Yala aw fana bɛ sɛgɛn tile bɛɛ la ni aw ye kunkolodimi sɔrɔ wa? Dimi min bɛ kɛ i n’a fɔ i kunkolo bɛ ka tila, i tɛ se ka yeelen filɛ, i bɛ kɔnɔboli kɛ... Nin ɲɔgɔnna kow bɛ i ka don o don baara bɛɛ gɛlɛya, tiɲɛ tɛ? Mɔgɔ dɔw fɛ, o bɛ kɛ siɲɛ kelen walima siɲɛ fila kalo kɔnɔ, dɔw fɛ, a bɛ na siɲɛ caman dɔgɔkun kɔnɔ, k’u ka ɲɛnamaya kɛ bɔnɛ ye. O la, kunkolodimi bɛ mɔgɔ minnu na tuma caman na i n’a fɔ nin, furakɛli fɛɛrɛ kura dɔ bɛ yen sisan, min bɛ nɔ bɔ kosɛbɛ. Bi an bɛ kuma fura suguya kɛrɛnkɛrɛnnen dɔ kan min bɛ wele ko CGRP Inhibitors.
N’an y’a fɔ cogo nɔgɔman na, nin CGRP balilanw ye mun ye?
Ninnu ye furaw ye minnu bɛ sɛbɛn dɔgɔtɔrɔ fɛ, dɔgɔtɔrɔ bɛ minnu sɛbɛn. U bɛ kɛ ka kunkolodimi furakɛ kosɛbɛ. Ni kunkolodimi basigilen walima kunkolodimi basigilen bɛ aw la, o fura in bɛ se ka bɛn aw ma.
N’an y’a fɔ cogo nɔgɔman na, ninnu ye fura suguya kɛrɛnkɛrɛnnenw ye minnu dabɔra kɛrɛnkɛrɛnnenya la ka kunkolodimi kunbɛn. Fura kɔrɔw tɛ i n’a fɔ fura kɔrɔw, olu bɛ baara kɛ ni u bɛ kunkolodimi bila mɔgɔ la cogo min na, o laɲini k’a ɲɛsin u yɛrɛ ma.
Nin fura in bɛ baara kɛ cogo di an farikolo kɔnɔ?
Walasa k’o faamuya, an ka kan ka fɔlɔ k’a dɔn CGRP ye min ye.
CGRP ye a surun ye min tɔgɔ ye ko Calcitonin Gene-Related Peptide . O ye farikolojɔlifɛn ye min bɛ sɔrɔ an farikolo la a yɛrɛ la. A ka c’a la, nin CGRP furakisɛ in bɛ fɛn dɔ kɛ an ye. Misali la, a bɛ dɛmɛ ka tansiyɔn kunbɛn ni a bɛ an ka joli siraw bonya (vasodilation).
Nka, kunkolodimi bɛ mɔgɔ minnu na, olu bɛ nin CGRP furakisɛ caman dilan ka tɛmɛ a wajibiyalen kan. O CGRP tɛmɛnen in bɛ dimi nɛrɛw lawuli kunsɛmɛ na, ka dimi taamasiɲɛw juguya. O fana bɛ kɛ sababu ye ka dimi mɛn ka mɛn.
CGRP inhibiteurs bɛ min kɛ, o ye k’o wale in jɔ sani a ka kɛ. Daɲɛ min ye ko ‘inhibit’ kɔrɔ ye ‘dabila’ walima ‘inhibit’ ye. O kɔrɔ ye ko fura ninnu bɛ kunkolodimi sababu yɛrɛ jɔ.
CGRP balilan suguya fila bɛ yen:
Nin fura ninnu bɛ se ka tila ka kɛ suguyaba fila ye ka da u baaracogo kan. Aw ka dɔgɔtɔrɔ bɛna ninnu ɲɛfɔ aw ye ka ɲɛ.
| Fura suguya | A bɛ baara kɛ cogo min na & Misaliw |
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| 1. CGRP Banakisɛfagalanw (moAbs) . | Olu bɛ i n’a fɔ ‘lafasali robo’ kɛrɛnkɛrɛnnenw minnu dabɔra laboratuwari kɔnɔ. I n’a fɔ an farikolo tangalanw bɛ banakisɛw kɛlɛ cogo min na, o ‘robotiw’ bɛ CGRP furakisɛ tɛmɛnenw ɲini joli la, k’u minɛ, k’u tiɲɛ. A bɛ di cogo min na:
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| 2. CGRP minɛbagaw kɛlɛbagaw (Gepants) . | A bɛ i n’a fɔ tulon min bɛ kɛ ni dɔnkilida sigilanw ye. Sani CGRP furakisɛ ka sigi farikolo yɔrɔw la, fura in bɛ taa o sigilanw minɛ. Komin sigilanw falen don, CGRP sigiyɔrɔ tɛ yen. O la, dimi taamasiɲɛ si tɛ bɔ. A bɛ di cogo min na:
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Nin suguya fila la jumɛn ka fisa ne ma?
O bɛ i ka dɔgɔtɔrɔ de bolo ka a latigɛ. A bɛna fura di aw ma min ka fisa aw ma ka kɛɲɛ ni aw ka kunkolodimi cogoya ye, aw ka nɔgɔya (don o don furakisɛ walima kalo o kalo pikiri), ani aw ka kɛnɛya bɛɛ lajɛlen.
Fura in nafa kunbabaw ye jumɛnw ye?
CGRP inhibiteurs ye fura suguya fɔlɔ ye min dabɔra kɛrɛnkɛrɛnnenya la ka kunkolodimi kunbɛn, wa a nɔfɛkow ɲɛnabɔra kosɛbɛ.
- Kunkolodimi caya bɛ dɔgɔya.
- Hali ni kunkolodimi kɛra, dimi juguya ni a taamasiɲɛ wɛrɛw bɛ dɔgɔya.
- Kungolodimi kuntaala bɛ surunya.
- kunkolodimi dɔw bɛ se ka bali pewu .
O bɛ lafiyaba di i ma i ka don o don baaraw, i ka baara, ani i ka kalan kɛli la k’a sɔrɔ i ma tigɛ.
Yala kɔlɔlɔ dɔw bɛ a la wa?
I n’a fɔ fura tɔw bɛɛ, kɔlɔlɔ dɔw bɛ se ka sɔrɔ, nka a ka ca a la, olu ka dɔgɔn.
| Kɔnɔnatumu misɛnnin minnu ka teli ka sɔrɔ | A man teli nka cogoya minnu ka kan ka kɔlɔsi |
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Min nafa ka bon kosɛbɛ: Ni aw ye nin kɔlɔlɔ ninnu dɔ ye walima ni taamasiɲɛ minnu tɛ deli ka kɛ, aw bɛ o fɔ aw ka dɔgɔtɔrɔ ye joona. | |
Ne bɛ se ka nɔ bɔ joona cogo di?
Nin tɛ fɛn ye min bɛna Changé su kelen kɔnɔ. a ka c' a la , aw bɛna a daminɛ ka fɛn ɲuman dɔ kɔlɔsi kalo kelen walima kalo fila kɔfɛ . Jateminɛw teliya bɛ bɔ fɛn caman na:
- CGRP balilan fura suguya min bɛ di aw ma.
- Aw bɛ kunkolodimi sɔrɔ siɲɛ joli?
- Aw ka kunkolodimi juguya.
- Aw ka kɛnɛya bɛɛ lajɛlen.
Kana jɔrɛ. Aw ka dɔgɔtɔrɔ bɛna o ɲɛfɔ aw ye. Min nafa ka bon, o ye ka muɲu ani ka taa a fɛ furakɛli la.
Kunkolodimi tɛ farigan ye min bɛ ban tile kelen walima tile fila kɔnɔ. O ye fɛn ye min bɛ nɔ bila i ka ɲɛnamaya bɛɛ la. O la, ni bi furakɛli kɛra i n’a fɔ nin, i bɛ se ka i ka ɲɛnamaya mara kokura.
Take-Home cikan
- CGRP Inhibitors ye bi fura suguya ye min bɛ se ka kɛ kosɛbɛ, min dilannen don kɛrɛnkɛrɛnnenya la kunkolodimi kunbɛnni kama.
- O bɛ farikolojɔli dumuni dɔ bali min bɛ wele ko CGRP, o min bɛ kunkolodimi bila mɔgɔ la.
- Nin fura in bɛ sɔrɔ cogo caman na, i n’a fɔ pikiri, furakisɛw, ani nugulafura.
- O bɛ se ka dɔ bɔ kosɛbɛ kunkolodimi caya ni a juguya la, ka aw dɛmɛ ka ɲɛnamaya kɛ cogo la min bɛ mɔgɔ lafiya.
- Sani aw ka furakɛli suguya o suguya daminɛ, aw bɛ baro kɛ a nafaw ni a kɔlɔlɔw kan ni dɔgɔtɔrɔ ye. Aw kana fura si tali daminɛ walima ka a dabila abada ni dɔgɔtɔrɔ ma ladilikan di aw ma.
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