An bɛɛ ye fura suguya caman mɛn bana suguya caman na, ɔnhɔn? Bi an bɛna kuma dɔrɔgu suguya dɔ kan min ni tɔw tɛ kelen ye dɔɔnin. Olu bɛ Weele ko ‘Protease Inhibiteurs’. N’a sɔrɔ aw ma nin tɔgɔ in mɛn, nka nin fura suguya in nafa ka bon banakisɛbana jugumanw kunbɛnni na i n’a fɔ sidabanakisɛ, sugunɛbilenni, ani COVID-19. O la sa, an k’a lajɛ ninnu ye fɛn minnu ye, u bɛ baara kɛ cogo min na, ani fɛn minnu nafa ka bon kosɛbɛ i ka kan ka minnu dɔn u ko la.
N’an y’a fɔ cogo nɔgɔman na, o poroteyizi balilanw ye mun ye?
N’an y’a fɔ cogo nɔgɔman na, protease inhibiteurs ye fura sugu dɔ ye min bɛ kɛ ka banakisɛw furakɛ . U ka baara kunba ye ka banakisɛ dɔ bali k’a yɛrɛ kopi kɛ ni a donna an fari la, o kɔrɔ ye ko a tɛ se ka jɛnsɛn ka taa a fɛ. Nin fura in bɛ banakisɛ in ‘bɔgɔ’ kosɛbɛ a ka jɛnsɛnni na.
Nin fura in bɛ dɔn kosɛbɛ ko banakisɛfagalan min bɛ kɛ ka sidabanakisɛ furakɛ. A bɛ kɛ fana ka sugunɛbilenni C ni COVID-19 furakɛ.
Tuma dɔw la, o poroteyizi balilanw bɛ di u kelen na (furakɛli kelen). Nka a ka ca a la, u ni banakisɛfagalan wɛrɛw bɛ fara ɲɔgɔn kan. O bɛ kɛ walasa ka dɔ fara furakɛli nafa kan. O cogo la, u bɛ Weele fana ko "booster".
Fura in furakɛcogo kunbabaw ye jumɛnw ye?
Fura suguya dɔ min bɛ wele ko protease inhibiteurs, o dagalen don walasa ka banakisɛ kɛrɛnkɛrɛnnen damadɔw furakɛ. An k’a lajɛ u ye min ye.
| Dɔgɔtɔrɔso cogoya | Baara kɛcogo |
|---|---|
| Sidabanakisɛ | Ni dɔgɔtɔrɔw bɛ sidabana furakɛ, dɔgɔtɔrɔw bɛ fura ninnu di u kelen na walima u bɛ kɛ "cocktail" kɔnɔ ni fura damadɔ wɛrɛw ye. O furakɛli faralen ɲɔgɔn kan, o bɛ wele ko banakisɛfagalanw (ART) . Tuma dɔw la, u bɛ kɛ fana walasa ka banakisɛw bali banakisɛ in tali kɔfɛ (banakisɛ tali kɔfɛ). |
| Sugunɛbilenni C | Protéase inhibiteurs bɛ kɛ banakisɛfagalanw faralen ɲɔgɔn kan walasa ka sugunɛbilenni C banakisɛ furakɛ pewu. |
| COVID-19 | Dɔgɔtɔrɔw b’a fɔ ko aw ka protéase inhibiteur fila fara ɲɔgɔn kan (misali la Paxlovid®) walasa ka dɔ bɔ bana jugumanw na minnu bɛ sɔrɔ COVID-19 banakisɛ fɛ. |
Nin fura in bɛ baara kɛ cogo di?
Walasa k’o faamu, an ka misali fitinin dɔ ta. Miiri k’a filɛ, banakisɛ ye izini ye min bɛ farikolojɔlifɛnw cakɛda jan dɔ dilan. Walasa ka baara kɛ ni o cakɛda jan in ye baara kama, a ka kan ka tigɛ ka kɛ fɛn misɛnninw ye minnu bɛ baara kɛ. Banakisɛ bɛ baara kɛ ni ‘sizo’ kɛrɛnkɛrɛnnen minnu ye o tigɛ in na, olu ye anzimuw ye minnu bɛ wele ko ‘proteases’ .
O la, fura suguya dɔ min bɛ wele ko ‘Protease Inhibitors’, o bɛ min kɛ, o ye o ‘sizo’ ninnu ka wale dabila. A bɛ iko sizo blun. O kɔ, banakisɛ tɛ se ka farikolojɔli dumuniw tigɛ a mago bɛ minnu na. O de kosɔn, banakisɛ tɛ se ka kopi kura kɛ a yɛrɛ la ka banakisɛ don an ka selilɛriw la.
Protéase inhibiteurs suguya jumɛnw bɛ yen?
Ikomi banakisɛ kelen-kelen bɛɛ n’a ka protéase enzyme don, protease inhibiteur suguya wɛrɛw bɛ kɛ ka sidabanakisɛ, sugunɛbilenni C, ani COVID-19 furakɛ. Fɛɛrɛ nɔgɔman dɔ fana bɛ yen walasa k’u dɔn.
- Fura minnu bɛ kɛ ka sidabana furakɛ, olu tɔgɔw ka teli ka laban ni "-navir" ye .
- Fura minnu bɛ kɛ sugunɛbilenni na, olu tɔgɔw ka teli ka laban ni "-previr" ye.
Protéase inhibiteurs (banakisɛfagalanw) minnu bɛ sidabanakisɛ furakɛ
Olu bɛ poroteyizi (protéase enzyme) bali min bɛ wele ko HIV-PR, sidabanakisɛ bɛ baara kɛ ni min ye walasa ka a yɛrɛ kopiw dilan.
- Atazanawiri (Atazanavir) bɛ sɔrɔ
- Darunawiri (Darunavir) ye
- Fosamprenawiri (Fosamprenavir) bɛ sɔrɔ
- Indinaviri (Indinavir) fura (indinavir).
- Lopinawiri (lopinavir) bɛ sɔrɔ
- Nɛlifinaviri (Nelfinavir) ye
- Ritonawiri (Ritonavir) bɛ sɔrɔ
- Saquinavir (Saquinavir) bɛ sɔrɔ a la
- Tipranawiri (Tipranavir) (Tipranavir).
Protéase inhibiteurs (banakisɛfagalanw) minnu bɛ sugunɛbilenni C furakɛ
Olu bɛ anzimu dɔ bali min bɛ wele ko NS3/4A serine protease, sugunɛbilenni banakisɛ bɛ min kɛ ka a yɛrɛ kopiw dilan.
- Boceprevir (Boceprevir) (Boceprevir) (Boceprevir).
- Glecaprevir (Glekapreviri) (Glecaprevir) (Glecaprevir).
- Grazoprevir (Grazoprevir) (Grazoprevir).
- Paritaprevir (Paritaprevir) ye
- Simeprevir (banakisɛfagalan).
- Telapreviri (télaprevir) (télaprevir).
Protéase inhibiteurs (banakisɛfagalanw) minnu bɛ COVID-19 furakɛ
Paxlovid® ye protéase inhibiteur fila faralen ye ɲɔgɔn kan, nirmatrelvir ni ritonavir, minnu bɛ kɛ ka COVID-19 furakɛ.
Ne bɛ se ka fura ɲuman sugandi cogo di ne ye?
Sisan, i bɛ se k’i yɛrɛ ɲininka nin fura ninnu bɛ se ka mun kɛ ne ye.Aw ka dɔgɔtɔrɔ dɔrɔn de bɛ se ka o ko latigɛ. A bɛna fɛn caman jateminɛ ni a bɛ fura sugandi min bɛnnen don i ma kosɛbɛ.
- Banakisɛ kɛrɛnkɛrɛnnen jumɛn bɛ aw la?
- Aw ka kɛnɛya bɛɛ lajɛlen ani furakɛli cogoya wɛrɛ minnu bɛ se ka kɛ aw la (misali la sukarodunbana, dusukunnabana).
- Aw bɛ fura wɛrɛ minnu ta sisan (i n’a fɔ jɛɲɔgɔnya bɛ se ka kɛ ninnu ni ɲɔgɔn cɛ).
- Yala aw ye fura wɛrɛw ta ka tɛmɛ nin bana in na wa?
- Fura in ɲɛtaa bɛ bɔ banakisɛ suguya la min bɛ aw la.
- Fura kɔlɔlɔw walima gɛlɛya minnu bɛ se ka sɔrɔ fura in fɛ, olu ko la.
O la, a nafa ka bon kosɛbɛ aw ka fura minnu ta, ani furakɛli cogoya wɛrɛ minnu bɛ aw la ni aw bɛ taa dɔgɔtɔrɔso la, aw ka olu bɛɛ ɲɛfɔ ka jɛya. O bɛ se ka dɔ bɔ kɔlɔlɔ jugumanw na.
Fura ninnu kɔlɔlɔ ni u nafa ye mun ye?
I n’a fɔ fura tɔw bɛɛ, poroteyizi balilanw nafa ni kɔlɔlɔ fila bɛɛ bɛ u la.
Nafa kunbabaw
- I n’a fɔ ART furakɛli dɔ ye sidabanakisɛ bɛ mɔgɔ min na, o bɛ dɛmɛ ka sidabanakisɛ hakɛ to farikolo la hakɛ la min tɛ se ka dɔn.
- A bɛ dɛmɛ ka sugunɛbilenni C banakisɛ furakɛ.
- A bɛ dɛmɛ don ka COVID-19 bana dɔ bali ka juguya.
Kɔnɔnatumu kɔlɔlɔ minnu bɛ se ka sɔrɔ
A kɔlɔlɔw bɛ bɔ fura min na, aw bɛ fura wɛrɛ minnu ta, ani aw ka kɛnɛya cogoya de la. A nafa ka bon ka kuma dɔgɔtɔrɔ fɛ o ko la ani ka to kunnafoni na.
| Kɔnɔnatumu suguya | Misaliw |
|---|---|
| Kɔnɔnatumu minnu ka teli ka ye | |
| Gɛlɛya minnu bɛ sɔrɔ tuma caman na | Kɔnɔdimi, kɔnɔboli ni fɔɔnɔ, kɔnɔboli |
| Fari kurukuruniw | |
| Sɔgɔsɔgɔ, sɛgɛn, dumuni duman kabakoma da la | |
| Sugunɛbilenni | |
| Yɛlɛma donna farikolo tulumafɛnw tilatilali la (lipodystrophie) . | |
| Kɔnɔnatumu jugumanba minnu ka kan ka jateminɛ joona | |
| Gɛlɛya jugumanbaw | Sugunɛ tiɲɛni, kɔnɔna joli |
| Faribana jugumanba min bɛ kɛ ni kurukuruw ye minnu bɛ dimi, kurukuruniw (Stevens-Johnson syndrome) . | |
| Sukaro hakɛ caman sɔrɔli joli la (sukarodunbana), kolosinsinnan hakɛ cayalenba (sɔgɔsɔgɔninjɛ hakɛ cayalenba) . | |
| Dusukunnabana (dusukun tantanni), gɛlɛya minnu bɛ dusukun kuran na | |
Ne bɛ se ka mun kɛ walasa ka furakɛli nɔgɔya?
Ni aw bɛ nin furakɛli in kɛ, aw bɛ se ka fɛn caman kɛ walasa ka kɔlɔlɔ dɔw dɔgɔya ani ka furakɛli nɔgɔya.
- Aw bɛ aw ka fura ta i n’a fɔ dɔgɔtɔrɔ y’a fɔ cogo min na tigitigi, a waati bɛnnen na, a tata hakɛ bɛnnen na. Aw kana a tata hakɛ kelen tɛmɛ.
- Aw bɛ ji caman min. O bɛ se ka dɔ bɔ a nɔ na sugunɛ na.
- Aw bɛ aw yɛrɛ tanga fura wɛrɛw tali ma minnu bɛ se ka kɛ ni aw ka furaw ye. Aw bɛ dɔgɔtɔrɔ ɲininka o ko la.
- fura dɔw bɛ baara kɛ ka ɲɛ ni u ni dumuni kɛra . Dɔw bɛ dumuni tulumaw de wajibiya. Aw bɛ dɔgɔtɔrɔ ɲininka aw ka fura tacogo la ani ka tugu o laadilikan kɔ.
Tuma jumɛn na ne ka kan ka taa dɔgɔtɔrɔso la?
Ni aw ye kɔlɔlɔ dɔw sɔrɔ furakɛli senfɛ walima ni haminanko dɔw bɛ aw la furakɛli ko la, aw bɛ taa dɔgɔtɔrɔso la joona.
Kɛrɛnkɛrɛnnenya la, ni aw ye nin kɔlɔlɔ juguman ninnu dɔ sɔrɔ, aw bɛ dɔgɔtɔrɔ ka laadilikan ɲini joona ka sɔrɔ aw ma mɛn walima aw bɛ taa dɔgɔtɔrɔso la min ka surun aw la, aw bɛ se ka kɔrɔtɔko ɲɛnabɔ (ETU).
- Farigan
- Hakili ɲagami walima hakili la fɛn caman Changements
- Fari walima ɲɛkisɛ jɛman (jaundice) .
- Kurukuruni, dimi, walima kurukuru min bɛ jɛnsɛn yɔrɔ bɛɛ
- Kɔnɔdimi jugumanba
- Fɔɔnɔ jugumanba
Take-Home cikan
- Protéase inhibiteurs ye fura suguya barikamaba ye min bɛ kɛ ka banakisɛw furakɛ i n’a fɔ sidabanakisɛ, sugunɛbilenni, ani COVID-19.
- O bɛ banakisɛ bali ka caya (ka kopiw kɛ) farikolo la.
- fura ninnu ka kan ka ta dɔgɔtɔrɔw ka ladilikanw dɔrɔn de kɔnɔ . A nafa ka bon kosɛbɛ ka dɔgɔtɔrɔ ka fura tata hakɛ ni a waati labato kosɛbɛ.
- Kɔnɔnatumuw bɛ se ka sɔrɔ, k’a ta dimi misɛnniw na ka taa a bila gɛlɛya jugumanw na. Ni bana taamasiɲɛ jugu dɔw ye aw ye, aw bɛ taa dɔgɔtɔrɔso la joona.
- Aw man kan ka fura tali dabila walima ka a tata hakɛ Changer ni dɔgɔtɔrɔ ma ladilikan di aw ma kun si la.
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