An ka dɔn dɔrɔn cɛfarin fitinin fila kan minnu b’an ka kolotugudaw jɔ: Osteoblasts ani Osteoclasts!

Yala i delila ka miiri i kolow la wa? Tuma caman na, an b’u jate fɛn barikamaw ye, fɛn minnu tɛ Changé. Nka o tɛ ten. An kolow ye farikolo ɲɛnamaw ye , i n’a fɔ an farikolo tɔ. N’a sɔrɔ i tɛna o miiri, nka u bɛ ka bonya tuma bɛɛ, ka tiɲɛ, ka bila u nɔ na, ​​k’a ta denmisɛnya la fo ka se balikuya ma dɔrɔn, nka an ka ɲɛnamaya bɛɛ kɔnɔ! Kɔnɔnatumu suguya fila minnu nafa ka bon kosɛbɛ minnu bɛ dɛmɛ don nin baara kabakoma in na, olu bɛ wele ko `Osteoblasts` ani `Osteoclasts`. An ka kuma dɔɔnin nin fila in kan bi, wa?

`Osteoblastes` ye jɔnw ye? U bɛ mun kɛ?

N'an y'a Fɔ cogo nɔgɔman na, `Osteoblasts` ye "Mason Jars" ye minnu b'an kolo jɔ. Tuma dɔw la, u bɛ Weele fana ko `kolo-banakisɛw`. U de b’an kolo barika bonya, ka kolo kura dilan. `Osteoblastes` ka baara kunbaba saba bɛ yen:

• Kolo kura jɔli ( kolo jɔli).
• Ni an bɛ kɔrɔbaya, o kɔrɔ ye ko ni an bɛ bonya ka bɔ denmisɛnya la ka taa se balikuya ma, an kolo bɛ Changé ka bɛn an farikolo cogoya ma, o ye wale ye min bɛ wele ko `remodeling`.
• Kolow kɛnɛyali ni u karilen don, ni u karilen don, walima ni u joginna .

Miiri k’a filɛ, ni an kolo dɔ mago bɛ ka bonya, ka Changé cogo dɔ la, walima ka kɛnɛya a karilen kɔfɛ, o `Osteoblasts` selilɛriw bɛ lawuli ni kemikɛli kɛcogo suguya caman ye an farikolo kɔnɔ, walima `hormones` fɛ. O kɔfɛ, o `Osteoblasts` selilɛriw bɛ fara ɲɔgɔn kan ka ɲagami kɛrɛnkɛrɛnnen dɔ dilan k’a bɔ min bɛ wele ko `bone matrix` . Nin `kolo matirili` in bɛ Kɛ ni `poroteyini` ye i n'a fɔ `kolajɛ` ani `kalisiyɔmu` ani `fositɛri`, olu ye fɛnɲɛnamafagalanw ye minnu nafa ka bon kosɛbɛ an kolo la. Nin baara in bɛ i n'a fɔ mɔgɔ min bɛ `bɛton` bɔn n'a bɛ siraba jɔ. A bɛ se ka sira kura yɛrɛ de jɔ. Walima a bɛ se ka baara kɛ ni o `bɛton` kelen in ye walasa ka sira kɔrɔ dɔ ka faraw ni karilenw fa. O cogo kelen na, `Osteoblasts`, `Masons`, bɛ baara kɛ ni nin `kolo matirili` `bɛton` ye walasa ka kolo kura jɔ, ka kolo kɔrɔw barika bonya, ka kolo karilenw kɛnɛya. Kolotuguda kura jɔlen kɔfɛ o cogo la, `Osteoblasts` selilɛri dɔw bɛ kɛ o kolo kura in yɔrɔ dɔ ye. O kɔfɛ, u bɛ wele ko `Osteocytes` . N’o tɛ, ni u mago tɛ u ka baara la tuguni, o selilɛriw bɛ sa.

An ka dɔɔnin dɔn minnu bɛ wele ko `Osteocytes`?

Kolotugudaw bɛ i n'a fɔ "lakananikɛla" minnu bɛ an kolo kɔnɔ.I n'a fɔ. An kolo fanba bɛ Kɛ o `Osteocytes` selilɛriw de la. U bɛ to ka degun walima degun sugu min bɛ an kolo la, u bɛ o kɔlɔsi. Ni an bɛ taama, ka boli, walima ka fɛn dɔ kɔrɔta, hali ni nɔba dɔ bɛ a la i n’a fɔ kolo kari, o `Osteocytes` ninnu b’a dɔn. O waati la, olu de bɛ taamasiyɛnw ci `Osteoblasts` (minnu bɛ jɔ) ani `Osteoclasts` (minnu bɛ kari - an bɛna kuma o kan kɔfɛ) fila bɛɛ ma k'a fɔ ko "gɛlɛya dɔ filɛ nin ye, na k'a labɛn. Misali la, ni kolo dɔ karilen don walima ni a karilen don, `Osteocytes` de bɛ teliya ka farikolokisɛ wɛrɛw lase o yɔrɔ la, ka a yɔrɔ karilenw bɔ, ka dɛmɛ don ka kolo kura jɔ ani k’a kɛnɛya.

O la, `Osteoclasts` ye seli sugu jumɛnw ye?

Kolotugudaw ye "saniya baarakɛlaw" ye minnu bɛ farikolokisɛ kɔrɔw tiɲɛnenw labɔ ani ka u bɔ an kolo la. A bɛ iko fɛnw tiɲɛni baarakɛlaw. U de bɛ sira Di kolotugudaw ma walasa u ka kolo kura jɔ.

Hakilila nɔgɔn dɔ ye nin ye: `Blast` bɛ i n'a fɔ `Builders`, `Clasts` bɛ i n'a fɔ `Cleaners`.

Kolotugudaw bɛ anzimu kɛrɛnkɛrɛnnenw bɔ. O anzimu ninnu bɛ kolo kɔrɔw labɔ ka u tiɲɛ. U bɛ kɛ sababu ye ka kemikɛli kɛ kolotuguda kɔrɔw sanfɛ, k’o yɔrɔw labɔ ani ka sira di farikolo yɔrɔ kura barikamaw ma. Nka ni kolotugudaw ye kolotugudaw labɔ, a tɛ i n’a fɔ asidi bɛ nɛgɛ dɔ dun i n’a fɔ a bɛ kɛ cogo min na dessin animé kɔnɔ. nin wale in bɛ kɔrɔsi kosɛbɛ wa a bɛ kɛ tigitigi . Kolotugudaw bɛ yɔrɔw dɔrɔn de labɔ, kolotugudaw (lakanabagaw) minnu kofɔra ka tɛmɛ, olu ye taamasiyɛn minnu kɛ ko "an ka kan k'a bɔ yen, o de ye nin ye." Kolociw bɛ anzimu minnu bɔ, olu bɛ kolotuguda barikama tiɲɛ ani ka a kɔnɔfɛnw minɛ kokura. O kɔ, dingɛ misɛnninw bɛ bɔ kolo sanfɛ. Ni o dingɛw kɛra ka ban, kolotugudaw (so jɔbagaw) bɛ don ka yɔrɔw fa ni kolo kura ye. A bɛ iko jɛkulu ka cɛsiri!

Nin `Osteoblasts` ni `Osteoclasts` selilɛriw bɛ cogo di?

O farikolokisɛ fla bɛɛ ka dɔgɔn kosɛbɛ wa u bɛ Sɔrɔ an ka kolotugudaw kɔkanna datugulan (`kolo lamini`) la ani kolo yɛrɛ kɔnɔ.

• A ka ca a la kolotugudaw ye farikolokisɛ misɛnninw ye minnu bɛ i n’a fɔ kubɛri.
• Kolotugudaw ka bon dɔɔni ka tɛmɛ kolotugudaw kan. U ye sɛrɛkili ye, u cogoya bɛ i n’a fɔ dôme.

Bana minnu ka teli ka kɛ, olu ye jumɛnw ye minnu bɛ nɔ bila o farikolokisɛw ka baara la?

Kolotugudaw ni kolotugudaw ye an kolo yɔrɔ fila ye minnu nafa ka bon kosɛbɛ. O la, bana o bana bɛ an kolo minɛ, o fana bɛ se ka nɔ bila o farikolokisɛw ka baara la. Gɛlɛyaba dɔw filɛ nin ye minnu b’an kolo bali ka fanga sɔrɔ ani ka fanga mara:

• Koloci - O ye ni kolotugudaw bɛ fin, ka barika dɔgɔya, ka kari nɔgɔya la.
• Koloci - Nin ye koloci ɲɛbila ye. Kolow ka denso bɛ daminɛ ka dɔgɔya.
• Hyperparathyroïdie - Hormones (banakisɛfagalanw) bɔli kojugu parathyroïde glandes fɛ, o bɛ kɛ sababu ye ka calcium bɔ kolo la.
• `Paget ka kolo bana (osteitis deformans)` - O cogo la, kolo dilancogo bɛ tiɲɛ, o bɛ kɛ sababu ye ka kolo fanga dɔgɔya ani ka kɛ fɛn ye min bɛ se ka tiɲɛ.

Yala sɛgɛsɛgɛli kɛrɛnkɛrɛnnen dɔw bɛ kɛ walasa ka o seliluw dɔn wa?

A ka ca a la, sɛgɛsɛgɛli kɛrɛnkɛrɛnnenw tɛ kɛ walasa ka a dɔn aw ka kolotugudaw walima aw ka kolotugudaw bɛ baara kɛ cogo min na. A ka ca a la dɔgɔtɔrɔw bɛ kolo bɛɛ kɛnɛya sɛgɛsɛgɛ, sanni u ka farikolokisɛ kɛrɛnkɛrɛnnenw lajɛ. Nka tuma dɔw la, joli sɛgɛsɛgɛli (laboratuwari) bɛ se ka kɛ walasa ka a dɔn aw ka kolotugudaw bɛ baara kɛ cogo min na walima ka dɛmɛ don ka bana dɔ sɛgɛsɛgɛ i n’a fɔ koloci. Sɛgɛsɛgɛli minnu ka teli ka kɛ walasa ka aw kolo kɛnɛya lajɛ, olu dɔw filɛ nin ye:

• Kolow sɛgɛsɛgɛli (DXA scan) : O bɛ kɛ ni rezow ye minnu ka dɔgɔn walasa ka aw kolo fanga hakɛ jateminɛ. A bɛ se ka dɛmɛ don ka a dɔn ni aw kolo bɛ ka fin ni aw kɔrɔla, walima ni koloci walima koloci taamasiɲɛw bɛ aw la.
• Witamini D sɛgɛsɛgɛli (` Witamini D 25-hydroxy test`) : A bɛ a lajɛ ni aw bɛ `Witamini D` caman sɔrɔ.
• Kalisiyɔmu sɛgɛsɛgɛli : O bɛ kalisiyɔmu hakɛ lajɛ aw joli la, wa a bɛ se ka kalisiyɔmu hakɛ fana lajɛ aw ka sugunɛ na sanga 24 kɔnɔ.
• `Intact parathyroïde hormone (IPTH)` sɛgɛsɛgɛli : A bɛ parathyroïde hormone hakɛ lajɛ.
• Kɛrɛyatinini sɛgɛsɛgɛli : O bɛ a lajɛ ni aw ka sugunɛ bɛ baara kɛ ka ɲɛ.

An ka kan ka mun kɛ walasa an kolo ka to kɛnɛya la?

Fɛn damadɔ bɛ yen aw bɛ se ka minnu kɛ walasa aw kolo ka kɛnɛya ani ka barika sɔrɔ. Aw bɛ se ka fɛn minnu kɛ, olu dɔw filɛ nin ye:

• Aw bɛ dumuni nafama dunni ɲuman dun , kɛrɛnkɛrɛnnenya la dumuni minnu falen don kalisiyɔmu ni witamini D la.
• Aw bɛ farikoloɲɛnajɛ kɛ ka girinya ta . O kɔrɔ ye ko farikoloɲɛnajɛ min bɛ girinya don i kolo la, i n’a fɔ taama , boli, ani ɛrɛzɛnsun jiginni.
• Aw bɛ aw yɛrɛ tanga sigarɛtimin ma pewu . Sigarɛtimin bɛ kojuguba lase kolo ma.
• Aw bɛ kalisiyɔmu ni witamini D caman sɔrɔ.Aw ye aw janto ni aw bɛ ka bɛrɛ sɔrɔ. Ni a mago bɛ a la, aw bɛ furakisɛw ta dɔgɔtɔrɔ ka laadilikanw kɔnɔ.
• Aw bɛ to ka dɔgɔtɔrɔso lajɛw kɛ . Ni aw ye bana walima fɛn dɔ yeli ye, aw bɛ taa dɔgɔtɔrɔso la joona.

Danfara jumɛn bɛ `Osteoblasts` ni `Osteocytes` cɛ?

`Osteoblasts` ni `Osteocytes` fila bɛɛ ye farikolokisɛw ye minnu bɛ dɛmɛ don ka an kolow jɔ ani k’u ladon. Nka danfara dɔɔnin bɛ o ni ɲɔgɔn cɛ.

• Kolotugudaw ye farikolokisɛw ye minnu bɛ kolo kura jɔ, ka kolo kɔrɔw falen, k’a dilan. Olu de bɛ kolotugudaw labɔ ka farikolo yɔrɔ kuraw jɔ.
• kolotugudaw ye farikolokisɛw ye minnu bɛ sɔrɔ kolotuguda kɔgɔlenw kɔnɔ . Olu de bɛ degun ni degun dɔn kolo la ani ka taamasiɲɛw ci kolotugudaw ni kolotugudaw ma, k’a fɔ ko “gɛlɛya bɛ yan, a ka kan ka ɲɛnabɔ.”.

A laban na, an ka kan ka to an hakili la min na (Take-Home Message) .

Sisan i y’a faamu cogo min na nin farikolokisɛ misɛnnin fila minnu bɛ wele ko `Osteoblasts` ani `Osteoclasts`, olu bɛ nɔba bila an kolo kɛnɛya la. U bɛ baara kɛ ɲɔgɔn fɛ tuma bɛɛ, k’an kolo dɛmɛ u ka bonya, ka u kuraya, ka to barika la. I n’a fɔ cɛfarin minnu ma dɔnkili da.

A nafa ka bon kɛrɛnkɛrɛnnenya la mɔgɔ minnu si tɛmɛna san 65 kan, muso minnu ye kalolabɔ kɛ, ani minnu ka furakɛli kuntaalajan bɛ u la, olu ka dɔgɔtɔrɔ ka ladilikan ɲini ani ka taa dɔgɔtɔrɔso la tuma bɛɛ. O bɛ a to dɔgɔtɔrɔw bɛ se ka aw kolo kɛnɛya kɔlɔsi ani ka koloci walima koloci taamasiɲɛw dɔn joona.

O la, aw bɛ aw janto aw kolo fana na. Dumuni ɲuman kɛli, farikoloɲɛnajɛ kɛli, ani ɲɛnamaya kɛcogo ɲuman na, olu de nafa ka bon kosɛbɛ!