Ðe ami le dodom le wò ŋutilã ƒe akpa vovovowoa? Mina míasrɔ̃ nu tso Lipodystrophy ŋu!

Èkpɔ ami ƒe ɖiɖi kpata le wò ŋutilã ƒe akpa aɖewo, alo ami ƒe dzidziɖedzi si mèdi o le teƒe bubuwo kpɔa? Esia ate ŋu anye nusi womate ŋu asusu o ɣeaɖewoɣi. Egbea míele nu ƒom tso nɔnɔme sia tututu ŋu. Le atikewɔwɔ me la, woyɔa esia be Lipodystrophy . Mègatsi dzi o, togbɔ be ŋkɔa aɖi nusi wɔ nuku hã la, mina míaƒo nu tso eŋu bɔbɔe.

Nukae nye Lipodystrophy?

Kpuie ko la, Lipodystrophy nye ami ƒe bu keŋkeŋ alo eƒe akpa aɖe, nusi míeyɔna zi geɖe be "ami," le teƒe aɖewo, alo ami ƒe ƒoƒo ɖe ŋutilã ƒe akpa vovovowo le mɔ si mesɔ o nu.

Tsɔe be èle lolo dzi ɖem kpɔtɔ le wò ŋutilã ƒe akpa aɖewo, abe wò abɔwo kple afɔwo ene, evɔ ami si sɔ gbɔ ɖe dziwò le teƒewo abe wò mo kple kɔ ene. Esiae nye nusi dzɔna le Lipodystrophy me. Nɔnɔme sia ƒomevi vovovowo li, siwo dometɔ aɖewo nye domenyiŋusẽfianu (i.e., nane si wodzi mí kplii), gake bubuwo hã va dona emegbe le atikewɔwɔ ƒe nɔnɔme bubuwo ta. Wo dometɔ ɖesiaɖe gblẽa nu le amewo ŋu le mɔ vovovowo nu eye dzesi vovovowo le wo ŋu.

Nukatae ami (ami ƒe lãkusi) le vevie na míaƒe ŋutilã alea gbegbe ɖo?

Fifia ɖewohĩ ànɔ eŋu bum be, "Zi alesi ami dzi ɖe kpɔtɔe la, zi nenemae wòanyo wui." Gake le nyateƒe me la, ami ƒe lãkusi wɔa dɔ vevi geɖe le míaƒe ŋutilã me. Kpɔe ɖa:

• Ŋusẽdzraɖoƒe: Ami siawo mee wodzraa nuɖuɖumeŋusẽ si sɔ gbɔ wu si míekpɔna tso nuɖuɖu si míeɖuna me ɖo abe ŋusẽ ene.
• Ametakpɔkpɔ nana: Enaa míaƒe ŋutilã ƒe ŋutinu vovovowo kpɔa ame ta abe akɔtaɖonu ene.
• Dzoxɔxɔ me léle ɖe asi: Eléa ŋutilã ƒe dzoxɔxɔ ɖe te eye wòkpɔa mía ta tso vuvɔ me.
• Lãmetsiŋusẽ ƒe dodo: Lãmetsi vevi geɖewo, abe Leptin ene, dona eye woɖea wo ɖe go yia ʋukawo me.
• Dɔdzẽ dzi ɖuɖu: Ekpena ɖe ame ŋu hã be wòaɖu abi si le ŋutilãa me dzi.

Eyata ne ami sia bu alo ƒu ɖe eme le mɔ si mesɔ o nu le ami ƒe ʋuʋu ta la, menye ɖeko míaƒe dzedzeme trɔna ko o, ke boŋ lãmenugbagbeviwo ƒe dɔwɔwɔ vevi siwo le ŋutilãa me hã gblẽna. Ame geɖe siwo ŋu lipodystrophy le la le afɔku me be woaxɔ dɔlélewo abe suklidɔ ene eye ʋumemi ƒe agbɔsɔsɔ si mesɔ o le woƒe ʋu me.

Ðe lipodystrophy ƒomevi aɖewo lia?

Ẽ, woate ŋu ama Lipodystrophy ɖe hatsotso vevi eve me: domenyiŋusẽfianu kple esi woxɔ.

Domenyiŋusẽfianu ƒe Lipodystrophy Ƒomeviwo

Esiawo nye domenyinu, si fia be ƒomevi siwo dzɔna le domenyiŋusẽfianu ƒe tɔtrɔ ta.

• Congenital General Lipodystrophy (CGL): Esiae nye Berardinelli-Seip ƒe dɔléle.Wogayɔnae be. Esia nye nɔnɔme si mebɔ kura o. Le esia me la, ami si le ŋutilãa me la buna keŋkeŋ kloe alo eƒe akpa gãtɔ buna. Domenyiŋusẽfianu ƒe gbɔdzɔgbɔdzɔ aɖe si nɔa anyi le vidzidzi me gbɔe esia tsona. Zi geɖe la, woate ŋu akpɔ nɔnɔme sia le eƒe agbenɔƒe gbãtɔ me.
• Ƒome ƒe Lãmetsiŋusẽ ƒe Dɔléle (FPLD): Esia hã nye domenyiŋusẽfianu ƒe nɔnɔme. Ke hã, zi geɖe la, wokpɔnɛ le eƒe tsitsime. Le nɔnɔme sia me la, ami meganɔa ɖevia ƒe afɔwo kple abɔwo koŋ me o, eye ami geɖe ƒoa ƒu ɖe mo kple kɔ me.

Lipodystrophy si Xɔa Ƒomeviwo

Esiawo nye ƒomevi siwo dona le mía dzidzi megbe kple le míaƒe agbenɔɣi le susu vovovowo ta.

• Acquired Generalized Lipodystrophy (AGL): Wogayɔnae be Lawrence syndrome , nɔnɔme sia nana ami dzi ɖena kpɔtɔna, zi geɖe le mo, kɔ, abɔ, kple afɔwo me. Ami ƒe ɖiɖi sia ate ŋu adzɔ kabakaba, le kwasiɖa ʋɛ aɖewo megbe, alo vivivi le ɣleti alo ƒe geɖe me. Zi geɖe la, edzea egɔme tso ɖevime alo ƒewuiwo me, gake ate ŋu adzɔ le ƒe ɖesiaɖe me. Nu geɖe li siwo ate ŋu ahe AGL vɛ.
• Acquired Partial Lipodystrophy (APL): Wogayɔnae be Barraquer-Simons syndrome , nɔnɔme sia nana ami si dona le mo, kɔ, abɔ, kple akɔta vivivi le ɖevime. Ami ate ŋu asɔ gbɔ ɖe ame aɖewo hã me le teƒewo abe ƒodo, afɔ, kple akɔta ene. Zi geɖe la , APL do ƒome kple dɔlélenutsiŋutete ƒe nɔnɔmewo .
• Highly active antiretroviral therapy (HAART)-induced lipodystrophy (LD-HIV): Lipodystrophy sia ƒomevi dzɔna ɖe amesiwo ŋu amegbetɔ ƒe dɔlélenutsiŋutete ƒe dɔlékui (HIV) le dzi ne woxɔ dɔlékuiwutike si wɔa dɔ ŋutɔ (HAART) si me HIV-1 protease inhibitors le vɔ . Nɔnɔme sia ƒe dzɔdzɔ nɔ te ɖe atikewɔwɔa ƒe sesẽ kple ɣeyiɣi didi si wòaxɔ dzi. Zi geɖe la, ami si le amesiwo ŋu LD-HIV le la ƒe abɔwo, afɔwo, kple mo dzi ɖena kpɔtɔna vivivi. Ame aɖewo hã ate ŋu ami fũu akpa le woƒe mo, kɔ, akɔta, kple akɔta.
• Localized Lipodystrophy: Esia nye ne ami bu le ŋutilã ƒe akpa sue aɖe ko. Le kpɔɖeŋu me, nɔnɔme sia ate ŋu ado mo ɖa ne wodo atikewo (abe insulin ene) ɖe teƒe ɖeka enuenu. Edzena abe do sue aɖe ene, gake zi geɖe la, ŋutigbalẽ si le edzi la mekpɔa ŋusẽ ɖe edzi o.

Ðe Lipodystrophy kple Lipoatrophy nye nu ɖeka?

Lipodystrophy nye nya si wozãna na ami ƒe mama si mesɔ o. Edo ƒome kple Lipoatrophy , si fia be ami ƒe ɖiɖi hã. Dzɔdzɔmeŋutinunyala kple ɖɔkta aɖewo zãa nya evea siaa tsɔ ɖɔa nɔnɔme ɖeka ma ke. Kpuie ko la, Lipoatrophy nye Lipodystrophy ƒe akpa sue aɖe.

Ameka ŋue nɔnɔme sia gblẽa nu le wu? Aleke gbegbe wòbɔe?

Lipodystrophy ƒomevi akpa gãtɔ dzea egɔme tso ɖevime, gake ƒomevi siwo woxɔ ate ŋu adze egɔme le ame tsitsiwo hã me.

Negbe HAART-induced lipodystrophy (LD-HIV) , koe lipodystrophy si woxɔna ƒomevi bubuwo bɔ ɖe nyɔnuwo me wu. Esi HIV dɔlékuia bɔ ɖe ŋutsuwo me wu ta la, LD-HIV hã bɔ ɖe ŋutsuwo me wu.

Le goawo katã me la, lipodystrophy mebɔ kura o . Gake lipodystrophy ƒomevi siwo woxɔ (le agbemeŋkekewo katã me) va le bɔbɔm ɖe edzi le atike aɖewo ƒe nugbegblẽ le ame ŋu ta.

Aleke lipodystrophy kpɔa ŋusẽ ɖe nye ŋutilã dzii?

Lipodystrophy ƒomevi ɖesiaɖe gblẽa nu le ŋutilãa ŋu le mɔ vovovowo nu, gake nu vevi eve aɖewo li siwo bɔ: ami ƒe bu kple lãmetsi si nye leptin ƒe anyimanɔmanɔ.

Ŋusẽ si ami siwo bu kpɔna ɖe ŋutilãa dzi

Lãmenugbagbevi siwo woyɔna be adipocytes ye le míaƒe ami ƒe lãkusiwo me . Ami ƒe tsitete siwo ade 90% le adipocyte cell ɖesiaɖe me. Ami siawo dzraa ami (triglycerides) ɖo. Ne ami ƒe lãmenugbagbevi siawo gblẽ le ami ƒe ʋuʋu ta la, womete ŋu dzraa ami ɖo nyuie o.

Le Lipodystrophy ƒe dɔléle aɖewo me la, ami sia si bu la nɔa míaƒe ŋutilã ƒe lãkusi bubuwo me vodadatɔe, le kpɔɖeŋu me, aklã, dɔgbo, alo lãmekawo me. Esia ate ŋu ahe lãmesẽkuxiwo abe:

• Aklãdɔléle si me ami le / aklã me steatosis
• Insulin ƒe dɔlélenutsiŋutete kple insulin ƒe agbɔsɔsɔ si dzina ɖe ʋu me (hyperinsulinemia) .
• Suklidɔ (Suklidɔ) .
• Triglycerides ƒe agbɔsɔsɔ si le ʋu me ƒe dzidziɖedzi (hypertriglyceridemia) .
• Dɔgbo ƒe dɔléle
• Lãmetsiŋusẽ ƒe dɔléle
• Coronary ʋukawo ƒe dɔléle

Gake ɖo ŋku edzi be menye amesiame si ŋu lipodystrophy le lae axɔ nɔnɔme siawo o. Wo dometɔ aɖewo ƒe nɔnɔmewo fa wu, gake bubuwo ya ƒe nɔnɔmewo ate ŋu asẽ wu.

Dɔ si Leptin ƒe Agbɔmasɔmasɔ Kpɔna Ðe Ŋutilãa Dzi

Esi ami ƒe lãmekawo buna le amesiwo ŋu ami ƒe ʋuʋu le ŋu la, lãmetsi aɖewo hã buna, vevietɔ lãmetsi si nye leptin .

Leptin nye lãmetsi aɖe si míaƒe ami ƒe lãkusiwo wɔna. Ekpena ɖe mía ŋu míeléa míaƒe kpekpeme si sɔ me ɖe asi le ɣeyiɣi didi aɖe me. Ènya alesi wòawɔea? To nana be míase le mía ɖokui me be míeɖi ƒo eye míaɖu míaƒe dɔwuame dzi. Dzɔdzɔmeŋutinunyalawo gale numekuku wɔm tso leptin ŋu kokoko. Woxɔe se be leptin kpɔa ŋusẽ ɖe míaƒe lãmenugbagbeviwo ƒe dɔwɔwɔ , lãmenugbagbeviwo ƒe dɔwɔwɔ, kple dɔlélenutsiŋutete ƒe dɔwɔwɔ dzi.

Ame siwo ŋu lipodystrophy le ate ŋu akpɔ leptin ƒe agbɔsɔsɔ si dzi ɖe kpɔtɔ, si ate ŋu ahe dɔwuame si gbɔ eme, insulin ƒe dɔmawɔmawɔ nyuie, kple lãmesẽkuxi bubuwo vɛ.

Nukawoe nye lipodystrophy ƒe dzesiwo?

Esi wònye be lipodystrophy ƒomevi geɖe li ta la, dzesiawo hã to vovo ŋutɔ.

Dzesi si bɔ wue nye ami ƒe ɖiɖi si dze ƒã eye wònɔa anyi ɖaa le ŋutilã ƒe akpa aɖewo, evɔ le ɣeyiɣi ma ke me la, ami ƒe ƒoƒo ɖe ŋutilã ƒe akpa bubuwo le mɔ si mesɔ o alo esi womedi o nu.

Le kpɔɖeŋu me, amesiwo ŋu ami ƒe akpa aɖe ƒe ʋuʋu (APL) le la ƒe ami dzi ɖena kpɔtɔna vivivi le woƒe mo, kɔ, abɔwo, kple akɔta le woƒe ɖevime. Ame aɖewo siwo ŋu APL le hã ate ŋu ami ami fũu akpa le teƒewo abe ƒodo, afɔ, kple akɔta ene.

Le lipodystrophy ƒomevi si le ŋuwò kple ƒe si nèxɔ nu la, ɖewohĩ màde dzesi lãmesẽkuxi gã aɖeke o ƒe geɖe. Gake lipodystrophy ƒomevi geɖe nana ʋumemi, triglycerides, kple sukli (glucose) ƒe agbɔsɔsɔ dzina ɖe ʋu me. Wò ɖɔkta ate ŋu ade dzesi esiawo to ʋudodokpɔ edziedzi, abe ʋumemi ƒe akpa aɖe kple lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe akpa vevi aɖe ene me .

Lipodystrophy ƒomevi aɖewo, vevietɔ lipodystrophy ƒe akpa aɖe, ate ŋu asesẽ be woakpɔ. Eya ta ele vevie be nàyi ɖɔkta gbɔ ne dzesi yeyewo va dze wò alo viwòa dzi alo ne dzesi aɖe si li xoxo la gagblẽ ɖe edzi, eɖanye nuka gbɔe wòtso o.

Nukawoe hea lipodystrophy vɛ?

Nusiwo hea lipodystrophy vɛ la toa vovo le domenyiŋusẽfianu alo esi woxɔ nu.

Nusiwo Hea Domenyiŋusẽfianu ƒe Lipodystrophy vɛ

Domenyiŋusẽfianu ƒe lipodystrophy ƒomeviwo – si nye congenital generalized lipodystrophy (CGL) kple family partial lipodystrophy (FPLD) – tso domenyiŋusẽfianu ƒe tɔtrɔ aɖewo gbɔ .

Domenyiŋusẽfianu ƒe tɔtrɔ nye tɔtrɔ le míaƒe DNA ƒe ɖoɖo nu. Míaƒe DNA ƒe ɖoɖoe nye nusi naa nyatakaka siwo míaƒe lãmenugbagbeviwo hiã be woawɔ woƒe dɔwo. Eyata ne DNA ƒe ɖoɖo sia ƒe akpa aɖe mede blibo o alo gblẽ la, míate ŋu adze domenyiŋusẽfianu ƒe dɔléle aɖe ƒe dzesiwo gɔme.

• Nusiwo hea ami ƒe ʋuʋu le ame ŋu le dzidzime me (CGL): domenyiŋusẽfianu siwo nye AGPAT2, BSCL2, CAV1 , kple CAVIN1 ƒe tɔtrɔ gbɔe CGL ƒomevi 1 va ɖo 4 tsona. Domenyiŋusẽfianu siawo le vevie na lãmenugbagbevi siwo dzraa ami ɖo (adipocytes) le míaƒe ami ƒe lãkusi me ƒe tsitsi kple dɔwɔwɔ. Domenyiŋusẽfianu siawo ƒe tɔtrɔ kpɔa ŋusẽ ɖe ami lãmenugbagbeviwo ƒe wɔwɔme kple dɔwɔwɔ dzi. Ðevi si ŋu CGL le nyia domenyiŋusẽfianu ƒe tɔtrɔ siawo dome tso wo dzilawo gbɔ. Ne domenyiŋusẽfianu si trɔ la ƒe kɔpi ɖeka le dzila eveawo siaa si gɔ̃ hã la, zi geɖe la, womeɖea dzesi aɖeke fiana o.
• Nusiwo Hea Ƒome ƒe Ami ƒe Akpaɖekedzimademade (FPLD) vɛ: Dzɔdzɔmeŋusẽ ƒe tɔtrɔ le domenyiŋusẽfianu geɖe me ate ŋu ahe FPLD vɛ. Nusi bɔ wue nye LMNA.Domenyiŋusẽfianu aɖe si woyɔna be LMNA ƒe tɔtrɔ. LMNA domenyiŋusẽfianu kple domenyiŋusẽfianu bubu siwo kpɔa gome le FPLD me fiaa mɔ ami lãmenugbagbeviwo be woadzra ami ɖo eye woawɔ protein vovovo siwo le vevie na ami dzraɖoƒe. Ne domenyiŋusẽfianu siawo dometɔ aɖe ƒe tɔtrɔ aɖe dzɔ la, ekpɔa ŋusẽ gbegblẽ ɖe ami ƒe lãmenugbagbeviwo ƒe tsitsi, woƒe wɔwɔme, alo dɔwɔwɔ dzi. FPLD ƒe dɔléle akpa gãtɔ nyea domenyinyi le autosomal dominant ƒe ɖoɖo nu . Esia fia be domenyiŋusẽfianu si trɔ ƒe kɔpi ɖeka ƒe amesinɔnɔ le lãmenugbagbevi ɖesiaɖe me sɔ gbɔ be wòahe dɔlélea vɛ. Ɣeaɖewoɣi la, amesi ŋu FPLD le nyia tɔtrɔa ƒe dome tso wo dzila siwo ŋu dɔlélea le dometɔ ɖeka gbɔ. Le go bubuwo me la, domenyiŋusẽfianu ƒe tɔtrɔ yeye siwo dzɔ le vome gbɔe wotsona, eye woate ŋu adzɔ ne dɔlélea medze ƒomea me kpɔ o gɔ̃ hã.

Nusiwo Hea Acquired Lipodystrophy vɛ

Atikewo, dɔlélenutsiŋutete ƒe dɔwɔwɔ , alo dɔlélenutsiŋutete gbɔe lipodystrophy si woxɔ ate ŋu atso . Togbɔ be domenyiŋusẽfianu aɖeke meli si dzi woanɔ te ɖo axɔ ami ƒe ʋuʋu tẽ o hã la, numekula aɖewo xɔe se be domenyiŋusẽfianu ate ŋu anɔ ame aɖewo si be woaxɔ ami ƒe ʋuʋu si woxɔ.

• Nusiwo Hea Acquired Generalized Lipodystrophy (AGL) vɛ: AGL ate ŋu adzɔ le dɔléle aɖe xɔxɔ vɔ megbe alo le dɔlélenutsiŋutete ƒe dɔléle aɖe megbe. Dɔlékui siwo wogblɔ be wodo ƒome kple AGL dometɔ aɖewoe nye:
• Koklozi (Koklozi / varicella) .
• Aɖuɖɔtoedɔ
• Kɔdzidede (pertussis) .
• Aɖuɖɔtoedɔléle
• Aklãdɔléle
• Ƒumeŋuɖui ƒe dɔléle
• Nucleosis ɖeka ƒe dɔléle (Mononucleosis / mono) .

Kakaɖedzi mele eŋu be àxɔ AGL le esi dɔlékui siawo le ŋuwò ta ko o.

Dɔlélenutsiŋutete ƒe nɔnɔme siwo do ƒome kple AGL dometɔ aɖewoe nye:

• Dɔlélenutsiŋutete ƒe ʋumenugbagbeviɣidɔ
• Aklãdɔléle si dɔlékuiwutikewo ƒe dɔlélenutsiŋutete wɔna
• Ðeviwo ƒe ŋutigbalẽ ƒe dɔléle
• Lãmetsiŋusẽ ƒe ƒunukpeƒetetedɔ
• Sjogren ƒe dɔlélea
• Ʋusɔgbɔdɔ si tsoa dɔlélenutsiŋutete gbɔ

Ne dɔlélenutsiŋutete ƒe dɔléle siawo le ŋuwò la, womate ŋu agblɔ be àxɔ AGL godoo o.

Zi geɖe la, womate ŋu ade dzesi nusi gbɔ AGL tsona o (idiopathic).

• Nusiwo Hea Acquired Partial Lipodystrophy (APL) vɛ: Dzɔdzɔmeŋutinunyalawo xɔe se be míaƒe dɔlélenutsiŋutete si gblẽa ami ƒe lãmenugbagbeviwo vodadatɔe gbɔe APL tsona. Ame siwo ŋu APL le ƒe 80% kple edzivɔ ƒe ʋu me Complement 3 le .Protein aɖe si woyɔna be complement factor ƒe agbɔsɔsɔ sue aɖe le eme. Zi geɖe la, protein sia kpɔa gome le míaƒe dɔlélenutsiŋutete ƒe dɔwɔwɔ me. Zi geɖe la, autoantibody si woyɔna be complement 3-nephritic factor nɔa amesiwo ŋu APL le ƒe ʋu me. Autoantibody nye protein si le dɔlélenutsiŋutete me si dzea lãmeka siwo le lãmesẽ me dzi vodadatɔe hegblẽa nu le wo ŋu.

• Nusiwo hea ami ƒe ʋuʋu si tsoa dɔlékuiwutike si wɔa dɔ ŋutɔ (HAART) vɛ (LD-HIV): Dzɔdzɔmeŋutinunyalawo meka ɖe nusita HAART, si me HIV-1 protease inhibitors le la dzi haɖe o.

Nya nyuiae nye be mehiã be ame akpa gãtɔ siwo dzea HIV dɔdamɔnu gɔme fifia la natsi dzi fũu ɖe ami ƒe ʋuʋu ŋu o, elabena HIV-tike yeyewo nana be nɔnɔmea megadzɔna o.

Aleke nàwɔ anya ne lipodystrophy le ŋuwò?

Ne lipodystrophy ƒe dzesiwo le ŋuwò la, wò ɖɔkta ado wò ŋutilã kpɔ, abia wò atikewɔwɔ ŋutinya kple ƒomea ƒe atikewɔwɔ ŋutinya, eye emegbe wòaɖe gbe be woawɔ dodokpɔ aɖewo atsɔ aɖo kpe dɔlélea dzi ahakpɔe ɖa be nu bubuwo hã li siwo gbɔ wò dzesiawo tso hã.

Dodokpɔ kawoe wozãna tsɔ nyaa lipodystrophy?

Wò ɖɔkta ate ŋu aɖe gbe be woawɔ dodokpɔ geɖe atsɔ anya ami ƒe ʋuʋu kple/alo akpɔe ɖa be nu bubuwo hã li siwo gbɔ wò dzesiawo tso hã. Esiawo dometɔ aɖewoe nye:

• Full-body MRI (Magnetic Resonance Imaging) scan: MRI zãa magnet gã aɖe, radio ƒutsotsoewo, kple kɔmpiuta tsɔ wɔa ŋutinuwo kple nu bubu siwo le wò ŋutilã me ƒe nɔnɔmetata tsitotsito. Wò ɖɔkta ate ŋu aɖe gbe be woawɔ dodokpɔ sia atsɔ akpɔ ami ƒe wɔwɔme kple eƒe mama le wò ŋutilã me.
• Comprehensive Metabolic Panel: Esia nye ʋudodokpɔ si me wodzidzea nu vovovo 14 siwo le wò ʋu me. Enaa nyatakaka veviwo tso wò ŋutilã ƒe atikewo ƒe dadasɔ kple lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu. Ðɔktaa alé ŋku ɖe wò ʋumesukli (glucose) ƒe agbɔsɔsɔ kple aklã me enzymewo ŋu koŋ .
• Lipid Panel: Esia hã nye ʋudodokpɔ. Edzidzea ami ƒe molecule siwo woyɔna be lipids ƒe agbɔsɔsɔ le wò ʋu me. Zi geɖe la, dodokpɔ sia lɔa ʋumemi ƒe dzidzenu ene kple triglyceride dzidzedze ɖe eme. Zi geɖe la, lipodystrophy nana ʋumemi ƒe agbɔsɔsɔ si mesɔ o.
• Leptin Dodokpɔ: Esia dzidzea leptin ƒe agbɔsɔsɔ le wò ʋu me. Ne lipodystrophy le ŋuwò eye wò leptin ƒe agbɔsɔsɔ le ʋɛ wu alesi wòle dzɔdzɔmee la, esia ate ŋu ana nàkpɔ alesi wò ŋutilã awɔ nui ɖe leptin ɖɔliɖɔli ƒe atikewɔwɔ ŋu.
• Domenyiŋusẽfianu Dodokpɔ: Ne wò ɖɔkta susui be Lipodystrophy ƒomevi aɖe si ƒe dome nènyi (domenyiŋusẽfianu) le ŋuwò la, ate ŋu aɖo aɖaŋu be nàdo domenyiŋusẽfianu kpɔ atsɔ aɖo kpe dɔlélea dzi.
• Ayiku me lãmenugbagbeviwo ɖeɖe:Esia bia be woaɖe ayiku ƒe lãkusi aɖe ɖa to amekoko me ahadoe kpɔ le nusuekpɔmɔ̃ me. Wò ɖɔkta ate ŋu aɖe gbe be woado wò ayikuwo kpɔ be ami ƒe ʋuʋu gblẽ nu le wò ayikuwo ŋu hã.

Nukawoe nye atike siwo wozãna na ami ƒe ʋuʋu?

Lipodystrophy dada kple edzikpɔkpɔ nɔ te ɖe ƒomevi tɔxɛ si le ŋuwò dzi, kple nenye be dɔléle bubu siwo do ƒome kplii, abe suklidɔ alo ʋumemi ƒe agbɔsɔsɔ si mesɔ o ene le ŋuwò.

Atike siwo wozãna zi geɖe tsɔ kpɔa ami ƒe ʋuʋu gbɔe nye:

• Atike si woatsɔ aɖɔli leptin: Wò ɖɔkta ate ŋu aŋlɔ lãmetsi si nye leptin si wowɔ si woyɔna be metreleptin . Zi geɖe la, leptin mesɔ gbɔ ɖe amesiwo ŋu ami ƒe ʋuʋu le o la me. Lãmetsi sia kpena ɖe ŋutilãa ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu nyuie eye ate ŋu aɖe ʋumemi kple triglyceride ƒe agbɔsɔsɔ si sɔ gbɔ hã dzi akpɔtɔ.
• Suklidɔ kple insulin ƒe dɔmawɔmawɔ nyuie ƒe atikewɔwɔ: Ne insulin ƒe dɔlélenutsiŋutete kple/alo suklidɔ le ŋuwò le ami ƒe ʋuʋu ta la, wò ɖɔkta ate ŋu aŋlɔ atike siwo woano abe pioglitazone, metformin, sulfonylureas , alo thiazolidinediones ene na wò be nàtsɔ adae. Ðewohĩ ahiã be ame aɖewo siwo ŋu lipodystrophy le hã nano insulin si wowɔ atsɔ ada woƒe suklidɔa. Ðewohĩ ahiã hã be nàtsɔ suklidzidzenu akpɔ wò ʋumesukli ƒe agbɔsɔsɔ edziedzi le aƒeme .
• Triglyceride kple ʋumemi ƒe agbɔsɔsɔ dzi ɖuɖu: Zi geɖe la, atike siwo woano siwo kpena ɖe ame ŋu wòdaa suklidɔ ate ŋu akpe ɖe ame ŋu wòaɖu ʋumemi ƒe agbɔsɔsɔ dzi. Wò ɖɔkta ate ŋu aŋlɔ statinwo abe rosuvastatin kple pravastatin ene hã na wò . Ðewohĩ ahiã be amesiwo me triglyceride sɔ gbɔ ɖo nano fibric acid derivatives alo n-3 polyunsaturated fatty acids , abe esiwo le tɔmelãmi me ene, ƒe kpeɖeŋutɔ.
• Atsyɔ̃ɖoɖo ƒe amekoko kple dɔdamɔnu: Ame siwo ŋu ami ƒe ʋuʋu le le teƒe siwo atsyɔ̃ɖoɖo ƒe akpa aɖewo le, abe mo, akɔta, kple vidzinuwo ene, ate ŋu awɔ atsyɔ̃ɖoɖo ƒe dɔ na wo be woƒe dzedzeme nanyo ɖe edzi eye woaka ɖe wo ɖokui dzi. Amekola siwo wɔa ami ate ŋu awɔ ami ƒe lãmeka siwo le wo ɖokui si ƒe dodo, mo gbugbɔgatu to aŋekotoku siwo me woɖea mɔ le zazã me, kple silicone alo nu bubu siwo wotsɔ dea ame me. Woateŋu azã amiɖeɖe alo amekoko ƒe mɔnuwo hã atsɔ aɖe ami siwo womedi o ɖa le teƒewo abe asike alo kɔ megbe (si woyɔna zi geɖe be "buffalo hump" ).

Nu geɖe gale dzɔdzɔmeŋutinunyalawo si woasrɔ̃ tso alesi woada ami ƒe ʋuʋu kple alesi woakpɔ egbɔe ŋu. Ne wole nu geɖe kpɔm tso alesi lãmenugbagbeviwo ƒe dɔwɔwɔ sesẽe ŋu la, atikewɔmɔnu geɖe ate ŋu ava.

Ðe woate ŋu axe mɔ ɖe lipodystrophy nua?

Zi geɖe la, womate ŋu axe mɔ ɖe Lipodystrophy nu o.

Womate ŋu axe mɔ ɖe domenyiŋusẽfianu ƒe lipodystrophy nu o, elabena domenyiŋusẽfianu ƒe tɔtrɔ si ƒe dome wonyi gbɔe wotso. Ne èle ɖoɖo wɔm be yeadzi vi la, se afɔku si le vi si ŋu domenyiŋusẽfianu ƒe dɔléle aɖe le dzidzi me gɔme eye nàƒo nu kple wò ɖɔkta tso domenyiŋusẽfianu dodokpɔ ŋu.

Zi geɖe la, dɔlékui alo dɔlélenutsiŋutete ƒe dɔléle gbɔe lipodystrophy si woxɔna tsona. Togbɔ be woate ŋu axe mɔ ɖe dɔlékui aɖewo abe koklozi kple kɔdzidɔ ene to atikewɔmɔnu me hã la, womate ŋu axe mɔ ɖe dɔlékui bubuwo kple dɔlélenutsiŋutete ƒe dɔléle siwo do ƒome kple ami ƒe ʋuʋu si woxɔna nu o.

Nukae nye lipodystrophy ƒe ŋgɔdonya?

Mɔkpɔkpɔ na lipodystrophy nɔ te ɖe lipodystrophy ƒomevi si le asiwò dzi koŋ, kple nenye be nɔnɔme alo kuxi bubu siwo do ƒome kplii, abe suklidɔ, aklã alo ayiku ƒe kuxiwo ene le ŋuwò.

Atsyɔ̃ɖoɖo ƒe ɖɔɖɔɖo le teƒe siwo ami mesɔ gbɔ ɖo o kple teƒe siwo ami sɔ gbɔ ɖo kpena ɖe amesiwo ŋu ami ƒe ʋuʋu le ƒe agbenɔnɔ nyona ɖe edzi.

Ne wokpɔ be ami ƒe ʋuʋu le ŋuwò alo viwòa la, ƒo nu kple wò ɖɔkta tso nusi nàkpɔ mɔ na kple alesi nàwɔ akpɔ dɔlélea gbɔ nyuie wu ŋu.

Ɣekaɣie wòle be nàkpɔ ɖɔkta tso ami ƒe ʋuʋu ŋu?

Ne ède dzesii be wò alo viwò ƒe ŋutilã me ami yi edzi le ɖiɖim le teƒe aɖewo koŋ, alo be ami le dzidzim ɖe edzi le teƒe aɖewo la, ƒo nu kple wò ɖɔkta.

Ne wokpɔe be Lipodystrophy le ŋuwò alo viwòa ŋu la, ele be nàdo go kple wò atikewɔlawo ƒe ƒuƒoƒoa edziedzi akpɔ egbɔ be wò atikewɔwɔa le dɔ wɔm nyuie na wò.

Mlɔeba la, nu siwo dzi wòle be woaɖo ŋkui

Lipodystrophy nye dɔléle si mebɔ o gake wòsẽa ŋu ŋutɔ. Togbɔ be atike aɖeke meli o hã la, atikewɔwɔ aɖewo ate ŋu akpe ɖe ame ŋu woakpɔ eƒe dzesiwo kple nɔnɔme siwo do ƒome kplii, abe suklidɔ kple ʋumemi ƒe agbɔsɔsɔ si mesɔ o ene gbɔ.

Atikewɔwɔ to vovo ŋutɔ tso ame ɖeka gbɔ yi bubu gbɔ. Eyata wò atikewɔlawo ƒe ƒuƒoƒoa awɔ dɔ kpli wò awɔ ɖoɖo si anyo na wò. Mègavɔ̃ be yeabia nya wò ɖɔkta o. Wole afima be yewoakpe ɖe ŋuwò. Sidzedze sia akpe ɖe ŋuwò godoo be nànɔ agbe si me lãmesẽ le!

` lipodystrophy, ami ƒe lãkusi, leptin, domenyiŋusẽfianu, si woxɔ, suklidɔ, ʋumemi, triglyceride, HIV, lãmenugbagbeviwo ƒe dɔwɔwɔ ƒe dɔlélewo