Nukae nye Aldosterone? Na míadi alesi wòkpɔa ŋusẽ ɖe wò ʋu ƒe sisi dzii ɖa!

Èse Aldosterone ŋkɔ kpɔa? Ðewohĩ wò ɖɔkta yɔe, alo ɖewohĩ èse ŋkɔa ne èle nu ƒom tso wò ʋu ƒe sisi ŋu. Le nyateƒe me la, enye lãmetsi sue aɖe gake wòle vevie ŋutɔ le míaƒe ŋutilã me. Ekpena ɖe mía ŋu míeɖɔa sodium kple potassium ƒe agbɔsɔsɔ si le míaƒe ŋutilã me ɖo eye wònana míaƒe ʋu ƒe sisi nɔa anyi. Eyata, mina míaƒo nu tso Aldosterone ŋu egbea le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu, enyoa?

Nukae nye aldosterone? Afikae wòtso?

Kpuie ko la, Aldosterone nye lãmetsi aɖe si wò adrenal glandwo wɔna . Ènya nusiwo nye adrenal gland siawoa? Wonye lãkusi sue eve siwo ƒe nɔnɔme le abe dzogoe etɔ̃ ene siwo le abe kposɔ suewo ene le wò ayiku tame. Wonye míaƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa aɖe . Lãmenugbagbevi siawo wɔa lãmetsiŋusẽ geɖe siwo le vevie na míaƒe ŋutilã.

Lãmetsiŋusẽwo le abe atikewo ƒe dɔla siwo wɔa ɖoɖo ɖe míaƒe ŋutilã ƒe dɔwɔwɔ ŋu ene. Wozɔa mɔ to ʋukawo me hegblɔa nusi woawɔ kple ɣeyiɣi si woawɔe na ŋutinuwo, lãmekawo, kple lãmeka bubuwo.

Fifia, lãmetsi sia , si nye Aldosterone, kpɔa sodium kple potassium ƒe agbɔsɔsɔ si le wò ʋu me dzi. Woyɔa sodium kple potassium siawo be elektrikŋusẽnamɔ̃wo . Esiawoe kpena ɖe ŋutilãa ƒe tsiwo ŋu wòda sɔ eye wokpena ɖe lãmekawo kple lãmekawo ŋu be woawɔ dɔ nyuie. Azɔ hã, Aldosterone kpɔa tsi agbɔsɔsɔme si ayikuawo gbugbɔ xɔna la dzi. Esia nana ʋu ƒe agbɔsɔsɔ dzina ɖe edzi eye wògblẽa nu le ʋu ƒe sisi ŋu.

Eyata eɖanye wò aldosterone ƒe agbɔsɔsɔ le sue alo sɔ gbɔ o, ate ŋu akpɔ ŋusẽ ɖe wò lãmesẽ dzi.

Subɔsubɔdɔ kae aldosterone wɔna na míaƒe ŋutilã?

Dɔ vevitɔ si aldosterone wɔnae nye be wòakpe ɖe ŋuwò nàɖɔ wò ʋu ƒe sisi nyuie. Ekpena ɖe dɔ vevi sia ŋu le mɔ geɖe nu:

• Aldosterone naa dzesi ŋutinuwo abe wò ayiku kple dɔgbo ene be sodium si wotsɔ dea wò ʋu me nadzi ɖe edzi alo be potassium si dona le wò aɖuɖɔ me nadzi ɖe edzi.
• Ne sodium ƒe agbɔsɔsɔ dzi ɖe edzi alea la, ŋutilãa tea tsi léle ɖe asi, si wɔnɛ be ʋua ƒe agbɔsɔsɔme dzina ɖe edzi.

Esiawo katã le vevie, ne ʋu ƒe sisi le sue, be wòagaɖo eƒe nɔnɔme nyuitɔ me.

Le mɔ si mele tẽ o nu la, aldosterone hã kpena ɖe ŋuwò be wò ʋu ƒe pH (i.e. acid-base balance) kple electrolyte ƒe agbɔsɔsɔ nanɔ anyi.

Aleke wokpɔa aldosterone ƒe agbɔsɔsɔ dzii? Mina míalé ŋku ɖe eŋu nyuie!

Aldosterone nye lãmetsiŋusẽ, enzyme, protein, kple dɔwɔwɔ ƒe kadodo sesẽ aɖe si woyɔna be Renin-Angiotensin-Aldosterone System (RAAS) ƒe akpa aɖe . Eƒe dɔ vevitɔe nye be wòaɖu ʋu ƒe sisi dzi.

Bu esia be enye afɔɖeɖe ɖesiaɖe si woawɔ:

1. Gbã la, ne wò ʋu ƒe sisi ɖiɖi , enzyme aɖe si woyɔna be renin dona tso wò ayiku me yia wò ʋu me.

2. Renin sia yia ɖagbãa protein aɖe si woyɔna be angiotensinogen , si wowɔna le wò aklã me. Kakɛawo dometɔ ɖekae nye angiotensin I. Esia mewɔa dɔ ɣemaɣi o, si fia be mekpɔa ŋusẽ boo aɖeke ɖe edzi o.

3. Emegbe, Angiotensin-Converting Enzyme (ACE) si tso wò lãkusi me gena ɖe eme eye wògbãa Angiotensin I sia wòzua kakɛ geɖe wu. Kakɛ mawo dometɔ ɖekae nye lãmetsiŋusẽ si wɔa dɔ si woyɔna be Angiotensin II .

4. Afi siae Angiotensin II wɔa dɔ vevi la le:

• Ðekae nye be woadzi ʋu ƒe sisi ɖe edzi to ʋuka suewo (arterioles) ƒe lãmekawo ƒe gliwo nana me.
• Bubue nye be "ewɔa dzesi" na wò adrenal glands be woaɖe aldosterone ɖa.
• Egblɔna na wò lãkusi hã be wòaɖe Antidiuretic Hormone (ADH) , si wogayɔna be Vasopressin , la ɖa.

5. Eyata, Aldosterone kple ADH wɔa dɔ ɖekae gblɔna na ayikuwo be sodium nanɔ ŋutilãa me. Aldosterone nana ayikuawo ɖea potassium doa goe le aɖuɖɔ me. Ne sodium ƒe agbɔsɔsɔ le ʋua me dzi ɖe edzi la, tsi nɔa ŋutilãa me. Esia nana ʋu ƒe agbɔsɔsɔ kple ʋu ƒe sisi dzina ɖe edzi.

Aleae wowua Renin-Angiotensin-Aldosterone System nui. Èse ɖoɖo ma gɔmea?

Lãmetsiŋusẽ bubuwo abe corticosteroids , estrogen, kple thyroid lãmetsiwo hã ate ŋu awɔ dɔ le ɖoɖo sia ŋu.

Ne kuxi aɖe le ɖoɖo sia ƒe akpa aɖe ŋu la, ate ŋu akpɔ ŋusẽ ɖe wò ʋu ƒe sisi kple sodium kple potassium ƒe agbɔsɔsɔ dzi. Gake ele vevie be nàɖo ŋku edzi be nu bubu geɖewo ate ŋu akpɔ ŋusẽ ɖe wò ʋu ƒe sisi dzi, abe ʋumemi ƒe agbɔsɔsɔ, domenyiŋusẽfianu, kple atike aɖewo ene.

Aleke woawɔ akpɔ aldosterone ƒe agbɔsɔsɔ?

Dodokpɔ vevitɔ si ɖɔktawo zãna tsɔ léa ŋku ɖe kuxi siwo do ƒome kple aldosterone ŋue nye Aldosterone: Renin Ratio Test . Esi wònye be renin kple aldosterone do ƒome kplikplikpli ta la, dodokpɔ sia ate ŋu anya nenye be kuxia nye kuxi si le aldosterone wɔwɔ kple dɔwɔwɔ ŋu ko, alo ne kuxi aɖe le renin-angiotensin ƒe ɖoɖoa ŋutɔ ŋu.

Le Aldosterone: Renin Ratio Test sia gome la, zi geɖe la, woɖea ʋu tso ʋuka aɖe si le wò alɔnu me.

Ðɔktawo ate ŋu adzidze aldosterone ƒe agbɔsɔsɔ si tututu le wò ʋu kple/alo aɖuɖɔ me hã.

Ɣeaɖewoɣi la, wò ɖɔkta ate ŋu aɖe gbe be woado ka si wotsɔ dea ʋuka me kpɔ be woaɖe ʋu tso ʋuka aɖe si le wò ayiku me (hena renin) alo ʋuka aɖe si le wò ayiku me (hena aldosterone) me. Esia nye dodokpɔ si keklẽŋusẽŋutinunyala si wona hehee etɔxɛe wɔna le kɔdzi.

Nukae nye aldosterone ƒe agbɔsɔsɔ si sɔ?

Aldosterone ƒe agbɔsɔsɔ si sɔ ate ŋu ato vovo vie tso nudokpɔƒe ɖeka yi bubu. Eyata, kpɔ egbɔ be yelé ŋku ɖe agbɔsɔsɔme si sɔ ŋu le wò dodokpɔxɔ ƒe nyatakaka me, alo bia wò ɖɔkta ne nya aɖe le asiwò ku ɖe wò dodokpɔ me tsonu ŋu.

Aldosterone ƒe agbɔsɔsɔ si sɔ le ʋua me la toa vovo le ƒexɔxɔ nu. Le goawo katã me la, agbɔsɔsɔ si sɔ la le ale:

• Le vidzĩ siwo xɔ ɣleti 1 va ɖo 12 gome la: 5.8 – 110.0 nanograms le desilita ɖeka me (ng/dL) .
• Le ɖevi siwo xɔ tso ƒe 1 va ɖo ƒe 5 gome la: < 36.0 ng/dL
• Le ɖevi siwo xɔ tso ƒe 6 va ɖo 9 gome la: < 24.0 ng/dL
• Le ɖevi siwo xɔ tso ƒe 10 va ɖo ƒe 11 gome la: < 15.0 ng/dL
• Le ɖevi siwo xɔ tso ƒe 12 va ɖo ƒe 14 gome la: < 22.0 ng/dL
• Le sɔhɛ siwo xɔ tso ƒe 15 va ɖo ƒe 17 gome la: 3.0 – 32.0 ng/dL
• Ame tsitsi siwo xɔ tso ƒe 18 va ɖo ƒe 99: 3.1 – 35.4 ng/dL

Ne wole aldosterone ƒe agbɔsɔsɔ kpɔm le gaƒoƒo 24 ƒe aɖuɖɔ dodokpɔ me la, agbɔsɔsɔ si sɔ la le microgram 3 – 25 dome le gaƒoƒo 24 ɖesiaɖe me (3 – 25 mcg/24 hrs).

Nukae dzɔna ne aldosterone ƒe agbɔsɔsɔ dzi ɖe edzi?

Ne aldosterone ƒe agbɔsɔsɔ sɔ gbɔ wu alesi wòle dzɔdzɔmee la, míeyɔnae be hyperaldosteronism .

Nusi koŋ gbɔ esia tsonae nye Primary Aldosteronism , si wogayɔna be Conn ƒe dɔléle . Nɔnɔme sia tsoa dɔdzẽ si menye kansa o ( benign) si dona zi geɖe le wò adrenal glands dometɔ ɖeka me gbɔ.Esia wɔnɛ be lãkusia wɔa aldosterone geɖe wu alesi wòle be wòawɔ. Ne aldosterone ƒe agbɔsɔsɔ dzi ɖe edzi la, sodium ƒe agbɔsɔsɔ dzina ɖe edzi ( hypernatremia ) eye potassium ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna ( hypokalemia ). Esia ate ŋu ana elektrikŋusẽ ƒe dadasɔ nawɔ dɔ.

Aldosterone ƒe agbɔsɔsɔ si sɔ gbɔ ƒe dzesiwo

Le aldosteronism gbãtɔ gome, si fia be ne aldosterone ƒe agbɔsɔsɔ dzi ɖe edzi la, dzesiwo abe:

• Ʋusɔgbɔdɔ (Hypertension) .
• Taɖuame
• Lãmetsiwo ƒe gbɔdzɔgbɔdzɔ , vevietɔ ne potassium ƒe agbɔsɔsɔ le sue ŋutɔ
• Tsikɔwuame si gbɔ eme kple aɖuɖɔtoe enuenu

Ne dzesi siawo le ŋuwò la, ele vevie ŋutɔ be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo enumake.

Nukae dzɔna ne aldosterone ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ?

Ne aldosterone ƒe agbɔsɔsɔ ɖiɖi wu alesi wòle dzɔdzɔmee la, míeyɔnae be hypoaldosteronism . Esia nye aldosterone ƒe anyimanɔmanɔ, alo eƒe dɔmawɔmawɔ nyuie. Ne aldosterone ƒe agbɔsɔsɔ dzi ɖe kpɔtɔ la, sodium ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna ( hyponatremia ), potassium ƒe agbɔsɔsɔ dzina ɖe edzi ( hyperkalemia ), eye ŋutilãa wɔa acid fũ akpa ( metabolic acidosis ).

Nu geɖe li siwo ate ŋu ahe hypoaldosteronism vɛ:

• Addison ƒe dɔléle: Esia nye dɔléle si mebɔ o. Wogayɔnae be Adrenal Insufficiency Gbãtɔ . Enye dɔléle si dɔlélenutsiŋutete ŋutɔ hena vɛ . Esia fia be wò ŋutɔ wò dɔlélenutsiŋutete dzea adrenal glands ƒe gota gome (cortex) dzi. Wowɔa lãmetsiŋusẽ siwo nye aldosterone kple cortisol siaa le afima. Esia wɔnɛ be lãmetsiŋusẽ eveawo siaa ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna.
• Congenital Adrenal Hyperplasia (CAH): Esia nye domenyiŋusẽfianu ƒe dɔléle siwo gblẽa nu le adrenal glands ŋu ƒe ƒuƒoƒo. Wodzia amesiwo ŋu CAH le kple enzyme aɖewo siwo hiã be woatsɔ awɔ lãmetsi siwo adrenal glands wɔ la ƒe anyimanɔmanɔ.
• Lãmesẽnya aɖewo: Suklidɔ, ayikudɔ, aɖi si me lifi le, alo atikewɔwɔ me dɔléle sesẽwo le amesiwo ŋu suklidɔ le ate ŋu axɔ hypoaldosteronism.
• Atike aɖewo: Atike siwo me steroid mele o siwo tsia dzodzodzoetsitsi nu (NSAIDs) , HeparinAtike siwo wonana tsɔ daa dzidɔ hã ate ŋu ahe nɔnɔme sia vɛ.

Aldosterone ƒe agbɔsɔsɔ si mede ame dzi o ƒe dzesiwo

Le goawo katã me la, aldosterone ƒe agbɔsɔsɔ si bɔbɔ (Hypoaldosteronism) ate ŋu ahe dzesiwo abe:

• Ʋusɔgbɔdɔ (Hypotension) .
• Lãmetsiwo ƒe gbɔdzɔgbɔdzɔ
• Xeɖeɖe
• Dzi ƒe tsotso
• Dzi ƒe tsotso ƒe masɔmasɔ (Arrhythmia) .

Le nusi gbɔ wò hypoaldosteronism tso nu la, dzesi bubuwo ate ŋu adze le ŋuwò. Le kpɔɖeŋu me, le Addison ƒe dɔlélea me la, cortisol ƒe agbɔsɔsɔ si bɔbɔ ate ŋu ana ŋutigbalẽ natrɔ (abe teƒe siwo do viviti kple ŋutigbalẽ ƒe ʋuʋu ene) eye sukli naɖiɖi le ʋu me ( hypoglycemia ).

Ne dzesi siawo dometɔ aɖe le ŋuwò la, yi ɖɔkta gbɔ enumake.

Mlɔeba la, nusiwo dzi wòle be woaɖo ŋkui (Take-Home Message) .

Aldosterone nye lãmetsi aɖe si hiã vevie be wòaɖu ʋu ƒe sisi dzi. Ne esesẽna na wò be nàlé ʋu ƒe sisi nyuie me ɖe asi eye tɔtrɔwo le wò ʋu me potassium ƒe agbɔsɔsɔ hã ŋu la, anyo be nàƒo nu kple wò ɖɔkta tso ʋu ƒe sisi dzi kpɔkpɔ ƒe mɔnu bubuwo kple dodokpɔ bubuwo ŋu. Emegbe ate ŋu aɖe gbe be woawɔ dodokpɔwo akpɔe ɖa be aldosterone ƒe agbɔsɔsɔ si mesɔ o gbɔe wò dzesiawo tso hã.

Mele mɔ kpɔm be nyatakaka sia aɖe vi na wò! Nɔ lãmesẽ me!

` Aldosterone, Aldosterone, Lãmetsiŋusẽ, Ʋu ƒe sisi, Adrenal Glands, Sodium, Potassium