Ðe ʋusɔgbɔdɔ le ŋuwòa , si woyɔna zi geɖe be "ʋusɔgbɔdɔ"? Anɔ eme be èle atike ɖeka, eve, alo ɖewohĩ esi wu nenema gɔ̃ hã si wò ɖɔkta ŋlɔ na wò la zãm xoxo. Ke hã, togbɔ be èle atike wɔm hã la, ɖe nègasena le ɖokuiwò me kokoko be yeƒe ʋu ƒe sisi dzi ɖuɖu sesẽa? Ne nenemae la, ke ɖewohĩ nusi gbɔ wòtso la manye nusi nèkpɔ mɔ na zi geɖe o. Egbea la, míedi be míaƒo nu tso atikewɔwɔ me nɔnɔme aɖe koŋ si ate ŋu ahe ʋusɔgbɔdɔ si dzi ɖuɖu sesẽ, si atikewo mete ŋu ɖuna o vɛ ŋu: Hyperaldosteronism. Togbɔ be ŋkɔa aɖi nya sesẽ hã la, mina míamae ɖe nya bɔbɔewo me.
Nukae Nye Hyperaldosteronism ƒe Dɔléle?
Kpuie ko la, hyperaldosteronism dzɔna ne wò adrenal glands wɔ lãmetsi aɖe si woyɔna be "aldosterone" si gbɔ eme.
Ðewohĩ ànɔ ɖokuiwò biam be: nukae nye adrenal gland siawo , eye nukae nye aldosterone?
Kpɔe ɖa le susu me be lãkusi sue eve siwo ƒe nɔnɔme le abe kpo suewo ene, bɔbɔ nɔ wò ayikuwo tame tututu . Esiawoe nye wò adrenal glandwo. Wonye wò lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa vevi aɖe . Lãmetsi sue siawo wɔa lãmetsiŋusẽ geɖe siwo hiã vevie na wò ŋutilã ƒe gbesiagbedɔwo .
Lãmetsiŋusẽ ɖeka koŋ si lãkusi siawo wɔnae nye aldosterone . Eƒe dɔ vevitɔe nye be wòaɖɔ wò ʋu ƒe sisi ɖo to sodium kple potassium ƒe agbɔsɔsɔ si le wò ʋukawo me la dadasɔ me. Àte ŋu abu lãmetsi sia abe ʋukuku ƒe kpovitɔ si le mɔ fiam ʋuwo ƒe sisi le mɔ si dzi amewo sɔ gbɔ ɖo dzi ene.
Eyata le hyperaldosteronism me la, wowɔa aldosterone fũ akpa. Esia nana be sodium ƒe agbɔsɔsɔ dzina ɖe edzi le wò ŋutilã me esime potassium ƒe agbɔsɔsɔ dzi ɖena kpɔtɔna. Nusi dona tso eme mlɔebae nye ʋusɔgbɔdɔ (ʋu ƒe sisi) kple hypokalemia (potassium si mebɔ o le ʋu me) .
Wole ƒomevi vevi eve me
Ðɔktawo ma nɔnɔme sia ɖe hatsotso eve me le nusi gbɔ wòtso nu.
1. Hyperaldosteronism Gbãtɔ: Wogayɔnae be "Conn ƒe dɔléle," esia dzɔna ne nya la le adrenal glands me tẽ, si wɔnɛ be wowɔa aldosterone wògbɔa eme.
2. Secondary Hyperaldosteronism: Le go sia me la, adrenal glands la le lãmesẽ me. Ke boŋ wole wo ʋãm be woawɔ aldosterone si sɔ gbɔ ɖe kuxi aɖe si dzɔ tso ŋutilãa ƒe akpa bubuwo ta.
Ameka ŋue wògblẽa nu le wu?
Dɔléle sia dzena le amesiwo xɔ tso ƒe 30 va ɖo ƒe 50. Numekukuwo hã ɖee fia be ebɔ vie le nyɔnuwo me wu ŋutsuwo.
Numekukuwo ɖee fia be amesiwo katã ŋu ʋusɔgbɔdɔ le ƒe 5% va ɖo 10% ate ŋu anye hyperaldosteronism gbãtɔ. Vevietɔ wu la, eŋutinunyalawo xɔe se be le amesiwo ŋu ʋusɔgbɔdɔ si me atikewo mete ŋu ɖuna o le dome la, alafa memamãa ate ŋu asɔ gbɔ va ɖo 25%.
Nukawoe nye dzesiawo?
Ɣeaɖewoɣi la, ne nɔnɔmea mesẽ o la, ɖewohĩ màkpɔ dzesi aɖeke kura o. Ke hã, ame geɖe ɖea dzesiwo fiana.
Dzesi si bɔ wue nye ʋusɔgbɔdɔ , vevietɔ ne ekpɔtɔ nye dzimesesẽ togbɔ be wozã ʋusɔgbɔdɔtike geɖe hã.
Dzesi bubuwo dona tso ʋusɔgbɔdɔ kple potassium ƒe agbɔsɔsɔ si mede o (hypokalemia) ƒe ƒuƒoƒo gbɔ. Mina míama nusiawo me eme nakɔ.
| Wᴐe be | Dzesi Siwo Ate Ŋu Akpɔ |
|---|---|
| Dzesi siwo tso Ʋusɔgbɔdɔ gbɔ |
|
| Dzesi siwo tso Potassium si mebɔ o gbɔ |
|
Ðo ŋku edzi be mehiã be nàkpɔ dzesi siawo katã o. Ðewohĩ ɖeka alo eve koe anɔ ame aɖewo si.
Nukatae Hyperaldosteronism dzɔna?
Abe alesi míegblɔe va yi ene la, nusiwo gbɔ wòtsona la to vovo le ƒomevi eveawo nu.
Nusiwo Hea Hyperaldosteronism Gbãtɔ Gbɔna
Le afisia la, kuxia dzɔna tso adrenal gland ŋutɔ me.
- Nusi gbɔ wòtsona wu: Zi geɖe la, dɔdzẽ si menye kansa o (adrenal adenoma) nɔa adrenal gland dzi. Esia menye kansa o, eyata mehiã be woavɔ̃ o. Ðeko dɔdzẽ sia naa aldosterone sɔ gbɔ akpa.
- Nu bubu siwo mebɔ o siwo gbɔ wòtsona:
- Adrenal gland ɖeka ƒe lolome (unilateral adrenal hyperplasia).
- Aldosterone ƒe wɔwɔ to kansa ƒe dɔdzẽ (adrenocortical carcinoma) dzi - esia ƒã ŋutɔ.
- Domenyiŋusẽfianu ƒe nɔnɔme aɖe (ƒome me hyperaldosteronism).
Nusiwo hea Hyperaldosteronism Evelia vɛ
Le afisia la, adrenal glands le lãmesẽ me, gake nu bubu aɖee ʋãa wo. Nusi koŋ gbɔ wòtsoe nye ʋu ƒe sisi ɖe ayikuawo me dzi ɖeɖe kpɔtɔ .
Be míase esia gɔme la, anyo be míanya nu tso ŋutilãa ƒe ɖoɖo ɖedzesi si le ʋu ƒe sisi dzi kpɔkpɔ ŋu: Renin-Angiotensin-Aldosterone System .
Bu eŋu be enye kɔsɔkɔsɔ ƒe nuwɔna:
1. Ne wò ʋu ƒe sisi ɖiɖi alo sodium ƒe agbɔsɔsɔ le wò ʋu me ɖiɖi la, wò ayikuwo dea dzesii.
2. Emegbe ayikuawo ɖea enzyme aɖe si woyɔna be "renin" ɖea ʋukawo me.
3. Renin wɔa dɔ ɖe protein si aklã wɔ si woyɔna be "angiotensinogen" dzi, eye wòtrɔnɛ wòzua "angiotensin I."
4. Eyome, wotrɔa Angiotensin I sia wòzua “Angiotensin II.”
5. Mlɔeba la, Angiotensin II siae nana wò ʋu ƒe sisi dzina ɖe edzi to wò ʋukawo ƒe ʋuʋu kple wò ʋukawo ƒe ʋuʋu be woawɔ aldosterone me.
Le Hyperaldosteronism evelia gome la, atikewɔwɔ me nɔnɔme aɖe si le eme ɖea ʋu ƒe sisi yi wò ayikuwo me dzi kpɔtɔna. Eyata wò ayikuwo bua vodadatɔe be wò ŋutilã ƒe ʋu ƒe sisi ɖiɖi akpa. Le esia ta la, wò ayikuwo hea kɔsɔkɔsɔ ƒe dɔwɔwɔ vɛ be yeabia kpekpeɖeŋu. Esia wɔnɛ be wowɔa lãmetsi si nye aldosterone wògbɔa eme, togbɔ be wò ŋutilã mehiãe ŋutɔŋutɔ o hã.
Nɔnɔme siwo ɖea ʋu ƒe sisi yi ayikuwo me dzi kpɔtɔna eye wòhea Hyperaldosteronism evelia vɛ dometɔ aɖewoe nye:
- Ʋuka siwo naa ʋu ayikuwo ƒe ʋuʋu (Obstructive renal artery disease).
- Nɔnɔme siwo me tsi ƒoa ƒu ɖe ŋutilã me, abe Dzi ƒe dɔmawɔmawɔ nyuie ene.
- Aklã ƒe ʋuka me dɔléle.
- Nephrotic syndrome, si nye ayiku ƒe dɔléle ƒomevi aɖe.
Aleke ɖɔkta awɔ anya dɔléle siae?
Ne èdzro wò dzesiwo me kple wò ɖɔkta—vevietɔ ne ègblɔ be wò ʋusɔgbɔdɔ mele dɔ wɔm ɖe atike siwo wozãna ɖaa ŋu o—la, woate ŋu asusui be nɔnɔme sia le ye ŋu. Emegbe wò ɖɔkta aɖe gbe be woawɔ dodokpɔ geɖe atsɔ aɖo kpe dɔlélea dzi.
1. Ʋudodokpɔ:
- Le ʋumenugbagbeviɣidɔ si wowɔna edziedzi me la, sodium ƒe agbɔsɔsɔ si dzi ɖe edzi vie (Hypernatremia) kple potassium ƒe agbɔsɔsɔ si bɔbɔ (Hypokalemia) nana ɖikeke nɔa ame ŋu zi geɖe.
- Eyome, ʋudodokpɔ tɔxɛ eve li siwo wozãna koŋ tsɔ dea dzesi nɔnɔme sia: Plasma Renin Concentration (PRC) alo Plasma Renin Activity (PRA) dodokpɔwo.
- Ne Hyperaldosteronism gbãtɔ le ŋuwò la, zi geɖe la, wò renin ƒe agbɔsɔsɔ (PRC kple PRA) aɖiɖi wu alesi wòle dzɔdzɔmee.
- Ne Hyperaldosteronism evelia le ŋuwò la, wò renin ƒe agbɔsɔsɔ asɔ gbɔ wu alesi wòle.
2. Aldosterone ƒe Nutete Dodokpɔ:
- Le dodokpɔ sia me la, wonaa sodium (dze) ƒe agbɔsɔsɔ si dzi ɖe edzi wò le ɣeyiɣi aɖe koŋ me, to nu me alo to dzetsi si wodona ɖe ʋuka me (IV) dzi.
- Le esia megbe la, woƒoa wò aɖuɖɔ nu ƒu le gaƒoƒo 24 me tsɔ dzidzea aldosterone ƒe agbɔsɔsɔ si le eme.
- Le ame si le lãmesẽ me gome la, sodium ɖuɖu ƒe dzidziɖedzi nana ŋutilãa ɖea aldosterone ƒe wɔwɔ dzi kpɔtɔna le dzɔdzɔme nu. Gake le amesi ŋu Hyperaldosteronism le gome la, esia medzɔna o.
3. Nɔnɔmetatawo Dodokpɔwo:
- Ne ʋudodokpɔwo ɖo kpe edzi be Hyperaldosteronism gbãtɔe le ŋuwò la, wò ɖɔkta ate ŋu abia be woawɔ CT scan (Computed Tomography scan) atsɔ ade dzesi nusi gbɔ wòtso, abe alesi woakpɔe ɖa be adrenal gland tumor aɖe le ŋuwò ene.
Dɔdamɔnu kawoe li?
Atikewɔwɔ ƒe ɖoɖowo nɔ te ɖe nusi gbɔ wòtso dzi bliboe. Gake taɖodzinu vevitɔe nye be nàkpɔ wò ʋu ƒe sisi nyuie.
- Le Hyperaldosteronism gbãtɔ si tso dɔdzẽ gbɔ gome la:
Zi geɖe la ɖɔktawo kafua amekoko be woaɖe dɔdzẽa kple lãkusi si ŋu dɔlélea le la ɖa . Le amekoko megbe la, dɔnɔ geɖe kpɔnɛ be yewoƒe ʋu ƒe sisi kple potassium ƒe agbɔsɔsɔ gatrɔna ɖe yewo ŋu. Ame aɖewo ate ŋu ahiã kokoko be woayi edzi anɔ ʋu ƒe sisi ƒe atikewo zãm le dɔwɔwɔ nɛ vɔ megbe.
- Le nu bubu siwo gbɔ wòtso kple Hyperaldosteronism evelia ta la:
Le nɔnɔme siawo me la, atikewɔwɔ lɔ atikewo zazã ɖe eme . Gakpe ɖe eŋu la, ne enye nɔnɔme evelia la, dɔléle si gbɔ wòtso (le kpɔɖeŋu me, dzidɔ) gbɔ kpɔkpɔ le vevie ŋutɔ.
Atike siwo woŋlɔna na ame zi geɖe dometɔ aɖewoe nye:
- Spironolactone (Aldactone®) ƒe dɔlékuiwutike .
- Eplerenone (Inspra®) ƒe dɔwɔwɔ.
- Amiloride (Midamor®) ƒe ʋuƒoƒo .
Taflatse de dzesii be atike siwo xea mɔ na aldosterone ƒe dɔwɔwɔ, abe Spironolactone ene, zazã ɣeyiɣi didi ate ŋu ahe nugbegblẽ le ŋutsuwo ŋu, abe tsitretsitsi ƒe dɔmawɔmawɔ nyuie alo no ƒe lolome (Gynecomastia) ene. Ne èse veve alo nugbegblẽ le ŋuwò la, mègahe ɖe megbe gbeɖe le nuƒoƒo tso wo ŋu na wò ɖɔkta o.
Nukae nye nukpɔsusu kple kuxi siwo ate ŋu ado tso eme?
Wò nyagblɔɖi, alo nukpɔsusu si anɔ asiwò ɣeyiɣi didi, nɔ te ɖe nusi gbɔ wòtso dzi koŋ.
Ne wode dzesi Hyperaldosteronism gbãtɔ kaba eye wodae nyuie la, zi geɖe la, emetsonuwo nyo ŋutɔ. Le Hyperaldosteronism evelia gome la, emetsonua nɔ te ɖe alesi woate ŋu akpɔ atikewɔwɔ me nɔnɔme si gbɔ wòtso gbɔ nyuie dzi.
Nɔnɔme sia ƒe kuxi veviwo tsoa ʋusɔgbɔdɔ si nɔa anyi didi, si dzi womeɖu o, si ate ŋu ahe dzitodzito me dɔléle sesẽwo vɛ gbɔ.
| Kuxi Vevi Siwo Ate Ŋu Ate Ŋu Ado Goe |
|---|
| Atrial fibrillation (dzi ƒe tsotso si mesɔ o) . |
| Left ventricular hypertrophy (dzia ƒe xɔ vevitɔ ƒe lolome) . |
| Dzidɔ |
| Gbagbãdᴐ |
Le susu sia ta la, wò ʋu ƒe sisi dzi ɖuɖu nyuie le vevie ŋutɔ.
Ðe woate ŋu axe mɔ ɖe nɔnɔme sia nua?
Zi geɖe la, womate ŋu axe mɔ ɖe nɔnɔme sia nu o elabena zi geɖe la, eƒoa ke ɖe to ɖe ŋutilã ƒe dɔwɔwɔ ememetɔwo me. Gake nya nyuiae nye be ne wonya de dzesii ko la, atikewɔwɔ nyuie ate ŋu axe mɔ ɖe kuxi sesẽ siwo anɔ anyi ɣeyiɣi didi nu.
Gbedasi si Wotsɔ Yi Aƒeme
- Ne wò ʋu ƒe sisi dzi ɖuɖu gakpɔtɔ le sesẽm togbɔ be èle atike geɖe zãm hã la, kpɔ egbɔ be yeƒo nu kple yeƒe ɖɔkta .
- Hyperaldosteronism nye nɔnɔme si tsoa lãmetsi si nye aldosterone ƒe dzidziɖedzi fũ gbɔ.
- Ate ŋu anye gbãtɔ (si dzɔ tso lãkusia me) alo evelia (si tso atikewɔwɔ me nɔnɔme bubu gbɔ).
- Woate ŋu akpɔe nyuie to ʋudodokpɔ tɔxɛwo kple nɔnɔmetatawo ɖeɖe me.
- Woate ŋu adae dzidzedzetɔe to amekoko alo atikewo zazã me, le nusi gbɔ wòtso nu.
- Nu vevitɔ kekeake si wòle be nànyae nye be esia nye dɔléle si woate ŋu ada; ne nusiwo ŋu nètsi dzi ɖo la, di atikewɔlawo ƒe aɖaŋuɖoɖo enumake.
Hyperaldosteronism, aldosterone, adrenal glands, Conn ƒe dɔléle, ʋusɔgbɔdɔ, ʋusɔgbɔdɔ, nyaƒoɖeamenu, potassium, sodium, ayiku, lãmetsiŋusẽwo
