What is Diabetes Insipidus (DI)? Let's talk about it simply.

When you hear the word 'diabetes', you think of high blood sugar, right? That's what most people know. But today we're talking about a completely different, less common condition that has a similar name. This is called Diabetes Insipidus (DI). What happens in this case is not that the blood sugar level increases, but that there is a problem with the body's water control.

What exactly is Diabetes Insipidus (DI)?

Simply put, what happens here is that a hormone that sends a message to our kidneys, "Keep some of the water your body needs, don't let it all out as urine," is either reduced in our body, or the kidneys don't respond to that hormone.

Because of this, the kidneys are unable to retain water in the body. As a result, a large amount of water in the body is excreted with urine. So you feel excessively thirsty. This disease gets its name because the urine that comes out has no sweet taste and is like water. That is why some people call it "water diabetes".

Is this a dangerous situation?

This is usually not a serious, life-threatening illness. If an adult drinks enough water, it is very unlikely to die from it. However, it can be a bit more dangerous for young children, the elderly, or those with mental illnesses. Because they may not feel thirsty properly or may not be able to ask for water.

Imagine, a healthy person excretes about 1-2 liters of urine per day. But someone with DI can excrete as much as 3-20 liters of urine per day! This excessive urination is called Polyuria. This causes the body to lose a dangerous amount of water and become dehydrated . Not only that, but the balance of electrolytes, such as sodium and potassium, which are essential for the functioning of our nervous system, is also lost.

The four main types of Diabetes Insipidus (DI)

There are four main types of this condition. Each type has different causes, treatments, and long-term effects. But in most cases, you can manage the condition well with the advice of your doctor.

1. Central Diabetes Insipidus (Central Diabetes Insipidus)

This is the most common type. What happens here is that the body does not produce enough of the hormone vasopressin, which helps maintain fluid balance in our body.

A head injury could be the main cause of this.. Damage to the part of the brain that makes the hormone vasopressin, or to the pituitary gland that stores it. This can also be caused by things like infections, surgery, and brain tumors. Sometimes, young babies can be born with this condition due to genetic reasons.

Mild DI can sometimes be controlled with a low-sodium diet. However, many people need to take a synthetic hormone called desmopressin. This can be taken as a pill, nasal spray, or injection.

The most important thing is to take the exact dosage your doctor tells you to take and to control the amount of water you drink. Drinking too much water can cause headaches, dizziness, and a dangerous drop in sodium levels in the body.

2. Kidney-related DI (Nephrogenic Diabetes Insipidus)

What happens here is that even though the brain is producing the hormone vasopressin properly, the kidneys cannot 'hear' that message. That means the kidneys do not respond to it. This can be present from birth, or it can develop later.

Things that can cause this are:

• Long-term kidney disease.
• Some medications. For example, medications like lithium, foscarnet, and clozapine.
• Increased calcium levels in the blood (hypercalcemia).
• Decreased potassium levels in the blood (hypokalemia).
• Urinary tract obstruction.

If the underlying cause of this condition is treated, it is sometimes possible to completely cure this DI condition.

3. DI (Dipsogenic Diabetes Insipidus) caused by excessive thirst

This is caused by a malfunction in the hypothalamus, the thirst center in the brain, causing the urge to drink water uncontrollably. This can also be caused by some mental health conditions. There is no effective treatment for this yet. However, things like ice cubes and mouthwashes can help reduce dry mouth. One dangerous risk here is that drinking too much water can lead to water intoxication .

4. Gestational Diabetes Insipidus (DI) that occurs during pregnancy

Many women can develop this condition during the last 3 months of pregnancy. It is caused by hormonal changes or an enzyme in the placenta that breaks down the hormone vasopressin. Those who are carrying twins are at a slightly higher risk. However, it is usually a mild condition and goes away completely within a few weeks after the baby is born.

DI management and features to watch out for

The two things we should be most concerned about in any type of DI are dehydration and electrolyte imbalance . You should always be aware of the symptoms of these.

If you have these symptoms, the best thing you can do is to see your family doctor as soon as possible. With this condition, you can live a normal, healthy life with proper treatment and medical guidance.