Ðe nèsena le ɖokuiwò me be yeƒe ŋutilã le avu wɔm kpli ye tso ememea? Ate ŋu anye Antisynthetase Syndrome!

Ðe nèsena le ɖokuiwò me ɣeaɖewoɣi be nane le fu ɖem na wò tso ememea? Ate ŋu anye be ɖeko wò ƒunukpeƒewo le veve sem, gbɔgbɔtsixe tsi ƒowò vie, alo àde dzesi tɔtrɔ sue aɖewo gɔ̃ hã le wò ŋutigbalẽ ŋu. Mègaɖe nusiawo ɖa ko be wonye nane si le dzɔdzɔm o. Ɣeaɖewoɣi la, ŋutinya aɖe si sesẽ wu nɔa megbe na wo. Egbea míele nu ƒom tso nɔnɔme aɖe si mebɔ o, gake woate ŋu akpɔ egbɔ si woyɔna be Antisynthetase Syndrome ŋu.

Nukae nye Antisynthetase Dɔléle? Kpuie ko la,...

Antisynthetase Syndrome nye dɔléle si mebɔ kura o. Nusi dzɔna le esia me enye be dɔdzẽ le míaƒe ŋutilã katã me, si fia be nɔnɔme aɖe abe dɔdzẽ ene. Le nyateƒe me la, esia nye dɔléle si dɔlélenutsiŋutete ŋutɔ hena vɛ. Fifia èle biabiam be nukae nye dɔléle si tsoa dɔlélenutsiŋutete gbɔ hã.

Bu eŋu kpɔ be dɔlélenutsiŋutete aɖe le míaƒe ŋutilã si . Ele abe aʋakɔ si kpɔa míaƒe dukɔa ta ene. Lãmenugbagbeviwo kple ŋutinu siwo le nuɖoanyi sia me kpɔa mía ta tso dɔlékuiwo, dɔlékuiwo, kple dɔlékui siwo hea dɔléle vɛ la si me. Gake le dɔléle si dɔlélenutsiŋutete ŋutɔ wɔna me la, ametakpɔnu sia mewɔa dɔ nyuie o. Esusuna be mía ŋutɔwo ƒe lãmenugbagbevi kple lãkusi siwo le lãmesẽ me nye "futɔwo" eye wòdzea wo dzi dzedze gɔme. Ele abe mía ŋutɔwo ƒe aʋakɔ si le mía ŋutɔwo ƒe aƒewo dzi dzem ene. Ðɔktawo gɔ̃ hã mete ŋu kpɔ nusita tututu nusia dzɔna la dze sii haɖe o.

Le Antisynthetase Syndrome me la, míaƒe dɔlélenutsiŋutete ate ŋu akpɔ ŋusẽ ɖe míaƒe ŋutilã ƒe akpa siwo gbɔna dzi:

• Lãmetsiwo
• Ƒunukpeƒewo
• Dzitodzito
• Ŋutigbalẽ
• Ʋukawo

Nu vevitɔe nye be nàyi ɖɔkta gbɔ ne ède dzesi ƒunukpeƒevevi yeye aɖe, ŋutigbalẽ ƒe tɔtrɔ, alo gbɔgbɔ sesẽ, evɔ mèŋe aɖaba ƒu edzi o.

Aleke gbegbee dɔléle sia mebɔ o?

Esia (Antisynthetase Syndrome) nye dɔléle si mebɔ kura o . Esesẽna be míagblɔ ame agbɔsɔsɔme si tututu wòle. Elabena ame ʋɛ aɖewo koe wogblɔna be woxɔa dɔa ƒe sia ƒe. Ɣeaɖewoɣi la, dzesi siawo ɖi dɔléle bubuwo ƒe dzesiwo, eye ate ŋu adzɔ be ame aɖeke makpɔe o.

Nukawoe nye Antisynthetase Syndrome ƒe dzesiwo?

Dzesi siwo nàkpɔ la anɔ te ɖe alesi wò dɔlélenutsiŋutete le dɔ wɔm nyuie le wò ŋutilã me kple alesi wòle nu gblẽm le eŋu vevie dzi.

Zi geɖe la, dɔléle bubu geɖe ƒe dzesiwo nɔa amesiwo ŋu Antisynthetase Syndrome le ŋu ɖekae. Mina míalé ŋku ɖe nusiwo wonye ŋu:

• Myositis: Esia nye lãmekawo ƒe dɔdzẽ si nɔa anyi didi. Esia nana lãmekawo sea veve eye wògbɔdzɔna.Edzɔna. Bu eŋu kpɔ, èsena le ɖokuiwò me be yegbɔdzɔ ale gbegbe be màte ŋu akɔ wò abɔwo gɔ̃ hã o. Ɣeaɖewoɣi la, lãmeka siwo le wò ŋɔti me la gbɔdzɔna, si wɔnɛ be wòsesẽna be nàmi nuɖuɖu kple nunono. Míeyɔa ema be nuɖuɖumadzroame .

• "Mechanic ƒe asiwo": Ðe esia menye ŋkɔ wɔnuku aɖe vie oa? Afi siae ŋutigbalẽ si le asibidɛwo kple asibidɛwo ƒe axawo dzi la ƒoa ke ɖe to eye wògbãna le. Eɖi mɔ̃ɖaŋudɔwɔla si wɔa dɔ kple ami kple ami ŋkeke bliboa ƒe asiwo.

• Interstitial lung disease (ILD): Esiae nye esime lãkusi si le yakotoku suesuesue siwo le míaƒe lãkusiwo me kple ʋuka siwo ƒo xlã wo dome la gblẽna. Esia ate ŋu ana gbɔgbɔtsixe natsi ame (gbɔgbɔtsixetsixe) , akɔta ƒuƒu , ɖeɖi nate ame ŋu , eye akɔta nase veve . Ele abe alesi nèdze anyi tso atrakpui aɖe dzi ene.

• Ƒunukpeƒetetedɔ: Esia nye ne ƒunukpeƒe atɔ̃ alo esi wu nenema dze dɔ le ɣeyiɣi ɖeka me. Esia nana ƒunukpeƒewo sea veve, wosẽna, eye wovuvuna . Ðewohĩ àse le ɖokuiwò me be yeƒe lãme sẽ ne èfɔ le ŋdi me.

• Raynaud ƒe nudzɔdzɔ (Raynaud ƒe dɔléle evelia): Le esia me la, asibidɛwo ƒe nugbɔ kple afɔbidɛwo ƒe amadede trɔna (wotrɔna zua blɔ, emegbe wozua blɔ, emegbe wozua dzĩ) eye woƒe lãme gbãna, vevietɔ ne vuvɔ le wo ŋu. Ele abe wò asibidɛwo le ʋuʋum le tsikpe aɖe ɖeɖe le nufamɔ̃ me vɔ megbe ene.

• Asrã: Ðeko ame aɖewo ate ŋu axɔ asrã dɔlékui aɖeke manɔ woƒe ŋutilã me o. Esia fia be ŋutilã ƒe dzoxɔxɔ dzina ɖe edzi le dɔlélenutsiŋutete ƒe dɔwɔwɔ sia ta.

Nukae hea Antisynthetase Dɔlélea vɛ?

Womenya nusi tututu gbɔ dɔléle sia tso haɖe o . Gake ɖɔktawo kpɔe be dɔlékuiwutike tɔxɛ aɖe le amesiwo ŋu dɔléle sia le dometɔ geɖe ƒe ʋu me. Dɔlékuiwutike siawo ɖenɛ fiana be woƒe dɔlélenutsiŋutete le woawo ŋutɔ ƒe ŋutilã dzi dzem le esi teƒe be wòakpɔ wo ta. Míeyɔa esiawo be (autoantibodies) , si gɔmee nye "ɖokuiwutikewo".

Fifia kpɔ ɖa, dɔlékuiwutikewo nye protein siwo kpɔa mía ta ne nu gbegblẽ aɖe ge ɖe míaƒe ŋutilã me. Wole abe atike ƒe dzesi siwo míaƒe dɔlélenutsiŋutete zãna ene. Dɔlékuiwutike siawo dea dzesi amedzidzela siwo gblẽa nu le ame ŋu abe dɔlékuiwo kple dɔlékuiwo ene be wonye "afɔku." Gake ne dɔléle aɖe si dɔlélenutsiŋutete wɔna le ŋuwò la, wò dɔlélenutsiŋutete wɔa dɔlékuiwutike siwo dzea lãmenugbagbevi siwo le lãmesẽ dzi dzi vodadatɔe eye woɖea wo ɖa.

Zi geɖe la, autoantibodies siwo dzea enzyme siwo woyɔna be tRNA synthetases dzi la nɔa amesiwo ŋu Antisynthetase Syndrome le la si. tRNA synthetases siawo nye enzyme vevi siwo ŋu viɖe le siwo míaƒe ŋutilã hiã be wòate ŋu awɔ dɔ nyuie.

Enye nya ɣaɣla kokoko be nusita míaƒe dɔlélenutsiŋutete dzea autoantibodies siawo wɔwɔ gɔme. Gake ne kpeɖodzi le ŋuwò be autoantibodies siawo le wò ʋu me la, anɔ eme godoo be Antisynthetase Syndrome le ŋuwò.

Ele alea, tsɔe be ame aɖe le dzo dam le wò aƒea ŋgɔ. Ne èlé ŋku ɖe eŋu le ŋufɔke la, dzonu kakɛwo kple mɔ siwo wotɔ dzoe la kaka ɖe anyigba katã. Ðewohĩ mànya amesi tututu wotɔ dzonuawo, ɣeyiɣi si wotɔ dzoe, alo nusitae o. Gake kpeɖodziwo li be edzɔ. Le Antisynthetase Syndrome me la, le esi teƒe be toɣliɖeɖe si nèsena ne èle dzo dam eye avuwo navɔ̃ la, èkpɔa dzesi siwo ŋu míeƒo nu tsoe va yi.

Amekawoe le afɔku me wu be woaxɔ dɔléle sia?

Amesiame ate ŋu axɔ Antisynthetase Syndrome. Gake nyɔnuwo kple amesiwo xɔ ƒe 50 kple edzivɔ ate ŋu axɔ dɔléle sia. Nyɔnuwo ate ŋu axɔ dɔléle sia abe ŋutsuwo tɔ ene zi gbɔ zi eve.

Aleke wokpɔa Antisynthetase Syndrome ƒe dɔlélea?

Ðɔkta nɔa te ɖe wò dzesiwo, ŋutilãmedodokpɔ, kple dodokpɔ bubu geɖe dzi dea dzesi dɔléle sia.

Ðewohĩ ahiã be nàyi ɖɔkta si bi ɖe dɔléle siwo dɔlélenutsiŋutete hena vɛ me, si woyɔna be lãmekaŋutinunyala . Ado wò kpɔ ahabia wò dzesiwo hã. Ahiã be nàgblɔ nusiwo nye wò dzesiwo, ɣeyiɣi si nède dzesii zi gbãtɔ, kple ne nane na wògagblẽ ɖe edzi na ɖɔktaa.

Tsɔ kpe ɖe eŋu la, ahiã be woado wò kpɔ zi geɖe atsɔ aɖo kpe edzi be Antisynthetase Syndrome le ŋuwò eye nàɖe nɔnɔme bubu siwo ate ŋu ahe dzesi mawo tɔgbe vɛ la ɖa.

Dodokpɔ kawoe wozãna tsɔ dea dzesi dɔlélea?

Esia menye dodokpɔ ɖeka kolia si ate ŋu aɖo kpe dɔlélea dzi godoo o. Zi geɖe la, esia nyea ɖoɖo aɖe si woyɔna be vovototodedeameme ƒe dɔlélewo didi ƒe akpa aɖe . Esia fia be wò ɖɔkta awɔ dodokpɔ geɖe be yeanya nusi gbɔ wò dzesiawo tso, aɖe nɔnɔme bubuwo ɖa, eye mlɔeba wòakpɔe be Antisynthetase Syndrome le ŋuwò. Dodokpɔ siwo nàte ŋu awɔ dometɔ aɖewoe nye:

• Ʋudodokpɔ: Be woakpɔ alesi wò dɔlélenutsiŋutete le dɔ wɔm eye woakpɔe ɖa be dɔlékuiwutike siwo nye autoantibodies, siwo nye Antisynthetase Syndrome ƒe dzesi, le ŋuwò hã. Ʋudodokpɔ ate ŋu akpɔe hã be enzyme aɖewo siwo dona ɖe ʋua me ne lãmekawo gblẽ la ƒe agbɔsɔsɔ dzi ɖe edzi hã.
• Aɖuɖɔtoe me dzodzro: Be woalé ŋku ɖe ayiku ƒe dɔwɔwɔ ŋu eye woakpɔe ɖa be dɔlékuiwo alo kuxi bubu aɖewo le aɖuɖɔ me siwo ate ŋu ahe wò dzesiwo vɛ hã.
• Aklã ƒe dɔwɔwɔ dodokpɔ: Kpɔe ɖa be wò aklã alo gbɔgbɔtsixe ƒe dɔwɔwɔ gblẽ hã.
• Computed tomography (CT) scans alo nɔnɔmetatawo dodokpɔ bubuwo: Ðe foto lãkusiwo kple ŋutinu siwo le ŋutilãa me.
• (Elektrikŋusẽŋutinunya - EMG):Kpɔ lãmekawo ƒe dɔwɔwɔ ɖa.
• Magnetic resonance imaging (MRI) scan na lãmeka siwo ŋu dɔlélea le: be woatsɔ akpɔe ɖa be dɔdzẽ le wo ŋu hã.
• Biopsy nye dodokpɔ si me woɖea lãmeka alo lãkusi sue aɖe le.

Aleke wodaa Antisynthetase Dɔléleae?

Atike aɖeke meli na Antisynthetase Syndrome o. Gake wò ɖɔkta ate ŋu akpe ɖe ŋuwò nàkpɔ atike vovovo siwo ate ŋu akpe ɖe ŋuwò nàɖu wò dzesiwo dzi, aɖe ŋusẽ si wokpɔna ɖe wò gbesiagbegbenɔnɔ dzi dzi akpɔtɔ, eye wòaɖe wò ŋutinuwo ƒe gbegblẽ dzi akpɔtɔ.

Atikewɔwɔ si ƒomevi nèhiã la anɔ te ɖe afisi wò dzesiawo le kple alesi wosẽe dzi. Dɔdamɔnu siwo wozãna wu dometɔ aɖewoe nye esi:

• Corticosteroids: Esiawo nye atike siwo woŋlɔ na ame siwo ɖea vevesese kple abi dzi kpɔtɔna. Zi geɖe la, ɖɔktawo ŋlɔa atike siwo woyɔna be corticosteroids kpe ɖe atike siwo woyɔna be dɔlélenutsiŋutete ƒe dɔlékuiwutikewo ŋu.
• Dɔlélenutsiŋutete ƒe dɔlékuiwutikewo: Atike siawo wɔa dɔ to wò dɔlélenutsiŋutete ƒe mɔxexe ɖe lãmenugbagbevi kple lãkusi siwo le lãmesẽ me dzi dzedze me. Atike si ƒomevi nèhiã la anɔ te ɖe ŋutinu siwo ŋu wògblẽ nu le dzi. Dɔlélenutsiŋutete ƒe atike siwo bɔ wue nye methotrexate, azathioprine, kple mycophenolate . Àte ŋu ahiã cyclophosphamide, rituximab, alo tacrolimus hã.
• Atikewɔwɔ na Aklãdɔléle si le Interstitial Lung Disease (ILD): Woate ŋu ana atike wò be wòana gbɔgbɔ nanɔ bɔbɔe, alo woana oxygen-dɔdamɔnu wò ne èhiã oxygen bubu. Ahiã be nàwɔ dɔ kple aklãŋutinunyala aɖe be nàkpɔ wò gbɔgbɔtsixetsixe gbɔ.
• Lãmesẽnyawo gbɔ kpɔkpɔ: Lãmesẽdɔwɔla ate ŋu akpe ɖe ŋuwò be wò ŋutilã ƒe ʋuʋu nanyo ɖe edzi. Woate ŋu akpe ɖe ŋuwò nàɖu dzesi siwo do ƒome kple lãmekawo dzi alo aɖo aɖaŋu be nàwɔ gbɔgbɔme kamedede be wòado ŋusẽ wò lãkusiwo. Ðewohĩ ahiã be woawɔ aklãdɔ na wò hã .

Nukae dzɔna ne Antisynthetase Syndrome le ŋunye?

Wò ɖɔkta ate ŋu akpe ɖe ŋuwò nàkpɔ atikewɔmɔnu vovovo siwo ate ŋu akpɔ wò dzesiwo gbɔ.

Antisynthetase Syndrome nye dɔléle si nɔa anyi didi . Esia fia be ahiã be nàkpɔ dzesiawo gbɔ ɣeyiɣi didi aɖe (ɖewohĩ wò agbemeŋkekewo katã).

Ðe (Antisynthetase Syndrome) wua amea?

Zi geɖe la, Antisynthetase Syndrome mewua ame o . Zi geɖe la, womekpɔa ŋusẽ ɖe amesiwo ŋu dɔléle sia le ƒe agbenɔƒe dzi boo o. Ame geɖe nɔa agbe kple dɔléle sia le woƒe agbemeŋkekewo katã me, gake woate ŋu aɖu woƒe dzesiwo dzi to atikewɔwɔ me.

Gake ne lãkusidɔ sesẽ aɖe le ŋuwò alo kuxi bubu aɖe si gblẽa nu le wò gbɔgbɔtsixe ŋu la, ate ŋu awu wò. Gake ƒã ŋutɔ. Wò ɖɔkta agblɔ nusi nàkpɔ mɔ na, ​​kple dzesi siwo le tɔtrɔm ate ŋu anye gbɔgbɔtsixe ƒe kuxi sesẽwo ƒe dzesi gbãtɔwo na wò.

Ðe mate ŋu axe mɔ ɖe Antisynthetase Syndrome ƒe xɔxɔ nua?

Mɔ aɖeke meli si dzi woato axe mɔ ɖe Antisynthetase Syndrome nu o, elabena eŋutinunyalawo menya nusi tututu hea dɔlélea vɛ alo nusi dzia afɔkua ɖe edzi o.

Ɣekaɣie wòle be makpɔ ɖɔkta?

Ne dzesi yeyewo va dze ŋuwò, vevietɔ ne wova le sesẽm ɖe edzi la, yi ɖɔkta gbɔ . Ne èse le ɖokuiwò me be womele wò dzesiwo dzi ɖum nyuie abe alesi wowɔe tsã le wò atikewɔwɔ me ene o, alo ne wò dzesiwo le wò gbesiagbedɔwo wɔwɔ sesẽm la, ƒo nu kple wò ɖɔkta.

Ɣekaɣie wòle be mayi xɔ si me wowɔa dɔ kpata le?

Ne dzesi siawo dometɔ aɖe le ŋuwò la, yi xɔ si me wowɔa dɔ kpata le enumake alo nàƒo ka na 911 (alo xexlẽdzesi si le mia gbɔ) :

• Yagbɔgbɔ sesẽ kpata.
• Gbɔgbɔtsixe sesẽ (se le ɖokuiwò me abe ɖe màte ŋu agbɔ o ene).
• Ŋutilã, nuyi, alo asibidɛ ƒe amadede blɔ (cyanosis).
• Akɔtave alo eƒe kpekpeme.

Nya kawoe wòle be mabia nye ɖɔkta?

• Ðe Antisynthetase Syndrome alo dɔléle bubu si dɔlélenutsiŋutete hena vɛ le ŋunyea?
• Dodokpɔ ka ƒomevie wòle be mawɔ?
• Nukawoe nye atike nyuitɔ kekeake siwo dzi mato aɖu nye dzesiwo dzi?
• Ðe mahiã kamedede alo gbɔgbɔtsixe ƒe ɖɔɖɔɖoa?
• Aleke gbegbee mele afɔku me na lãkusi me kuxi sesẽwo?

Ŋkɔ bubu kawoe nye Antisynthetase Syndrome?

Ðɔktawo yɔa Antisynthetase Syndrome kple ŋkɔ bubuwo ɣeaɖewoɣi. Le kpɔɖeŋu me:

• (Antisynthetase ƒe anyimanɔmanɔ ƒe dɔléle) .
• (AS ƒe dɔléle) .
• (Anti-Jo1 ƒe dɔléle) .

Esiawo katã nye ŋkɔ vovovowo na nɔnɔme ɖeka.

Mlɔeba la, nusi dzi nàɖo ŋkui (Take-Home Message) .

Antisynthetase Syndrome nye dɔléle si mebɔ o si me wò dɔlélenutsiŋutete dzea wò ŋutilã dzi le esi teƒe be wòakpɔ tawò. Ðo dze kple wò ɖɔkta tso atikewɔwɔ siwo ate ŋu akpe ɖe ŋuwò nàɖe ŋusẽ si wò dzesiwo kpɔna ɖe wò gbesiagbegbenɔnɔ dzi dzi akpɔtɔ ŋu.

Agbenɔnɔ kple dɔléle si tsoa dɔlélenutsiŋutete gbɔ ateŋu anye dziɖeleameƒo ŋutɔ – ateŋu ase le eɖokui me abe wò ŋutilã le ameflunyawo gblɔm ene. Ne èhiã kpekpeɖeŋu be nàtrɔ ɖe tɔtrɔ siwo va le wò agbe me ŋu alo anɔ te ɖe nɔnɔmea nu la, bia wò ɖɔkta tso mɔ siwo dzi nàto axɔ susumedɔléle ŋuti aɖaŋuɖoɖo ŋu. Blanuiléle kple blanuiléle nye nusi sɔ, gake mehiã be wò ɖeka nàto eme o.

`Antisynthetase Syndrome, autoimmune dɔléle, myositis, interstitial lung disease, Raynaud ƒe nudzɔdzɔ, autoantibodies, ƒunukpeƒeveame, lãmekawo ƒe gbɔdzɔgbɔdzɔ