Nukae nye Langerhans Cell Histiocytosis (LCH) ƒe dɔléle? Ðe viwò suea ɖo afɔku mea?

Èse Langerhans Cell Histiocytosis, alo nusi míeyɔna kpuie be LCH ŋu nya kpɔa? Ðewohĩ ŋkɔa ɖi nya sesẽ vie eye wòdoa vɔvɔ̃ na ame. Gake le nyateƒe me la, esia nye dɔléle si mebɔ kura o si dzea mía vi suewo koŋ dzi, vevietɔ vidzĩ yeyewo kple ɖevi siwo mexɔ ƒe 15 haɖe o. Eyata mègatsi dzi o, mina míaƒo nu tso eŋu bɔbɔe, le Sinhalagbe me si gɔme nàte ŋu ase nyuie ŋutɔ, tsitotsito, abe ɖe nèle nu ƒom na xɔ̃wò vevi aɖe ene.

Nuka tututue nye (LCH)?

Kpuie ko la, (LCH) nye nɔnɔme si dzɔna ne Langerhans lãmenugbagbeviwo sɔ gbɔ akpa le ɖevi ƒe ŋutilã me, si nye lãmenugbagbevi tɔxɛ ƒomevi aɖe le míaƒe dɔlélenutsiŋutete me. Le nyateƒe me la, Langerhans lãmenugbagbevi siawo nye ʋumenugbagbevi ɣi ƒomevi aɖe. Woƒe dɔ vevitɔe nye be woawɔ avu kple dɔlékui siwo gena ɖe míaƒe ŋutilã me eye woakpɔ mía ta tso dɔléle me.

Zi geɖe la, lãmenugbagbevi siawo nɔa míaƒe ŋutilã katã me, vevietɔ le ŋutigbalẽ, lãkusi, ʋukawo, ƒumeŋuɖui, dɔgbo, kple aklã me. Gake le (LCH) gome la, Langerhans lãmenugbagbevi siawo ƒoa ƒu wògbɔa eme le teƒe ɖeka alo esi wu nenema. Ne edzɔ alea la, ŋutinu siawo ate ŋu agblẽ eye abi ate ŋu adzɔ.

Dɔlélea ƒe zɔzɔ ate ŋu ato vovo tso ame ɖeka gbɔ yi bubu gbɔ. Ðevi aɖewo hayana tso dɔlélea me keŋkeŋ ne wowɔ atike na wo nyuie. Nukutɔe la, ɣeaɖewoɣi, vevietɔ ne ŋutigbalẽa koe wògblẽ la, ate ŋu anyo ɖe edzi atike aɖeke mawɔmawɔe. Gake ne nɔnɔmea (LCH) gblẽ nu le ŋutinu veviwo abe ɖevia ƒe ƒumeŋuɖui, dɔgbo alo aklã ene ŋu la, ate ŋu ahiã be woawɔ atike nɛ vevie wu.

Ðe (LCH) nye kansa?

Esia nye nyabiase si le ame geɖe si. Le nyateƒe me la, numekula akpa gãtɔ bua LCH be enye kansadɔ, si fia be enye dɔdzẽ ƒe dɔléle. Gake fifia dzɔdzɔmeŋutinunyala aɖewo bunɛ be enye dɔléle si nana ame ƒe lãme ʋãna. Gake kansadɔdalawo nye ɖɔkta siwo bi ɖe kansa kple ʋumedɔlélewo me. Ɣeaɖewoɣi la, wozãa kansadɔdamɔnu, abe atikewɔmɔnu ene hã tsɔ daa dɔlélea.

Amekae dɔléle sia (LCH) gblẽa nu le wu?

LCH bɔ ɖe vidzĩ yeyewo kple ɖevi siwo xɔ tso ƒe 1 va ɖo ƒe 15. LCH mebɔ kura le ame tsitsiwo me o, gake menye nusi mate ŋu adzɔ o.

Aleke gbegbee esia bɔe?

Akɔntabubuwo ɖee fia be vidzĩ yeye miliɔn ɖesiaɖe dometɔ ɖeka alo eve xɔa LCH ƒe sia ƒe. Azɔ hã, ɖevi siwo mexɔ ƒe 15 haɖe o miliɔn ɖesiaɖe dometɔ atɔ̃ lɔƒoe wògblẽa nu le. Eyata àte ŋu akpɔe be nɔnɔme sia nye esi mebɔ kura o.

Nukae nye (LCH) ƒe dzesiwo?

LCH ƒe dzesiwo toa vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ. Ate ŋu agblẽ nu le ŋutilã ƒe akpa ɖeka ko ŋu, alo ate ŋu agblẽ nu le ame ƒe akpa geɖe ŋu. Eyata, dzesiawo nɔ te ɖe ɖevia ƒe ŋutilã ƒe akpa si ŋu wògblẽ nu le dzi.

Ne ƒuwo ŋue wògblẽ nu le:

Ðevi siwo ŋu LCH le ƒe 80% lɔƒo xɔa abi le woƒe ƒu ɖeka alo esi wu nenema me. Nukae ate ŋu ahe esia vɛ?

• Vuvu alo ƒunukpeƒetetedɔ ate ŋu adze le teƒewo abe taɖu, ƒu siwo ƒo xlã ŋkuwo, to ƒe ƒuwo, aɖuƒuwo, abɔwo, akɔta, akɔta, alo akɔtaƒuwo ene. Vuvu sia ate ŋu ase veve alo ate ŋu adzo.
• Taɖuame.
• Kɔ alo akɔtave.
• Nusiwo gbagbã.
• Azɔlizɔzɔ sesẽ.
• Limping.

Le ŋutigbalẽa dzi la:

Zi geɖe la, wobua ʋuʋudedi be enye ŋutigbalẽ me kansa (LCH) ƒe dzesiwo.

• Le vidzĩ suewo gome la, ʋuʋudedi si le abe vidzĩ ƒe ta ene ate ŋu adze le ta ŋu.
• Le ɖevi tsitsiwo kple ame tsitsiwo gome la, ate ŋu ana ʋuʋudedi si le abe ʋuʋudedi ene nado.
• Aɖuɖɔtoe siawo ate ŋu adze le ŋutilã ƒe akpa bubuwo hã (akɔta, abɔta, abɔta, dɔgbo, akɔta, akɔta). Woate ŋu anye vevesese, ʋuʋudedi, alo sesẽ.
• Ðevi aɖewo ate ŋu axɔ ʋuʋudedi siwo le dodom.
• Nuwo abe ɖaawo ƒe amadede ƒe tɔtrɔ, woƒe sesẽ, alo woƒe ʋuʋu hã ate ŋu adzɔ.

Ku ɖe nu me ŋu la:

Dzesi siwo woate ŋu akpɔ le nu me dometɔ aɖewoe nye:

• Aɖuwo ƒe ʋuʋu alo aɖuwo ƒe bu.
• Aɖu si wohe.
• Aɖuɖɔtoewo ƒe vuvu.
• Abi siwo le nuyiwo, aɖe, ŋgonu me, alo nu tame.

Aklã alo Aklã si do ƒome kple:

Ne ŋutinu siawo ŋue wògblẽ nu le la, dzesiwo abe:

• Ƒodo ƒe vuvu le aklã kple/alo dɔgbo ƒe lolome ta.
• Ŋutilã ƒe ɣie kple ŋku ƒe ɣie (jaundice).
• Ʋuʋudedi.
• Ɖeɖiteameŋu.
• Abi kple/alo ʋu si dona le ame ŋu bɔbɔe.

Ne ƒumeŋuɖui ŋue wògblẽ nu le:

Ƒumeŋuɖui mee wowɔa ʋumenugbagbeviwo le. Ne ekpɔ ŋusẽ ɖe edzi la:

• Ʋusɔgbɔdɔ, ŋutigbalẽ ƒe ɣie, ɖeɖiteameŋu, kple nuɖuɖu ƒe dzodzro le ʋumenugbagbevi dzĩwo ƒe ɖiɖi ta.
• Dɔlékuiwo xɔxɔ enuenu kple dzoxɔxɔ le ʋumenugbagbevi ɣiwo ƒe ɖiɖi ta.
• Ʋuʋudedi bɔbɔe kple/alo ʋu si dona le ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ si mede o ta.

Endocrine System (Endocrine System - Lãmetsiŋusẽwo):

LCH ate ŋu akpɔ ŋusẽ ɖe ɖevi ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ dzi, afisi wowɔa lãmetsiŋusẽwo le, abe pituitary gland kple thyroid gland ene.

• Ne egblẽ nu le pituitary gland ŋu: tsikɔwuame si gbɔ eme (polydipsia) kple aɖuɖɔɖɔɖɔ enuenu (si woyɔna hã be suklidɔ), tsitsi ƒe dɔmawɔmawɔ nyuie, sɔhɛmenɔɣi kaba alo esi tsi megbe, kple lolo.
• Ne lãkusia gblẽ nu le eŋu: lãkusia ƒe vuvu, lãkusi me lãmetsiŋusẽ ƒe agbɔsɔsɔ si mede o ƒe dzesiwo (hypothyroidism), kple gbɔgbɔ sesẽ.

Ku ɖe towo ŋu la:

• To me dɔlékuiwo xɔxɔ enuenu.
• Lãmetsi si le dodom tso towo me.
• Dzodzodzoetsitsi.
• Ʋuʋudedi si me ʋuʋudedi le.
• To ƒe vevesese.
• Tosese ƒe dɔmawɔmawɔ nyuie.

Ku ɖe ŋkuwo ŋu la:

• Ŋku siwo le ʋuʋum.
• Ʋuʋudedi le ŋkuwo tame.
• Nukpɔkpɔ ƒe kuxiwo.

Lãmetsiŋusẽ ƒe Ʋukawo:

• Lãmetsiŋusẽ siwo vuvu eye wole veve sem le kɔ, akɔta, kple/alo akɔta.

Titina Lãmetsiŋusẽ:

Esia fia be ahɔhɔ̃ kple/alo aklã ƒe ka ŋue wògblẽa nu le.

• Taɖuame.
• Taɖuame.
• Ʋuʋudedi.
• Tsikɔwuame si gbɔ eme.
• Aɖuɖɔɖɔɖɔ enuenu.
• Azɔlizɔzɔ sesẽ.
• Dadasɔ ƒe bu.
• Ŋutete be woaɖu ŋutilã ƒe ʋuʋu dzi o (ataxia).
• Nuƒoƒo alo nukpɔkpɔ sesẽ.
• Alɔ̃madɔmadɔ.
• Tɔtrɔ siwo vaa nuwɔna kple/alo ŋkuɖoɖonudzi me.

Dzitodzito:

Aklã me LCH, si nye dɔléle si gblẽa nu le aklã ŋu la bɔ ɖe ame tsitsiwo me wu. Amesiwo noa atama koŋue le afɔku me.

• Akɔtave.
• Kɔdzi ƒuƒu.
• Yagbɔgbɔ sesẽ.
• Ʋu ƒe kɔdzidede.
• Aklã ƒe dɔmawɔmawɔ nyuie (pneumothorax).

Dɔgbo ƒe Mɔnu:

Ne ɖevia ƒe dɔgbo, dɔgbo sue, kple/alo dɔgbo gã ŋue wògblẽ nu le:

• Dɔgbo ƒe vevesese.
• Ʋuʋudedi.
• Dɔmetɔtrɔ.
• Ʋu le aɖuɖɔ me.
• Tsitsi ƒe kpododonu le nunyuimakpɔɖu ta.

Vevietɔ: Dzesi siawo ate ŋu atso nɔnɔme bubu agbɔsɔsɔme ɖesiaɖe gbɔ, ke menye LCH ɖeɖeko o. Eyata ne dzesi siawo le viwòa ŋu la, ele vevie be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo enumake be woakpɔ dɔlélea nyuie.

Nukawoe hea (LCH) vɛ?

Ame siwo ŋu LCH le ƒe afã lɔƒo koe ŋutilã ƒe tɔtrɔ le domenyiŋusẽfianu si woyɔna be BRAF me. Somatic mutations nye tɔtrɔ siwo dzɔna le lãmenugbagbevi aɖewo me le fufɔfɔ megbe. Womenyi wo tso dzilawo gbɔ o, ke boŋ wodzɔna le vome le fugboea ƒe tsitsime.

Domenyiŋusẽfianu (BRAF) wɔa protein si kpɔa lãmenugbagbeviwo ƒe tsitsi kple woƒe tsitsi dzi. Zi geɖe la, woate ŋu aʋu protein sia ahatsi enu le atikewo ƒe dzesiwo nu. Gake ne domenyiŋusẽfianu sia ƒe tɔtrɔ aɖe va la, protein la tsia "on" nɔnɔme me ɣesiaɣi. Esia nana (LCH) lãmenugbagbeviwo tsina hemãna akpa. Esiae nana lãmenugbagbeviwo gblẽna eye dɔdzẽwo dzɔna.

Dzɔdzɔmeŋutinunyalawo kpɔe hã be domenyiŋusẽfianu bubu geɖewo ƒe tɔtrɔwo hã ate ŋu ahe dɔlélea vɛ. Le kpɔɖeŋu me, domenyiŋusẽfianu (MAP2K1), (RAS), kple (ARAF). Numekula aɖewo xɔe se be aɖi siwo le nutoa me kple dɔlékuiwo ƒe dɔlékuiwo hã ate ŋu ahe dɔlélea vɛ.

Nukawoe nye afɔku siwo ate ŋu ana (LCH)?

Nu aɖewo ate ŋu ana viwòa ƒe LCH xɔxɔ ƒe afɔkua nadzi ɖe edzi. Esiawo dometɔ aɖewoe nye:

• LCH ƒe ƒome ŋutinya ƒe amesinɔnɔ.
• Hispaniatɔwo ƒe to ƒe amesinɔnɔ (togbɔ be esia meku ɖe míaƒe dukɔa ŋu nenema o hã la, woƒo nu tso eŋu le nyatakakatsoƒewo).
• Sigaretnono (vevietɔ na ame tsitsi siwo ŋu lãkusi me dɔdzẽ (LCH) le).
• Atike aɖewo zazã le fufɔɣi.
• Ga, granite, alo ati ƒe ke ƒe gododo le dɔwɔƒe.
• Dɔlékuiwo le vidzĩ yeye ƒe ɣeyiɣia me.
• Atike siwo wokafu be woaxɔ le ɖevime o.

Nukawoe nye kuxi siwo ate ŋu ado tso (LCH) me?

Ðevi siwo ŋu LCH le ƒe 50% lɔƒo xɔa kuxi vovovowo le nɔnɔme sia ta. Le kpɔɖeŋu me:

• Abidede ame ŋu.
• Tsitsi ƒe megbetsitsi.
• Lãmetsiŋusẽ ƒe nuwɔametɔnyenye.
• Nɔnɔme aɖe abe suklidɔ (Diabetes insipidus) ene.
• Lãmetsiŋusẽ ƒe masɔmasɔ.
• Tosese ƒe kuxi.
• Susu ƒe lãmesẽkuxiwo (abe blanuiléle, dzimaɖitsitsi ene).
• Ƒu kple lãkusi ƒe kuxiwo.
• Aklã me ʋu ƒe sisi.
• Kansa evelia (e.g. ʋumenugbagbeviɣidɔ, ʋumenugbagbeviɣidɔ, Ewing sarcoma).

Aleke wowɔna dea dzesi LCH?

Viwòa ƒe ɖɔkta abia viwòa ƒe atikewɔwɔ ŋutinya gbã eye wòado eƒe ŋutilã kpɔ. Emegbe, woaɖe gbe be woawɔ dodokpɔ geɖe le dzesi siwo me tom viwòa le nu. Le dodokpɔ siawo me tsonu nu la, woate ŋu aɖo viwòa ɖe ɖeviwo ƒe ʋumenugbagbeviɣidɔdala/kansadɔdala, amesi awɔ ɖoɖo ɖe viwòa dada kple edzikpɔkpɔ ŋu.

Dodokpɔ kawoe wowɔna tsɔ dea dzesi dɔlélea?

Esi wònye be LCH ate ŋu adze ŋutilã ƒe akpa vovovowo dzi ta la, ehiã be woawɔ dodokpɔ geɖe hafi woate ŋu anya dɔlélea nyuie.

• Ʋudodokpɔ:
• Ʋu ƒe xexlẽme blibo (CBC): Esia léa ŋku ɖe ɖevia ƒe ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, kple ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ ŋu.
• Ʋu ƒe lãmenugbagbeviwo ƒe dodokpɔ: Esiawo léa ŋku ɖe nu aɖewo siwo ŋutilã ƒe ŋutinuwo kple lãkusiwo ɖena doa goe ƒe agbɔsɔsɔ ŋu.
• Aklã ƒe dɔwɔwɔ dodokpɔ: Esiawo léa ŋku ɖe nusiwo aklãa ɖena ɖe go ƒe agbɔsɔsɔ ŋu.

• Aɖuɖɔtoe dodokpɔwo:
• Aɖuɖɔtoe me dzodzro: Woléa ŋku ɖe ʋumenugbagbevi dzĩwo, ʋumenugbagbevi ɣiwo, protein, kple sukli agbɔsɔsɔme si le ɖevia ƒe aɖuɖɔ me ŋu.
• Tsimanɔamesi dodokpɔ: Esia doa aɖuɖɔ agbɔsɔsɔme si ɖevia le kple nenye be aɖuɖɔa va ƒoa ƒu ne wometsɔ tsi nɛ o hã.

• Nu gbagbewo ƒe lãmenugbagbeviwo ɖeɖe:
• Biopsy: Ðɔkta aɖe xɔa lãmenugbagbeviwo ƒe kpɔɖeŋu, eye dɔléleŋutinunyala aɖe léa ŋku ɖe eŋu le nusuekpɔmɔ̃ me be yealé ŋku ɖe LCH lãmenugbagbeviwo ŋu.
• Ƒumeŋuɖui ɖeɖe kple lãmenugbagbeviwo ɖeɖe: Wozãa aŋe si me do le tsɔ ɖea ƒumeŋuɖui, ʋu, kple ƒu sue aɖe ɖa le ɖevia ƒe akɔtaƒu me. Dɔléleŋutinunyala aɖe hã léa ŋku ɖe esia ŋu.

• Domenyiŋusẽfianu dodokpɔ:
• Wozãa ʋu alo lãkusi aɖe tsɔ léa ŋku ɖe tɔtrɔ siwo le (BRAF) domenyiŋusẽfianu me ŋu.

• Nɔnɔmetatawo ɖeɖe ƒe dodokpɔwo:
• X-ray: Woɖea ƒuwo kple ŋutilã ƒe ŋutinuwo ƒe fotowo. Ɣeaɖewoɣi la, wowɔa ƒuwo ŋuti numekuku le ŋutilã bliboa ŋu be woatsɔ adi nusiwo mesɔ o.
• Ƒuwo me toto: Wodoa nusi me keklẽŋusẽ le ɖe ʋuka aɖe me eye wozãa mɔ̃ aɖe tsɔ dia nusiwo mesɔ o siwo le ƒuawo me. Womegazãa esia fũ o.
• CT scan (Computed tomography - CT scan): Wona tsi tɔxɛ aɖe ɖevia be wòano alo wodoe ɖe ʋuka aɖe me, eye woɖea foto tsitotsito tso dzogoe vovovowo dzi le ŋutilãa me.
• Positron emission tomography (PET scan): Wodoa sukli si me keklẽŋusẽ le (glucose) sue aɖe ɖe ʋuka aɖe me, eye wotsɔa scanner la ƒoa xlã ŋutilãa tsɔ ɖea foto afisi wole suklia zãm le. Lãmenugbagbevi siwo ŋu dɔléle le dzena le keklẽm le fotoɖeɖe sia me.
• MRI scan (Magnetic resonance imaging - MRI scan): Wodoa nusi woyɔna be gadolinium ɖe ʋuka aɖe me eye wozãa magnet, radio ƒutsotsoewo, kple kɔmpiuta tsɔ ɖea foto tsitotsito ɖe wo nɔewo yome. Teƒe siwo dɔléle le dzena abe ɖe wòklẽna wu ene.
• Ultrasound: Ezãa gbeɖiɖi ƒe ƒutsotsoe siwo ŋu ŋusẽ geɖe le tsɔ wɔa ŋutilãa ƒe akpa si le eme ƒe nɔnɔmetatawo to megbe gbeɖiɖi siwo tso ŋutinuwo kple lãkusiwo me la ɖeɖefia me.

Aleke wowɔa atike na LCH?

LCH dada nɔ te ɖe afisi LCH lãmenugbagbeviwo le le ɖevia ƒe ŋutilã me kple nenye be dɔlélea nye "afɔku sue" alo "afɔku gã."

Ŋutinu siwo me afɔku mele boo o ye nye:

• Ŋutigbalẽ
• Ƒu
• Dzitodzito
• Lãmetsiŋusẽ ƒe lãkusiwo
• Dɔgbo ƒe dɔwɔwɔ
• Pituitary gland ƒe lãkusi
• Thyroid ƒe lãkusi
• Thymus ƒe lãmekawo

Ŋutinu siwo me afɔku le ŋutɔe nye:

• Aklã
• Aɖuɖɔtoe
• Ƒumeŋuɖui
• Titina ƒe lãmekawo ƒe dɔwɔwɔ (CNS) .

Ðɔktawo bua nɔnɔmea (LCH) be "sile-system LCH" kple "multi-system LCH." Esia fia be:

• Single-system (LCH): LCH lãmenugbagbeviwo le ŋutinu alo ŋutilã ƒe ɖoɖo ɖeka ƒe akpa ɖeka ko me. Ƒomevi si bɔ wue nye LCH si gblẽa nu le ƒuwo ɖeɖeko ŋu.
• Multisystem (LCH): Lãmenugbagbeviwo le ŋutinu eve alo esi wu nenema me, alo le ŋutilã bliboa me (LCH). Esia mebɔ vie wu ɖoɖo ɖeka (LCH) tɔ o.

Le go aɖewo me, vevietɔ esiwo ŋu ŋutigbalẽ alo ƒuwo ɖeɖeko (LCH) gblẽa nu le la, nɔnɔmea ate ŋu atso atike aɖeke mawɔmawɔe. Le nɔnɔme mawo me la, ɖɔktawo alé ŋku ɖe dɔlélea ŋu akpɔe ɖa be egatrɔ va alo kaka hã.

(LCH) Atikewɔwɔ ƒe Tiatia:

• Steroid zazã: Wò ɖɔkta ate ŋu azã steroid, abe prednisone ene, vevietɔ na ŋutigbalẽ ƒe LCH. Esiawo ɖea ʋumenugbagbevi ɣiwo ƒe dɔwɔwɔ dzi kpɔtɔna, si ate ŋu akpɔ ŋusẽ ɖe LCH lãmenugbagbeviwo hã dzi.
• Amekoko: Woate ŋu aɖe LCH ƒe dɔdzẽwo kple lãkusi siwo ƒo xlãe ɖa to amekoko me. Dɔwɔwɔ aɖe si woyɔna be curettage bia be woatsɔ dɔwɔnu ɖaɖɛ aɖe si le abe gaƒoƒo ene (curette) atutu LCH lãmenugbagbeviwo le ƒua me.
• Atikewo zazã: Esia bia be woana kansa lãmenugbagbeviwo be woagatsi o. Wowua lãmenugbagbeviawo alo woxea mɔ na wo be woagama o. Wonoa atike siawo to nu me, wodoa wo ɖe ʋuka alo lãmeka me, alo wotsɔa wo ƒoa ŋutigbalẽa ɣeaɖewoɣi abe kreme ene.
• Kekeli ƒe dɔdamɔnu: Wozãa X-ray siwo ŋu ŋusẽ geɖe le alo keklẽŋusẽ ƒomevi bubuwo tsɔ wua kansa lãmenugbagbeviwo alo xea mɔ na wo be woagatsi ahama o.
• Dɔlélenutsiŋutete ƒe atikewɔwɔ: Mɔnu si wozãna tsɔ zãa ɖevia ŋutɔ ƒe dɔlélenutsiŋutete tsɔ wɔa avu kple kansa. Wodoa ŋusẽ ŋutilã ƒe dzɔdzɔme ametakpɔnu to nusiwo ŋutilãa ŋutɔ wɔ alo esiwo wowɔ le nudokpɔƒe zazã me.
• Atikewɔwɔ si ŋu woɖo taɖodzinu ɖo: Ezãa atikewo alo nu bubuwo tsɔ dea dzesi kansadɔlékui aɖewo koŋ hedzea wo dzi. Le kpɔɖeŋu me, atike siwo woyɔna be BRAF inhibitors ate ŋu awu kansa lãmenugbagbeviwo to mɔxexe ɖe protein siwo hiã na lãmenugbagbeviwo ƒe tsitsi nu me. Monoclonal antibodies nye dɔlélenutsiŋutete ƒe protein siwo wowɔ le dodokpɔxɔ me.
• Stem cell transplant: Lãmenugbagbevi yeyewo dodo na ame be woatsɔ aɖɔli ʋumenugbagbevi siwo gblẽ le atikewɔmɔnu me.

Ðe woate ŋu axe mɔ ɖe LCH nua?

Woate ŋu axe mɔ ɖe LCH nu ƒe akpa gãtɔ elabena domenyiŋusẽfianu ƒe tɔtrɔ gbɔe wòtso. Míate ŋu aɖu afɔku aɖewo, abe ƒome ŋutinya kple to si me míetso ene dzi o. Ke hã, nanewo li míate ŋu akpɔ:

• Atamanono aɖeke manɔ eme o.
• Ƒo asa na atike aɖewo siwo gblẽa nu le ame ŋu le fufɔɣi.
• Atikewɔmɔnu siwo katã wokafu la xɔxɔ.

Nukae nye (LCH) ƒe ŋgɔdonya?

LCH ƒe mɔkpɔkpɔ nɔ te ɖe nu geɖe dzi:

• Ŋutilã ƒe dɔwɔwɔ alo ŋutinu nenie wògblẽa nu le?
• Ŋutilã ƒe dɔwɔwɔ alo ŋutinu siwo ŋu wògblẽa nu le.
• Alesi dɔlélea wɔa nu ɖe ​​atikewɔwɔ ŋu nyuie.

Zi geɖe la, ɖevi siwo ŋu ɖoɖo ɖeka (LCH) kple ɖoɖo geɖe (LCH) le siwo mekpɔa ŋusẽ ɖe aklã, dɔgbo, alo ƒumeŋuɖui dzi o la dzena le "afɔku sue" ƒe hatsotso me. Ne wowɔ atike na ɖevi siwo le hatsotso sia me la, mɔnukpɔkpɔ si ade 100% kloe be woatsi agbe. Gake dɔlélea ate ŋu agadzɔ ake eye/alo ahe kuxi bubu siwo nɔa anyi didi vɛ.

Ðevi siwo ŋu ʋumenugbagbeviɣidɔ (LCH) si gblẽa nu le aklã, dɔgbo, alo ƒumeŋuɖui ŋu le la dzena le "afɔku gã" ƒe hatsotso me.

Ɣekaɣie wòle be vinyea nayi ɖɔkta gbɔ?

Ne viwòa wu atikewɔwɔ vɔ megbe gɔ̃ hã la, ahiã be ɖɔkta nakpɔ viwòa edziedzi. Esia le alea elabena afɔku si le dɔlélea ƒe gbugbɔgadzɔ me lolo ŋutɔ. Eyata ahiã be woalé ŋku ɖe viwòa ŋu ƒe geɖe. Le dodokpɔ siawo siwo woawɔ atsɔ akplɔe ɖo me la, ahiã be woagawɔ dodokpɔ siwo wowɔ esime wokpɔ dɔlélea le ɖevia ŋu, abe ultrasound, MRI, CT scan, kple PET scan ene, ake. Ðɔktaa agblɔ zi nenie wòle be nàkplɔ viwòa avae.

Nya kawoe wòle be mabia vinye ƒe ɖɔkta?

Ðewohĩ nya geɖe anɔ asiwò ku ɖe dɔléle si wokpɔ le viwò ŋu ŋu. Anyo be nàŋlɔ wo ɖi eye nàtsɔ wo ava wò ɖɔkta gbɔ. Nyabiase aɖewo siwo nàte ŋu abiae nye esi:

• Aleke Langerhans cell histiocytosis akpɔ ŋusẽ ɖe vinye dzii?
• Ðe vinyea hiã atikewɔwɔa?
• Atikewɔwɔmɔnu kawoe li na vinyea?
• Nukawoe nye atikewɔwɔa ƒe nugbegblẽ le ame ŋu?
• Ðe vinyea ada gbe le eŋu keŋkeŋ to atike siawo zazã mea?
• Nukae nye vinye ƒe dɔlélea ƒe mɔkpɔkpɔ?
• Ðe kpekpeɖeŋunaha aɖewo li siwo nàte ŋu akafua?

Mlɔeba la, Gbedasi si Wotsɔ Yi Aƒeme

Langerhans Cell Histiocytosis (LCH) nye dɔléle si mebɔ o si dzea ɖeviwo dzi zi geɖe. Ne viwòa le nusia me tom la, ke ɖewohĩ èle seselelãme geɖe sem. Ðewohĩ àlé blanui ahanɔ vɔvɔ̃m ɖe viwòa ta. Ðewohĩ vɔvɔ̃ ɖo wò ŋutɔ le ememe, gake ɖewohĩ èle agbagba dzem be yeasẽ ŋu le gota. Wò seselelãmewo katã sɔ. Gake ɖo ŋku edzi be mehiã be wò ɖeka nàto mɔzɔzɔ sia me o. Viwòa ƒe atikewɔlawo nya nusi me tom nèle. Wole afima be yewoakpe ɖe ŋuwò le afɔɖeɖe ɖesiaɖe me, be woase viwòa ƒe nɔnɔmea gɔme, eye woana ŋusẽ wò be nànɔ te ɖe enu.

Ðo ŋku edzi be ne èkpɔ dɔlélea kaba eye nèdae nyuie la, ate ŋu ana viwòa nanɔ lãmesẽ me nyuie wu. Mègavɔ̃ o, tsɔ dzideƒo dze ŋgɔ esia.

` Langerhans Cell Histiocytosis, LCH, ɖeviwo ƒe dɔlélewo, kansa, domenyiŋusẽfianu ƒe tɔtrɔ, dzesiwo, atikewɔwɔ