Yala i ka mɔgɔ kanulen, laala i ba, i fa, i bamuso walima i bɛnbakɛ, Alzheimer bana bɛ a la wa? An bɛɛ b’a dɔn dusukasi ni dɛmɛnbaliya min bɛ sɔrɔ ni an hakili bɛ bɔ dɔɔnin dɔɔnin ani ka ɲinɛ ɲɛda dɔntaw kɔ. Tiɲɛ na, alzheimer bana ye bana ye min bɛ se ka kɛ sababu ye ka hakilijagabɔ kɛ, ka mɔgɔ hakili tiɲɛ ani ka mɔgɔ faga yɛrɛ. Hali ni fura tɛ nin bana in na, fura dɔw bɛ yen minnu bɛ se ka a sumaya ani ka lafiya dɔ di banabagatɔ ma. Bi an bɛna kuma o dɔrɔgu suguya kɛrɛnkɛrɛnnen dɔ kan. o ye NMDA jaabiw kɛlɛbagaw ye . Hali n’a tɔgɔ ka gɛlɛn dɔɔnin, an k’a Faamu nɔgɔya la.
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Kimiki maana fitinin min bɛ kɛ hakili la
An hakili ye yɔrɔ kabakoma ye. Nɛrɛmuguma miliyari caman bɛ a la, walima sɔgɔsɔgɔninjɛ. O farikolokisɛw bɛ kunnafoniw baara, ka kunnafoniw hakili to a la, ka farikolo yɔrɔ wɛrɛw fɔ u ka kan ka min kɛ, u kɛtɔ ka kuran ni kemikɛli taamasiɲɛw ci ɲɔgɔn ma ka segin ka na.
An bɛ ciden minnu bɛ o kemikoro taamasiɲɛw Ta, an b’olu Weele ko neurotransmetteurs. O cidenw dɔ ye glutamate ye .
I ka miiri dɔrɔn glutamate la i n’a fɔ kurun min bɛ cikan ta ka bɔ nɛrɛmuguma dɔ la ka taa dɔ wɛrɛ la. Nin kurun in mago bɛ kurun jɔyɔrɔ kɛrɛnkɛrɛnnen na walasa ka taa seli tɔ kelen na ka kurun jɔyɔrɔ. O kurunbonkari ye min wele ko NMDA minɛbaga (N-methyl-D-aspartate minɛbaga. Ni kurun min bɛ wele ko glutamate nɔrɔla nin NMDA port in na, a bɛ fɛn nafama wɛrɛ ci min bɛ wele ko calcium ka don selilɛri kɔnɔ. O kalisiyɔmu in de bɛ o cikan dafa ani k’an dɛmɛ ka fɛn dɔ kalan ani k’an hakili to fɛn dɔ la. Nin ye ko ye min bɛ kɛ cogo la min bɛ kɛ hakili kɛnɛman na.
O la sa, mun bɛ kɛ Alzheimer bana na?
Alzheimer bana bɛ mɔgɔ min na , o tigi hakili la , glutamate caman bɛ daminɛ ka bɔ . Min bɛ kɛ, o ye ko kalisiyɔmu caman bɛ woyo ka don o farikolo yɔrɔw la. Miiri k’a filɛ mun bɛ kɛ ni i ye jidaga dɔ fa ni ji caman ye? A bɛ fa. O cogo kelen na, ni kalisiyɔmu caman bɛ dalajɛ farikolokisɛw kɔnɔ, o farikolokisɛw bɛ daminɛ ka tiɲɛ. O tiɲɛni in de bɛ dɔ fara Alzheimer bana taamasiɲɛw kan dɔɔni dɔɔni.
NMDA Receptor Antagonists bɛ dɛmɛ cogo min na, o filɛ nin ye
Fura suguya min bɛ wele ko NMDA minɛbagaw kɛlɛbagaw, o bɛ baara kɛ ni o glutamate kurun wɛrɛw bɛ se ka jɔ yɔrɔ minnu na NMDA minɛyɔrɔ la, olu hakɛ dɔgɔyali ye. O kɔrɔ ye ko dɔrɔgu bɛ kurunbonkarila dɔw bali. nka min nafa ka bon kosɛbɛ , o ye ko fura ninnu bɛ a to cikan nafamaw ka woyo . O kɔrɔ ye ko u bɛ kalisiyɔmu tiɲɛni tiɲɛni dɔrɔn de kɔlɔsi k’a sɔrɔ u ma tiɲɛniba si lase hakili ka baarakɛcogo ɲuman ma. O bɛ dɔ bɔ farikolo yɔrɔw tiɲɛni na ani ka bana teliya kunbɛn.
Alzheimer bana furakɛli la, dɔgɔtɔrɔw ka teli ka furaw ta minnu bɛ farikolojidɛsɛ fura wɛrɛ laɲini min bɛ wele ko asetilkolini. Nka NMDA minɛbagaw kɛlɛbagaw ye fura suguya nafama ye minnu bɛ baara kɛ cogo wɛrɛ la.
NMDA minɛbaga kunba min dagalen don sisan Alzheimer bana furakɛli la, o ye memantine ye (a tɔgɔ ye ko Namenda XR). A ka ca a la dɔgɔtɔrɔw b’a sɛbɛn bana in taabolo danmadɔw fo ka se a jugumanba ma. Tuma dɔw la, mɛmantini bɛ di ka fara kolinɛsitɛrazi inhibiteurs kan minnu kofɔra ka tɛmɛ, olu bɛ dɔ fara asetilkolini hakɛ kan. O bɛ se ka kɛ sababu ye ka nɔ ɲuman bila banabagatɔ dɔw la.
Nka aw hakili to a la ko fura ninnu tɛ baara kɛ ɲɔgɔn fɛ bɛɛ la.
An k’an janto a kɔlɔlɔw fana na.
I n’a fɔ fura bɛɛ, nin fura in bɛ se ka kɔlɔlɔ misɛnniw lase a ma.
- Dimi de ye a taamasiɲɛ ye min ka teli ka kɛ.
- Ka fara o kan, fɛn dɔw fana bɛ se ka kɛ i n’a fɔ kungolodimi ni kɔnɔboli .
- A man teli kosɛbɛ, hakili ɲagami bɛ se ka kɛ hakili la .
Ni aw walima aw ka banabagatɔ ye ninnu dɔ sɔrɔ, aw ka kan ka aw ka dɔgɔtɔrɔ ladɔnniya joona . A man ɲi abada ka fura tali dabila walima ka fura tata hakɛ Changer i yɛrɛ ma.
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Check Availability →Fura wɛrɛ minnu bɛ nin denbaya in kɔnɔ ani u kɛcogo
Fura wɛrɛw bɛ nin denbaya in kɔnɔ minnu bɛ wele ko NMDA minɛbagaw kɛlɛbagaw. An bɛ u dɔw ye don o don ɲɛnamaya kɔnɔ. Dɔw farati ka bon dɔɔni, wa u bɛ kɛ dɔrɔgu ye. Dɔnniyakɛlaw fana bɛ ka ɲinini kɛ fura suguya in nafa kan hakilibana wɛrɛw la, i n’a fɔ Parkinson ka bana ani ALS (amyotrophic lateral sclerosis).
An ka kunnafoni wɛrɛw sɔrɔ o kan ja in kan min bɛ duguma.
| Dɔrɔgu Tɔgɔ | Baarakɛcogo kunba | Fɛn nafamaw ani farati minnu bɛ u la |
|---|---|---|
| Dextrométhorphane (Dɛkisitrɔmetɔrfan). | A bɛ sɔrɔ sɔgɔsɔgɔninjɛ furaw la. | A ka ca a la, farati tɛ a la, nka a bɛ se ka kɛ farati ye ni a tata hakɛ ka ca. |
| Ketamini (Ketamine) ye | Anestezi fura (adamadenw ni baganw kama). | A bɛ kɛ ka dimi mada opereli waati. Nka a tɔɔrɔla i n'a fɔ "kuluba dɔrɔgu". A bɛ se ka kɛ sababu ye ka hakilijagabɔ kɛ ani ka a yɛrɛ mabɔ farikolo la. Sɛgɛsɛgɛli bɛ sen na a kɛcogo kan bana dɔw la i n’a fɔ degun. |
| Fensikilidini (PCP) . | A bɛ kɛ ka juguya i n’a fɔ dɔrɔgu. | A daminɛ na, a dabɔra ka kɛ anestezi ye, a bɔra baara la ka da a kɔlɔlɔ jugumanw kan (hallucinations, confusion). Fura faratilen dɔ min bɛ wele ko "Mɛlɛkɛ buguri". A ni fariyakow bɛ tali kɛ ɲɔgɔn na. |
Take-Home cikan
- Hali ni Alzheimer bana tɛ se ka kɛnɛya pewu, NMDA minɛbagaw kɛlɛli furaw i n’a fɔ memantine bɛ se ka dɛmɛ don ka bana in taabolo danmadɔw fo ka se a jugumanw ma, u kɛtɔ ka dɔ bɔ tiɲɛni na kunsɛmɛnasumaya la.
- O furaw bɛ baara kɛ ni farikolojidɛsɛbanakisɛw lakanani ye ka bɔ glutamate tɛmɛnen na kunsɛmɛ na.
- I n’a fɔ fura tɔw bɛɛ, kɔlɔlɔw i n’a fɔ ɲɛnamini bɛ se ka sɔrɔ. Aw bɛ baro kɛ o kan ni aw ka dɔgɔtɔrɔ ye tuma bɛɛ. Aw kana fura tata hakɛ Changer abada walima ka fura tali dabila aw yɛrɛ ma.
- Nin dɔrɔgu suguya in, i n’a fɔ Ketamine ni PCP, olu bɛ kɛ dɔrɔgu ye, wa u farati ka bon kosɛbɛ. Danfaraba bɛ ninnu ni fura minnu bɛ di Alzheimer bana ma.
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