi dwuma. Nhwɛsoɔ:

• Toa w’apɔw-mu-teɛteɛ nhyehyɛe no so. Ebia wowɔ nipadua mu ayaresa mu, anaasɛ ebia woadan akɔ ofie apɔw-mu-teɛteɛ nhyehyɛe so. Sɛ wotoa saa adeyɛ yi so a, ɛbɛboa ma wo ntini ahorow no ayɛ den sɛnea wubetumi.
• Di ``akwahosan asetra kwan akyi.'' Sɛ wudidi yiye, da yiye, di adwennwen ho dwuma, na wokura w'abusuabɔ a ɛho hia mu a, wo nyinaa bɛte nka sɛ wo ho ye.
• Kɔka akuw a wɔboa wɔn ho. Wubetumi anya adwene mu ahoɔden ne afotu a mfaso wɔ so pii afi nnipa afoforo a wɔafa ade koro no ara mu anaasɛ wɔrefa mu no hɔ. Ɛyɛ fɛ nso sɛ wobɛte nka sɛ "Ɛnyɛ me nkutoo na merefa eyi mu."
• Hwɛ sɛnea wɔyɛ nsakrae wɔ fie ne adwumam. Nneɛma pii wɔ hɔ a ɛboa ma obi tumi tu ne nneɛma a ɛboa a ebetumi aboa nnipa a wɔadi dɛm wɔ nipadua mu ma wɔayɛ da biara da nnwuma ayɛ mmerɛw.
• Kɔ wo duruyɛfo nkyɛn daa. Kɔ so ne wo duruyɛfo nni nkitaho. Sɛ wuhu sɛnkyerɛnne foforo bi te sɛ ɛyɛ den sɛ wobɛmene, anaasɛ sɛ sɛnkyerɛnne bi a ɛwɔ hɔ dedaw no mu yɛ den a, ka kyerɛ wo duruyɛfo ntɛm ara.
• Hwɛ nnuruyɛ mu sɔhwɛ ahorow mu. Nhwehwɛmufo hwehwɛ ayaresa foforo a ebia ɛbɛboa wɔ nipadua mu myositis a wɔde ka ho no mu bere nyinaa. Wubetumi nso de wo ho ahyɛ sɔhwɛ ahorow yi mu.

Saa tebea yi a wɔfrɛ no `Inclusion body myositis` no taa ba wɔ mfinimfini mfe mu, bere a anidaso biara nni hɔ. Obiara nhwɛ kwan sɛ obenya yare bi a wontumi nsa mpofirim a ɛkɔ so yɛ den. Ebetumi ayɛ den kakra sɛ wubegyina wɔn a wodwen wo ho no ano na woakyerɛkyerɛ mu akyerɛ wɔn, titiriw sɛ wɔntee yare yi ho asɛm da a.

Nanso kae sɛ, eyi yɛ yare a enyin brɛoo paa. Enti, bere pii wɔ hɔ a yɛde besusuw nsakrae a ɛda yɛn anim no ho na yɛayɛ nsakrae ma ɛne no ahyia. Obiara ntumi nka sɛnea eyi bɛka wo no yiye. Nanso,Sɛ wofa ɔkwan a ɛyɛ anidaso so a, nneɛma pii wɔ hɔ a wubetumi ayɛ de akura w’akwahosan ne wo yiyedi nyinaa mu wɔ mfe a ɛreba no mu.

Nneɛma a ɛho hia paa a ɛsɛ sɛ yɛkae (Take-Home Message) .

Okay, enti yɛaka `Inclusion Body Myositis (IBM)` ho asɛm pii. Nea etwa to no, nneɛma a ɛho hia sen biara a ɛsɛ sɛ wokae ni:

• IBM yɛ yare a ɛma ntini mu yɛ mmerɛw a ɛkɔ so yɛ den a ɛtaa ba bere a obi adi mfe 50. Ɛyaw no nyɛ den, nanso bere kɔ so no, ebetumi aka da biara da dwumadi ahorow.
• Eyi nni aduru biara , nanso apɔw-mu-teɛteɛ ne apɔw-mu-teɛteɛ betumi aboa ma ntini ahoɔden akɔ so atra hɔ bere tenten biara a ɛbɛyɛ yiye.
• Ebia sɛnkyerɛnne ahorow no bi ne sɛ ɛyɛ den sɛ wobɛkyere nneɛma, hintidua bere a ɔnam, ne aduan a ɛyɛ den sɛ ɔbɛmene .
• Wonnim nea ɛde ba ankasa (`idiopathic`), nanso ebetumi ayɛ ɔhaw wɔ nipadua no mu tumi a ɛko tia nyarewa no ho.
• Wɔnam ntini mu nhwehwɛmu nkutoo so si yare no so dua koraa.
• Eyi nyɛ nea ɛde nkwa to asiane mu , nanso ebetumi aka asetra pa.
• Ɛho hia paa sɛ wobɛkɔ so anya adwempa, di nnuruyɛfo afotu akyi, na woanya mmoa a ɛho hia.

Sɛ wo anaa obi a wunim no rehu saa sɛnkyerɛnne ahorow yi a, ɛbɛyɛ papa sɛ wobɛhwehwɛ aduruyɛfo afotu. Kae sɛ ɛnyɛ wo nko ara, nnipa pii wɔ hɔ a wobetumi aboa!

` Ntini mu mmerɛwyɛ, IBM yare, nipadua mu ayaresa, ntini mu nyarewa, nkwakoraa ne mmerewa akwahosan, mene a ɛyɛ den, ntini mu nyarewa