Yala aw ka dɔgɔtɔrɔ ye fura suguya dɔ fɔ aw ye min bɛ wele ko SERM walima SERD minnu bɛ kɛ ka sinji kansɛri furakɛ wa? Aw kana aw hakili ɲagami, nin tɔgɔ ninnu bɛ se ka fɔ ko u ka gɛlɛn dɔɔnin. Bi, an bɛna kuma daɲɛ nɔgɔmanw na u ye fɛn minnu ye, u bɛ baara kɛ cogo min na, ani i ka kan ka fɛn minnu dɔn u ko la. ninnu ye fura suguya fila ye minnu nafa ka bon kosɛbɛ , minnu bɛ se k' an dɛmɛ ka sinji kansɛri kɛlɛ .
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SERMw ye mun ye? U bɛ baara kɛ cogo di?
N’an y’a fɔ cogo nɔgɔman na, SERMw (Selective Estrogen Receptor Modulators) ye fura suguya ye min bɛ sinji kansɛribanakisɛw falenni dabila. Nka, u bɛ baara kɛ kansɛri suguya kɛrɛnkɛrɛnnen dɔrɔn de kan. O ye kansɛri suguya ye min bɛ wele ko Oestrogène Recepteur-Positif . Sinna kansɛri minnu bɛ ye an ka jamana kɔnɔ, olu 75% dɔrɔn de bɛ nin suguya in na.
Miiri k'a filɛ, o kansɛribanakisɛw bɛ ni "antenne" fitininw ye u sanfɛla la. Furakɛcogo la, an bɛ o fɛnw wele ko . Ni ɔrimɔni ɔrimɔni min bɛ an farikolo la, o nɔrɔla o antɛniw na, kansɛribanakisɛ bɛ taamasiɲɛ sɔrɔ ko a bɛ “tila ka bonya ka taa a fɛ.”
SERMw bɛ min kɛ, o ye nin ye:
U bɛ taa o antɛniw bali, o kɔrɔ ye ko jaabiw. O kɔfɛ, ɔrimɔni ɔrimɔni (hormone) tɛ sɔrɔ yɔrɔ la ka na a yɛrɛ nɔrɔ. Ikomi a tɛ taamasiɲɛ sɔrɔ, kansɛribanakisɛw falenni bɛ jɔ walima a fanba bɛ kɔlɔsi.
Min nafa ka bon, o ye, a bɛ Weele ko ‘sugandili’ kun dɔ de kama. Hali ni o fura ninnu bɛ ɔrimɔni ka baara bali sin na, u bɛ a to ɔrimɔni ka baara kɛ ka ɲɛ farikolo yɔrɔ wɛrɛw la, i n’a fɔ kolo ni denso. O de b'u Kɛ mɔgɔ kɛrɛnkɛrɛnnenw ye.
SERM suguyaw n’u nafaw
SERM suguya kunbaba damadɔ bɛ yen minnu dabɔra sinji kansɛri la.
| Fura tɔgɔ | Baarakɛcogo kunbabaw |
|---|---|
| Tamokisifɛni (Tamoxifen) ye |
|
| Toremifeni (Toremifene) ye | |
| Raloxifene ) ye |
O la, SERDw ye mun ye?
SERDw (Selective Estrogen Receptor Downregulators) ye fura suguya ye min fanga ka bon dɔɔni ka tɛmɛ SERMw kan. I n’a fɔ SERMw, u bɛ ɔrimɔni sɔrɔyɔrɔw fana bali. Nka ka fara o kan, SERDw bɛ dɔ bɔ furakisɛw hakɛ la (downregulate) ani ka sɔrɔyɔrɔ tɔw baara fana Changer, o b’a to u tɛ baara kɛ kosɛbɛ.
Sisan, SERD suguya fila bɛ yen minnu dabɔra:
- Fulvestrant ) ye
- Elacestrant ) ye
Olu bɛ di kɛrɛnkɛrɛnnenya la sinji kansɛri jugumanw ma, minnu bɛ sɔrɔ ɔrimɔni tali la ani minnu tɛ HER2 sɔrɔ . HER2-negatif kɔrɔ ye ko kansɛribanakisɛw tɛ ni farikolojɔlifɛn ye min bɛ wele ko HER2 u ɲɛda la min bɛ u dɛmɛ ka bonya.
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Check Availability →Fura in bɛ kɛ cogo di?
- SERMw: Olu fanba bɛ sɔrɔ furakisɛw cogo la. Aw ka dɔgɔtɔrɔ bɛna a fɔ aw ye ko aw ka miligaramu 20 fo miligaramu 40 ta tile kɔnɔ. Ni aw bɛ fura ninnu ta walasa ka kansɛri bali ka segin, a ka ca a la aw ka kan ka to ka u ta fo san 5 fo san 10.
- SERDw : Misali la, Fulvestrant bɛ na i n’a fɔ pikiri.Fila. Nin pikiri fila ninnu bɛ kɛ fasa dɔ la min bɛ kɔkolo la. U bɛ di siɲɛ saba furakɛli kalo fɔlɔ kɔnɔ, o kɔfɛ siɲɛ kelen kalo kɔnɔ o kɔfɛ.
SERMw ni SERDw bɛ di cogo jumɛnw na?
Ko damadɔ bɛ yen dɔgɔtɔrɔ bɛ se ka furakɛli ninnu sɛbɛn minnu na.
| Kunnandiya | Ɲɛfɔli |
|---|---|
| Sani opereli ka kɛ (Therapy néoadjuvant) . | Ni aw ka kuru ka bon, fura in bɛ se ka di sani opereli ka kɛ walasa ka a dɔgɔya ani ka a bɔli nɔgɔya. |
| Opereli kɔfɛ (Thérapie adjuvant) . | Nin furakɛli in bɛ kɛ walasa ka kansɛribanakisɛ misɛnniw tiɲɛ minnu bɛ se ka to opereli kɔfɛ ani ka kansɛri bali ka segin. |
| Kansɛri min bɛ sɔrɔ kɔfɛ | Ni kansɛri jɛnsɛnna farikolo yɔrɔ wɛrɛw la barajuru kɔkan, fura ninnu bɛ se ka dɛmɛ don ka a bonya kunbɛn walima k’a sumaya. |
| Walasa ka bana kunbɛn | Hali ni sinji kansɛri ma sɔrɔ aw la, ni aw ka a sɔrɔli farati ka bon ni a sɔrɔli hakɛ cayalenba ye ka a sababu kɛ fɛnw ye i n’a fɔ jamu, SERMw bɛ se ka di aw ma walasa ka dɔ bɔ o farati la. |
Nin furakɛli ninnu kɔlɔlɔ ni farati jumɛnw bɛ u la?
I n’a fɔ fura suguya bɛɛ, o furaw bɛ se ka kɔlɔlɔw lase mɔgɔ ma. Nka bɛɛ t’u sɔrɔ. A nafa ka bon ka a dɔn kɔlɔlɔ minnu bɛ se ka sɔrɔ.
SERMw kɔlɔlɔw
Kɔnɔnatumu minnu bɛ ye tuma caman na, olu ni kalolabɔ waati bɛ tali kɛ ɲɔgɔn na.
- Fɛnɲɛnɛma-fiɲɛw
- Musoya jalen, ji bɔli, walima joli dɔɔni
- Sufɛ sumaya
- Fɔɔnɔnege
- Dusukunnataw bɛ Changé
Kɔnɔnatumuw kɔlɔlɔ minnu man ca nka u ka jugu:
- Denso kansɛri farati dɔɔni dɔɔni
- Joli kurulenw senw na (Deep Vein Thrombosis, walima DVT) walima joli kurulenw fogonfogon la (Pulmonary Embolisme) .
- Ɲɛkisɛw (cataractes).
- Musow kolo finman sani u ka kalolabɔ ka ban
SERDw kɔlɔlɔw
- Dimi dɔɔni dɔɔni pikiri kɛyɔrɔ la
- Fɔɔnɔnege
- Kolo, farikolo walima kolotugudaw dimi
- Kunkolodimi
- Baarakɛbaliya
- Fɛnɲɛnɛma-fiɲɛw
A nafa ka bon kosɛbɛ: SERDw bɛ se ka joli segin furakisɛw hakɛ dɔgɔya, olu bɛ joli kuruli dɛmɛ. O bɛ se ka dɔ fara joli bɔli kan dɔɔni. Ani fana, nin fura fila bɛɛ man ɲi abada kɔnɔmaya waati walima ni aw b’a fɛ ka kɔnɔ ta . A nafa ka bon ka bangekɔlɔsi fɛɛrɛ dɔ kɛ min tɛ ɔrimɔni ye, ni aw bɛ fura ninnu ta ani san kelen ni kɔ furakɛli jɔlen kɔfɛ.
Ni dɔgɔtɔrɔ ye fura in fɔ aw ye, aw bɛ kuma a fɛ o ko la. Aw kana siran ka ɲininkaliw kɛ i n’a fɔ: "Fura in bɛna nafa jumɛnw lase ne ma?", "Ne bɛ se ka kɔlɔlɔ jumɛnw makɔnɔ?", ani "Ne mago bɛna kɛ fura in tali la fo waati joli?"
Take-Home cikan
- SERMw ni SERDw ye furaw ye minnu bɛ se ka kɛ kosɛbɛ sinji kansɛri la min bɛ sɔrɔ ɔrimɔni tali la. U bɛ ɔrimɔni ɛsitorojɛni ka baara bali, o min nafa ka bon kansɛribanakisɛw falenni na.
- Nin fura ninnu bɛɛ man ɲi bɛɛ ma. Aw ka dɔgɔtɔrɔ dɔrɔn de bɛ se ka furakɛli ɲuman dɔn aw ye ka kɛɲɛ ni kansɛri suguya ye, aw si hakɛ ani aw ka kɛnɛya.
- Kɔnɔnatumuw bɛ se ka sɔrɔ, nka u fanba bɛ se ka kunbɛn. Aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ dimi o dimi kan, hali ni a ka dɔgɔ cogo o cogo.
- A nafa ka bon kosɛbɛ ka i yɛrɛ tanga kɔnɔmaya ma ni i bɛ fura in ta. Aw ye aw jija ka dɔgɔtɔrɔ dɔ lajɛ bangekɔlɔsi fɛɛrɛ bɛnnenw kan.
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