Jigiya kura bɛ sinji kansɛri la: An ka PI3K Inhibitors dɔn cogo nɔgɔman na (PI3K Inhibitors for ER+ Breast Cancer)

Ni an ye sinji kansɛri daɲɛ mɛn, an caman bɛ siran. Nka an ka kan ka min faamuya min nafa ka bon kosɛbɛ, o ye ko sinji kansɛri bɛɛ tɛ kelen ye. U suguya tɛ kelen ye. A suguya dɔ ye ‘estrogen receptor positive’ ye walima i n’a fɔ an b’a wele cogo min na dɔgɔtɔrɔso la , ER+ (Estrogen-Receptor-Positive) sinji kansɛri . Tiɲɛ na, sinji kansɛri minnu sɔrɔla, olu 80% dɔrɔn de bɛ nin suguya in na. O la bi an bɛna kuma fura suguya kura dɔ kan, min ye ɲɛtaa sɔrɔ, fura minnu sɔrɔla ka nin ER+ sinji kansɛriw furakɛ.

Fɔlɔ, an k’a lajɛ, ER+ sinji kansɛri ye mun ye?

N’an b’a fɔ cogo nɔgɔman na, ɔrimɔni ɔrimɔni min bɛ an farikolo la, o bɛ o kansɛribanakisɛw dɛmɛ u ka bonya. Miiri k’a filɛ, o kansɛribanakisɛw bɛ ni ‘kɔlɔsili’ (recepteurs) kɛrɛnkɛrɛnnenw ye u ɲɛda la, ɔrimɔni ɔrimɔni bɛ se ka nɔrɔ minnu na. Ni ‘kɔlɔsili’ min bɛ wele ko ɔrimɔni ɔrimɔni ɔrimɔni, o donna o ‘kɔlɔsili’ in kɔnɔ, kansɛribanakisɛw bɛ ‘siginiden’ sɔrɔ walasa ka tila ka bonya.

O de kama dɔgɔtɔrɔw ka teli ka ER+ kansɛriw furakɛ ni ɔrimɔni furakɛli ye . O furakɛli ninnu bɛ baara kɛ ni ‘kɔlɔsili’ (ɛsitorojɛni) bali ka siri ‘kɔlɔsili’ (minɛnw) la. Nka tuma dɔw la, kɛrɛnkɛrɛnnenya la ni kansɛri jɛnsɛnna farikolo fan bɛɛ la (a kɔrɔtalen don walima a bɛ taa yɔrɔ wɛrɛw la), o kansɛribanakisɛw bɛ kɛ namaratɔw ye kosɛbɛ. U bɛ kɛ fɛn ye min bɛ se ka nin ɔrimɔni furakɛli ninnu kɛlɛ, o kɔrɔ ye ko u tɛ furakɛli jaabi ka ɲɛ. O waati de la an mago bɛ furakɛli kura la minnu bɛ nɔ bɔ.

Kansɛribana banakisɛw ka ‘bonya jiginni’ - PI3K ani PIK3CA jamu

Dɔgɔtɔrɔw ni dɔnnikɛlaw tun bɛ ka o kansɛriw sababuw ɲini minnu bɛ se ka banakisɛw kɛlɛ, u ye fɛn kɛrɛnkɛrɛnnen dɔ sɔrɔ: fiɲɛ dɔ bɛ PI3K (Phosphatidylinositol-3-Kinase) sira la , o ye taamasiɲɛ jɔnjɔn ye min bɛ farikolokisɛw falencogo, u tilacogo ani u ka ɲɛnamaya kɔlɔsi.

Miiri nin PI3K sira in na i n’a fɔ ‘switchboard’ belebeleba dɔ seli kɔnɔ. A bɛ desizɔnw kɔlɔsi ni selilɛri ka kan ka bonya walima ni a ka kan ka tila. , fɛnba minnu bɛ nin sɛgɛsɛgɛlikɛlan in kɔlɔsi , olu dɔ ye PIK3CA jamu ye .

Kansɛribanatɔ dɔw la, nin PIK3CA jamu in bɛ ni fɛn falen ye , o kɔrɔ ye ko fɛn dɔ b’a la ka Changé walima ka a tiɲɛ. A bɛ i n’a fɔ ‘bonya’ sɛgɛsɛgɛlikɛlan min bɛ switchboard kan, o bɛ siri ka ‘da’ tuma bɛɛ. O kɔ, farikolokisɛw bɛ daminɛ ka tila ani ka bonya k’a sɔrɔ u ma se ka u yɛrɛ minɛ. O de ye kansɛri sababuba ye. Sɛgɛsɛgɛliw y’a jira ko ER+ sinji kansɛri bɛ banabagatɔ 40% ɲɔgɔn na, nin PIK3CA jamu jiginni in bɛ u la.

O la, nin PI3K Inhibiteurs ninnu ye mun ye?

Yan, o gɛlɛya in ɲɛnabɔcogo la, fura suguya dɔ bɛ ka don a kɔnɔ min bɛ wele ko PI3K inhibiteurs . Nin fura ninnu bɛ fɛn nɔgɔman min kɛ, o ye ka ‘kɔrɔya sɛgɛsɛgɛlikɛlan’ (PI3K sira) min kofɔ ka tɛmɛ, n’o sirilen bɛ ‘kan’, o dabila ka ɲɛ.

A ka ca a la, o furaw bɛ sɔrɔ da la furaw cogo la. A ka ca a la, nin fura in bɛ di banabagatɔw ma ka fara ɔrimɔni furakɛli kan min kofɔra ka tɛmɛ (ɛsitorojɛni balilan).

Ne bɛ se k’a dɔn cogo di ni nin furakɛli in bɛnnen don ne ma?

Nin ye ɲininkali ye min nafa ka bon kosɛbɛ. PI3K inhibiteurs tɛ di sinji kansɛribanatɔ bɛɛ ma. U dabɔra kɛrɛnkɛrɛnnenya la ka:

• Muso minnu bɛ kalolabɔ kɔfɛ ani banabagatɔ cɛmanw ta.
• Kansɛri ka kan ka kɛ HR+ (Hormone-Recepteur-Positif) ani HER2-Negatif ye .
• Fɛn min nafa ka bon kosɛbɛ: Kansɛri banakisɛw ka kan ka kɛ ni PIK3CA jamu jiginni ye .

Walasa k’a dɔn ni nin jamu jiginni in bɛ aw ka kansɛri la, aw ka dɔgɔtɔrɔ bɛna sɛgɛsɛgɛli kɛrɛnkɛrɛnnen kɛ. A ka ca a la o bɛ kɛ ni joli ta ye walima farikolo yɔrɔ fitinin dɔ (biopsie) min bɛ bɔ tumu na. O sɛgɛsɛgɛli jaabiw bɛna a jira ni nin furakɛli in bɛnnen don aw ma.

Nin fura ninnu bɛ se ka kɔlɔlɔ jumɛnw lase mɔgɔ ma?

I n’a fɔ kansɛri furakɛli suguya bɛɛ, PI3K balilanw bɛ se ka kɔlɔlɔ dɔw lase mɔgɔ ma. Nka, o kow tɛ kɛ bɛɛ la cogo kelen na. Ani fana, fɛɛrɛ dɔw bɛ yen sisan walasa ka nin kɔlɔlɔ ninnu kunbɛn.

A kɔlɔlɔ minnu ka teli ka sɔrɔ, olu dɔw ye:

• Dusukunnata ni fɔɔnɔ
• Dumuni nege dɔgɔyali ani farikolo girinya dɔgɔyali
• Da kɔnɔ joginda
• Kunsigi bɔli
• A bɛ nɔ o nɔ bila sugunɛ, sugunɛ walima kɔnɔboli baara la
• Faridimi, a ka jugu tuma dɔw la, o bɛ se ka kɛ, o bɛ kɛ sababu ye ka fari bɔ walima ka kurukuru.
• Sukaro caman sɔrɔli joli la : Nin ye kɔlɔlɔ ye min ka teli ka kɛ fura suguya in kɛrɛnkɛrɛnnen na, barisa PI3K sira bɛ sukaro sɛnɛcogo la an farikolo la.

Aw kana siran nin kɔlɔlɔ ninnu ɲɛ. Aw ka dɔgɔtɔrɔ bɛna aw lajɛ tuma bɛɛ ni ninnu tɛ. Ni a mago bɛ a la, a bɛna dɔ bɔ fura tata hakɛ la, ka a tali dabila dɔɔni (fura seli), walima ka fura wɛrɛ di aw ma walasa ka kɔlɔlɔw kunbɛn. Aw kana fura tali dabila abada walima ka a tata hakɛ Changer ni aw ma dɔgɔtɔrɔ ɲininka.

Sɛgɛsɛgɛliw y’a jira ko ni aw ye sukarodunbana fura ta walasa ka sukaro hakɛ kunbɛn walima ka tugu dumuni nafama na, ni tulumafɛnw ka ca ( ketogenic diet ) o bɛ se ka dɔ fara fura in nafa kan. Nka, a nafa ka bon aw ka kuma dɔgɔtɔrɔ fɛ sani aw ka dumuni caman Changer.

Yala nin furakɛli in bɛ nɔ bɔ tiɲɛ na wa?

Awɔ. O de ye ko ye min nafa ka bon kosɛbɛ. Kɛnɛyaso sɛgɛsɛgɛli caman y’a jira ko banabagatɔ minnu bɛ ni sinji kansɛri ER+ ye, ni PIK3CA fɛn falen bɛ u la, olu bɛ se ka nafa sɔrɔ PI3K balilan na ni a ni ɔrimɔni furakɛli faralen don ɲɔgɔn kan.

Sɛgɛsɛgɛliba dɔ y’a jira ko banabagatɔ minnu ye fura in faralen ɲɔgɔn kan, olu ka ɲɛnamaya bɛ se kalo 11 ɲɔgɔn ma, u ma taa ɲɛ . O tun tɛ kalo 6 bɔ banabagatɔw la minnu ka jamu jiginni ye kelen ye, minnu ma PI3K balilanw ta. Nin ye yɛlɛmaba ye ani jigiyaba. O ɲɛtaa in kosɔn, fura kuraw bɛ ka labɛn nin fura suguya in na sisan.