Nusianu si wòle be nànya tso ALP ƒe asixɔxɔ ŋu le wò ʋu ƒe nyatakaka me (Alkaline Phosphatase - ALP) .

Ðe wodo ʋu kpɔ, tsɔ nyatakakaa, lé ŋku ɖe ŋɔŋlɔdzesi kple xexlẽdzesi siwo le edzi ŋu, eye nèsusu be, "Nukae nye esia?" Le ŋɔŋlɔdzesi gbogboawo abe ALT, AST, kple GGT dome la, ɖewohĩ èkpɔ asixɔxɔ aɖe si woyɔna be "ALP" hã. Ame geɖe tsia dzi vie ne wokpɔ esia. Eyata, egbea míaƒo nu tso nusi Alkaline Phosphatase sia, alo ALP kpuie, nye, nusi dim wòle le dodokpɔ sia me, kple nusi wòle be míanya ne eƒe asixɔxɔwo trɔ ŋu.

Nuka tututue nye ALP?

Kpuie ko la, Alkaline Phosphatase (ALP) nye enzyme si le míaƒe ŋutilã katã me. Enzyme nye protein ƒomevi tɔxɛ aɖe si le míaƒe lãmenugbagbeviwo me. Abe mɔ̃ si zɔna kabakaba le dɔwɔƒe ene la, enzyme siawo kpena ɖe atike vovovo siwo wɔa dɔ le míaƒe ŋutilã me ŋu hewɔa wo kabakaba. Enzyme siawo akpe geɖe le míaƒe ŋutilã me.

Togbɔ be ɖɔktawo le numekuku wɔm tso ALP ŋu ƒe geɖe hã la, womenya nusi tututu eƒe dɔwɔwɔ nye 100% haɖe o. Ke hã, wokpɔe be ekpɔa gome le nu vevi geɖe siwo yia edzi le ŋutilãa me la me.

Ne wole nu ƒom tso ALP ŋu la, woyɔnɛ zi geɖe be "aklã me enzyme." Nusitae nye be míaƒe aklã mee ALP bɔ ɖo wu. Gake menye aklã me koe wòku ɖo o. Wokpɔnɛ le teƒe bubuwo hã.

• Wò ʋumenugbagbeviɣimɔ̃wo: Mɔ̃ siwo tsɔa ʋumenugbagbeviɣidɔ si aklã wɔna yia aɖuɖɔtoe me, afisi wodzranɛ ɖo le.
• Le wò ƒuwo me: Ema fia le wò ƒuwo me.
• Le ayikuwo me.
• Dɔgbowo.
• Vidada funɔwo ƒe vidzidɔ.

Eyata ne ALP ƒe agbɔsɔsɔ si le wò ʋu me sɔ gbɔ alo le sue le mɔ si mesɔ o nu la, enye dzesi be ate ŋu agblẽ nu le ŋutinu siawo dometɔ ɖeka ŋu alo atrɔ le dɔwɔwɔ aɖe me.

Nukae nye ALP ʋudodokpɔ?

ALP ʋudodokpɔ dzidzea ALP ƒe agbɔsɔsɔ si le wò ʋu me. Abe alesi míegblɔe va yi ene la, togbɔ be ALP le ŋutilã bliboa me hã la, ALP dzɔtsoƒe vevi eve siwo ƒoa ƒu ɖe ʋua mee nye aklã kple ƒuwo. Eyata ne ALP ƒe agbɔsɔsɔ le ʋua me dzi ɖe edzi la, ate ŋu anye aklãdɔ alo ƒumedɔléle aɖe ƒe dzesi. Gake ɖo ŋku edzi be ALP dodokpɔ ɖeɖe mate ŋu anya dɔléle aɖe o.

ALP dodokpɔ ƒomevi vevi eve li.

1. ALP dodokpɔ si wowɔna edziedzi: Esiae nye dodokpɔ si wowɔna zi geɖe. Zi geɖe la, ne ɖɔkta bia tso asiwò be nàwɔ `Comprehensive Metabolic Panel (CMP)` alo `Liver Panel (LFT)`, si léa ŋku ɖe aklã ŋu la, alɔ ALP ƒe asixɔxɔ hã ɖe eme godoo.

2. ALP isoenzyme dodokpɔ:Esia nye dodokpɔ tɔxɛ aɖe vie. Ðeko ALP dodokpɔ si wowɔna edziedzi la gblɔa ALP agbɔsɔsɔme si le wò ʋu me na wò. Gake isoenzyme dodokpɔ sia ate ŋu ana nànya tututu nenye be ALP si sɔ gbɔ ɖe wò ʋu me la tso wò aklã, ƒuwo, alo teƒe bubu aɖe. Ne wò ALP ƒe agbɔsɔsɔ sɔ gbɔ ŋutɔ la, wò ɖɔkta ate ŋu adɔ dodokpɔ sia be yeanya nusi tututu gbɔ wòtso. Gake esesẽ vie eye wòxɔ asi, eyata menye dodokpɔxɔwo katãe wɔa esia o.

Nukatae míehiã ALP dodokpɔ sia?

Susu geɖe ate ŋu anɔ anyi siwo tae wò ɖɔkta ate ŋu abia be woado ALP kpɔ ɖo.

• Dodokpɔ: Ɣeaɖewoɣi la, ne dzesi aɖeke mele eŋu o hã la, wodoa ALP kpɔna abe wò ƒe sia ƒe dodokpɔ CMP alo LFT ƒe nyatakaka si nèwɔna edziedzi ƒe akpa aɖe ene be woakpɔ kuxi aɖe le aklã alo teƒe bubu aɖe ŋu hafi dzesiawo nadze.
• Kpɔkpɔ: Ne aklã alo ƒumedɔ le ŋuwò xoxo la, wozãa dodokpɔ sia hã tsɔ léa ŋku ɖe eŋu nenye be nɔnɔmea le nyonyom ɖe edzi, ele nenema ke, alo le gbegblẽm ɖe edzi le atikewɔwɔ me.
• Abe kpekpeɖeŋu nana le dɔlélewo didi me ene: Ne dzesi siwo do ƒome kple aklã alo ƒumeŋuɖui le ŋuwò la, ALP dodokpɔ nye dɔléle didi ƒe akpa vevi aɖe.

Dzesi siwo ate ŋu ana ɖɔkta nabu ALP dodokpɔ ŋu

Ne dzesi siwo le ete la le ŋuwò la, wò ɖɔkta ate ŋu aɖo wò ɖe dodokpɔ sia wɔwɔ me.

Nukae dzɔna do ŋgɔ na ʋudodokpɔa kple le ewɔɣi?

Ne wò ɖɔkta gblɔ na wò be nàwɔ ALP dodokpɔ sia abe CMP ƒe akpa aɖe ene la, ahiã be nàtsi nu adɔ abe gaƒoƒo 10-12 ene. Gake àte ŋu ano tsi. Gake ne wobia tso asiwò be nàwɔ ʋudodokpɔ la, wò ɖɔkta ana mɔfiame tɔxɛwo wò ku ɖe nu si nàwɔ hafi adoe kpɔ ŋu. Ele vevie ŋutɔ be míawɔ ɖe mɔfiame mawo dzi.

Nu siawoe dzɔna zi geɖe ne woɖe ʋu.

1. Ànɔ zikpui dzi, eye dɔnɔdzikpɔla alo atikewɔla aɖe akpɔ ʋuka si sɔ le wò alɔnu si me nàɖe ʋu le. Zi geɖe la, esia nɔa wò abɔta ƒe akpa si le eme.

2. Ne èke ɖe ʋukaa ŋu vɔ la, tsɔ nane abe aha si wotsɔ tutui ene klɔ teƒea nyuie.

3. Emegbe, wotsɔa aŋe sue aɖe dea ʋukaa me eye woɖea ʋu. Le ɣeyiɣi sia me la, àte ŋu ase veve vie, abe anyidi sue aɖe si le ƒoƒom wò ene.

4. Ne èƒo ʋu agbɔsɔsɔme si hiã na dodokpɔa nu ƒu ɖe mɔ̃ me vɔ la, ɖe aŋea ɖa eye nàtsɔ kotoku kakɛ aɖe ami teƒe si woɖe ʋua le.

5. Ne ʋua nu tso ko la, wotsɔa aŋɔ sue aɖe ƒoa teƒea eye wowua dɔa nu.

Dɔwɔwɔ bliboa mexɔa aɖabaƒoƒo atɔ̃ o. Ðewohĩ abi kple abi aɖewo anɔ afisi woɖe ʋua le. Gake ema nu ayi le ŋkeke ɖeka alo eve megbe.

Aleke nèse nyatakakaa me nyawo gɔmee?

Zi geɖe la, àte ŋu axɔ akɔntabubua le ŋkeke ɖeka alo eve megbe. Nyatakakawo abe esiawo ene le nyatakakaa me:

• Dodokpɔa ƒe ŋkɔ (e.g. Alkaline Phosphatase).
• Wò emetsonu (ALP ƒe asixɔxɔ si le wò ʋu me).
• Normal range.
• Eɖanye wò asixɔxɔ sɔ, kɔkɔ, alo bɔbɔ o.

Nusiwo dzi ame geɖe da asi ɖoe nye dukɔwo dome unit 44 va ɖo 147 le lita ɖeka me (44 va ɖo 147 IU/L). Gake le teƒe aɖewo la, wobua esia hã be enye 30 va ɖo 120 IU/L.

Azɔ hã, ALP ƒe xexlẽme siwo sɔ la toa vovo le ƒe si woxɔ kple ŋutsu alo nyɔnu nyenye nu.

• Ðeviwo kple sɔhɛwo: Le dzɔdzɔme nu la, ALP sɔ gbɔ ɖe ɖeviwo kple ƒewuiviwo me elabena woƒe ƒuwo le tsitsim.
• Le ƒe 15-50 dome: Ŋutsuwo ƒe ALP ƒe agbɔsɔsɔme sɔ gbɔ vie wu nyɔnuwo.
• Ne míele tsitsim: ALP ƒe agbɔsɔsɔ gadzina ɖe edzi vie ne míele tsitsim.
• Le fufɔɣi: Ebɔ be vidada funɔwo ƒe ALP ƒe agbɔsɔsɔ dzina ɖe edzi elabena ALP dzɔna le vidzidɔa me.
• Ne ƒu ƒe gbagbã haya: Ne ƒu aɖe gbã la, ALP ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi ne ƒu ƒe lãmenugbagbeviwo va le dɔ wɔm ne ele dɔ dam.

Nukae ALP ƒe dzidziɖedzi fia?

Ne wò ALP ƒe agbɔsɔsɔ dzi ɖe edzi la, esɔ be nàtsi dzimaɖi vie. Gake nu gbãtɔ si dzi wòle be míaɖo ŋkui enye be ALP ƒe agbɔsɔsɔ si dzi ɖe edzi vie menyea dɔléle sesẽ aɖe ƒe dzesi ɣesiaɣi o. Wò ɖɔkta ate ŋu atso nya me be yemagawɔ dodokpɔ bubu aɖeke o eye ɖeko wòagalé ŋku ɖe wò ALP ƒe agbɔsɔsɔ ŋu le ɣeyiɣi kpui aɖe megbe.

Gake ALP ƒe agbɔsɔsɔ si sɔ gbɔ ŋutɔ nye nusi ɖea aklã ƒe gbegblẽ alo ƒu ƒe dɔléle fiana sẽŋu. Ne wò nyatakaka gblɔ be ALP dzi ɖe edzi la, wò ɖɔkta ate ŋu abia be woawɔ dodokpɔ bubuwo (e.g., isoenzyme dodokpɔwo, aklã me dodokpɔwo) be woakpɔ nusi gbɔ wòtso.

Woate ŋu ama susu vevi siwo tae ALP ate ŋu adzi ɖe edzi ɖo ɖe hatsotso eve me.

Nusiwo gbɔ wòtsona siwo do ƒome kple aklã kple ʋumenugbagbeviɣiwo

• Cholestasis of pregnancy: Aklãdɔ si ate ŋu adzɔ le fufɔfɔ ƒe akpa mamlɛa me.
• Aklã ƒe ʋuʋu: Aklã ƒe gbegblẽ tegbee dzɔna ne aklã me lãmenugbagbeviwo ku eye abi ƒe lãkusi va xɔ ɖe wo teƒe.
• Aklãdɔ: Aklã ƒe dɔdzẽ. Esia ate ŋu atso dɔlékuiwo, aha sesẽ, alo nu bubuwo gbɔ.
• Bile duct obstruction: Ʋuka si tsɔa ʋumenugbagbeviɣi tso aklã me ƒe xexe le aɖuɖɔtoe me kpewo, kansa ƒe dɔdzẽ, alo nu bubuwo ta.
• Mononucleosis: Wogayɔnae be "nugbugbɔgbugbɔdɔ," dɔlékui ƒe dɔléle sia ate ŋu ana aklãa navuvu ɣeaɖewoɣi.

Nusiwo do ƒome kple ƒu (ƒunukpeƒewo).

• Paget ƒe ƒu ƒe dɔléle: Nɔnɔme si mebɔ o si me ƒuwo gbãna eye wogatsina le mɔ si mesɔ o nu.
• Osteogenic sarcoma: Kansa ƒomevi aɖe si dzea egɔme tso ƒuwo me.
• Ƒuwo ƒe kaka: Kansa tso teƒe bubu, abe no alo lãkusi ene, kakana yia ƒuwo me.
• Hyperparathyroidism: Calcium ƒe agbɔsɔsɔ si dzina ɖe edzi le ʋua me le lãmetsiŋusẽ siwo parathyroid gland la ɖena fũu akpa ta.
• Hyperthyroidism: Lãmetsiŋusẽ ƒe dɔwɔwɔ fũ akpa le lãkusi me.
• Osteomalacia: Nɔnɔme si me ƒuwo gbɔdzɔna eye wogbãna bɔbɔe le vitamin D ƒe anyimanɔmanɔ ta. Ne esia dzɔ ɖe ɖeviwo dzi la, míeyɔnɛ be Rickets.
• Gbagbãƒe si daa gbe le ame ŋu.

Nukawoe ate ŋu ahe ALP ƒe agbɔsɔsɔ si bɔbɔ vɛ?

Ƒã ŋutɔ be ALP ƒe agbɔsɔsɔ naɖiɖi le mɔ si mesɔ o nu, gake susu geɖe li siwo tae wòle nenema ɖo.

• Nunyuimakpɔɖui: Nunyiame siwo ŋutilã hiã la makpɔmakpɔ.
• Zinc ƒe anyimanɔmanɔ.
• Magnesium ƒe anyimanɔmanɔ.
• Hypothyroidism: Lãmetsiŋusẽ ƒe dɔwɔwɔ dzi ɖena kpɔtɔna.
• Domenyiŋusẽfianu ƒe dɔléle siwo mebɔ o: Nɔnɔme siwo mebɔ kura o abe `Hypophosphatasia` kple `Wilson dɔléle` ene.

Ðe wòle be matsi dzi ne nye ALP ƒe agbɔsɔsɔme sɔ gbɔ alo le suea?

Ame siwo le lãmesẽ me abe ɖeka le 20 ɖesiaɖe me ate ŋu akpɔ dodokpɔ me tsonu siwo to vovo na esiwo sɔ. Nu bubuwo hã ate ŋu akpɔ ŋusẽ ɖe ALP ƒe asixɔxɔwo dzi.

• Atike aɖewo: Atike aɖewo, abe fufɔfɔtikewo ene.
• Wò nuɖuɖu.
• Fufɔfɔ.
• Ƒe: Abe alesi míedzro eme va yi ene la, asixɔxɔ si le ɖevi siwo le tsitsim ŋu lolo ŋutɔ.
• Vodada si dzɔna le ʋua xɔɣi, etsɔtsɔ yi teƒe bubu, alo edodokpɔ me.

Eyata wò ɖɔkta manɔ te ɖe ALP ƒe asixɔxɔ ɖeɖeko dzi awɔ nyametsotso gbeɖe o. Adzro nu siwo gbɔna la katã me:

• Wò atikewɔwɔ ŋutinya bliboa.
• Atike kawoe nèle zãm fifia?
• Aleke gbegbe wò ALP ƒe asixɔxɔ lolo alo le suee.
• Dodokpɔ bubu siwo wodo kpɔ kpe ɖe ALP ŋu ƒe emetsonuwo (e.g. ALT, GGT, Bilirubin).
• Ðe dzesi aɖewo le ŋuwòa?

Ne ètsɔ nusiawo katã ƒo ƒui la, àkpɔe ɖa be ehiã be nàgawɔ dodokpɔ bubuwo alo awɔ atike na wò hã.