Somatostatin ye mun ye? An ka nin ɔrimɔni kabakoma in dɔn an farikolo la!

Bi an bɛna kuma kemikɛli ciden dɔ kan min ka bon kosɛbɛ ani min nafa ka bon kosɛbɛ an farikolo kɔnɔ. A tɔgɔ ye ko somatostatin. N’a sɔrɔ i ma o tɔgɔ mɛn fɔlɔ. Nka yala i b’a dɔn wa, a bɛ dɛmɛ ka fɛn caman mara an farikolo la, i n’a fɔ gundola hakilitigi. An ka a lajɛ somatostatin ye min ye, a bɛ baara kɛ cogo min na, ani a nafa ka bon an ka kɛnɛya la cogo min na.

Somatostatin ye mun ye tigitigi?

N’an y’a fɔ cogo nɔgɔman na, somatostatin ye ɔrimɔni ye min bɛ bɔ an farikolo la. Sisan, i bɛ se k’i yɛrɛ ɲininka ‘ɔrimɔni’ ye mun ye. A ka nɔgɔn kosɛbɛ. Ɔrimɔni ye kemikɛlifɛnw ye minnu bɛ cikanw ta an farikolo yɔrɔw ni ɲɔgɔn cɛ. U bɛ i n’a fɔ ‘postew’ an farikolo la. O cikanw b’a fɔ an farikolo yɔrɔw, an fari ani an farikolo yɔrɔw ye ko u ka fɛn dɔ kɛ walima ka fɛn dɔ kɛli dabila.

O la, nin ɔrimɔni kɛrɛnkɛrɛnnen in min bɛ wele ko somatostatin , o bɛ ɔrimɔni wɛrɛw dilanni dabila kosɛbɛ, ka baara dɔw kɔlɔsi an ka dumunikɛminɛnw na (kɔnɔnatumu (GI)), ani fana a bɛ farikolokisɛw tilatilali teliya fana kɔlɔsi (kɛrɛnkɛrɛnnenya la kansɛribanakisɛw). A bɛ i n'a fɔ sirako polisi, ni fɛn dɔ cayara kojugu, a bɛ taamasiyɛn di ko "Okay, okay, stop now."

Nin somatostatin in bɛ bɔ min?

Sisan an k’a lajɛ nin somatostatin ɔrimɔni kabakoma in bɛ bɔ yɔrɔ min na an farikolo la. A bɛ Bɔ tiɲɛ na yɔrɔ damadɔ la:

• Kɔnɔnatumu (GI) : Nin ye farikolo yɔrɔ jan ye min bɛ i n’a fɔ tubabufura, min bɛ bɔ da la ka taa a bila kɔnɔbara la min b’an dɛmɛ ka an ka dumuni dun. Aw banakɔtaa bɛ yɔrɔ min na, o de ye nin ye.
• Pankreyasi: Nin ye gland ye min bɛ sɔrɔ an kɔnɔbara kɔnɔ. Glande ye farikolo yɔrɔ ye min bɛ kemikɛlifɛn dɔw bɔ. Pankreyasi bɛ anzimuw dilan minnu bɛ dumuniw sɔgɔsɔgɔ, ka fara ɔrimɔni nafamaw kan i n’a fɔ inisɔndiya ni gulukagɔni .
• Hypothalamus: O bɛ sɔrɔ an kunkolo la. A bɛ i n’a fɔ an farikolo ‘kɔlɔsili-yɔrɔ’. A bɛ dɛmɛ ka homeostasis sabati (i n’a fɔ ka kɔnɔna sigida sabatilen mara). A bɛ cikanw fana di pituitaire gland ma, o min bɛ hypothalamus jukɔrɔ, walasa ka ɔrimɔni dɔw bɔ.
• Central Nervous System (CNS): O bɛ an kunkolo ni an kɔkolo sen don a la. O farikolo-ɲɛnajɛ in de sababu fɛ cikanw bɛ Bɔ hakili la ka Taa farikolo tɔ la.

Somatostatin tɔgɔ wɛrɛw

Somatostatin fana bɛ dɔn ni tɔgɔ damadɔ wɛrɛw ye. Ni aw ka dɔgɔtɔrɔ ye nin tɔgɔ ninnu dɔ fɔ, n’a sɔrɔ u bɛ kuma kelen de kan:

• SS, SST walima SOM
• Ɔrimɔni min bɛ bonya bali (GHIH) .
• Somatotropin bɔli -facteur inhibiteur (SRIF) .
• Somatotropin bɔli -banakisɛ balilan (SRIH) .

Yala somatostatin fana bɛ kɛ fura ye wa?

Ɔwɔ, tuma dɔw la, dɔgɔtɔrɔw bɛ somatostatini sintetiki kɛ fura ye walasa ka bana dɔw furakɛ. I n'a fo:

• Kɔnɔnabana dɔw
• akɔrɔmegali ye bana ye min man teli ka sɔrɔ farikolo bɛ bonya hormone caman dilan .
• Kansɛri suguya dɔw bɛ wele ko neuroendocrine tumors (NETs) .
• Endocrine system (i n’a fɔ glandular system min bɛ ɔrimɔni bɔ) bana wɛrɛw dɔw.

Ɔrimɔni somatostatin ka baara kunbabaw ye jumɛnw ye?

O bɛ ɲɛ, sisan an k’a lajɛ nin somatostatin ɔrimɔni in baara kunba ye mun ye.

N’an y’a fɔ cogo nɔgɔman na, a ka baara kunba ye ka ɔrimɔni wɛrɛw bɔli dabila an ka kɔnɔnatumuw fɛ ani ka fɛn dɔw bɔli kɔlɔsi kɛnɛyaso kɔnɔ.

‘Endocrine system’ bɛ tali kɛ farikolo la min bɛ ɔrimɔni bɔ an farikolo glandew la ka taa joli la. Misali dɔw ye ɲɛgɛnɛsiralabanaw, ɲɛgɛnɛsiralabanaw ani sugunɛbaralabanaw ye . ‘Exocrine system’ bɛ tali kɛ sistɛmu la min bɛ furaw bɔ glandew fɛ ka tɛmɛ duct fɛ. misaliw ye sɔgɔsɔgɔninjɛ ni sumaya glandew ye .

O la, i n’a fɔ ka jibolisira faga, somatostatin bɛ ɔrimɔni ni fɛn dɔw bɔli dabila waati dɔɔni kɔnɔ, an farikolo mago tɛ minnu na. Miiri dɔrɔn, n’i ye jibolisira da wuli dɔrɔn, ji bɛ tiɲɛ, tiɲɛ tɛ? O cogo kelen na, ni farikolo bɛ ɔrimɔni caman dilan ka tɛmɛ a mago bɛ min na, gɛlɛyaw bɛ se ka sɔrɔ. Somatostatin bɛ o kɔlɔsi.

Fɛn wɛrɛ ye ko somatostatin fana bɛ dɛmɛ ka farikolokisɛw bali ka tila joona cogo la min tɛ bɛn, i n’a fɔ kansɛribanakisɛw.

A bɛ baara kɛ fana i n’a fɔ farikolo-ɲɛnajɛ-fɛn min bɛ an ka farikolo-ɲɛnajɛ-yɔrɔ (CNS) la. Nɛrɛmuguma ye kemikɛli ciden ye min bɛ farikolojɔlifɛn dɔ (sɔgɔsɔgɔninjɛ) bila ka nɔ bila selilu wɛrɛ la.

Somatostatin bɛ nɔ bila an farikolo yɔrɔw la cogo min na

Sisan an k’a lajɛ somatostatin bɛ nɔ bila an farikolo yɔrɔ kelen-kelen bɛɛ la cogo min na:

• Hypothalamus kɔnɔ: Somatostatin bɛ an ka ɲɛgɛnɛsiralabanaw ka ɔrimɔni bɔli dabila, i n’a fɔ bonya hormone , thyroïde stimulant hormone (TSH) , ani prolactin .
• Pankreyasi kɔnɔ: Yan, insuline , .A bɛ pankreyasi hormones bɔli bali i n’a fɔ glucagon ani gastrin , ani fana a bɛ pankreyasi enzymes bɔli bali minnu bɛ dumuni toli dɛmɛ.
• Dumunikɛcogo la (GI tract): A bɛ dɔ bɔ kɔnɔbara la, o min bɛ lawuli ni an bɛ dumuni kɛ. a bɛ dan sigi dumunikɛminɛnw bɔli la fana i n' a fɔ sekɛrɛtini ni gastrini .
• Nɛrɛmuguma kɔnɔ (CNS): Yan, a bɛ kɛ sababu ye ka cikanw lasecogo caman Changer par nerveux (neurotransmission) ani hakilijiginw dilancogo.

Mun de bɛ kɛ sababu ye ka somatostatin bɔli kɛ?

O bɛ ɲɛ, o la sisan, n’a sɔrɔ i b’i yɛrɛ ɲininka ko: ‘Nin somatostatin bɛ bɔ cogo di? Mun de bɛ o lase mɔgɔ ma?’ Ni an bɛ se ka tiɲɛ fɔ, hali bi dɔnnikɛlaw ma a faamu kosɛbɛ an farikolo bɛ nin somatostatin in bɔli kunbɛn cogo min na, ani farikolo yɔrɔ minnu bɛ a bɔli daminɛ. Fɔlɔ, a Sɔrɔla ko selilu suguya ni farikolojɔlifɛn suguya damadɔ bɛ o ko la.

Sɛgɛsɛgɛli dɔ y’a jira ko sukaro , n’o ye an farikolo fanga sɔrɔyɔrɔba ye, o tɛ somatostatin bɔli dɔrɔn kɔlɔsi, nka a bɛ dɔ fara a bɔli kan fana. O sɛgɛsɛgɛli kɔnɔ, dɔnnikɛlaw y’a kɔlɔsi ko ni sukaro hakɛ dɔgɔyara joli la, inisɔndiya bɛ somatostatin bɔli lawuli (i n’a fɔ a bɛ insuline bɔli dabila), ani ni sukaro hakɛ cayara joli la , glucagon bɛ somatostatin bɔli lawuli (i n’a fɔ a bɛ sukaro bɔli dabila).

O kɔrɔ ye ko ikomi inisɔndiya bɛ sukaro hakɛ dɔgɔya, ni aw ka sukaro hakɛ dɔgɔyara, somatostatin bɛ bɔ walasa a kana jigin dɔɔni dɔɔni, walasa ka inisɔndiya bɔli dabila. Fɛnw bɛ mara cogo min na an farikolo la, o ye kabako ye, tiɲɛ tɛ?

Gɛlɛya ni cogoya minnu bɛ sɔrɔ somatostatin fɛ

A ka ca a la, gɛlɛyabaw minnu bɛ sɔrɔ somatostatini na, olu man teli ka sɔrɔ. nka banaba min bɛ sɔrɔ , o ye kansɛri suguya ye min man ca kosɛbɛ , n' o bɛ wele ko somatostatinoma . Nin ye kuru ye min bɛ sɔrɔ kɔnɔbara basigilen na. Nin kuru in bɛ sɔrɔ kɔnɔbara la walima dumunikɛminɛnw na (GI tract). O bɛ kɛ sababu ye ka somatostatin (somatostatin) bɔli kɛ ka tɛmɛ a dan kan.

Nin bana in, n’a bɛ wele ko somatostatinoma, o bɛ se ka kɛ k’a sɔrɔ a ma kɛ cogo si la, walima a bɛ se ka kɛ ni jamu dɔw ye . O cogoya dɔw ye:

• Neoplasi endocrine multiple (MEN suguya fɔlɔ):Nin fana ye bana ye min man teli kosɛbɛ, min bɛ sɔrɔ jamu fɛ, kuru caman bɛ bɔ min na farikolo yɔrɔw la minnu tɛ kelen ye.
• Neurofibromatose type 1 (NF1): Nin fana ye bana ye min bɛ sɔrɔ cɛya la. A bɛ kafe-au-lait nɔw ni kuru ɲumanw bila fari la.
• Von Hippel-Lindau bana : Nin fana ye bana ye min man teli ka sɔrɔ cɛya la. A bɛ se ka kɛ sababu ye ka tumu juguman walima kuru jugumanba bila kunsɛmɛ na, kɔkolo la, ɲɛw la, sugunɛ na, kɔnɔbara la ani sugunɛbara la.

Ni somatostatin bɛ bɔ ka tɛmɛ, endocrine hormone caman wɛrɛw bɔli bɛ dɔgɔya kosɛbɛ. O taamasiɲɛw bɛ se ka kɛ i n’a fɔ bana caman wɛrɛw taamasiɲɛw. O la, a bɛ se ka gɛlɛya tuma dɔw la ka bana dɔ sɛgɛsɛgɛ ka ɲɛ, min bɛ wele ko somatostatinoma.

Min nafa ka bon, o ye ko nin gɛlɛya minnu bɛ sɔrɔ somatostatin fɛ, olu man ca kosɛbɛ , o kɔrɔ ye ko mɔgɔ fanba tɛ hami foyi la.

Ani fana, kunnafoniw ka dɔgɔn kosɛbɛ minnu b’a jira ko somatostatin hakɛ dɔgɔyara ka tɛmɛ a cogo kɔrɔ kan mɔgɔ farikolo la.

Sɛgɛsɛgɛli jumɛnw bɛ somatostatin hakɛ lajɛ?

Ikomi gɛlɛya minnu bɛ sɔrɔ somatostatini fɛ, olu man ca, a ka ca a la dɔgɔtɔrɔw tɛ bɛɛ ka somatostatini hakɛ sɛgɛsɛgɛ. Nka ni siga bɛ kuru dɔ la min man teli ka sɔrɔ, o bɛ somatostatini caman bɔ min bɛ wele ko somatostatinoma, i n’a fɔ a fɔra cogo min ka tɛmɛ, joli sɛgɛsɛgɛli dɔ bɛ kɛ min bɛ wele ko somatostatin-like-immunoreactivity (SLI) walasa k’a dɔn.

Tuma jumɛn na ne ka kan ka taa dɔgɔtɔrɔso la ne ka somatostatin hakɛ ko la?

A ka ca a la, aw man kan ka hami aw ka somatostatini hakɛ la, barisa gɛlɛya damadɔw bɛ sɔrɔ o la.

Nka ni bana dɔ sɔrɔla denbaya kɔnɔmɔgɔ gɛrɛgɛrɛ dɔ la (bangebaga walima balimakɛ) i n’a fɔ endocrine neoplasie multiple type 1 (MEN type 1), neurofibromatose type 1 (NF1), walima Von Hippel-Lindau bana, a nafa ka bon ka o fɔ dɔgɔtɔrɔ ye. Ikomi ninnu ye banaw ye minnu bɛ sɔrɔ ciyɛn fɛ, aw bɛ se ka kɛ fana ka somatostatinoma sɔrɔ. O kɔfɛ, aw ka dɔgɔtɔrɔ bɛ se ka sɛgɛsɛgɛliw kɛ walasa ka a dɔn ni bana in bɛ aw la.

Fɛn minnu nafa ka bon kosɛbɛ an ka kan ka to an hakili la (Take-Home Message) .

Okey, donc, fɛn nafamaba minnu ka kan ka to i hakili la an ye kuma minnu kan bi, olu filɛ nin ye:

• Somatostatin ye ‘master’ hormone ye min jɔyɔrɔ ka bon kosɛbɛ an farikolo la, ka ɔrimɔni wɛrɛw kɔlɔsi.
• A bɛ fɛnw kɔlɔsi kosɛbɛ i n’a fɔ ɔrimɔni wɛrɛw dilanni, dumunikɛminɛnw baarakɛcogo, ani farikolokisɛw tilacogo teliya.
• Gɛlɛya minnu bɛ sɔrɔ somatostatini na, olu ka ca kosɛbɛ.Gɛlɛya belebeleba ye kuru ye min man teli ka sɔrɔ, n’a bɛ wele ko somatostatinoma.
• Ni aw ka denbaya kɔnɔ mɔgɔ o mɔgɔ bɛ ni jamu banaw ye i n’a fɔ MEN suguya fɔlɔ, NF1, walima Von Hippel-Lindau bana , aw bɛ kuma aw ka dɔgɔtɔrɔ fɛ o ko la.
• Aw kana siran nin ɲɛ fu. A nafa ka bon ka nin sigida kabakoma ninnu dɔn an farikolo la.

O la, somatostatin ye fɛn ye min tɛ kuma, nka a nafa ka bon kosɛbɛ, an farikolo la. Ni a b’a ka baara kɛ ka ɲɛ, siran foyi t’an bolo!

` Somatostatin, Somatostatin, Ɔrimɔni, Pankreyasi, Hypothalamus, Dumunikɛcogo, Somatostatinoma, Somatostatinoma, GHIH, Endocrine System, Kansɛri