An ka kunnafoni sɔrɔ Anticorps-Drug Conjugates (ADCs) kan - ‘magic bullet’ min bɛ kansɛribana banakisɛw sɔrɔ ka fura lase?

N'an y'a Fɔ ko "kansɛri", daɲɛ minnu bɛ Nà an hakili la o yɔrɔnin bɛɛ, olu dɔ ye "chimiothérapie" ye. Mɔgɔ caman bɛ siran nin fura in ɲɛ barisa a bɛ kunsigi bɔ, wa a ka gɛlɛn farikolo ma. Nka, furakɛli dɔnniya ɲɛtaa fɛ, fɛɛrɛ kuraw donna diɲɛ kɔnɔ minnu bɛ se ka kansɛribanakisɛw dɔrɔn de laɲini ani ka dɔ bɔ kosɛbɛ farikolokisɛ kɛnɛmanw tiɲɛni na. Bi, an bɛna kuma furakɛli fɛɛrɛ dɔ kan min ye ɲɛtaa ba sɔrɔ kansɛri furakɛli diɲɛ kɔnɔ, wa a bɛ baara kɛ i n’a fɔ ‘magic bullet’. O ye Anticorps-Drug Conjugates ye, walima ADCs i n’a fɔ an b’u wele cogo min na ni surunya ye.

N’an y’a fɔ cogo nɔgɔman na, nin Anticorps-Drug Conjugate (ADC) in ye mun ye?

Miiri k’a filɛ, i ka kan ka parsela lase mɔgɔ kelen dɔrɔn ma yɔrɔ la, yɔrɔ min na mɔgɔw ka ca. A tun bɛna nɔgɔya cogo di k’o tigi sɔrɔ k’o parsela lase sanni k’a tila-tila bɛɛ cɛ? O de bɛ nin ADC in kɛ.

ADC ye yɔrɔ saba faralen ye ɲɔgɔn kan. Ni an b’a fɛ k’a fɔ tigitigi, a bɛ i n’a fɔ ‘bɔnba hakilitigi’ min dilannen don ni fɛɛrɛ kuraw ye.

1. Banakisɛfagalan : Nin ye an ka ‘danfaralan’ ye. Protéines kɛrɛnkɛrɛnnenw bɛ yen (an b’o wele ko ``tumor antigènes'') minnu bɛ kansɛribanakisɛw sanfɛ dɔrɔn. Nin banakisɛfagalan in dilannen don walasa a ka taa nɔrɔ farikolojɔlifɛnw na minnu bɛ o kansɛribanakisɛw kan. A bɛ iko kilisi min bɛ don a ka dakun bɛnnin na. Ikomi o farikolojɔli dumuniw tɛ farikolokisɛ kɛnɛmanw na, o farikolojɔlifɛn in tɛ nɔrɔ u la. Ikomi ninnu bɛ dilan kɛrɛnkɛrɛnnenya la laboratuwaraw kɔnɔ, an b’u wele fana ko ``Monoclonal Anticorps''.

2. Simifura: Nin ye fɛn ye min bɛ o foroko kɔnɔ. A bɛ kansɛri fura dɔ kɛ min barika ka bon kosɛbɛ ka tɛmɛ min bɛ di chimiothérapie basigilen na. Ikomi a bɛ taa kansɛribanakisɛ la k’a ɲɛsin a yɛrɛ ma, a bɛ se ka fura barikama dɔ di a ma k’a sɔrɔ a ma kojugu kɛ kɛnɛma farikolokisɛ kɛnɛmanw na.

3. Linker : Nin ye ‘gum’ ye min bɛ spy (Anticorps) ni bombe (Chemo drug) minɛ ɲɔgɔn na. Nin jɛɲɔgɔnya in baara ye ka fura in bali ka bɔ fo banakisɛfagalan ka kansɛribana sɔrɔ ka don a kɔnɔ. Kansɛribana donna dɔrɔn, o jɛɲɔgɔnya in bɛ kari, ka fura bɔ.

Nin ‘misile biologique’ in bɛ baara kɛ cogo di?

O taabolo in ka di kosɛbɛ. An k’a lajɛ min bɛ kɛ senfɛ-senfɛ.

• Taabolo fɔlɔ : ADC fura bɛ pikiri kɛ banabagatɔ jolisira la kɔgɔjilama fɛ.
• Taabolo 2nan : Nin fura in bɛ taa farikolo fan bɛɛ la joli fɛ. Nka, n’a bɛ taa taama na, farikolo tangalan yɔrɔ bɛ baara kɛ i n’a fɔ GPS, ka kansɛribanakisɛw bɛ yɔrɔ min na, a bɛ o sɔrɔ.
• Taabolo 3nan : Ni kansɛribana dɔ sɔrɔla, banakisɛfagalan bɛ taa ka ‘datugu’ farikolojɔlifɛn kɛrɛnkɛrɛnnen dɔ kan (antigène) o selilɛri sanfɛ.
• Taabolo 4nan : Ni a datugulen don nin cogo la, kansɛribana bɛ a miiri ko nin ye a sago ye. O la a bɛ nin ADC pake bɛɛ sama a yɛrɛ kɔnɔ.
• Taabolo 5nan : Ni a donna kansɛribanakisɛ kɔnɔ, a kɔnɔna na, anzimuw bɛ o ‘jolikɛlan’ tiɲɛ.
• 6nan : Ni ɲɔgɔndan bɛ kari, chimiothérapie fura barikamaba min tun sirilen bɛ a la, o bɛ bɔ kansɛribanakisɛ kɔnɔ.
• Taabolo 7nan : Fura in fanga bonya kosɔn, kansɛribanakisɛ bɛ tiɲɛ ka bɔ a kɔnɔ.

Kansɛri suguya jumɛnw bɛ furakɛ ni ADC ye?

ADC tɛ kansɛri suguya bɛɛ furakɛ. Sisan, dɔgɔtɔrɔw bɛ nin furakɛli in jateminɛ kansɛri suguya dɔw la, kɛrɛnkɛrɛnnenya la ni furakɛli wɛrɛw ma ɲɛ (`(kansɛri min tɛ se ka furakɛ)`), kansɛri seginna (`(segin)`), walima ni a jɛnsɛnna farikolo yɔrɔ wɛrɛw la (`(metastasize)`).

An k’o ɲɛfɔ ka taa a fɛ ja in kɔnɔ min bɛ duguma.

ADC fura caman bɛ kɛ diɲɛ kɔnɔ

ADC fura tan ni fila ni kɔ bɛ yen kaban minnu dabɔra baarakɛda dɔw fɛ i n’a fɔ FDA Ameriki. Misali dɔw ye ninnu ye:

• Brentuximab vedotin (Adcetris®): A bɛ kɛ joli kansɛriw la i n’a fɔ Hodgkin lymphoma.
• Trastuzumab emtansine (Kadcyla®): A bɛ kɛ ka sinji kansɛri HER2 sɔrɔ, o min jɛnsɛnna farikolo fan bɛɛ la.
• Sacituzumab govitecan (Trodelvy®): A bɛ kɛ ka sinji kansɛri ni sugunɛbara kansɛri furakɛ min tɛ se ka kɛ siɲɛ saba.

Yala fura in kɔlɔlɔ si tɛ a la wa?

Hali n’a fɔra ko "tiɲɛ min bɛ kɛ farikolokisɛ kɛnɛmanw na, o ka dɔgɔn", o kɔrɔ tɛ ko nin furakɛli in kɔlɔlɔ si tɛ yen. Nka, ni i y’a suma ni chimiothérapie basigilen ye, tuma caman na, o furaw bɛ se ka kunbɛn. Kɔnɔnatumu minnu bɛ sɔrɔ, olu bɛ se ka ɲɔgɔn ta banabagatɔ ni banabagatɔ cɛ, ka kɛɲɛ ni kansɛri suguya ye, a hakɛ ani banabagatɔ ka kɛnɛya bɛɛ.

Aw ka kansɛri furakɛli jɛkulu bɛna aw kɔlɔsi kosɛbɛ aw ka furakɛli bɛɛ kɔnɔ. Ni kɔlɔlɔ dɔw kɛra, u bɛna furakɛli teliya la di aw ma.

Kɔnɔnatumuw kɔlɔlɔ minnu ka teli ka sɔrɔ:

• Sɛgɛn
• Dusukunnata ni fɔɔnɔ
• Jolidɛsɛ
• Leukopenie (jolikisɛ finmanw hakɛ dɔgɔyali) .
• Joli joli segin furakisɛw hakɛ dɔgɔyali (`(Trombocytopenie)`) .
• Anorexie (dumuni dunbaliya).
• Kɔnɔboli walima kɔnɔboli
• Kungolodimi, farigan
• Periférique neuropathie - farikolo yɔrɔw bɛ sɔgɔsɔgɔ ani ka kirin
• Fari kurukuruniw

A nafa ka bon kosɛbɛ ka teliya ka dɔgɔtɔrɔ ladɔnniya o ko ninnu dɔ la kelen na, hali ni u ka dɔgɔn.

Yala an bɛ se ka jigiya sɔrɔ o furakɛli in na wa?

Ɔwɔ, tiɲɛ yɛrɛ la. ADC ye furakɛli ye min ye jigiya kura lase kansɛribanatɔ caman ma. Kɔlɔsiliw y’a jira ko banabagatɔ minnu bɛ ADC furakɛli kɛ, olu si bɛ mɛn ka tɛmɛ banabagatɔw kan minnu bɛ chimiothérapie standard dɔrɔn ta.

Wa o foro in bɛ ka yiriwa teliya la kosɛbɛ. Nin waati in na, kɛnɛyako sɛgɛsɛgɛli 100 ni kɔ bɛ sen na diɲɛ fan bɛɛ. Dɔnniyakɛlaw b’a ɲini ka ADCw dilan minnu bɛ se ka kɛ ka ɲɛ ani minnu kɔlɔlɔ ka dɔgɔ kansɛri suguya caman na. O la, an bɛ se k’a jigi da ko don nataw la, an bɛna se ka nin ‘magic bullet’ furakɛli in sɔrɔ kansɛri suguya caman wɛrɛw la.