Esɔ be nàvɔ̃ ne wò ɖɔkta gblɔ na wò alo viwò be ayiku ƒe kuxi aɖe le ŋuwò, eye le ɣeyiɣi ma ke me la, egblɔ ŋkɔ didi aɖe si sesẽ abe `Complement 3 Glomerulopathy` ene na wò. Woyɔa esia be `C3G` kpuie. Esia nye ayikudɔ si mebɔ kura o. Togbɔ be ɖeviwo kple sɔhɛ tsitsiwo koŋue dɔléle sia gblẽa nu le hã la, le nyateƒe me la, ate ŋu adze egɔme le ƒe ɖesiaɖe me. Eyata egbea, mina míaƒo nu tso dɔléle sia si woyɔna be C3G ŋu, abe ɖe míele nu ƒom na mía xɔlɔ̃ aɖe ene, le mɔ bɔbɔe aɖe ŋutɔ nu.
Nukae nye C3G sia?
Kpuie ko la, C3G nye ayikudɔ si tso "complement system" gbɔ, si nye míaƒe ŋutilã ƒe dɔlélenutsiŋutete ƒe akpa aɖe, si mele dɔ wɔm nyuie o. Kpekpeɖeŋunaɖoɖo sia le abe kpovitɔwo ƒe ha si wɔa avu kple dɔlékui kple dɔlékui siwo gena ɖe míaƒe ŋutilã me ene. Gake le amesi ŋu C3G le gome la, nuɖoanyi sia ƒe dɔwɔwɔ me gblẽna, eye wòdzea woawo ŋutɔ ƒe ayikuwo gbegblẽ gɔme.
C3G dɔléle ƒomevi vevi eve li:
1. Dɔléle si woyɔna be Dense Deposit Disease (DDD) .
2. C3 Glomerulonephritis (C3 Glomerulonephritis - C3GN) ƒe dɔléle .
Domenyiŋusẽfianu (ɖewohĩ domenyiŋusẽfianu) alo lãmesẽkuxi bubu siwo doa mo ɖa le agbe me gbɔ ate ŋu atso ƒomevi evea siaa gbɔ.
Nukae hea esia vɛ? Nukae dzɔna ɖe ayikuwo dzi?
Bu míaƒe ayikuwo be wonye tii ƒe tsilénuwo. Woyɔa tsilénu siawo be glomeruli . Esiawoe kɔa míaƒe ʋu, kɔa eŋu, eye woɖea gbeɖuɖɔ siwo míedi o ɖa to aɖuɖɔ me.
Le C3G dɔlélea me la, dɔmawɔmawɔ nyuie si míeyɔ va yi le kpeɖeŋutɔ ƒe ɖoɖoa me gblẽa nu le ʋuʋudedi siawo siwo woyɔna be glomeruli ŋu. Ne nu sia gblẽ la, ʋuʋudedi siwo le ʋuʋudedi me la lolona, eye proteinwo, kpakple ʋumenugbagbevi dzĩwo kple ɣiwo, siwo wòle be woanɔ ʋua me la, dzea dodo gɔme ɖe aɖuɖɔa me. Le ɣeyiɣi aɖe megbe la, nusiwo gblẽ le ame ŋu sia ate ŋu adzi ɖe edzi eye wòana ayiku nawɔ dɔ nyuie gɔ̃ hã. Numekuku aɖewo ɖee fia be DDD gblẽa nu le sɔhɛwo ŋu wu C3GN.
Nukae nye C3G dɔlélea ƒe dzesiwo?
Menye amesiame si ŋu C3G le la akpɔ dzesi mawo ke o. Ke hã, ele vevie be nànya esia. Na míalé ŋku ɖe dzesi veviawo ŋu.
| Dzesi si dzena | Numeɖeɖe bɔbɔe aɖe |
|---|---|
| Protein si le aɖuɖɔ me (Proteinuria) . | Protein si sɔ gbɔ ɖe aɖuɖɔ me. Aɖuɖɔa ate ŋu anye futukpɔ, alilikpo, alo viviti. Ne nɔnɔme sia nu sẽ (nephrotic syndrome) la, dzesi bubuwo abe ʋuʋudedi ene hã ate ŋu ado mo ɖa. |
| Ʋu si le aɖuɖɔ me (Hematuria) . | Ne ayiku me tsiwo gblẽ la, enaa ʋumenugbagbevi dzĩwo ƒoa ƒu ɖe aɖuɖɔ me. Aɖuɖɔa ate ŋu azu dzĩ, pink, alo aŋutiɖiɖi. |
| Edema ƒe ʋuʋu | Esi ayikuawo mele dɔ wɔm nyuie o ta la, tsi ƒoa ƒu ɖe ŋutilãa me, si wɔnɛ be afɔwo, asiwo, afɔkpodziwo, kple ŋkuwo ƒo xlãe. |
| Ʋusɔgbɔdɔ | Ʋukawo ƒe nyaƒoɖeamenu si dzi ɖe edzi le tsi si womeɖe le ayikuawo me nyuie o ta. |
| Ðeɖiteameŋu kple alɔ̃dɔdɔ | Esi ayikuawo meɖea gbeɖuɖɔwo nyuie o ta la, woƒoa ƒu ɖe ʋua me. Esia ate ŋu agblẽ nu le ahɔhɔ̃a ŋu eye wòana ɖeɖi nate ame ŋu, alɔ̃dɔdɔ, eye wòasesẽ na ame be wòatsɔ susu aɖo nu ŋu. Ayikudɔ hã ate ŋu ahe ʋusɔgbɔdɔ vɛ, si hã ate ŋu ana ɖeɖi nate ame ŋu geɖe wu. |
| Dɔlékuiwo Xɔxɔ Enuenu | Kpekpeɖeŋunaɖoɖo si gbɔdzɔ ɖea ŋutilã ƒe ŋutete be wòawɔ avu kple dɔlékuiwo dzi kpɔtɔna, si ate ŋu ana ame naxɔ dɔlékuiwo enuenu. |
| Ŋku ƒe Kuxiwo | Nukpɔkpɔ ƒe dɔmawɔmawɔ nyuie ate ŋu atso protein kple ami (drusen) siwo le ŋku ƒe ŋkume ƒe dɔwɔwɔ gbɔ. |
| Ami ƒe tsɔtsɔ ɖe ŋutigbalẽa me edziedzi (Acquired partial lipodystrophy) . | Ne ami ƒe lãmenugbagbeviwo tsɔtsrɔ̃ to kpeɖeŋutɔ ƒe ɖoɖoa dzi ate ŋu ana ŋutilãa ƒe akpa aɖewo natsi, evɔ akpa bubuwo ya ate ŋu alolo eye ami geɖe anɔ wo me. |
Tsɔ kpe ɖe eŋu la, dzesiwo abe ʋuʋudedi, ʋuʋudedi, nuɖuɖu ƒe dzodzro, alɔ̃madɔmadɔ, ŋutigbalẽ si ƒu eye wòle ʋuʋum, ga ƒe vivi le nu me, kple lãmekawo ƒe ʋuʋu le zã me ate ŋu ado mo ɖa le ayiku ƒe dɔmawɔmawɔ nyuie me .
Aleke nèwɔ kpɔ esia, Ðɔkta?
Mɔ ɖeka kolia si dzi woato anya C3G dɔlélea godooe nye be woaɖe ayiku me . Esia bia be woatsɔ ayiku ƒe lãkusi sue aɖe ade atike si naa alɔ̃dɔdɔ si mesẽ o me eye woadoe kpɔ le nusuekpɔmɔ̃ me. Esia koe nye mɔ si dzi woato anya alesi gbegbe ayikuawo gblẽe.
Tsɔ kpe ɖe eŋu la, wò ɖɔkta ate ŋu aɖo aɖaŋu na wò be nàdo ʋu kple aɖuɖɔ kpɔ eye ɖewohĩ nàdo domenyiŋusẽfianu kpɔ.
Nukae wòle be mabia ɖɔktaa?
Le ɣeyiɣi sia tɔgbe me la, ɖewohĩ nyabiase geɖe anɔ susu me na wò. Dzro nusiawo me eme nakɔ kple wò ɖɔkta. Le kpɔɖeŋu me:
- Aleke mewɔ va xɔ C3G?
- C3G ƒomevi ka ƒomevie le asinye? (DDD alo C3GN?)
- Mɔ nyuitɔ kawo dzie mato akpɔ nye lãmesẽ dzi le dɔléle sia ta?
- Atikewɔwɔmɔnu kawoe le asinye?
- Nukae mate ŋu akpɔ mɔ na le etsɔme le dɔléle sia ta?
Nukawoe nye atike siwo wozãna na esia?
Ne míagblɔe tututu la, atike ɖeka aɖeke meli si ate ŋu ada C3G dɔlélea keŋkeŋ haɖe o. Gake atikewɔmɔnu vovovowo li siwo ate ŋu aɖu dɔlélea dzi, aɖe dɔlélea ƒe dzesiwo dzi akpɔtɔ, eye woaɖe ayikuwo ƒe gbegblẽ dzi akpɔtɔ.
- Kpɔ ʋu ƒe sisi kple protein ƒe dodo dzi: Ʋu ƒe sisi ƒe atikewo (Angiotensin-converting enzyme (ACE) inhibitors kple Angiotensin II type-1 receptor blockers (ARBs)) ate ŋu aɖe protein ƒe dodo le aɖuɖɔ me dzi akpɔtɔ eye wòana dɔlélea nayi edzi blewu.
- Lãmetsiŋusẽ dzi ɖuɖu: Ne ʋumemi sɔ gbɔ (hyperlipidemia) le ŋuwò la, numekukuwo ɖee fia be atike siwo ɖea ʋumemi dzi kpɔtɔna ate ŋu akpe ɖe ŋuwò nàɖu C3G dɔlélea ƒe gbegblẽ dzi.
- Dɔlélenutsiŋutete ƒe atikewo: Atike siwo tea dɔlélenutsiŋutete ɖe to, abe glucocorticoids kple mycophenolate mofetil (MMF) ene, ƒe ƒuƒoƒo ate ŋu axe mɔ ɖe dɔlélea gbugbɔgadzɔ nu le dɔnɔ aɖewo ŋu.
- Egbegbe atikewɔwɔwo: Atike siwo tsia kpeɖeŋutɔ nu abe `eculizumab` ateŋu akpɔ kpeɖeŋutɔ ƒe ɖoɖoa ƒe dɔwɔwɔ dzi eye wòana dɔlélea ƒe ŋgɔyiyi nagbɔdzɔ. Gakpe ɖe eŋu la, wole nu srɔ̃m tso atike yeye aɖe si woyɔna be `iptacopan` ŋu fifia. Eɖe emetsonu siwo ŋugbe wodo ŋutɔ fia, eyata woda asi ɖe edzi be woawɔ numekuku le eŋu kabakaba.
Aleke wòle be malé be na ɖokuinye?
Abe atikewo ene la, ale si nèléa be na ɖokuiwò hã le vevie ŋutɔ le dɔléle sia dzi ɖuɖu me.
- Nuɖuɖu si naa lãmesẽ: Ƒo atikutsetse, amagbe, mɔli, kple nuku gbogbo aɖewo. Ðe ami, dze, kple sukli dzi kpɔtɔ. Ðewohĩ wò ɖɔkta agblɔ na wò be nàɖe potassium, sodium (dze), alo phosphate si nèɖuna dzi akpɔtɔ. Mègawɔ tɔtrɔ gã aɖeke le wò nuɖuɖu ŋu gbeɖe ne mèbia wò ɖɔkta gbã o.
- Lé be na wò lãmesẽ: Ne èse le ɖokuiwò me be yeƒe lãme sẽ hã la, no wò atikewo abe alesi wò ɖɔkta gblɔe ene pɛpɛpɛ. Gblɔ atike, vitamin, alo kpeɖeŋutɔ bubu ɖesiaɖe si nèzãna na wò ɖɔkta.
- Kamedede: Kamedede ate ŋu akpe ɖe ŋuwò nàdɔ alɔ̃ nyuie, ana ŋusẽ nanɔ ŋuwò, eye wòaɖe dzidɔ ƒe afɔkua dzi akpɔtɔ. Ðo dze kple wò ɖɔkta tso kamedede ƒe ɖoɖo si sɔ na wò ŋu.
- Ƒo asa na atamanono: Esia nyo ŋutɔ na wò lãmesẽ bliboa.
- Ðe ahanono dzi kpɔtɔ: Ðo dze kple wò ɖɔkta tso ahanono ŋu eye nàdi aɖaŋuɖoɖo.
Nukae míate ŋu akpɔ mɔ na le etsɔme?
Ne wonya kpɔe be C3G dɔlélea le ŋuwò ko la, wò atikewɔlawo akpe ɖe ŋuwò nàkpɔ atikewɔwɔ ƒe ɖoɖo nyuitɔ kekeake.
Le go aɖewo me la, dɔlélea te ŋu nu sẽna. Ame siwo ŋu C3G le la dometɔ siwo ade 50% xɔa ayikudɔ si ƒe nuwuwu (ESRD) le ƒe 10 me tso esime wokpɔ dɔlélea. Le ɣeyiɣi sia me la, ŋutete si le ayikuwo ŋu be woaɖe gbeɖuɖɔwo ɖa la bu keŋkeŋ. Ðewohĩ ahiã be woado ayiku na ame alo ado ayiku na ame .
Gake ele vevie be míaɖo ŋku edzi be le ayiku dodo vɔ megbe gɔ̃ hã la, mɔnukpɔkpɔ gã aɖe li be C3G dɔlélea nagadze le ayiku yeyea me. Eyata ƒo nu kple wò ɖɔkta didi tso tiatia nyuitɔ si nàwɔ na wò ŋu.
Wò atikewɔlawo ƒe ƒuƒoƒoa ate ŋu anye ayikuŋutinunyala, ʋumenugbagbeviɣidɔdala, kple dɔléleŋutinunyala. Ele vevie be ƒomedodo nyui nanɔ mía kple wo dome.
Gbedasi si Wotsɔ Yi Aƒeme
- C3G nye ayikudɔ si mebɔ o gake wòsẽa ŋu ŋutɔ, si tsoa nusi gblẽ le ame ƒe kpeɖeŋutɔ ƒe dɔwɔwɔ ŋu, si nye ŋutilã ƒe dɔlélenutsiŋutete ƒe akpa aɖe, gbɔ.
- Dzesi vevitɔwo ate ŋu anye protein alo ʋu si le aɖuɖɔ me, vuvu, ʋusɔgbɔdɔ, kple ɖeɖiteameŋu.
- Wokpɔa dɔlélea godoo to ayiku me lãmenugbagbeviwo me dzodzro me.
- Togbɔ be atike aɖeke meli koŋ na esia o hã la, woate ŋu aɖu dɔlélea dzi eye woakpɔ ayikuwo ta to ʋu ƒe sisi dzi ɖuɖu, atike siwo léa dɔlélenutsiŋutete nu, kple agbenɔnɔ si me lãmesẽ le me.
- Ele vevie ŋutɔ be nànɔ kadodo me kple wò atikewɔlawo ƒe ƒuƒoƒoa ɣesiaɣi eye nàwɔ ɖe woƒe mɔfiamewo dzi pɛpɛpɛ.
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