Ne èxɔ abi sue aɖe la, ʋua nu tsona le ɣeyiɣi aɖe megbe, alo? Esia tso ametakpɔnu wɔnuku aɖe si le míaƒe ŋutilã me gbɔ. Gake le ame aɖewo gome la, ʋu ƒe sisi ƒe ɖoɖo sia medzɔna nyuie o. Abi sue aɖe gɔ̃ hã ate ŋu ana ʋu nayi edzi. Egbea míele nu ƒom tso ʋusɔgbɔdɔ, si nye domenyiŋusẽfianu si nana ʋu megena nyuie o ŋu.
Aleke mawɔ anya ne ʋusɔgbɔdɔ le ŋunye?
Kpuie ko la, ne míaƒe ŋutilã te ʋu si le dodom la, atikewo ƒe dɔwɔwɔ ƒe kɔsɔkɔsɔ aɖe dzea egɔme xea mɔ nɛ. Nusi dona tso esia me mlɔebae nye ʋu ƒe sisi (Fibrin clot). Protein tɔxɛ geɖe siwo le míaƒe ʋu me kpena ɖe mía ŋu míewɔa ʋu ƒe sisi sia. Míeyɔa esiawo be "nu siwo naa ʋu ƒe sisi" alo Nusiwo nana ʋu sina .
Ʋusɔgbɔdɔ nye domenyiŋusẽfianu ƒe dɔléle si me ʋu ƒe sisi ƒe nusiwo nana ʋu sina tona dometɔ ɖeka, vevietɔ Nu VIII alo Factor IX, bu alo eƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Esia fia be ʋua metsina le mɔ si sɔ nu o.
Ne ɖɔkta aɖe susui be ʋusɔgbɔdɔ le ŋuwò la, woado ʋu kpɔ na wò zi geɖe be woakpɔ alesi wò ʋu le ƒoƒom nyuie. Dodokpɔ siawo dometɔ aɖewoe nye:
- Woɖea wò ʋu ƒe kpɔɖeŋu aɖe, tsɔa atike tɔxɛwo tsakana le dodokpɔxɔ me, eye emegbe wodoa wo kpɔna be ʋuka aɖe dzɔna hã, eye ne ele nenema la, alesi wòdzɔna kabakabae hã.
- Ne dodokpɔ siawo mesɔ o la, ekema woawɔ ʋudodokpɔ tɔxɛ bubuwo na wò be woatsɔ akpɔ Factor VIII kple Factor IX ƒe agbɔsɔsɔ le wò ʋu me.
Dodokpɔ siawo akpe ɖe wò ɖɔkta ŋu wòanya ʋusɔgbɔdɔ ƒomevi si tututu le ŋuwò (A alo B) kple alesi gbegbe wòsẽe.
Nukawoe nye ʋusɔgbɔdɔ ƒe atikewo?
Atike vovovowo li na ʋusɔgbɔdɔ. Atikewɔwɔ si ƒomevi nèhiã la anɔ te ɖe ʋusɔgbɔdɔ ƒomevi si le ŋuwò kple eƒe sesẽ dzi.
Le kpɔɖeŋu me, ne ʋusɔgbɔdɔ si nu mesẽ o le ŋuwò la, ne èxɔ abi alo ne èle dzadzram ɖo ɖe amekoko ŋu ko hafi wòahiã be woawɔ atike na wò. Gake ne ʋusɔgbɔdɔ sesẽ aɖe le ŋuwò eye ʋu le dodom enuenu la, ahiã be woawɔ atike na wò edziedzi be ʋu nagado le ŋuwò o eye nàkpɔ wò ƒunukpeƒewo ta tso nuwɔametɔnyenye kple nuwɔametɔnyenye me.
Dɔdamɔnu vevitɔwoe nye esiawo:
| Atikewɔwɔ ƒe mɔnu | Numeɖeɖe bɔbɔe aɖe |
|---|---|
| Nusiwo nana ʋu ƒe sisi (Factor Replacement Therapy) nana . | Ʋu ƒe sisi ƒe nusi bu alo esi mebɔ o (Factor VIII alo IX) nana to ʋuka me (to ʋuka me) ye nye atike vevitɔ. |
| Atike ƒomevi bubuwo | Atike bubuwo nana be wòakpe ɖe ame ŋu wòaɖu ʋu ƒe dodo dzi, eɖanye ʋu ƒe sisi ƒe nuwɔna alo esi mele eme o. |
| Ʋuʋudedi ƒe ƒunukpeƒewo kple kuxi bubuwo dada | Ƒunukpeƒewo ƒe gbegblẽ le ʋu si dona enuenu, lãmesẽnyawo gbɔ kpɔkpɔ, kple agbenɔnɔ ƒe tɔtrɔ ta dzi ɖuɖu. |
Mina míalé ŋku ɖe atike siwo koŋ wozãna ŋu nyuie.
Wona factor VIII amesiwo ŋu ʋusɔgbɔdɔ A le, eye wonaa factor IX amesiwo ŋu ʋusɔgbɔdɔ B le. Wowɔa nu siawo le mɔ vevi eve nu:
1. Ʋumenugbagbeviɣidɔ si wotsɔ na
2. DNA si wowɔ/si wogbugbɔ ƒo ƒu tsoe
Fifia wotrɔ asi le nu yeye ƒomeviwo ŋu be woanɔ ŋutilãa me eteƒe nadidi, si fia be atike ʋɛ aɖewo koe hiã wu tsã.
| Atikea ƒe ŋkɔ | Zãzã kple dɔwɔwɔ |
|---|---|
| Emicizumab-kxwh (HEMLIBRA) ƒe lãmesẽnyawo gbɔ kpɔkpɔ . | Atike si wonana be woatsɔ axe mɔ ɖe ʋudodo nu alo aɖe ʋudodo dzi akpɔtɔ le amesiwo ŋu ʋusɔgbɔdɔ A. Ewɔa dɔ to factor VIII si bu la ɖɔliɖɔli le mɔ bubu nu. Wodonɛ abe atike si wodona ɖe ŋutigbalẽ te ene zi ɖeka le kwasiɖa me. |
| Desmopressin (DDAVP) ƒe atike . | Atike si wonana amesiwo ŋu ʋusɔgbɔdɔ si nu mesẽ o le A. Enaa factor VIII ƒe agbɔsɔsɔ dzina ɖe ʋua me hena ɣeyiɣi aɖe. Woate ŋu atsɔe ade ʋuka me, to atike si wodona ɖe lãme na ame me, alo abe atike si woatsɔ aƒu gbe ɖe ŋɔti me ene. |
| Atike siwo tsia fibrinolytic nu (e.g. Tranexamic acid) . | Esiawo nye atike siwo woate ŋu ano abe atikekuiwo ene. Wowɔa dɔ to mɔxexe ɖe ʋu ƒe sisi nu be wòagavu kaba akpa o me. Le go aɖewo me la, wozãa wo kpe ɖe factor therapy ŋu. |
| Obizur ƒe ŋkɔ | Esia nye factor VIII ƒomevi aɖe si wokpɔna tso ha gbɔ. Womezãnɛ tsɔ daa domenyiŋusẽfianu ƒe ʋusɔgbɔdɔ o, ke boŋ wozãnɛ tsɔ daa dɔléle aɖe si mebɔ o, si dzea egɔme emegbe si woyɔna be Acquired Haemophilia A. Fufɔfɔ, kansa, alo atike aɖewo ate ŋu atso nɔnɔme sia gbɔ. |
Nya bubuwo kple wo dzi kpɔkpɔ
Ele be míalé ŋku ɖe kuxi bubu geɖe siwo dona tso ʋusɔgbɔdɔ me hã ŋu.
Ʋu si le dodom le ƒunukpeƒewo
Esiae nye ʋusɔgbɔdɔ ƒe kuxi sesẽtɔ kekeake. Ne ʋu le dodom le ƒunukpeƒewo abe klo, abɔta, alo afɔkpodzi ene la, ele vevie be woaxɔ factor therapy enumake. Ne womewɔ esia o la, ƒunukpeƒea ate ŋu agblẽ tegbee, si ana wòase veve, avuvu, eye wòasesẽ be wòaʋuʋu le ɣeyiɣi aɖe megbe. Ne ʋu le dodom la, gbɔ ɖe eme eye nàtsɔ tsikpe awɔ ƒunukpeƒea abe alesi wò ɖɔkta gblɔe ene. Ne vevesesea kple vuvua nu fa vɔ la, kamedede le vevie ŋutɔ be ƒunukpeƒea nagaʋuʋu eye ŋusẽ nagaɖo eŋu.
Lãmesẽfefewo wɔwɔ
Ʋusɔgbɔdɔ ƒe dɔléle mefia be nànɔ aƒeme ɣesiaɣi o. Gake nunya le eme be nànɔ adzɔge tso kamedefefe siwo me wodoa ka kple ame le siwo ate ŋu ana ame naxɔ abi la gbɔ. Le kpɔɖeŋu me, kamedefefewo abe rugby kple kɔdada ene mesɔ o. Gake kamededewo abe tsiƒuƒu, azɔlizɔzɔ, kple gasɔdodo (le mɔ si le dedie nu) nyo na ŋutilãa ŋutɔ. Anyo wu be nàƒo nu kple wò ɖɔkta tso kamedede siwo sɔ na wò kple esiwo mele be nàwɔ o ŋu.
Kuxi kawoe ate ŋu ado mo ɖa le atikewɔwɔ me?
Togbɔ be atike siwo wozãna fifia le dedie ŋutɔ hã la, kuxi eve aɖewo li siwo ŋu wòle be míanya.
1. Ʋumedɔlélewo: Tsã, le ƒe 1970 kple 1980 ƒeawo me la, afɔku gã aɖe nɔ anyi be woakaka dɔlékuiwo abe HIV kple aklãdɔ ene to ʋumenugbagbeviɣidɔ ƒe atikewɔwɔ me. Gake fifia megahiã be woatsi dzi ɖe ema ŋu o.Fifia la, wodoa ʋudolawo kpɔna nyuie ŋutɔ. Wodoa ʋu katã kpɔna be dɔlékuiwo le eme hã eye emegbe wotsɔa mɔnu tɔxɛ aɖewo daa dɔe be woagawɔ dɔ o hafi woazãe le atikewɔwɔ me. Eyata afɔkua le sue ŋutɔ fifia. Gake esi wònye ʋusɔgbɔdɔléla ta la, ele vevie ŋutɔ be woado atike na aklãdɔléle A kple B.
2. Dɔlélenutsiŋutete ƒe tɔtrɔ (Inhibitors): Ɣeaɖewoɣi la, míaƒe ŋutilã ƒe dɔlélenutsiŋutete wɔa vodada le factor protein si míena tso egodo ŋu be enye ‘futɔ’ eye wòdzea edzi dzedze gɔme. Míeyɔa esia be mɔxenuwo ƒe wɔwɔme . Ekema factor therapy si míena la mewɔa dɔ nyuie o. Esia sesẽ vie. Esia tae wò ɖɔkta ado wò (alo viwòa) ƒe ʋu kpɔ edziedzi be yeakpɔe ɖa be nuwɔna sia ƒomevi dzɔna hã.
Gbedasi si Wotsɔ Yi Aƒeme
- Ʋusɔgbɔdɔ nye ʋu ƒe sisi ƒe dɔléle si ƒe dome míenyi. Wo dometɔ vevi eveawoe nye ʋusɔgbɔdɔ A (Nu VIII ƒe anyimanɔmanɔ) kple ʋusɔgbɔdɔ B (Nu IX ƒe anyimanɔmanɔ).
- Wotoa ʋudodokpɔ tɔxɛ aɖewo dzi dea dzesi dɔlélea.
- Atikewɔwɔ vevitɔe nye be woana ʋu ƒe sisi na ŋutilãa si bu alo bɔbɔ to ʋuka aɖe me.
- Dɔdamɔnu siwo wozãna egbea la le dedie ŋutɔ eye wowɔa dɔ nyuie. Afɔku siwo nɔ anyi va yi la ƒe akpa gãtɔ nu yi.
- Ne ʋu le dodom le ƒunukpeƒe aɖe me la, ele vevie be woayi atikewɔƒe enumake. Esia ate ŋu akpe ɖe ame ŋu be wòagagblẽ nu le ƒunukpeƒea ŋu tegbee o.
- Dzro agbenɔnɔ kple kamedede ƒe ɖoɖo si sɔ na wò me kple wò ɖɔkta ɣesiaɣi. Ele vevie ŋutɔ be nàwɔ ɖe wò ɖɔkta ƒe aɖaŋuɖoɖo dzi.
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