So wowɔ akisikuru a ɛte sɛɛ wɔ w’asaabo mu? (Renal Angiomyolipoma) – Mma ɛnhaw wo, momma yɛnka eyi ho asɛm nkɔ akyiri!

So woasusuw pɛn sɛ akisikuru ahorow betumi aba yɛn asaabo mu? Ɛtɔ mmere bi a, wohu saa akisikuru yi wɔ akwanhyia mu bere a wɔreyɛ biribi foforo ho nhwehwɛmu a wonni sɛnkyerɛnne biara no. Sɛ nhwɛso no, akisikuru bi a ɛba asaabo mu, nanso ɛtaa nyɛ kokoram (i.e. ɛnyɛ nea ɛyɛ hu), wɔfrɛ no `(Renal Angiomyolipoma)` anaa `(AML)`. Ɛwom sɛ ebia edin no bɛyɛ te sɛ nea ɛyɛ den kakra de, nanso momma yɛnka ho asɛm tiawa, wɔ ɔkwan a wubetumi ate ase so.

Dɛn ne eyi `(Renal Angiomyolipoma)` anaa `(AML)`?

Sɛ yɛbɛka no tiawa a, Renal Angiomyolipoma yɛ akisikuru a ɛba w’asaabo mu. Nea eye sen biara ne sɛ saa akisikuru yi mu dodow no ara nyɛ kokoram (ɛnyɛ bɔne) . Eyi kyerɛ sɛ ɛnyɛ nea ɛbɛyɛ yiye sɛ wɔde ɔhaw kɛse biara bɛba. Nanso, wɔ tebea horow a ɛntaa nsi mu no, saa akisikuru yi betumi apaapae na ama mogya atu , na ebetumi ayɛ nea emu yɛ den koraa, na ɛtɔ mmere bi mpo a ɛde ne nkwa to asiane mu.

Afei ebia woresusuw ho sɛ, "Dɛn na ɛkyerɛ sɛ obi benya akisikuru?" Yɛn nipadua no wɔ nkwammoaa a ɛpaapae na enyin sɛnea ɛsɛ na ama yɛn nipadua no akɔ so atra hɔ. Nanso ɛtɔ mmere bi a saa nkwammoaa yi fi ase nyin a wontumi nni so na ɛboro so . Ɛno na akisikuru bi ba. Saa akisikuru a wɔfrɛ no `(Renal Angiomyolipoma)` yi yɛ afã atitiriw abiɛsa:

• Mogya ntini ahorow
• Ntini mu nkwammoaa
• ne srade nkwammoaa (srade) .

Eyinom baasa nyinaa bom yɛ aduaba soronko yi.

Saa tebea yi na wɔfrɛ no `(AML)` abu so dɛn?

Nokwarem no, eyi ne asaabo mu akisikuru a ɛnyɛ hu (a ɛnyɛ kokoram) a abu so sen biara . Akontaabu kyerɛ sɛ tebea yi ka nnipa 1,000 biara mu 2 kosi 6 . Ɛtaa ba mmea a wɔadi boro mfe 50. Enti, sɛ woyɛ ɔbea a wowɔ saa mfe yi mu a, eye sɛ wubehu eyi.

So eyi `(Renal Angiomyolipoma)` ne nyarewa afoforo wɔ abusuabɔ?

Yiw, ɛtɔ mmere bi a wobetumi ahu saa `(Renal AML)` tebea yi a ɛka akwahosan ho haw afoforo pii ho. Ɛne sɛ, su bi wɔ hɔ a ɛma saa `(AML)` akisikuru yi nyin wɔ nnipa a wɔwɔ saa nyarewa no mu. Nyarewa a ɛtete saa no bi ne:

• Lymphangioleiomyomatosis (LAM) - Eyi yɛ yare a ɛntaa nsi a ɛka ahurututu titiriw.
• Neurofibromatosis type 1 - Eyi yɛ awosu mu tebea a ɛma akisikuru ba ntini mu.
• Tuberous Sclerosis Complex (TSC) - Eyi nso yɛ awosu mu tebea. Akisikuru a ɛnyɛ hu ba nipadua no afã horow te sɛ amemene, asaabo, koma, ahurututu, ne honam ani. Wɔtaa hu AML akisikuru nso wɔ tebea yi mu.
• `(von Hippel-Lindau yareɛ)` - Wei nso yɛ awosuo mu tebea, a ɛtumi ma akisikuru ne nsuo a ɛyɛ nsuo ayɛ no ma wɔ akwaa ahodoɔ mu.

Enti, sɛ wowɔ saa tebea yi a, nnuruyɛfo nso bɛhwehwɛ `(AML)`.

Dɛn nti na eyi `(Renal Angiomyolipoma)` nyin? Dɛn na ɛde ba?

Ade titiriw nti a yɛyɛ eyi ne yɛnWɔfrɛ nsakrae a ɛba awosu mu nkwaadɔm mu sɛ awosu mu nsakrae. Sɛ yɛbɛka no pɛpɛɛpɛ a, nsakrae yi ba wɔ awosu mu nkwaadɔm abien a wɔfrɛ no `(TSC1)` anaa `(TSC2)` mu. Wɔfrɛ saa awosu mu nkwaadɔm yi "tumor suppressor genes" . Ɛne sɛ, awosu mu nkwaadɔm yi dwumadi ne sɛ ɛbɛhwɛ sɛnea yɛn nkwammoaa no nyin a yɛmpɛ no so.

Saa `(TSC)` awosu mu abɔde yi ma protein bi a wɔfrɛ no tuberin . Saa protein yi boa ma wɔhwɛ nkwammoaa nyin ne wɔn kɛse so. Enti, susuw ho hwɛ, sɛ nkwaadɔm mu nsakrae anaa nsakrae bi ba saa `(TSC)` awosu mu abɔde yi mu a, dɛn na ɛba? Afei tuberin protein no a wɔyɛ no sɛe. Afei sɛnkyerɛnne a ɛkyerɛ sɛ "wogyae" nkwammoaa no nkɔ yiye. Ne saa nti, nkwammoaa no fi ase nyin a wontumi nni so , na awiei koraa no, akisikuru te sɛ `(AML)` ba. So wote ase?

Dɛn ne `(Renal Angiomyolipoma)` ho sɛnkyerɛnne?

Nnipa pii nnim mpo sɛ wɔwɔ Renal AML! Eyi te saa efisɛ mpɛn pii no, yare no ho sɛnkyerɛnne biara nni hɔ . Wohu no kwa bere a wɔyɛ asaabo mu nhwehwɛmu (te sɛ ultrasound scan) esiane biribi foforo nti nkutoo.

Nanso, ɛntaa mma sɛ saa `(AML)` akisikuru yi betumi de sɛnkyerɛnne ahorow aba. Ɛtɔ mmere bi a, wohu akisikuru no esiane tebea bi a wɔfrɛ no `(retroperitoneal hemorrhage)` nti . Eyi yɛ aniberesɛm kɛse kakra. Sɛ yɛbɛka no tiawa a, akisikuru no fã bi mu paapae na efi ase mogya kɔ baabi a ɛwɔ yafunu no akyi no. Eyi yɛ tebea a egye ntɛmpɛ na ebetumi de nkwa ato asiane mu.

Nea ɛka ho no, sɛnkyerɛnne afoforo pii wɔ hɔ a wɔntaa nhu koraa:

• Anemia - Wei kyerε sε nipadua no nni mogya mu nkwammoaa kɔkɔɔ a εte apɔw a εdɔɔso.
• Ɛyaw anaa ahotɔ a wobɛte nka wɔ yafunu, akyi, ne akyi berɛmo mu .
• Mogya anaa mogya mu nkwammoaa a ɛwɔ nsu mu (Hematuria) .
• Mogya mmoroso (Hypertension) .
• Asaabo a entumi nyɛ adwuma yiye - Eyi ho yɛ na yiye.
• Sɛ wote akisikuru bi nka a ɛte sɛ nea wɔakyere no wɔ nsa mu .
• Nsuo mu yareɛ .

Sɛ wowɔ saa sɛnkyerɛnne yi mu biako anaa nea ɛboro saa a, ɛbɛyɛ papa sɛ wobɛhwehwɛ aduruyɛfo afotu.

Ɔkwan bɛn so na wohu saa yare yi `(Renal Angiomyolipoma)`?

Sɛnea yɛadi kan aka no, mpɛn pii no, wohu saa ``AML'' akisikuru yi wɔ akwanhyia mu. Wohu wɔn bere a wɔreyɛ yafunu mu nhwehwɛmu esiane biribi foforo nti, anaasɛ bere a wɔreyɛ nnipa a wɔwɔ nyarewa a ɛfa ho, te sɛ ``Tuberous Sclerosis'' a yɛadi kan aka ho asɛm no mu nhwehwɛmu daa.

Oduruyɛfo betumi ahu sɛ wowɔ adwene mu AML denam mfoninitwa nhwehwɛmu pii a ɔbɛyɛ a ɛtwa wo yafunu mu mfonini no so :

• (CT scan) (Kɔmputa so Tomography mfonini) .
• (MRI) (Magnetic Resonance Mfonini a Wɔde Yɛ Nneɛma) .
• `(Nnyigyei a ɛyɛ den scan)` (Nnyigyei a ɛyɛ den so scan) .

Mpɛn pii no, mfoninitwa nhwehwɛmu yi biako dɔɔso sɛ ɛbɛma wɔahu yare no. Esiane sɛ srade wɔ Renal Angiomyolipomas yi mu nti, ɛtaa yɛ sika kɔkɔɔ kɔkɔɔ wɔ scan ahorow mu. Saa akisikuru yi kɛse betumi afi sɛntimita 1 kosi bɛyɛ sɛntimita 20 . Ne kɛse a wɔtaa hu no bɛyɛ sɛntimita 9.

Nanso, sɛ ɛtɔ mmere bi a nnuruyɛfo kuw no ntumi nhu no yiye sɛ ebia akisikuru bi nyɛ hu anaasɛ kokoram wom nso ɛ? Sɛ ɛba saa a, ebia wɔbɛkamfo akyerɛ sɛ wɔnyɛ asaabo mu nhwehwɛmu . Nea ɛka eyi ho ne oprehyɛn a wɔde yi akisikuru no fã ketewaa bi na wɔde afiri a wɔde hwɛ nneɛma nketenkete hwehwɛ mu. Eyi bɛboa ma wɔahu sɛ ebia nkwammoaa no yɛ kokoram anaasɛ ɛnte saa.

Dɛn ne ayaresa a wɔde sa `(Renal Angiomyolipoma)`?

`(Renal Angiomyolipoma)` ayaresa betumi ayɛ soronko kɛse. Egyina nneɛma pii so, te sɛ akisikuru no kɛse, sɛ ebia sɛnkyerɛnne ahorow bi wɔ hɔ anaa, ne w’akwahosan nyinaa. Ayaresa atitiriw pii wɔ hɔ a wobetumi apaw:

1. Nneɛma a wɔde hwɛ nneɛma so denneennen:

Wɔsan frɛ eyi sɛ "hwɛ na twɛn." Sɛ Renal Angiomyolipoma no sua (mpɛn pii no ennu sɛntimita 4) na enni sɛnkyerɛnne biara a , ebia wo duruyɛfo bɛkyerɛ ɔkwan yi. Wɔremma wo ayaresa biara. Nanso, wɔbɛhwɛ wo so sɛ nsakrae biara aba akisikuru no mu denam scan ahorow a wɔbɛyɛ no daa so .

2. Nnuru a wɔde di dwuma:

AML akisikuru binom yɛ wɔn ade wɔ nnuru kuw bi a wɔfrɛ no mTOR inhibitors ho . Eyinom yɛ ayaresa ahorow a wɔde wɔn ani si so a wɔde wɔn ani si awosu mu nkwaadɔm mu nsakrae so. Saa nnuru yi betumi asiw akisikuru no kwan sɛ ɛrenyin anaasɛ ɛbɛtew so.

3. Oprehyɛn a wɔyɛ:

Oduruyɛfo no betumi akamfo akyerɛ sɛ wɔnyɛ oprehyɛn wɔ nsɛm a edidi so yi mu:

• Sɛ `(AML)` de sɛnkyerɛnne ahorow ba (e.g. ɛyaw, mogya a ɛtɔ).
• Sɛ akisikuru no yɛ sɛntimita 4 anaa nea ɛboro saa (efisɛ akisikuru akɛse no taa pae na mogya tu).
• Sɛ adwenem naayɛ bi wɔ hɔ sɛ ebia akisikuru no yɛ kokoram a .
• Sɛ woyɛ ɔbea a woadi mfe a wobɛwo (hormone nsakrae bere a wonyinsɛn no betumi atew asiane a ɛwɔ hɔ sɛ akisikuru no benyin na apae no so).
• Wote beae a ɛyɛ den sɛ wubenya ɔhwɛ a egye ntɛmpɛ anaa nnwuma a wɔde di akyi (efisɛ, wɔ tebea a egye ntɛmpɛ te sɛ mogya a ɛretu mu no, ɛho hia sɛ wɔsa yare ntɛm).

Akwan pii wɔ hɔ a wɔfa so sa oprehyɛn:

• Embolization: Nea ɛka eyi ho ne sɛ wobesiw mogya ntini a ɛde mogya kɔ akisikuru no mu no ano. Eyi yɛ adeyɛ a mfaso wɔ so kɛse wɔ nsɛm a mogya tu esiane Renal AML nti no mu.
• `(Nephrectomy)` (Nephrectomy): 1. Nnipa a wɔde wɔn ho hyɛ mu.Wɔ eyi mu no, woyi asaabo a ayɛ basaa no fã bi anaa ne nyinaa fi hɔ.
• Nephrectomy fã bi anaa Nephron-sparing oprehyɛn: Eyi hwehwɛ sɛ woyi akisikuru no nkutoo, na wogyaw asaabo no fã a ɛte apɔw no. Nnuruyɛfo bɔ mmɔden sɛ wɔde saa kwan yi bedi dwuma bere biara a ɛbɛyɛ yiye.
• Radiofrequency ablation: Eyi de ɔhyew a ano yɛ den di dwuma de sɛe ntini a ɛnyɛ ne kwan so (akisikuru).

So metumi atew asiane a ɛwɔ hɔ sɛ menya Renal AML no so?

Sɛ yɛbɛka nokware a, biribiara nni hɔ a yebetumi ayɛ de asiw awosu mu nsakrae a ɛde `(Renal Angiomyolipoma)` ba no ano. Wɔyɛ nneɛma a ɛsisi a yentumi nyɛ ho hwee.

Nanso, sɛ wowɔ tebea horow a ɛbata ho a yɛadi kan aka ho asɛm no bi (e.g. Tuberous Sclerosis Complex, Lymphangioleiomyomatosis, Neurofibromatosis type 1, von Hippel-Lindau yare) , ɛho hia yiye sɛ woyɛ mfonini ho nhwehwɛmu daa . Afei, sɛ AML anya nkɔso a, wobetumi ahu no ntɛm . Saa kwan no so no, wobetumi afi ayaresa a ɛho hia no ase ntɛm na asiane a ɛwɔ hɔ sɛ wobenya ɔhaw ahorow no so atew.

Sɛ mewɔ saa tebea yi a, dɛn na ɛsɛ sɛ mehwɛ kwan?

Asɛmpa no ne sɛ Renal Angiomyolipomas dodow no ara yɛ nketewa na ɛntaa mma ɔhaw a emu yɛ den . Nanso, ɔha biara mu kakraa bi betumi abɛyɛ ɔyare bɔne anaasɛ mogya atu kɛse. Enti, ɛho hia sɛ wohwɛ wɔn yiye sɛ wowɔ Renal AML a. Wo duruyɛfo bɛkyerɛ wo mpɛn dodow a ɛsɛ sɛ woyɛ mfoninitwa nhwehwɛmu.

Kae sɛ AML betumi asan aba bio wɔ ayaresa akyi mpo. Enti, ɛho hia yiye sɛ wo ne w’aduruyɛfo kuw no bɛkɔ so adi nkitaho na woakɔhwɛ wo daa sɛnea wɔkamfo kyerɛ no.

Bere bɛn na ɛsɛ sɛ mehwehwɛ aduruyɛ mu afotu?

Sɛ wɔahu sɛ wowɔ adwene mu AML, anaasɛ wowɔ tebea bi a ɛne AML wɔ abusuabɔ a, ɛho hia sɛ wuhu mogya a ɛba akyi berɛmo mu no ho sɛnkyerɛnne . Sɛ wuhu saa sɛnkyerɛnne ahorow yi bi a, kɔ oduruyɛfo ntɛm ara :

• Sɛ mogya wɔ wo nsu mu a.
• Sɛ wowɔ ɛyaw a ɛkɔ so daa a ennyae wɔ wo yafunu atifi anaa w’asen mu a.
• Sɛ wuhu sɛnkyerɛnne ahorow a ɛkyerɛ sɛ wo ho adwiriw wo a:
• Kesereneeyɛ
• Koma a ɛbɔ ntɛmntɛm
• Adwene a ɛyɛ basaa
• Ahome a emu nnɔ
• Wora a ɛyɛ mmerɛw

Sɛ wuhu biribi te sɛ eyi a, ntwentwɛn wo nan ase.

Awiei koraa no, nea ɛsɛ sɛ wokae (Take-Home Message) .

Okay, enti `(Renal Angiomyolipoma)` anaa `(AML)` a na yɛreka ho asɛm no yɛ akisikuru a ɛba wɔ asaabo mu, na ɛtaa nyɛ kokoram (benign).. Mpɛn pii no, wohu eyi wɔ akwanhyia mu, wɔ sɔhwɛ foforo mu. Sɛ wɔahu sɛ wowɔ saa `(Renal AML)` yi a, mma wo ho nnyɛ wo hu . Wo ne wo duruyɛfo nkasa na si ayaresa anaa ɔkwan a wɔfa so hwɛ nneɛma so a eye ma wo ho gyinae.

Ade a ɛho hia sen biara ne sɛ wobɛhwɛ saa akisikuru yi so daa . Sɛ woyɛ saa a, wubetumi asiw tebea a emu yɛ den te sɛ mogya a ɛretu no ano. Efisɛ sɛ biribi a ɛte saa si a, ebetumi de nkwa ato asiane mu. Enti, di wo duruyɛfo akwankyerɛ akyi na yɛ nhwehwɛmu wɔ bere ano. W’akwahosan wɔ wo nsam!

` Asaabo mu Angiomyolipoma, AML, Asaabo mu Akisikuru, Asaabo mu Yare, Tuberous Sclerosis, Asaabo mu Mogya, Awosu mu Nsakrae