Ðe wò ɖɔkta gblɔ atike ƒomevi aɖe si woyɔna be SERMs alo SERDs tsɔ daa no me dɔdzẽ na wòa? Mègatsi dzi o, ŋkɔ siawo aɖi nya sesẽ vie. Egbea, míaƒo nu tso nusiwo wonye, alesi wowɔa dɔe, kple nusiwo wòle be nànya tso wo ŋu le nya bɔbɔewo me. Esiawo nye atike vevi eve ŋutɔ siwo ate ŋu akpe ɖe mía ŋu míawɔ avu kple no me dɔdzẽ .
Nukae nye SERM-wo? Aleke wowɔa dɔe?
Kpuie ko la, SERMs (Selective Estrogen Receptor Modulators) nye atike ƒomevi aɖe si xea mɔ na no me dɔdzẽ lãmenugbagbeviwo ƒe tsitsi. Gake kansa ƒomevi aɖe koŋ ŋue wowɔa dɔ le. Emae nye kansa ƒomevi si woyɔna be Estrogen Receptor-Positive . No me dɔdzẽ siwo wokpɔna le míaƒe dukɔa me ƒe 75% koe nye esia ƒomevi.
Bu eŋu kpɔ, "antenna" sue aɖewo koe le kansa lãmenugbagbevi siawo ŋu le woƒe gowo dzi. Le atikewɔwɔ me la, míeyɔa dɔlékui siawo be . Ne lãmetsi si nye estrogen si le míaƒe ŋutilã me lé ɖe antenna siawo ŋu la, kansa lãmenugbagbevi la xɔa dzesi be “wòama eye wòatsi geɖe wu.”
Esiae nye nusi SERM-wo wɔna:
Woyina ɖaxea mɔ na antenna mawo, si fia be woxea mɔ na antennawo. Ekema afi aɖeke meli si estrogen lãmetsiŋusẽa ava lé ɖe eɖokui ŋu le o. Esi mexɔa dzesia o ta la, kansa lãmenugbagbeviwo ƒe tsitsi nu tsona alo wokpɔa wo dzi le akpa gãtɔ me.
Nu vevitɔe nye be, woyɔe be ‘tiatia’ le susu aɖe ta. Togbɔ be atike siawo xea mɔ na estrogen ƒe dɔwɔwɔ le no me hã la, wonaa lãmetsiŋusẽa wɔa dɔ nyuie le ŋutilã ƒe akpa bubuwo abe ƒuwo kple vidzidɔ ene. Emae na wole etɔxɛ.
SERM ƒomeviwo kple wo zazã
SERM ƒomevi vevi geɖe li siwo dzi woda asi ɖo na no me dɔdzẽ.
| Atikea ƒe ŋkɔ | Zãzã ƒe nɔnɔme veviwo |
|---|---|
| Tamoxifen si woyɔna be tamoxifen |
|
| Toremifene ƒe atike | |
| Raloxifene ƒe atike |
Eyata nukae nye SERD-wo?
SERDs (Selective Estrogen Receptor Downregulators) nye atike ƒomevi aɖe si wɔa dɔ sesĩe vie wu SERMs. Abe SERM-wo ene la, woxea mɔ na estrogen-xɔlawo hã. Gake tsɔ kpe ɖe eŋu la, SERD-wo ɖea nusiwo xɔa dɔlékuiwo ƒe xexlẽme dzi kpɔtɔna (ɖea wo dzi kpɔtɔna) eye wotrɔa lãmenugbagbevi susɔeawo ƒe dɔwɔwɔ hã, si wɔnɛ be womewɔa dɔ nyuie o.
Fifia la, SERD ƒomevi eve li siwo dzi woda asi ɖo:
- Fulvestrant ƒe nya
- Elacestrant ƒe atike
Wotsɔa esiawo naa no me dɔdzẽ siwo de ŋgɔ, siwo me lãmetsiŋusẽ ƒe dɔléle le kple esiwo me HER2 mele o koŋ. HER2-negative fia be protein si woyɔna be HER2 mele kansa lãmenugbagbeviwo ƒe anyime si kpena ɖe wo ŋu wotsina o.
Aleke woazã atike siae?
- SERMs: Esiawo ƒe akpa gãtɔ va le atikekui ƒe nɔnɔme me. Wò ɖɔkta agblɔ na wò be nàno 20mg va ɖo 40mg gbesiagbe. Ne èle atike siawo zãm be yeatsɔ axe mɔ na kansa ƒe tɔtrɔgbɔ la, zi geɖe la, ahiã be nàyi edzi anɔ wo nom ƒe 5 va ɖo 10.
- SERDs: Le kpɔɖeŋu me, Fulvestrant va abe atike siwo wodona ɖe lãme na ame ene.Eve. Wodoa atike eve siawo ɖe lãmeka aɖe si le akɔta me. Wonaa wo zi etɔ̃ le atikewɔwɔ ƒe ɣleti gbãtɔ me eye emegbe zi ɖeka le ɣletia me le ema megbe.
Nɔnɔme kawo mee wonaa SERM kple SERD le?
Nɔnɔme geɖe li siwo me wò ɖɔkta ate ŋu aŋlɔ atike siawo na wò le.
| Mɔnukpɔkpɔ | Numeɖeɖe |
|---|---|
| Hafi woawɔ dɔ nɛ (Neoadjuvant Therapy) . | Ne wò dɔdzẽ lolo la, woate ŋu ana atike sia hafi awɔ dɔ na wò be wòaɖe edzi eye wòana wòanɔ bɔbɔe be woaɖee ɖa. |
| Le amekoko megbe (Adjuvant Therapy) . | Wowɔa atike sia be woatsɔ atsrɔ̃ kansa ƒe lãmenugbagbevi sue ɖesiaɖe si ate ŋu asusɔ le amekoko vɔ megbe eye be woaxe mɔ na kansa la be wòagatrɔ ava o. |
| Na Kansa si le Mlɔetɔ | Ne kansa la kaka ɖe ŋutilã ƒe akpa bubu siwo mele noa godo o la, atike siawo ate ŋu akpe ɖe eŋu wòaɖu eƒe tsitsi dzi alo ana wòanɔ blewu. |
| Hena Mɔxexe Ðe Enu | Ne no me dɔdzẽ mexɔ wò kpɔ o hã la, ne afɔku si le asiwò be nàxɔe sɔ gbɔ wu mamã dedie le nusiwo le abe domenyiŋusẽfianu ene ta la, woate ŋu aŋlɔ SERM-tikewo na wò be woatsɔ aɖe afɔku ma dzi akpɔtɔ. |
Nukawoe nye atike siawo ƒe nugbegblẽ kple afɔku siwo le wo me?
Abe atike ɖesiaɖe ene la, esiawo ate ŋu agblẽ nu le ame ŋu. Gake menye amesiamee xɔa wo o. Ele vevie be nànya nu gbegblẽ siwo ate ŋu ado tso eme.
SERM-wo ƒe nugbegblẽ le ame ŋu
Nusiwo wokpɔna zi geɖe la sɔ kple esiwo wokpɔna le dzinukpɔkpɔ me.
- Dzoxɔxɔ ƒe keklẽ
- Vidzidɔ ƒe ƒuƒu, tsi si dona le lãme na ame, alo ʋu si dona vie
- Zã me fifia
- Xeɖeɖe
- Seselelãme trɔna
Nusiwo mebɔ o gake wosẽa ŋu:
- Vidzidɔ me kansa ƒe afɔkua ƒe dzidziɖedzi sue aɖe ŋutɔ
- Ʋu ƒe sisi le afɔwo me (Deep Vein Thrombosis, alo DVT) alo ʋu ƒe sisi le lãkusi me (Pulmonary Embolism) .
- Ŋku ƒe ʋuʋu
- Ƒuwo ƒe ƒuƒu le nyɔnuwo ŋu hafi woƒe dzinukpɔkpɔ nu tso
SERD-wo ƒe nugbegblẽ le ame ŋu
- Vevesese hena ɣeyiɣi aɖe le afisi wodo atikea le
- Xeɖeɖe
- Ƒu, lãmeka, alo ƒunukpeƒeveame
- Taɖuame
- Dɔsesẽwɔwɔ
- Dzoxɔxɔ ƒe keklẽ
Vevietɔ ŋutɔ: SERD ate ŋu aɖe ʋumenugbagbevi dzĩwo ƒe xexlẽme dzi akpɔtɔ, si kpena ɖe ʋu ŋu. Esia ate ŋu ana ʋudodo ƒe afɔkua nadzi ɖe edzi vie. Azɔ hã, womeɖo aɖaŋu be nàzã atike siawo evea siaa gbeɖe le fufɔɣi alo ne èle agbagba dzem be yeafɔ fu o . Ele vevie be woazã mɔxexeɖefufɔfɔnu si me lãmetsiŋusẽ mele o ne wole atike siawo nom kple ƒe ɖeka ya teti le atikewɔwɔ vɔ megbe.
Ne wò ɖɔkta do susua ɖa be woawɔ atike sia la, ƒo nu tso eŋu nɛ. Mègavɔ̃ be yeabia nyawo abe, "Viɖe kawoe atike sia aɖe nam?", "Nu kawoe mate ŋu akpɔ mɔ na?", kple "Ɣeyiɣi didi kae wòahiã be mano atike sia?"
Gbedasi si Wotsɔ Yi Aƒeme
- SERM kple SERD nye atike siwo wɔa dɔ ŋutɔ na no me dɔdzẽ si me estrogen xɔla le. Woxea mɔ na lãmetsi si nye estrogen, si le vevie na kansa lãmenugbagbeviwo ƒe tsitsi ƒe dɔwɔwɔ.
- Menye atike siawo katãe sɔ na amesiame o. Wò ɖɔkta koe ate ŋu anɔ te ɖe kansa ƒomevi, ƒe si nèxɔ, kple wò lãmesẽ dzi anya atike nyuitɔ kekeake na wò.
- Nusiwo ate ŋu agblẽ le ame ŋu ate ŋu ado mo ɖa, gake woate ŋu akpɔ wo dometɔ akpa gãtɔ dzi. Ƒo nu tso vevesese ɖesiaɖe si ado mo ɖa ŋu na wò ɖɔkta, aleke kee wòɖale sue o.
- Ele vevie ŋutɔ be nàƒo asa na fufɔfɔ esime nèle atike sia nom. Kpɔ egbɔ be yebia yeƒe ɖɔkta tso mɔxexeɖefufɔfɔnu ƒe mɔnu siwo sɔ ŋu.
💬 Comments (0)
Womeɖo nya aɖeke ɖe amewo haɖe o. Tsɔ wò nyaŋuɖoɖo kpe ɖe afisia zi gbãtɔ.
Tsɔ wò nyaŋuɖoɖo kpee