Nukae nye Gastrin? Ðe wògblẽa nu le wò dɔgbo ƒe kuxiwo ŋua?

Èbu nu nenie yia edzi le míaƒe ŋutilã me, vevietɔ ne míeɖu nu vɔ ŋu kpɔa? Atikewo ƒe dɔla suewo ƒe ƒuƒoƒo aɖe le míaƒe ŋutilã me siwo kpena ɖe nusiawo katã ŋu wòdzɔna. Míeyɔa lãmetsi siawo be lãmetsiŋusẽwo. Egbea míele nu ƒom tso lãmetsi tɔxɛ mawo dometɔ ɖeka ŋu. Emae nye gastrin. Gastrin sia le vevie ŋutɔ na míaƒe nuɖuɖumeŋusẽ ƒe dɔwɔwɔ.

Nuka tututue Gastrin wɔna?

Enyo, azɔ mina míakpɔ nusi xɔlɔ̃ sia si woyɔna be Gastrin wɔna na míaƒe ŋutilã ɖa. Dɔ vevi geɖewo le esi.

• Dɔgbo me acid wɔwɔ: Nu vevitɔe nye be nàgblɔ na wò dɔgbo be wòaɖe gastric acid ɖa. Dɔgbo me acid siae nye nusi míeyɔna be hydrochloric acid. Esia manɔmee la, esesẽna ŋutɔ be woaɖu nuɖuɖu.
• Dɔgbo ƒe lãmekawo ƒe dɔwɔwɔ: Gastrin kpena ɖe wò dɔgbo ƒe lãmekawo hã ŋu wòwɔa dɔ nyuie, si fia be enaa dɔgbo ƒe ʋuʋu, si kpena ɖe nuɖuɖu tsakana hegbãa wo ŋu.
• Ðo Ƒodo ƒe Gli Yeye: Ele be míawɔ míaƒe dɔgbo ƒe akpa si le tsɛ, si nye lãkusi, yeyee ɣesiaɣi. Gastrin kpena ɖe esia hã ŋu.
• Aɖuɖɔtoe kple dɔgbo ƒe ʋuʋu: Gastrin, kpakple lãmetsi bubu si woyɔna be cholecystokinin, kpena ɖe wò aɖuɖɔtoe kple dɔgbo ŋu be woatsi eye wòaɖe nuɖuɖumemiwo dona.

Vovototo kae le Gastrin kple Gastric acid dome?

Ðe esia ɖi nusi tɔtɔa ame viea? Kpuie ko la, ele alea. Gastrin nye lãmetsiŋusẽ aɖe . Ele abe lɛta ene. Lɛta sia gblɔ na dɔgboa be, "Enyo, azɔ ɖe asi le gastric acid ŋu." Emegbe dɔgbo me acid sia naa nuɖuɖumeŋusẽ si nye pepsin wɔa dɔ. Ame eve siawo ƒo ƒu wɔa dɔgbo me tsi si le míaƒe dɔgbo me. Èse egɔmea?

Afikae wowɔa gastrin le?

Ŋutinu siwo le míaƒe nuɖuɖumeŋusẽ me koŋue wɔa gastrin. Lãmenugbagbevi tɔxɛ aɖe si woyɔna be G-lãmenugbagbeviwo mee lãmetsi sia tsona. Ŋɔŋlɔdzesi "G" tsi tre ɖi na "gastrin."

Gastrin akpa gãtɔ tsoa wò dɔgbo me , vevietɔ wò dɔgbo ƒe akpa si le anyime (míeyɔnɛ be antrum). G-lãmenugbagbevi siawo le dɔgbo ƒe lãkusi siwo le wò dɔgbo ƒe gli me. Tsɔ kpe ɖe eŋu la, gastrin aɖewo tsoa duodenum, si nye wò dɔgbo sue ƒe akpa gbãtɔ, kple dɔgbo me.

Nu kawoe kpɔa ŋusẽ ɖe gastrin ƒe dodo dzi?

Ewɔ nuku ŋutɔ be gastrin dona ne èbu nuɖuɖu ŋu! Aleke nèwɔ nya ema? Míaƒe ahɔhɔ̃ kple nuɖuɖumeŋusẽ do ƒome ɣesiaɣi to lãmeka tɔxɛ aɖe si woyɔna be vagal nerves dzi. Nyatakakawo zɔa mɔ yia ŋgɔ kple megbe to lãmeka siawo me.

Eyata ne èbu nuɖuɖu ŋu la, vagal nerves siwo le wò ahɔhɔ̃ me ɖoa gbedasi ɖe dɔgboa be, "Enyo, nuɖuɖu gbɔna, ɖe asi le gastrin ŋu eye nàdzra ɖo ɖe nuɖuɖumeŋusẽ ŋu." Emegbe ne èdze nuɖuɖu gɔme la, lãmeka siwo le wò dɔgbo me dea dzesii be nuɖuɖu ge ɖe eme eye gastrin geɖe dona.

Nu bubu siwo doa ŋusẽ gastrin ƒe dodo:

• Dɔgbo ƒe pH ƒe dzidziɖedzi (si fia be ne acid si le eme dzi ɖe kpɔtɔ).
• Wohea dɔgboa ƒe gliwo ne nuɖuɖu ge ɖe eme.
• Nuɖuɖu aɖewo , vevietɔ esiwo me protein le, gena ɖe dɔgboa me.

Gastrin nana dɔgboa me acid dona, si naa pepsin wɔa dɔ. Esiawo ƒo ƒu gbãa protein siwo le dɔgboa me eye woɖua wo. Gastrin hã nana lãmeka siwo le dɔgboa me la ʋãna.

Aleke nàwɔ atɔ te gastrin ƒe dodo?

Ne nuɖuɖu le ƒuƒlu le wò dɔgbo me eye wòyi ɖe dɔgbo suea ƒe akpa gbãtɔ, si nye dɔgboa me la, nuɖuɖumeŋusẽ ƒe akpa si kplɔe ɖo dzea egɔme. Ɣemaɣie gastrin ƒe dodo dzea egɔme dzi ɖeɖe kpɔtɔ. Ne nuɖuɖu do le dɔgboa me eye aɖi si le dɔgboa me dzina ɖe edzi la, gastrin dzi ɖena kpɔtɔna.

Ne nuɖuɖu ge ɖe dɔgboa me la, wò dɔgbo kple dɔgbo ɖea woƒe nuɖuɖume tsiwo dona. Emegbe, míaƒe nuɖuɖumeŋusẽ ɖea lãmetsi bubu si woyɔna be somatostatin dona. Somatostatin sia tsia lãmetsiŋusẽ bubuwo (abe gastrin ene). Ele abe ɖe nètsi switch aɖe ene.

Aleke woawɔ akpɔ gastrin ƒe agbɔsɔsɔ?

Ʋudodokpɔ tɔxɛ aɖe li be woatsɔ akpɔ wò gastrin ƒe agbɔsɔsɔ. Míeyɔa esia be gastrin dodokpɔ. Lãmesẽdɔwɔla, abe ɖɔkta alo dɔnɔdzikpɔla ene, ɖea ʋu sue aɖe tso ʋuka aɖe si le wò alɔnu me heɖonɛ ɖe dodokpɔxɔ me be woadoe kpɔ.

Nukatae nye gastrin ƒe agbɔsɔsɔ le vevie?

Ðɔktawo léa ŋku ɖe wò gastrin ƒe agbɔsɔsɔ ŋu be yewoakpɔe ɖa be esɔ gbɔ akpa hã . Gastrin ƒe agbɔsɔsɔ si bɔbɔ ɖe anyi mebɔ o, gake gastrin ƒe agbɔsɔsɔ si sɔ ate ŋu afia dɔgbo ƒe dɔléle kple nɔnɔme aɖewo.

Nukae gastrin ƒe agbɔsɔsɔ si dzi ɖe edzi (Hypergastrinemia) fia?

Ne gastrin ƒe agbɔsɔsɔ dzi ɖe edzi la, míeyɔnɛ be hypergastrinemia. Ɣeaɖewoɣi la, hypergastrinemia ate ŋu afia be dɔdzẽ siwo naa gastrin le wò ŋutilã me, siwo woyɔna be gastrinomas. Esiawo ate ŋu adzɔ le wò dɔgbo alo dɔgbo me.

Ɣebubuɣiwo la, hypergastrinemia ate ŋu afia be nane le wò dɔgbo me si le mɔ xem nɛ be wòagawɔ gastric acid o. Ne dɔgbo me acid dzi ɖe kpɔtɔ la, gastrin geɖe dona. Azɔ hã, dzesi siwo xea mɔ na gastrin ƒe wɔwɔme le dzɔdzɔme nu la me gblẽna.

Nukae dzɔna ne gastrin ƒe agbɔsɔsɔ dzi ɖe edzi?

Ne wò dɔgbo ƒe agbɔsɔsɔ sɔ gbɔ la, dɔgbo me acid ƒe agbɔsɔsɔ si le wò dɔgbo kple dɔgbo me ate ŋu asɔ gbɔ akpa. Acid si sɔ gbɔ akpa ate ŋu agblẽ nu le wò dɔgbo kple dɔgbo ƒe ametakpɔnu si le tsɛ la ŋu, si ana nàxɔ abi, si woyɔna hã be dɔgbo me abi ƒe dɔléle.

Azɔ hã, ne dɔgbo me acid sɔ gbɔ ɖe ame me la, ate ŋu ahe nɔnɔme aɖe si woyɔna be GERD (Gastroesophageal Reflux Disease) vɛ, si nye dɔléle si nɔa anyi didi si me acid dona ɖe ŋɔti me. Ne peptic ulcer disease alo GERD le ŋuwò eye meganyo ɖe edzi ne wozã atike o la, wò ɖɔkta ate ŋu alé ŋku ɖe wò gastrin ƒe agbɔsɔsɔ ŋu.

Atikewɔwɔ me nɔnɔme kawoe ate ŋu ado ƒome kple gastrin ƒe agbɔsɔsɔ fũ?

Ne gastrinomas le ŋuwò la, wò gastrin kple gastric acid siaa ƒe agbɔsɔsɔ ate ŋu adzi ɖe edzi. Gastrinomas nye dɔgbo ƒe ahɔhɔ̃mekawo ƒe dɔdzẽ (PET) ƒomevi aɖe si ɖea gastrin ɖe go. Woate ŋu anye kansa alo esiwo menye kansa o.

Nɔnɔme siwo hea gastrinomas vɛ:

• Zollinger-Ellison ƒe dɔlélea.
• Dɔlékuiwutike geɖe ƒe dɔdzẽ ƒomevi 1 (MEN1).

Nɔnɔme siwo me gastrin kple gastric acid dzina ɖe edzi le gastrinomas manɔmee:

• Ayiku ƒe dɔmawɔmawɔ nyuie atraɖii.
• Dɔgbo ƒe dodo ƒe mɔxexe (GOO).

Ne wò dɔgbo me acid ƒe agbɔsɔsɔ mesɔ gbɔ o la, ke ate ŋu anye be dɔgbo me acid sɔ gbɔ ɖe mewò gake gastric acid ƒe agbɔsɔsɔ si le mesɔ gbɔ o. Esia ate ŋu atso atrophic gastritis, si nye nɔnɔme si me lãmenugbagbevi siwo wɔa dɔgbo me acid la tsrɔ̃na le.

Nu vevi siwo gbɔ atrophic gastritis tsona:

• H. pylori ƒe dɔléle.
• Dɔléle siwo dɔlélenutsiŋutete tsona (e.g. autoimmune atrophic gastritis).

Nu bubu siwo gbɔ dɔgboa me acid ƒe wɔwɔme dzi ɖena kpɔtɔna:

• Atike siwo xea mɔ na acid, abe H2 blockers alo proton pump inhibitors (PPIs) ene.
• Vagotomy (amekoko be woaɖe vagal nerve ɖa alo woatsoe).

Nukae wòle be mawɔ ne gastrin ƒe agbɔsɔsɔ si sɔ gbɔ ƒe dzesiwo le ŋunye?

Ne dɔgbo ƒe dzesiwo le ŋuwò, vevietɔ ne edzena enuenu alo nɔa anyi ɣeyiɣi didi aɖe la, ele vevie be nàyi ɖɔkta gbɔ. Dzesi aɖewo siwo ate ŋu ado ƒome kple gastrin ƒe dzidziɖedzie nye esi:

• Dɔgbo ƒe vevesese alo ƒodo ƒe ʋuʋu.
• Akɔtave si nɔa anyi ɖaa kple nuɖuɖu ƒe dɔmawɔmawɔ nyuie.
• Acid reflux alo nuɖuɖu ƒe gege ɖe ŋɔti me.
• Kɔmeve si nɔa anyi ɖaa kple gbeɖiɖi ƒe ɖiɖi.
• Aɖuɖɔtoe si nɔa anyi ɖaa.
• Nuɖuɖumeŋusẽ ƒe kuxiwo.

Dzesi siawo ate ŋu afia be dɔgbo me acid sɔ gbɔ ɖe lãme na wò, alo be dɔgbo si me ʋu sina tona, dɔgbo ƒe dɔléle, alo GERD le ŋuwò. Esia ate ŋu ado ƒome kple gastrin alo mado ƒome kplii o. Gake ele vevie be woade dzesi dɔléle siawo ahada wo nyuie.

Ðo ŋku edzi be ne dzesi siawo tɔgbe le ŋuwò la, mègadze agbagba be yeade dzesi ɖokuiwò to nyatakakawo didi le internet dzi me o. Anyo wu be nàkpɔ ɖɔkta eye nàxɔ aɖaŋuɖoɖo.

Gbedasi si Wotsɔ Yi Aƒeme

Enyo, eyata mina míalé ŋku ɖe nu bɔbɔe aɖewo siwo dzi míaɖo ŋkui le gastrin si ŋu míeƒo nu tsoe ŋu.

• Gastrin nye lãmetsi vevi aɖe le míaƒe nuɖuɖumeŋusẽ me .
• Eƒe dɔ vevitɔe nye be wòagblɔ na dɔgboa be wòaɖe dɔgboa me acid ɖa .
• Ne wò dɔgbo me acid sɔ gbɔ akpa alo bɔbɔ akpa , ate ŋu ado ƒome kple gastrin.
• Ne dɔgbo ƒe dzesi aɖewo le ŋuwò, alo nɔnɔme aɖewo mele nyonyom ɖe edzi le atikewɔwɔ me o la, ɖɔkta ate ŋu ado wò dɔgbo ƒe agbɔsɔsɔ kpɔ.
• Gastrin ƒe agbɔsɔsɔ si sɔ ate ŋu anye atikewɔwɔ ƒe dzesi ɣeaɖewoɣi, eyata ele vevie be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo ne dzesiwo le ŋuwò.

Eyata, Gastrin nye nu sue aɖe gake ŋusẽ le eŋu si wɔa dɔ le ɖoɖoezizi me le míaƒe ŋutilã me. Esia nyanya anɔ vevie ŋutɔ na wò lãmesẽ. Ne nya bubu aɖewo gale asiwò la, mègahe ɖe megbe le wò ɖɔkta biabia me o.

` Gastrin, lãmetsiwo, nuɖuɖumeŋusẽ, dɔgbo me acid, dɔgbo ƒe abi, GERD, hypergastrinemia