Dɛn ne POEMS Syndrome? So wopɛ sɛ wuhu eyi nso?

So woate POEMS Syndrome ho asɛm pɛn? Eyi yɛ tebea a ɛntaa nsi a wɔntaa nte ho asɛm. Nanso, ɛho hia sɛ yehu ho kakra efisɛ ebetumi aka yɛn nipadua mu nhyehyɛe pii prɛko pɛ. Sɛ yɛbɛka no tiawa a, ɛyɛ tebea a emu yɛ den a ɛfa yɛn mogya ho. Ɛnnɛ, yɛbɛka nea POEMS Syndrome yɛ, nea ɛkyerɛ ne, sɛnea wohu, ne sɛ ebia ayaresa bi wɔ hɔ anaa.

Dɛn ankasa ne POEMS Syndrome?

Okay, ma yɛnhwɛ nea POEMS Syndrome yɛ. Eyi yɛ mogya mu yare a ɛntaa nsi ankasa. Yɛwɔ mogya mu nkwammoaa bi a wɔfrɛ no plasma nkwammoaa wɔ yɛn nipadua mu. Sɛ POEMS syndrome ba a, saa plasma nkwammoaa yi mu paapae na ɛdɔɔso wɔ ɔkwan a ɛnteɛ so, a wontumi nni so. Saa plasma nkwammoaa a ɛnteɛ yi ma protein soronko bi kɔ yɛn mogya mu. Wɔfrɛ no monoclonal protein, anaasɛ M-protein tiawa. Afei wubetumi asusuw ho, ɛnte saa? Sɛ mogya mu nkwammoaa a ɛnteɛ yi, M-protein, dɔɔso dodo wɔ mogya no mu a, ebetumi asɛe yɛn ntini ne yɛn mu akwaa ahorow.

Wonyaa edin POEMS no fii nkyerɛwde a edi kan a ɛwɔ yare yi ho sɛnkyerɛnne atitiriw anum no mu:

• P - Polyneuropathy: Eyi kyerɛ ntini a ɛsɛe wɔ nipadua no nyinaa mu. Wɔ ANOM mu no, saa ɔsɛe yi betumi ama woate ɛyaw anaa nkate afoforo a ɛnyɛ dɛ (te sɛ wo nan, wo nsa, wo nan ase, ne wo nsa a ɛyɛ wo yaw, wo ho hyew, ne nea ɛkeka ho).
• O - Organomegaly: Wei kyerε sε, emu akwaa no bεyε kεseε a εnyɛ ne kwan so. Ebia obi a ɔwɔ POEMS no akwaa te sɛ mmerɛbo, akyi berɛmo, ne ntini a ɛma mogya tu no ayɛ kɛse.
• E - Endocrinopathy: Sɛ yɛbɛka no tiawa a, eyi yɛ hormone haw. Wɔ POEMS mu no, hormone dodow a yɛn endocrine glands no gyae no betumi ayɛ nea ɛnteɛ. Ebia hormone ahorow bi fi nipadua mu boro so anaa kakraa bi.
• M - Monoclonal protein (M-protein): Eyi ne protein soronko a ɛboaboa ano wɔ mogya mu wɔ POEMS mu. Sɛ plasma nkwammoaa biako yɛ ne ho mfonini (clones) pii a, saa nkwammoaa no mu biara de saa M-protein yi ka mogya no ho. Awiei koraa no, M-protein dodow a ɛwɔ mogya no mu no kɔ soro kɛse.
• S - Honam ani nsakrae: Nnipa a wɔwɔ POEMS betumi anya honam ani nsakrae ahorow, te sɛ honam ani a ɛyɛ tuntum ne honam ani a ɛyɛ den.

Wɔsan frɛ POEMS yare no sɛ nnompe mu yare , Crow-Fukase yare , PEP yare , ne Takatsuki yare .

Hena na ɛda adi kɛse sɛ obenya POEMS syndrome?

POEMS syndrome yɛ tebea a ɛntaa nsi koraa. Ɛka nnipa kakraa bi pɛ wɔ wiase nyinaa. Wɔtaa hu no wɔ nnipa a wɔadi fi mfe 50 kosi 60. Ebetumi aka mmarima ne mmea nyinaa, nanso ɛte sɛ nea ɛtaa ba mmarima mu.

Dɛn ne POEMS yare no ho sɛnkyerɛnne?

Sɛnea yɛadi kan aka no, nkyerɛwde a ɛwɔ edin POEMS mu no kyerɛ sɛnkyerɛnne atitiriw no bi. Ɛne sɛ, Polyneuropathy, Organomegaly, Endocrinopathy, M-protein a ɛkɔ soro, ne honam ani nsakrae ne sɛnkyerɛnne atitiriw. Ɛkame ayɛ sɛ obiara a ɔwɔ POEMS no wɔ polyneuropathy ne M-protein a ɛkɔ soro. Nsɛnkyerɛnne afoforo betumi ayɛ soronko wɔ onipa biara ho.

Nsɛnkyerɛnne a efi polyneuropathy mu ba

Nsɛnkyerɛnne a ɛnam saa ntini a ɛsɛe yi so ba no na ɛtaa ba wɔ POEMS mu. Mpɛn pii no, wɔte ɛyaw no nka kɛse wɔ nan ne anan mu. Nanso ɛtɔ mmere bi a, ebetumi aka abasa ne nsa. Sɛnea ebia wobɛte nka bere a wowɔ saa tebea yi ni:

• Mrɛyɛ
• Tingling a ɛyɛ hu
• Nnipa a wɔyɛ mmerɛw
• Prickling / Pins-ne-needles ho nkate
• Ɔhyew a ɛyɛ hyew

Organomegaly - akwaa a ɛwɔ nipadua no mu a ɛtrɛw

Mfoninitwa akwan a nnuruyɛfo yɛ no betumi ahu sɛ ebia akwaa ahorow yi ayɛ kɛse anaa:

• Mmerɛbo (Mmerɛbo - `(Hepatomegaly)`) .
• Akisikuru (Splenomegaly) .
• Ntini a ɛma mogya tu (Nsu a ɛma mogya tu - `(Lymphadenopathy)`) .

Endocrinopathy - hormone haw ahorow

Hormone ho haw titiriw a ɛba wɔ POEMS mu ne nna mu hormone dodow a ɛso tew. Wɔfrɛ saa nna mu nkwaadɔm yi ``Testosterone`` wɔ mmarima mu ne ``Estrogen`` wɔ mmea mu. Nea ɛka ho no, ebia wubehu sɛnkyerɛnne ahorow te sɛ:

• Ɔhaw ahorow a ɛfa asikre dodow a ɛwɔ mogya mu (e.g. asikreyare) .
• Thyroid haw ahorow (e.g. Hypothyroidism) .
• Addison yareɛ (Adrenal insufficiency - `(Addison yareɛ)`) .

Mmarima betumi anya awo a ɛso atew na wɔn nufu ayɛ kɛse (Gynecomastia).

Wɔ mmea fam no , brayɛ betumi agyae (`(Amenorrhea)`), nufu betumi ayɛ kɛse. Wɔ nyinsɛn mu no, hormone `(Prolactin)` a ɛboa ma nufusu yɛ no betumi ayɛ nea ɛboro so. Enti, ebetumi aba sɛ nufusu bɛtu afi nufusu no mu sɛ wunnyinsɛn mpo a.

M-Protein a ɛkɔ soro

Ade titiriw a ɛwɔ POEMS mu ne M-protein dodow a ɛkɔ soro wɔ mogya no mu. M-protein a ɛboro so yi betumi ama akisikuru ayɛ mogya no mu. Afei nso, esiane M-protein a ɛdɔɔso nti, woNnompe betumi ayɛ den na ayɛ den (osteosclerosis) .

Honam ani nsakrae

Honam ani nsakrae ahorow betumi aba, te sɛ:

• Wora a ɛyɛ tuntum
• Wora a ɛyɛ den
• Nsateaa nnadewa fitaa
• Nwi a enyin wɔ w’anim ne w’anan mu a ɛkɔ soro
• Mogya ntini a ɛte sɛ cherries nketewa a enyin wɔ koko ho were so

Nsɛnkyerɛnne afoforo

Nea ɛka eyi ho no, wobetumi ahu sɛnkyerɛnne afoforo:

• Nsa ne anan a ɛho ahonhon
• Mu duru a wɔtew so a ntease biara nnim
• Ɛyaw a ɛba nnompe ne nkwaa mu
• Aniwa a ɛyɛ mmerɛw
• Ɔhome a ɛyɛ den
• Ɔbrɛ
• Huraeɛ

Ebia nnipa binom a wɔwɔ POEMS yare no nso benya tebea bi a wɔfrɛ no Castleman Disease (CD), a ɛka ntini a ɛma mogya tu no. Sɛ wowɔ Castleman Yare ho sɛnkyerɛnne a, ebia wo duruyɛfo nso besusuw sɛ POEMS.

Dɛn na ɛde POEMS yare no ba?

Sɛ wowɔ POEMS a, wunya sɛnkyerɛnne ne nsunsuanso ahorow esiane monoclonal plasma cell disorder nti . Sɛ yɛbɛka no tiawa a, plasma nkwammoaa a ɛnyɛ ne kwan so yɛ ne ho mfonini pii dodo. Dodow a saa nkwammoaa yi dɔɔso no, dodow no ara na ebetumi asɛe ntini ahorow. Saa nkwammoaa yi de M-protein ka mogya no ho, na ɛma M-protein dodow a ɛwɔ mogya no mu no kɔ soro. Ɛyɛ saa nkwammoaa ne M-protein a ɛboro so yi na ɛsɛe nhyehyɛe ahorow a ɛwɔ nipadua no mu.

Nanso, nyansahufo da so ara nnim nea enti a saa plasma nkwammoaa yi fi ase nyin wɔ ɔkwan a ɛnteɛ so wɔ nea edi kan no mu ankasa.

Nhwehwɛmufo ahu sɛ ebia protein bi a wɔfrɛ no Vascular Endothelial Growth Factor (VEGF) na ɛka ho. Nnipa dodow no ara a wɔwɔ POEMS syndrome no wɔ VEGF pii wɔ wɔn mogya mu. Nhwehwɛmu a wɔyɛ wɔ abusuabɔ a ɛda VEGF ne POEMS yare no ntam no da so ara kɔ so.

Ɔkwan bɛn so na wohu POEMS yare no? (Nyare a Wɔahu) .

Wo duruyɛfo bedi kan abisa wo w’ayaresa ho abakɔsɛm ne mprempren sɛnkyerɛnne ahorow ho asɛm. Afei, wɔbɛyɛ nipadua mu nhwehwɛmu de ahwɛ sɛ ebia POEMS yare no ho sɛnkyerɛnne bi wɔ hɔ anaa.

Nea ɛka ho no, oduruyɛfo no betumi ayɛ nhwehwɛmu ahorow pii nso, te sɛ:

• Mogya ne nsu mu nhwehwɛmu: Saa nhwehwɛmu yi betumi aboa ma woahu sɛ M-protein anaa VEGF dodow akɔ soro wɔ wo mogya anaa wo nsu mu anaa. Wobetumi nso ahwɛ sɛ mogya mu nkwammoaa dodow a ɛnteɛ anaa mogya mu nkwammoaa a ɛte sɛ nea ɛnteɛ. Eyinom betumi ayɛ ANOHYƐDE ho sɛnkyerɛnne.
• Mfoniniyɛ mu nhwehwɛmu: Nhwehwɛmu te sɛ X-ray ne CT scan betumi akyerɛ sɛ wo nnompe ayɛ den anaasɛ ayɛ den anaa. Saa nsakrae yi betumi aba bere a M-protein dodow kɔ soro no.
• Bone marrow biopsy: Eyi betumi ahu sɛ wowɔ plasma nkwammoaa a ɛte sɛ nea ɛnteɛ wɔ wo nnompe mu, anaasɛ plasma nkwammoaa dodow dɔɔso dodo.
• Electromyogram (EMG): EMG yɛ sɔhwɛ a wɔde susuw ntini ahorow no dwumadi. Ebetumi aboa wo duruyɛfo ma wahu polyneuropathy.

Ɛdenam wo sɛnkyerɛnne ahorow so no, wo duruyɛfo no nso betumi ayɛ nhwehwɛmu afoforo te sɛ ɔhome mu nhwehwɛmu, echocardiograms, anaa endocrine nhwehwɛmu.

Sɛ wɔahu sɛ wowɔ tebea bi a wɔfrɛ no Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) , a, wo duruyɛfo nso betumi asɔ wo ahwɛ sɛ wowɔ POEMS syndrome anaa.

Ɔkwan bɛn so na wodi POEMS yare no ho dwuma anaasɛ wɔsa?

Aduru biara nni hɔ a wɔde sa POEMS yare no. Nanso, ayaresa ahorow betumi aboa ma wɔadi yare no ho sɛnkyerɛnne ahorow so na wɔadi ho dwuma. Ayaresa a wobetumi apaw bi ne:

• Mframa a wɔde sa yare: Nea ɛka eyi ho ne sɛ wɔde mframa a ano yɛ den bɛkɔ plasma nkwammoaa a ɛnyɛ ne kwan so no so ma asɛe no.
• Chemotherapy: Wɔde nnuru a ekum kokoram, a wɔsan frɛ no ``Chemotherapy,'' di dwuma de kum anaasɛ ɛma plasma nkwammoaa a ɛnyɛ ne kwan so nyin brɛoo. Nnuru a wɔde sa POEMS no te sɛ aduru a wɔde sa multiple myeloma. Saa ayaresa ahorow yi tu mpɔn yiye na mpɛn pii no ɛmma ɔhaw ahorow a anibere wom mma.
• Autologous stem cell transplant: Saa adeyɛ yi de stem cells a ɛte apɔw si wo plasma nkwammoaa a ɛnteɛ ananmu. Stem cells ne nkwammoaa a enyin bɛyɛ nkwammoaa a ɛho akokwaw te sɛ plasma nkwammoaa. Wɔ nipadua foforo a wɔde ma yi mu no, wo duruyɛfo di kan yi ntini mu nkwammoaa a ɛte apɔw bi fi wo nipadua mu. Afei, wɔde nnuru a wɔde sa yare anaa mframa a wɔde sa yare di dwuma de sɛe mogya mu nkwammoaa a ɛnteɛ no. Sɛ wɔyɛ ayaresa no wie a, wɔsan de ntini mu nkwammoaa a wɔayi afi hɔ no gu wo nipadua mu. Afei wonyin bɛyɛ plasma nkwammoaa a ɛte apɔw.
• Apɔw-mu-teɛteɛ: Sɛ ɛyɛ den ma wo sɛ wobɛnantew esiane polyneuropathy nti a, saa ayaresa yi betumi aboa.

Nea ɛka ho no, oduruyɛfo no betumi akyerɛw nnuru te sɛ steroid a ɛbɛma yare no ho sɛnkyerɛnne no afi hɔ ne nnuru a ɛma obi ho yɛ hyew (nsu aduru) a ɛbɛma ne ho atew.

Dɛn ne nsɛnnennen a ɛbata POEMS yare no ho?

Wɔ POEMS syndrome mu no, ntini a ɛsɛe ne mmerɛwyɛ betumi ayɛ kɛse bere a bere kɔ so no. Ebetumi nso ama ayɛ den sɛ wobɛkɔ baabiara. Sɛ nsu pii boaboa ano wɔ baabi a ɛbɛn ahurututu no anaa koko no mu a, ebetumi ama ne koko ayɛ no yaw na ayɛ den sɛ ɔbɛhome.

Nanso kae sɛ, .Ayaresa a edi mu betumi ama ntini a ɛsɛe no asiw anaasɛ ama ayɛ brɛoo. Ebetumi nso aboa ma yare no ho sɛnkyerɛnne afoforo afi hɔ. Ntini a asɛe mpo betumi asa nkakrankakra bere a bere kɔ so no.

So nneɛma bi wɔ hɔ a ɛde POEMS yare no ba?

Mprempren wontumi nhu asiane biara a ɛbɛma obi anya POEMS yare no.

So wobetumi asiw POEMS yare no ano?

Nea ɛyɛ awerɛhow no, wontumi nsiw POEMS yare no ano.

Dɛn ne nnipa a wɔwɔ POEMS syndrome no nkɔmhyɛ?

W’akwahosan gyina nneɛma pii so, a nea ɛka ho ne wo nipadua no afã horow a ɛka wo, sɛnea wohu yare no ntɛmntɛm na wofi ase sa yare, ne sɛnea woyɛ w’ade wɔ ayaresa ho.

Ɛho hia sɛ wonya ayaresa ma ANOMNSƐM. POEMS syndrome betumi de nkwa ato asiane mu sɛ wɔansa a. Ɔkwan foforo so no, ayaresa a edi mu a ɛsɛe mogya mu nkwammoaa a ɛnteɛ no betumi aboa wo ma woatra ase akyɛ. Nea ɛka ho no, ayaresa betumi ama yare no ho sɛnkyerɛnne ahorow no afi hɔ na ama w’asetra atu mpɔn.

Nnipa dodow no ara a wɔwɔ POEMS nkwa nna yɛ bɛyɛ mfe 14. Ɛno kyerɛ sɛ nnipa bɛyɛ fã nkwa nna nnu mfe 14, bere a fã a aka no tra ase kyɛ. Wo nkwa nna gyina wo yare no ho osuahu pɔtee ne ayaresa so.

Bisa wo duruyɛfo no wo daakye ho asɛm sɛ obi a ɔwɔ POEMS syndrome.

Bere bɛn na ɛsɛ sɛ wokɔ oduruyɛfo nkyɛn wɔ POEMS syndrome ho?

Sɛ wuhu sɛnkyerɛnne biara a ɛfa POEMS syndrome ho, titiriw mmerɛwyɛ wɔ nsa ne nan mu , kɔ oduruyɛfo nkyɛn ntɛm ara.

Nsɛmmisa bɛn na ɛsɛ sɛ mibisa me duruyɛfo fa POEMS syndrome ho?

Wubetumi abisa nsɛm te sɛ eyinom:

• Me tebea no mu yɛ den dɛn?
• Ayaresa ahorow bɛn na mewɔ?
• Dɛn na ɛsɛ sɛ meyɛ na ama nsunsuanso bɔne a ɛbɛba no so atew anaasɛ adi ho dwuma?
• Mmoa adwuma bɛn na ɛwɔ hɔ ma me?
• So ɛsɛ sɛ mekɔ oduruyɛfo bi a ne ho akokwaw wɔ mogya mu nkwammoaa mu yare mu nkyɛn na wakyerɛ m’ayaresa kwan?

Bere bɛn na metumi asan akɔ me dwumadi ahorow a na meyɛ daa no so sɛ mewɔ POEMS syndrome a?

POEMS syndrome betumi aka sɛnea wubetumi ayɛ wo da biara da dwumadi ahorow. Wo duruyɛfo bɛkyerɛkyerɛ sɛnea tebea yi bɛka wo da biara da asetra mu akyerɛ wo.

So POEMS syndrome yɛ yare a nipadua no tumi ko tia nyarewa?

POEMS yɛ paraneoplastic yare a ɛma obi nya yare.Ɛnyɛ yare a nipadua no tumi ko tia nyarewa. Paraneoplastic syndrome yɛ sɛnkyerɛnne ahorow a wɔaboaboa ano a aduruyɛ mu tebea bi a ɛda adi mu de ba. Wɔ POEMS mu no, ɔhaw a ɛda adi ne sɛ plasma nkwammoaa a ɛnteɛ no ma M-protein pii wɔ mogya no mu (a ɛyɛ monoclonal plasma cell disorder). POEMS ho sɛnkyerɛnne no fi plasma nkwammoaa a ɛnteɛ ne M-protein a ɛsɛe nipadua no ntini ahorow no.

So POEMS syndrome ne multiple myeloma yɛ ade koro?

Multiple myeloma yɛ kokoram a ɛka plasma nkwammoaa. POEMS syndrome yɛ sɛnkyerɛnne ahorow a wɔaboaboa ano a plasma nkwammoaa a ɛnteɛ ne M-protein a ɛkɔ soro na ɛde ba. Nkwa dodow a POEMS yare no nya no ye sen nkwa nna a wɔhwɛ kwan wɔ multiple myeloma mu.

Nanso, nnuru a wɔde sa POEMS ne multiple myeloma no taa yɛ pɛ. Ebia sɛnkyerɛnne ahorow no bi nso te saa ara.

POEMS syndrome yɛ ɔyare a ɛyɛ den a wohu. Ebia ebegye wo duruyɛfo bere kakra ansa na wahu sɛ POEMS syndrome na ɛde wo sɛnkyerɛnne ahorow no ba na ɛnyɛ tebea foforo bi. Sɛ wohu sɛ wowɔ yare no wie a, wo ne w’aduruyɛfo kuw no nyɛ adwuma yiye na woahu ayaresa ahorow a ɛbɛma wo ho atɔ wo kɛse afi wo yare no ho sɛnkyerɛnne ahorow no mu. Bisa wo duruyɛfo no ahyehyɛde anaa mmoa akuw a wɔboa ankorankoro ne mmusua a wodi nsɛm a wɔahu te sɛ POEMS syndrome ho dwuma ho asɛm.

Nkrasɛm a Wɔde Kɔ Fie

Okay, enti yɛaka POEMS Syndrome ho asɛm pii nnɛ. Nea ɛho hia ne sɛ wobɛte ase sɛ eyi yɛ tebea a ɛntaa nsi, nanso anibere wom . Ebetumi aka yɛn nipadua mu nhyehyɛe pii.

• Wonyaa edin POEMS no fii nkyerɛwde a edi kan a ɛwɔ Engiresi din ahorow a ɛkyerɛ sɛnkyerɛnne atitiriw anum (ntini mu yare, nipadua no mu akwaa a ɛtrɛw, hormone mu haw, M-protein a ɛkɔ soro, ne honam ani nsakrae) mu.
• Nea ɛde eyi ba titiriw ne plasma nkwammoaa a ɛnteɛ ne M-protein a wɔyɛ no.
• Ɛwom sɛ wonni aduru a edi mũ de, nanso ayaresa a etu mpɔn wɔ hɔ a wɔde siw yare no ho sɛnkyerɛnne ahorow ano na ama asetra atu mpɔn.
• Ɛho hia yiye sɛ wuhu yare no na wofi ase sa yare no ntɛm .

Sɛ wowɔ saa sɛnkyerɛnne ahorow yi bi a, yɛsrɛ wo hwehwɛ aduruyɛfo afotu. Mma wo ho nnyɛ wo hu, sɛ wunya nsɛm a ɛfata ne aduruyɛ mu mmoa a, wubetumi agyina tebea yi ano.

` POEMS syndrome, mogya mu nyarewa, ntini a ɛsɛe, hormone haw, M-protein, honam ani nsakrae, plasma nkwammoaa