So wowɔ hua a ɛte sɛ apataa nso? Momma yensua Trimethylaminuria (TMAU) ho ade!

Ɛtɔ da bi wɔ yɛn asetena mu no, nneɛma a ɛyɛ nwonwa sisi, ɛnte saa? So woate tebea bi a obi nipadua, ne fifiri, ne home, anaa ne nsu hua te sɛ apataa a aporɔw ho asɛm pɛn? Ɛte sɛ nea ɛyɛ nwonwa, ɛnte saa? Nanso, tebea a ɛte saa wɔ hɔ ankasa. Eyi ne tebea a yɛrebɛka ho asɛm nnɛ, Trimethylaminuria, anaa `(TMAU)` tiawa. Nnipa binom nso frɛ no ``Fish Odor Syndrome``.

Dɛn ne trimethylaminuria (TMAU)?

Sɛ yɛbɛka no tiawa a, trimethylaminuria (TMAU) yɛ nipadua mu nneɛma a ɛsakra . Seesei ebia woresusuw nea nipadua mu nneɛma a ɛsakra no yɛ ho. Wɔ yɛn nipadua mu no, nnuru a ɛkɔ so, anaa nipadua mu nneɛma a ɛsakra , kɔ so ma ɛdan aduan a yedi no ma ɛbɛyɛ ahoɔden na ama yɛayɛ nneɛma a yɛn nipadua hia. Enzymes a ɛwɔ yɛn nipadua mu no boa ma saa nneɛma yi kɔ so yiye. Enti, wɔ tebea a wɔfrɛ no trimethylaminuria yi mu no, esiane nsakrae a ɛba enzyme pɔtee bi dwumadi mu nti, nnuru a wɔyɛ wɔ nipadua no mu no bi ntumi nsɛe no yiye. Ɛno nti na saa apataa hua a ɛnyɛ dɛ no fi fifiri, ɔhome, nnompe, ne nsu mu ba no.

Ebia woate sɛ nnuruyɛfo frɛ saa tebea yi `(TMAU)` anaa `(Fish Odor Syndrome)`. Wonnya nnyaa eyi ano aduru a edi mũ . Nanso, mma ɛnhaw wo. Wubetumi atew saa sɛnkyerɛnne ahorow yi so kɛse denam nea wudi ne nea wonom a wobɛsakra, samina ne nnuru bi a wode bedi dwuma, ne w’adwennwen a wubedi so .

Dɛn ne `(TMAU)` ahorow titiriw?

Trimethylaminuria ahorow atitiriw abien na ɛwɔ hɔ:

1. Primary Trimethylaminuria : Eyi ne nea wonya fi awo mu . Eyi kyerɛ sɛ nsakrae bi (`(Genetic mutations)`) a ɛba awosu mu nkwaadɔm (`(Genes)`) a wonya fi ɛna ne agya no nyinaa hɔ no na ɛde tebea yi ba.

2. Trimethylaminuria a ɛto so abien : Eyi ba akyiri yi wɔ asetra mu . Saa hua a ɛte sɛ apataa yi betumi afi aduruyɛ mu tebea horow bi anaa aduan a wɔde ka aduan ho mu aba.

Saa tebea yi abu so dɛn?

Nokwarem no, TMAU yɛ tebea a ɛntaa nsi koraa . Nhwehwɛmu bi kyerɛ sɛ ɛka nnipa 200,000 kosi ɔpepem biako biara mu biako pɛ wɔ wiase nyinaa. Nanso, wɔsan ka sɛ mmea betumi anya bi kakra sen mmarima.

Nanso, nhwehwɛmufoɔ binom gye di sɛ ebia nnipa a wɔwɔ `(TMAU)` dɔɔso wɔ ɔmanfoɔ mu sene sɛdeɛ akontabuo yi kyerɛ. Efisɛ nnipa pii susuw sɛ eyi yɛ wɔn ankasa ahotew ho haw . Enti, wɔnka ho asɛm nkyerɛ obiara anaasɛ wɔnkɔ oduruyɛfo nkyɛn esiane aniwu nti. Enti, wonnya diagnosis (`(Diagnosis)`).

Dɛn ne trimethylaminuria ho sɛnkyerɛnne ahorow?

Nsɛnkyerɛnne titiriw a ɛda adi kɛse ne hua a ɛte sɛ mpataa fi nipadua, ahome, ne fifiri mu . Ɛtɔ mmere bi a, saa hua yi betumi ayɛ nea ɛnyɛ dɛ araa ma ebetumi ama obi ho ayɛ no yaw. Wɔ nnipa binom fam no, ebetumi nso de ahome bɔne (`(Halitosis)`) ne hua a ano yɛ den a efi nsu mu ba.

Ɛtɔ da bi a, obi a ɔwɔ `(TMAU)` te saa hua yi nka kɛse bere a ne ho fifiri anaasɛ bere a wayɛ basaa. Nanso, wɔ nnipa binom fam no, saa hua yi mu yɛ den araa ma sɛ wɔkɔ dan bi a wɔte mu mu, wogyina sotɔɔ bi mu counter no atifi, anaasɛ wɔte bɔs anaa keteke fã koro mpo a, afoforo da so ara tumi te hua. Wo de susuw sɛnea ɛno yɛ den no ho hwɛ.

Dɛn ne nneɛma a ɛde `(TMAU)` ba?

Trimethylaminuria ba bere a enzyme bi a wɔfrɛ no `(FMO3)` a ɛwɔ yɛn nipadua mu no dwumadi asɛe no. `(FMO3)` gyina hɔ ma Flavin- containing monooxygenase 3. Saa enzyme yi adwuma titiriw ne sɛ ɛbɛhwɛ nnuru a wɔfrɛ no `( Trimethylamine )` a wɔyɛ wɔ yɛn nipadua mu no so. Saa trimethylamine yi na ɛde saa apataa hua no ba. Wɔyam saa trimethylamine yi bere a nnuan bi a yedi, sɛ nhwɛso no, mpataa, bankye, ne nkesua, ayɛ no yam no.

Nea ɛtaa ba ne sɛ: Sɛ trimethylamine boaboa ano wɔ yɛn nipadua mu a, enzyme `(FMO3)` ba na ɛpaapae, na ɛdan nnuru a hua nnim. Afei, ɛwom mpo sɛ efi yɛn aduan mu kɔ yɛn mogya mu de, nanso ɛnte hua.

Nanso, sɛ saa `(FMO3)` enzyme no ntumi nyɛ adwuma yiye a, dɛn na ɛba? Saa trimethylamine a ɛyɛ huam no boaboa ano wɔ yɛn nipadua mu. Sɛ ɛdɔɔso a, awiei koraa no, efi fifiri, ɔhome, nnompe, ne nsu mu fi adi, na saa apataa hua no fi adi. So wote ase?

Nnipa a wɔwɔ trimethylaminuria titiriw (`(Primary TMAU)`) nya saa tebea yi efisɛ wonya awosu mu nkwaadɔm a ɛyɛ `(FMO3)` enzyme (`(Abnormal FMO3 genes)`) no mfonini ahorow a ɛnyɛ ne kwan so fi wɔn maame ne wɔn papa nyinaa hɔ.

Wɔ trimethylaminuria a ɛto so abien (`(Secondary TMAU)`) mu no, wo `(FMO3)` enzyme no ntumi nsɛe trimethylamine esiane biribi foforo nti. Eyi betumi afi:

• Sɛ wowɔ aduruyɛ mu yare bi te sɛ mmerɛbo a entumi nyɛ adwuma yiye anaa mmerɛbo mu yare a ɔyare mmoawa de ba a, ebetumi asiw enzyme no dwumadi kwan na amma trimethylamine no ansɛe.
• Sɛ wo gut microbiome no nkari pɛ, a ɛkyerɛ sɛ mmoawa pa ne bɔne a ɛwɔ wo gut mu no nkari pɛ a, trimethylamine pii betumi ayɛ kɛse. Afei enzyme (FMO3) no ntumi nyi saa hua no nyinaa mfi hɔ.
• Sɛ wonom nnuru a choline anaa carnitine wom a, saa aduannuru yi boa ma trimethylamine ba.

Dɛn ne nsɛnnennen a ɛwɔ tebea yi mu?

Sɛnea tebea bi a wɔfrɛ no trimethylaminuria ka w’asetra pa(`(Asetra pa)`) betumi asɛe ade kɛse. Nhwehwɛmu kyerɛ sɛ nnipa a wɔwɔ saa tebea yi taa kwati abusuabɔ, nnwuma, ne fekubɔ ahorow efisɛ wosuro sɛ afoforo behu hua a ɛnyɛ dɛ no. Esiane eyi nti, nnipa a wɔwɔ saa tebea yi betumi anya adwenemyare ahorow. Nhwɛsoɔ:

• Brɛ
• Hahaahayɔ
• Dadwen ne ehu a ntease nnim (`(Paranoia)`) .

Ɛwom sɛ ɛntaa nsi koraa de, nanso wɔabɔ amanneɛ sɛ nnipa binom a wɔwɔ TMAU no wɔ adwene sɛ wobekum wɔn ho (`(Suicidal behavior)`). Eyi kyerɛ sɛnea tebea yi adwene mu nkɛntɛnso betumi ayɛ aniberesɛm.

Ɔkwan bɛn so na wohu sɛ obi anya trimethylaminuria?

Nnuruyɛfo hu TMAU denam trimethylamine dodow a ɛwɔ wo nsu mu a wosusuw so . Wɔtaa fa nsu mu nhwehwɛmu so na ɛyɛ eyi . Bio nso, ebia wo duruyɛfo bɛkamfo akyerɛ sɛ wɔnyɛ awosu mu nhwehwɛmu na ama woahu sɛ ebia wowɔ ɔkwan a edi kan (i.e., awosu) anaa nea ɛto so abien (i.e., nea woanya) no.

Dɛn ne nnuru a wɔde sa trimethylaminuria?

Ebia wo duruyɛfo bɛkamfo nneɛma ahorow a ɛbɛboa ma TMAU ho sɛnkyerɛnne ahorow no so atew.

• Aduan a wodi: Wɔkamfo kyerɛ sɛ wonyi nnuan bi a ɛma nipadua no yɛ nnuru a ɛde tebea no ba (TMAU) no fi hɔ.
• Samina ne aduru titiriw: Wɔkamfo kyerɛ sɛ wɔmfa samina ne aduru soronko a ɛboa ma mpataa hua a efi honam ani no so tew nni dwuma.
• Nnuru: Ɛtɔ mmere bi a, wobetumi akyerɛw nnuru nso ama obi.
• Adwene mu akwahosan ho mmoa: Wobetumi nso atu wo fo sɛ hwehwɛ adwene mu afotu a ɛbɛboa wo ma woagyina adwennwen a tebea yi de ba no ano.

Nnuan ahorow bɛn na ɛsɛ sɛ woyi fi hɔ?

Sɛ wowɔ trimethylaminuria a, nnuruyɛfo taa ka kyerɛ wo sɛ to nnuan a edidi so yi ano hye anaasɛ kwati koraa:

• Mpataa ne ɛpo mu nnuan afoforo (titiriw nkyene nsu mu mpataa) .
• Nkwaa (titiriw nkesua a wɔayam) .
• Mmɛn ne mmoa mu akwaa afoforo
• Atoko te sɛ soyabeans, chickpeas, ne lentils
• Nnuadewa a ɛyɛ mmeamudua te sɛ kabege, broccoli, cauliflower, ne Brussels sprouts
• Peanut, akutu
• Nufusu ne nufusu mu nneɛma (wɔ ebinom fam) .
• Nnuan ne aduannuru a wɔde ma a choline ne L-carnitine pii wom

Nea ɛho hia: Ɛnyɛ obiara na ɛsɛ sɛ oyi saa nnuan yi nyinaa fi hɔ. Ɛyɛ papa sɛ wo ne oduruyɛfo anaa aduannuru ho ɔbenfo bɛkasa na ama woahu nnuan a ɛfata wo.

Nnuru bɛn na wɔde ma `(TMAU)`?

Ebia wo duruyɛfo bɛkyerɛw nnuru te sɛ eyinom na ama TMAU ho sɛnkyerɛnne so atew:

• Nnuru a ekum ɔyare mmoawa ne probiotics : Saa nnuru yi boa ma mmoawa dodow a ɛwɔ wo dwensɔtwaa mu no so tew, na ɛnam so ma trimethylamine a wɔyɛ no so tew.
• Fango a wɔde yɛ adwuma : Eyi te sɛ sponge. Ɛtwe trimethylamine wɔ nipadua no mu na ɛboa ma ɛkɔ nipadua no mu.
• Nnuru a ekum adwenemhaw ne nnuru a ɛko tia dadwen : Wɔde saa nnuru yi ma de sa adwenemyare a nnipa binom a wɔwɔ TMAU hyia no.

Wo duruyɛfo nso betumi de wo akɔma adwenemyare ho mmoa . Adwene ne nneyɛe ho ɔbenfo anaa ɔfotufo a wo ne no bɛkasa no ho hia titiriw sɛ worepere wɔ obu a wowɔ ma wo ho ne nipadua mfonini ho nsɛm ho a. Adwene mu ayaresa betumi aboa wo ma woasua sɛnea wubegyina wo tebea no ano na woadi adwennwen ho dwuma.

Dɛn na obi a ɔwɔ trimethylaminuria betumi ahwɛ kwan?

Trimethylaminuria yɛ tebea a enni sabea . Eyi kyerɛ sɛ wontumi nsa no yare koraa anaasɛ n’ankasa ntumi nyɛ yiye. Nanso, sɛnea yɛadi kan aka no, ayaresa ne nneɛma bi wɔ hɔ a wubetumi ayɛ de atew TMAU ho sɛnkyerɛnne so na wɔatew nkɛntɛnso a tebea no nya wɔ w’asetra so no so.

Mɛyɛ dɛn ahwɛ me ho?

Ankasa ho a wobɛhwɛ ho hia yiye bere a wo ne TMAU te no. Nneɛma bi a ɛsɛ sɛ wususuw ho ni:

• Ankorankoro ahotew : Sɛ wode samina ne aduru a wɔde samina a `(pH)` bo sua di dwuma a, ebetumi aboa ma wo nipadua hua so atew. Bisa wo duruyɛfo no `(pH)` bo a ɛfata ma wo ne nneɛma a eye sen biara.
• Hwɛ yiye wɔ nea wudi ho : Nnuan pii betumi ama trimethylaminuria asɛe kɛse. Wo ne aduannuru ho ɔbenfo nkasa na ɔnyɛ w’aduan ne aduan a wobɛpaw ho nhyehyɛe sɛnea ɛbɛyɛ a wubenya aduannuru a wuhia.
• Di adwennwen ho dwuma : Adwennwen a ɛkɔ soro betumi ama TMAU ho sɛnkyerɛnne akɔ soro. Enti, bisa wo duruyɛfo akwan a wobɛfa so aboa ma w’adwennwen so atew. (sɛ nhwɛso no, nsusuwii, yoga, ahomegye apɔw-mu-teɛteɛ) .
• Hwehwɛ mmoa : Trimethylaminuria yɛ tebea a ɛntaa nsi, enti ebia wobɛte nka sɛ woayɛ ankonam na woatew wo ho. Enti, ebetumi ayɛ mmoa kɛse sɛ wo ne mmoa akuw a wobetumi ahu afoforo a wɔwɔ tebea koro no ara bɛbɔ .

Bere bɛn na ɛsɛ sɛ mekɔ me duruyɛfo nkyɛn?

Sɛ wo sɛnkyerɛnne no ankɔ yiye bere a woayɛ nsakrae wɔ w’aduan ne adwennwen ano aduru mu mpo akyi a, hwɛ hu sɛ wobɛkɔ wo duruyɛfo nkyɛn. Obetumi asusuw ayaresa afoforo a wubetumi asusuw ho ho.

Nsɛm bɛn na ɛsɛ sɛ mibisa me duruyɛfo?

Esiane sɛ trimethylaminuria yɛ tebea a ɛntaa nsi nti, ebia wunnim ho nsɛm pii. Nsɛmmisa bi a wubetumi abisa wo duruyɛfo ni:

• Dɛn nti na mekɔɔ tebea yi mu?
• Dɛn ne ayaresa a eye sen biara a wokamfo kyerɛ me?
• So wubetumi akamfo kuw bi a wɔboa anaa nhyehyɛe bi a metumi anya mmoa akyerɛ?

So nnipa a wɔwɔ trimethylaminuria betumi ate wɔn ho hua?

Eyi nso yɛ ɔhaw ma nnipa pii. Yiw, yɛtaa te yɛn ankasa fifiri ne nipadua hua, na nnipa a wɔwɔ `(TMAU)` tumi te wɔn ankasa hua. Nanso, ɛtɔ mmere bi a, sɛ wɔn ankasa hua yɛ wɔn su pɛ a, ebia wɔrenhu no denneennen te sɛ afoforo. Afei nso, ɛnyɛ obiara na obetumi aka sɛ ɔnte hua; ebia nnipa binom renhu mpo sɛ wɔn nipadua wɔ hua soronko bi.

Awiei koraa no, nkrasɛm a ɛho hia sen biara

Trimethylaminuria yɛ tebea a ebetumi ama obi ayɛ obi a ontumi nyɛ hwee ankasa, ɛnyɛ honam fam nko, na mmom adwene mu nso . Sɛ ɛmma nipadua mu yaw mpo a, ebetumi de ɛyaw kɛse ne akuru aba adwene mu. Nnipa binom a wɔwɔ saa tebea yi tew wɔn ho fi ɔmanfo ho na wɔbɔ mmɔden sɛ wɔbɛtra baabi a wɔatew wɔn ho, efisɛ wosuro sɛ wɔbɛyɛ ɔhaw ama afoforo. Bere a wɔasesa wɔn aduan na wɔadi afotu afoforo akyi mpo no, nnipa binom a wɔwɔ `(TMAU)` te nka sɛ ɛda so ara hia sɛ wɔma wɔn asetra twe wɔn ho fi afoforo ho. Saa tew a wobɛtew wo ho afi afoforo ho yi betumi ama woanya nneɛma te sɛ adwenemhaw ne dadwen.

Kae sɛ ɛnyɛ wo nkutoo na wowɔ hɔ . Sɛ worehu amane wɔ saa tebea yi mu a, yɛsrɛ wo mma w’ani nnwu anaasɛ nsuro sɛ wobɛsrɛ wo duruyɛfo no mmoa. Wobetumi ate nea worefa mu no ase na wobetumi aka nhyehyɛe ne nnwuma a ebetumi aboa wo ho asɛm akyerɛ wo. W’adwene mu akwahosan ho hia te sɛ wo nipadua akwahosan ara pɛ. Enti hwɛ hu sɛ wubesusuw ho nso.

` trimethylaminuria, mpataa hua, mpataa hua, nipadua hua, nipadua mu nneɛma mu nyarewa, FMO3 enzyme, trimethylamine