Ðe wò ʋumenugbagbevi dzĩwo ƒe xexlẽme sɔ gbɔ afɔkutɔea? Mina míaƒo nu tso Polycythemia Vera (PV) ŋu!

Ðe ɖeɖi tea ŋuwò zi geɖe, ɣeaɖewoɣi la, èsena le ɖokuiwò me be yeƒe towo le ɖiɖim, alo ɖeko nèsea ɖiɖi le wò to mea? Togbɔ be nusiawo adze abe nusiwo sɔ ene hã la, ɣeaɖewoɣi la, susu bubu aɖe ate ŋu anɔ megbe na wo. Eyata, dɔléle si ŋu míele nu ƒom tsoe egbea enye Polycythemia Vera (PV) , si nye nɔnɔme si ʋumenugbagbevi dzĩwo ƒe wɔwɔ fũ akpa le míaƒe ŋutilã me hena vɛ. Togbɔ be ŋkɔ didi aɖee nye esia vie hã la, mina míase egɔme bɔbɔe.

Nukae nye Polycythemia Vera (PV)? Kpuie ko la,...

Kpuie ko la, Polycythemia Vera (PV) nye nɔnɔme si me wò ŋutilã, vevietɔ wò ƒumeŋuɖui (si míeyɔna be ``ƒumeŋuɖui''), wɔa ʋumenugbagbevi dzĩ geɖe wu alesi wòle be wòawɔ . Abe alesi ʋuwo xaxa ene la, ne ʋuwo sɔ gbɔ akpa le mɔa dzi la, ʋu ƒe sisi va xea mɔ na ʋumenugbagbevi dzĩwo le míaƒe ŋutilã me akpa. Esia wɔnɛ be ʋua tsina eye wòzɔna blewu. Esia nana ʋu ƒe sisi ƒe afɔkua dzina ɖe edzi. Esia ate ŋu ahe nɔnɔme sesẽwo abe dzidɔ kple ʋusɔgbɔdɔ ene vɛ .

Menye esia ɖeɖeko o, ɣeaɖewoɣi la, dzesiwo abe ŋutigbalẽ ƒe ʋuʋu, to ƒe ɖiɖi (`(Tinnitus)`), dɔgbo ƒe vevesese, ŋɔti me ʋu, kple nukpɔkpɔ si me mekɔ o hã ate ŋu ado mo ɖa.

Polycythemia Vera (PV) nye dɔléle si nɔa anyi didi si womate ŋu ada keŋkeŋ o. Gake mègatsi dzi o. Ne èwɔ atike nyui na wò la, àte ŋu aɖu dzesiawo dzi eye nàɖe afɔku si le eƒe nugbegblẽ le ame ŋu me dzi akpɔtɔ. Ame aɖewo hã yɔnɛ be `ʋumenugbagbevi geɖe ƒe dɔléle gbãtɔ`, `ʋumenugbagbevi geɖe ƒe ʋumenugbagbeviɣi rubra vera`, `erythema` kple `Osler-Vaquez dɔléle`.

Ðe Polycythemia Vera (PV) nye kansaa?

Ẽ, esia nye kansa ƒomevi aɖe vavã. Gake menye nu sesẽ alo kaka kabakaba abe alesi míasusui ne míese nya kansa ene o. Esia nye ʋumenugbagbeviɣidɔ si le ƒuƒoƒo aɖe si woyɔna be `myeloproliferative neoplasm (MPN) me. `MPN` fia dɔlélewo ƒe ƒuƒoƒo si nana ʋumenugbagbevi ƒomevi vovovowo dzina fũ akpa.

Nu vevitɔ si gbɔ Polycythemia Vera (PV) tsonae nye tɔtrɔ (trɔtrɔ) le domenyiŋusẽfianu aɖe me le míaƒe ŋutilã me. Esia menye nusi wodzi mí kplii o, ke boŋ nusi dzɔna le míaƒe agbe me le susu aɖe si míenya o ta. Dɔléle sia doa mo ɖa blewu ŋutɔ. Zi geɖe la, wokpɔnɛ le ƒe 60 xɔxɔ vɔ megbe. Ƒã hafi kansa sia nana ame kuna tẽ. Afɔku vevitɔ tso kuxi siwo ʋu ƒe sisi hena vɛ gbɔ. Azɔ hã, le alafa memamã sue aɖe ko me la, ate ŋu atrɔ azu ʋumenugbagbeviɣidɔ sesẽ bubuwo.

Ameka dzie nɔnɔme sia gblẽ nu le wu?

Polycythemia Vera (PV) nye dɔléle si mebɔ kura o. Le dukɔ abe United States ene me la, edzena le ame siwo ade 50 le ame 100,000 ɖesiaɖe me. Ame siwo xɔ wu ƒe 60 mee wòbɔ ɖo wu.

Aleke dɔléle sia gblẽa nu le míaƒe ŋutilã ŋui?

Abe alesi míegblɔe va yi ene la, Polycythemia Vera (PV) nana ŋutilãa wɔa ʋumenugbagbevi dzĩwo fũ akpa. Lãmenugbagbeviwo ƒe agbɔsɔsɔ fũ alea nana ʋudodo, abi, kple ʋu ƒe sisi ƒe afɔkua dzina ɖe edzi. Esi ʋua ƒoa ke eye wòzɔna blewu ta la, míaƒe ŋutilã ƒe lãkusiwo kple ŋutinuwo mekpɔa ɔksidzin si wohiã o.

Esia hã dea dɔ geɖe míaƒe ŋutilã ƒe dɔgbo me. Dɔ vevi siwo dɔgboa wɔna dometɔ ɖekae nye be wòaɖe ʋu ahaɖe ʋumenugbagbevi xoxowo ɖa. Ne ʋumenugbagbevi dzĩwo dzi ɖe edzi la, dɔgboa hã wɔa dɔ fũu akpa, si ate ŋu ana wòavuvu eye wòase veve. Woyɔa esia be `(Splenomegaly)`. Le ɣeyiɣi aɖe megbe la, nɔnɔme sia ate ŋu ahe dzesi vovovo siwo me dzidzeme mele o vɛ. Azɔ hã, PV ate ŋu ahe nɔnɔme evelia bubuwo vɛ.

Afɔku kple kuxi kawoe le Polycythemia Vera (PV) ŋu?

Togbɔ be PV nye dɔléle si yia ŋgɔ hã la, afɔku li be ʋu natsi kpata le ʋumenugbagbeviwo ƒe dzidziɖedzi fũ ta. Le ɣeyiɣi aɖe megbe la, PV ate ŋu ahe nɔnɔme evelia bubuwo hã vɛ. Ƒã ŋutɔ hafi ate ŋu ava zu kansa sesẽ.

Ʋu ƒe sisi

Esiae nye afɔku vevitɔ kple esi ate ŋu adzɔ enumake wu le PV me. Ne ʋu ƒe sisi va dzɔ eye wòzɔ mɔ yi dzi alo ahɔhɔ̃a me la, ate ŋu ana dzidɔ alo ʋusɔgbɔdɔ nadze ame dzi . Ne ezɔ mɔ yi lãkusi me (Pulmonary Embolism - PE), ateŋu ahe ʋusɔgbɔdɔ vɛ le lãkusi me (aklã me ʋusɔgbɔdɔ) eye dzi nawɔ dɔ nyuie. Ne ʋu ƒe sisi tsi ʋuka aɖe me (Venous Thromboembolism - VTE) la, ate ŋu ana lãmenugbagbeviwo naku alo ʋukawo ƒe dɔmawɔmawɔ nyuie atraɖii. Ne ʋu ƒe sisi tsi ʋuka vevitɔ si yi aklã me (aklã ƒe ʋuka me ʋu ƒe sisi) la, ate ŋu ana ʋu natsi aklã me (Budd-Chiari syndrome), ʋusɔgbɔdɔ kple aklã ƒe dɔmawɔmawɔ nyuie.

Nɔnɔme evelia

Ne ʋumenugbagbevi dzĩwo dzɔ wògbɔ eme eye wogbã la, `uric acid` ƒe agbɔsɔsɔ le ŋutilã me dzina ɖe edzi. Esia ate ŋu ahe kuxi geɖe vɛ:

• Ayiku me kpewo: Ne uric acid ƒo ɖe ayiku me.
• Gout: Ƒunukpeƒetetedɔ si me vevesese le si dzɔna ne uric acid ƒo ƒu ɖe ƒunukpeƒewo.
• Dɔgbo me abi: Ʋumenugbagbevi dzĩ siwo sɔ gbɔ ɖe eme hã dzia dɔgbo me acid ƒe agbɔsɔsɔ ɖe edzi. Ʋumenugbagbevi dzĩ siwo sɔ gbɔ wu la nana ŋutilãa ɖea atike aɖe si woyɔna be histamine, si hã nana dɔgboa wɔa acid geɖe wu tsɔ wɔa avu kple dɔlékuia. Amesiwo ŋu PV le ate ŋu axɔ dɔgbo me abi (peptic ulcer disease) abe zi gbɔ zi ene ene.

Trɔ ɖe Ʋumenugbagbeviɣidɔ ŋu

Polycythemia Vera nye ƒumeŋuɖui me kansa, gake zi geɖe la, menye dɔléle si ate ŋu ade ame ƒe agbe afɔku me o. Ne wodae nyuie la, woate ŋu akpɔ edzi nyuie ƒe geɖe. Gake le ame aɖewo gome la, PV ate ŋu, togbɔ be ƒã hafi, .Ateŋu atrɔ azu ʋumenugbagbeviɣidɔ sesẽ aɖe abe `Acute Leukemia` ene.

Polycythemia Vera (PV) Dɔléle ƒe Afɔɖeɖewo

PV dɔlélea yia ŋgɔ ale:

• Gbãtɔ ƒe akpa (`Early PV`): Le afɔɖeɖe sia me la, dzesi ʋɛ aɖewo koe dzena alo womedzena kura o.
• PV ƒe ŋgɔyiyi: Ne PV le sesẽm ɖe edzi la, àte ŋu adze dzesi siwo meɖea fu na ame o gɔme, alo nɔnɔme evelia ate ŋu ado mo ɖa.
• Akpa si wozã: Woyɔa esia be “akpa si wozã.” Le ɣeyiɣi sia me la, ʋumenugbagbevi siwo mesɔ o siwo hea dɔlélea vɛ la dzina ɖe edzi eye woxea mɔ na ƒumeŋuɖui, si wɔa ʋumenugbagbeviwo la keŋkeŋ. Ne lãmenugbagbevi siawo siwo mesɔ o ku la, abi ƒe lãkusiwo dzɔna ɖe wo teƒe. Ne abi sia yɔ ƒumeŋuɖui akpa gãtɔ me la, mete ŋu wɔa ʋumenugbagbevi siwo le lãmesẽ me o. Nukutɔe la, esia hea ʋusɔgbɔdɔ vɛ – ʋumenugbagbevi dzĩ siwo le lãmesẽ me ƒe anyimanɔmanɔ. Enaa ʋudodo ƒe afɔkua hã dzina ɖe edzi.

Ʋumedɔ bubu siwo ate ŋu ado mo ɖa le PV megbe

Ne PV nu sẽ la, ate ŋu ahe ʋumedɔ bubuwo vɛ.

• Myelofibrosis (MF): Vovototo boo aɖeke mele PV ƒe ``afã si wozã'' kple ``Myelofibrosis (MF)'' , si nye ʋumekansa ƒomevi bubu dome o. Ðɔkta aɖewo bua wo nenema ke. ``Myelofibrosis'' nye ne lãmenugbagbevi siwo mesɔ o wɔ abi ƒe lãkusi le ƒumeŋuɖui me eye woyɔe fũ. Lãmenugbagbevi siawo siwo mesɔ o ate ŋu akaka ɖe ƒumeŋuɖui godo kple ŋutilã ƒe akpa bubuwo. ``MF'' hã nye ``myeloproliferative disorder.'' ``MF'' dɔnɔ siwo ade 10% xɔa ``Acute Myeloid Leukemia.''
• Myelodysplastic Syndrome (MDS): Ƒã ŋutɔ hafi PV ate ŋu ava zu nɔnɔme si woyɔna be Myelodysplastic Syndrome (MDS) . Esia nye nɔnɔme si me ʋumenugbagbeviwo metsina nyuie o, tsina le mɔ si mesɔ o nu, eye wokuna kabakaba. Ŋutilã mete ŋu wɔa lãmenugbagbevi siwo le lãmesẽ me, siwo tsi nyuie o, si wɔnɛ be ʋumenugbagbevi ƒomevi vovovowo ƒe xexlẽme dzi ɖena kpɔtɔna. MDS nu sẽ wu PV alo MF, eye afɔku 30% le eme be wòaxɔ Acute Myeloid Leukemia (AML).
• Acute Myeloid Leukemia (AML): Ame siwo ŋu Polycythemia Vera le la dometɔ siwo ade 3% xɔa Acute Myeloid Leukemia (AML) le ƒe 10 me tso esime wokpɔ dɔlélea. AML nye ʋumenugbagbeviɣidɔ sesẽ aɖe si dzea egɔme tso ƒumeŋuɖui me eye ate ŋu akaka kabakaba ayi ʋua me eye emegbe wòakaka ɖe ŋutilã ƒe akpa bubuwo. Ebia be woawɔ atike nɛ kaba, gake mɔnukpɔkpɔ si li be wòatsi agbe la lolo ŋutɔ.

Nukae nye Polycythemia Vera (PV) ƒe dzesiwo?

Zi geɖe la, dzesiawo dzena blewu ŋutɔ, eye ɣeaɖewoɣi la, ɖewohĩ dzesi aɖeke manɔ wo ŋu kura o. Gbã la, dzesi siwo me mekɔ o siwo bɔ ɖe dɔléle geɖe me lae nye:

• Taɖuame.
• Taɖuame.
• Ɖeɖiteameŋu.
• Ʋusɔgbɔdɔ.
• Nukpɔkpɔ si me mekɔ o alo nukpɔkpɔ eve.
• Towo ƒe ɖiɖi sese (`(Tinnitus)`).

Le ɣeyiɣi aɖe megbe la, dzesi siwo le tẽ wu ate ŋu adze:

• Fifia, vevietɔ le zã me.
• Gbɔgbɔ sesẽ, vevietɔ ne mlɔ anyi.
• Ŋutilã si le ƒoƒom, vevietɔ le tsi dzodzoe me tsilele vɔ megbe. (Esia nye PV ƒe dzesi aɖe si le tẽ vie)
• Afɔwo biã, dzoxɔxɔ, lãmetutudɔ, alo dzobibi le abɔwo me.
• Ʋu si le dodom alo abi si le dodom fũu akpa.
• Ʋu si dona le ŋɔti kple aɖuwo me.
• Be woanye ame tsɛ le susu aɖeke manɔmee.

Ne PV va nu sẽ eye wòyi ŋgɔ va zu nɔnɔme evelia la, dzesi siwo do ƒome kplii hã ate ŋu ado mo ɖa. Le kpɔɖeŋu me:

Splenomegaly ƒe Dzesiwo:

• Vevesese aɖe abe nane ene tsi ƒodoa ƒe miame ƒe akpa si le etame.
• Nuteƒekpɔkpɔ si yɔa dɔgbo me fũ.
• Ne meɖu nu vie gɔ̃ hã la, meɖi ƒo.

Dɔgbo me abi ƒe dzesiwo (`Peptic ulcer disease`):

• Vevesese si va kpena ɖe dɔgbo ƒe veve ŋu.
• Dzimeveve.
• Acid ƒe ʋuʋu.

Gout ƒe dzesiwo:

• Ƒunukpeƒewo ƒe vuvu si me vevesese le.
• Ƒunukpeƒewo ƒe sesẽ.
• Afɔbidɛ gã la ƒe vuvu.

Ayiku me kpewo ƒe dzesiwo:

• Vevesese le ƒodo ƒe akpa si le ete alo axadzi.
• Vevesese ne wole aɖuɖɔ tom.
• Ehiã be nàɖe aɖuɖɔ enuenu.

Budd-Chiari ƒe dɔlélea ƒe dzesiwo:

• Aklã vuvu, vevesese le ƒodo ƒe ɖusime ƒe akpa si le etame, kple ʋuʋudedi.
• Ŋku kple ŋutigbalẽ ƒe ɣie (jaundice).
• Ascites kple Edema ƒe dɔléle.

Deep Vein Thrombosis (DVT) ƒe Dzesiwo:

• Abɔ alo afɔ ƒe vuvu kple vevesese ne woka asi eŋu.
• Dzo alo dzoxɔxɔ le teƒe ma.
• Ʋuka siwo le dodom ƒe dzedzeme le ŋutigbalẽa ƒe gowo dzi.

Ʋu ƒe sisi le lãkusi me ƒe dzesiwo (Pulmonary Embolism - PE):

• Akɔtave kpata.
• Yagbɔgbɔ kpuie.
• Dzi ƒe tsotso dzina ɖe edzi.

Ʋusɔgbɔdɔ ƒe dzesiwo (le PV dɔlélea ƒe nuwuwu):

• Taɖuame (vertigo) ƒe taɖuame.
• Ŋutilã si ƒe ŋutigbalẽ le ɣie.
• Ɖeɖiteameŋu.

Nukae hea Polycythemia Vera (PV) vɛ?

Polycythemia Vera (PV) dzea egɔme tso míaƒe ƒuwo ƒe akpa falɛfalɛ si le abe ƒumeŋuɖui ene si woyɔna be ƒumeŋuɖui la me. Afi siae wowɔa ʋumenugbagbevi yeyewo le. PV dzea egɔme kple domenyiŋusẽfianu ɖeka ƒe tɔtrɔ le lãmenugbagbevi ɖeka me le ƒumeŋuɖui me. Ɣeyiɣi siwo wu 90% la, tɔtrɔ sia nɔa domenyiŋusẽfianu si woyɔna be JAK2 me.

Domenyiŋusẽfianu sia si trɔna la gblɔna na lãmenugbagbevi si nye lãmenugbagbevi la be wòayi edzi anɔ vi dzim. Lãmenugbagbevi ɖesiaɖe si wowɔ la yi edzi le eɖokui gbugbɔm. Mlɔeba la, lãmenugbagbevi siawo siwo mesɔ o la yɔa ƒumeŋuɖui me fũ, si wɔnɛ be teƒe aɖeke meganɔa lãmenugbagbevi siwo sɔ la si o.

Zi geɖe la, `JAK2` domenyiŋusẽfianu ƒe tɔtrɔ sia menye nusi ƒe dome míenyi o. Enye nusi dzɔna le agbe me, le susu siwo womenya o ta. Gake ƒã ŋutɔ la, wogblɔ be ƒomea me tɔ geɖe xɔ PV.

Aleke wokpɔa dɔléle si nye Polycythemia Vera (PV)?

Xexeame ƒe Lãmesẽ Habɔbɔ (WHO) do susu vevi etɔ̃ siwo dzi woato anya Polycythemia Vera (PV) ƒe dɔlélea ɖa. Ele be ɖɔkta naɖo kpe dzidzenu etɔ̃awo katã dzi.

Dzeside 1: Ʋudodokpɔ si me ʋumenugbagbevi dzĩwo sɔ gbɔ ɖo:

Woate ŋu adzidze ʋumenugbagbevi dzĩwo:

• Hemoglobin (protein si le ʋumenugbagbevi dzĩwo me) ƒe agbɔsɔsɔ si sɔ gbɔ .
• Hematocrit ƒe agbɔsɔsɔ si sɔ gbɔ (ʋumenugbagbevi dzĩ siwo le ʋua me ƒe alafa memamã).
• Ʋu ƒe agbɔsɔsɔ si sɔ gbɔ (ʋumenugbagbevi dzĩwo ƒe agbɔsɔsɔ).

Dzeside 2: Ƒumeŋuɖui ƒe lãmenugbagbeviwo ɖeɖe si ɖe nusiwo gbɔna dometɔ ɖeka fia:

• Ʋumenugbagbevi geɖe akpa le ƒumeŋuɖui me, alo
• Megakaryocytes (lãmenugbagbevi siwo wɔa ʋumenugbagbevi dzĩwo) tsitsiwo ƒe anyinɔnɔ fũ.

Dzeside 3: Woate ŋu aɖo dzidzenu etɔ̃lia gbɔ ne woɖe eve siawo dometɔ ɖesiaɖe fia:

• JAK2 domenyiŋusẽfianu ƒe tɔtrɔ ƒe anyinɔnɔ to molecule dodokpɔ me, alo
• Ʋudodokpɔ ɖo kpe edzi be `erythropoietin' (lãmetsi si doa ŋusẽ ayikuwo be ʋumenugbagbevi dzĩwo nawɔ) ƒe agbɔsɔsɔ le ʋua me le sue ŋutɔ.

"Ðɔkta aɖe alé ŋku ɖe nusiawo katã ŋu be yeagblɔ na wò tututu nenye be Polycythemia Vera le ŋuwò alo mexɔe o. Eyata ne dzesi aɖewo le ŋuwò la, anyo wu be nàkpɔ ɖɔkta eye nàxɔ aɖaŋuɖoɖo."

Aleke wowɔa atike na Polycythemia Vera (PV)?

Le PV ƒe gɔmedzedze la, edada le bɔbɔe vie. Dɔdamɔnu siwo bɔ dometɔ aɖewoe nye:

Phlebotomy (ʋu ƒe dodo) .

Esiae nye atike vevitɔ kple esi bɔ wu na PV. Wowɔa esia le mɔ ma ke nu abe alesi nàdo ʋu ene. Lãmesẽdɔwɔla dea aŋe ʋuka aɖe me le wò alɔnu eye wòɖea ʋu sue aɖe ɖa (zi geɖe la, anɔ abe pint ɖeka ene, gake agbɔsɔsɔa ate ŋu ato vovo le wò nɔnɔmea nu). Esia ɖea wò ʋu ƒe agbɔsɔsɔ bliboa kple ʋumenugbagbevi siwo sɔ gbɔ wu ƒe xexlẽme dzi kpɔtɔna.

Aspirin si ƒe agbɔsɔsɔme le sue

Esia nye atike si nàte ŋu aƒle le atikedzraƒe. Zi geɖe la, woŋlɔnɛ be woatsɔ aɖe ʋu ƒe sisi ƒe afɔkua dzi akpɔtɔ. Ne aspirin noe le agbɔsɔsɔ sue aɖe me zi ɖeka gbesiagbe la, exea mɔ na ʋumenugbagbevi dzĩwo be woagalé ɖe wo nɔewo ŋu o. Ekpena ɖe ame ŋu hã be wòaɖe dzesiwo abe abɔ kple afɔwo ƒe vuvu ene dzi akpɔtɔ. Gake esẽna ɖe dɔgboa dzi vie eye wònaa ʋu si dona le ame ŋu la dzina ɖe edzi. Eyata esia menye susu nyui aɖeke ne dɔgbo me abi le ŋuwò o.

Ne wò dzesiawo nu sẽ, alo ne ʋu ƒe sisi va yi (ʋumenugbagbeviɣidɔ) le ŋuwò kpɔ la, woate ŋu atsɔ wò ade ƒuƒoƒo si me afɔku le ŋutɔ me eye woate ŋu aɖo aɖaŋu bubuwo atsɔ awɔ atike na wò. Esiawo dometɔ aɖewoe nye:

Atikewɔwɔ siwo woatsɔ aɖe ʋuʋudedi dzi akpɔtɔ:

Ne PV nu sẽ la, ɖɔkta ate ŋu aŋlɔ atikewo abe esiawo ene atsɔ ada ʋuʋudedia:

• Antihistamines: Esiawo nye atike siwo wozãna zi geɖe na nulɔdɔwo.
• Fotodada: Atikewɔwɔ si me wotsɔa kekeli si me keklẽŋusẽ le (UVA) tsakana kple atike aɖe si woyɔna be psoralen (si nye lãmenugbagbeviwo ƒe atike si nana ŋutigbalẽa sea veve ɖe kekeli ƒe atikewɔwɔ nu).
• SSRI (Selective Serotonin Reuptake Inhibitors): Esiawo nye atike ƒomevi aɖe si woŋlɔna na blanuiléle zi geɖe. Gake ne wona wo le agbɔsɔsɔ si bɔbɔ ŋutɔ me la, wokpɔe hã be wowɔa dɔ nyuie na ŋutilã me dzesi siwo nɔa anyi ɖaa abe ʋuʋudedi ene.

Atike siwo ɖea ʋumenugbagbevi dzĩwo ƒe xexlẽme dzi kpɔtɔna:

Woate ŋu azã esiawo ɖeɖeko alo woazã wo ɖekae. Kpɔɖeŋuwo:

• `Hydroxyurea`
• `Interferon alfa`
• `Ruxolitinib`
• `Busulfan`

Dɔdamɔnu dodokpɔwo

Esiawo naa mɔnukpɔkpɔ amewo be woate atikewɔmɔnu yeyetɔwo kpɔ eye woakpe asi ɖe atikewɔwɔ ŋuti numekukuwo ŋu. Atike siwo ŋu wole numekuku wɔm le fifia dometɔ aɖewoe nye:

• `Peginterferon si nye alfa-2a`
• `Givinostat`
• `Idasanutlin` ƒe nyawo

Ƒumeŋuɖui dodo na ame

Le go aɖewo me la, woate ŋu akafui be woado ƒumeŋuɖui na ame. Ðɔkta anɔ te ɖe nu geɖe dzi awɔ nyametsotso sia, abe alesi wò dɔlélea nu sẽe kple alesi wò ŋutilã ate ŋu ada dɔe ene.

Beléle si kpena ɖe ame ŋu

Ne wò PV yi edzi le gbegblẽm ɖe edzi togbɔ be wowɔ atike nɛ hã la, wò ɖɔkta ƒe susu anɔ wò dzesiwo dzi kpɔkpɔ ŋu. Le PV ƒe akpa mamlɛawo me la, àte ŋu akpɔ ʋusɔgbɔdɔ kple dɔgbo si lolo. Woate ŋu ana atikewo wò abe:

• Vevesesenutsitikewo.
• Ʋudodo.
• Kekeli ƒe atikewɔwɔ si mebɔ o na aɖuɖɔtoe.

Nukae nye ame si ŋu Polycythemia Vera (PV) le ƒe agbenɔƒe?

Numekuku siwo wowɔ nyitsɔ laa ɖee fia be ame ƒe agbenɔƒe le mama dedie nu le Polycythemia Vera (PV) dɔlélea didi vɔ megbe anɔ abe ƒe 20 ene. Ƒe si ame xɔna le mamã dedie nu la anɔ abe ƒe 77 ene. Nusi koŋ gbɔ ku tsonae nye kuxi siwo dona tso ʋu ƒe sisi gbɔ (anɔ abe 33%). Nu evelia si gbɔ wòtsonae nye kansa (anɔ abe 15%).

"Mègavɔ̃ na akɔntabubu siawo o. Esiawo nye dzidzenu siwo sɔ. Ne èxɔ atike nyuitɔ eye nètrɔ agbenɔnɔ la, àte ŋu anɔ lãmesẽ me ɣeyiɣi didi."

Aleke mawɔ akpɔ ɖokuinye dzi ahakpɔ nye dzesiwo gbɔ?

Ne èle agbe kple Polycythemia Vera (PV) la, ele vevie be nànɔ kadodo me kple wò ɖɔkta edziedzi. Esia akpe ɖe wò ɖɔkta ŋu wòalé ŋku ɖe alesi wò dɔlélea le ŋgɔ yim ŋu. Àte ŋu agblɔ alesi nèle nu wɔm ɖe atikewɔwɔ ŋui kple nenye be nugbegblẽ aɖewo le fu ɖem na wò hã na wò ɖɔkta . Àte ŋu anɔ agbe eteƒe nadidi dzesi sesẽ aɖeke manɔmee.

Tsɔ kpe ɖe dodokpɔ kple atikewɔwɔ edziedzi ŋu la, wò ɖɔkta aɖo aɖaŋu na wò hã be nàwɔ tɔtrɔ bɔbɔe aɖewo le agbenɔnɔ me siwo ate ŋu akpe ɖe ŋuwò nàxe mɔ ɖe ʋu ƒe sisi kple kuxi bubuwo nu. Le kpɔɖeŋu me:

• Kamedede. Kamedede vi aɖe gɔ̃ hã ate ŋu akpe ɖe ʋu ƒe sisi nyuie wu.
• Ƒo asa na atamanono. Sigaretnono nana wò ʋukawo me mekɔna o.
• Ƒo asa na nuto siwo me oxygen mesɔ gbɔ ɖo o. Ne woto teƒe kɔkɔwo la, ate ŋu ana oxygen naɖiɖi le ʋu me.
• Kpɔ wò ʋu ƒe sisi dzi. Kpekpeme si sɔ me léle ɖe asi akpe ɖe esia ŋu.

Togbɔ be Polycythemia Vera (PV) nye kansa ƒomevi aɖe hã la, ame geɖe nɔa agbe nyuie ƒe bla nanewo le esi wokpɔ dɔlélea le wo ŋu vɔ megbe. Kansa sia dzɔna elabena wowɔa lãmenugbagbeviwo le mɔ si dzi womate ŋu aɖu o nu. Ke hã, exɔa ɣeyiɣi didi hafi ʋumenugbagbevi dzĩwo ƒe wɔwɔ si dzi womeɖu o la tea ŋusẽkpɔkpɔ ɖe dziwò. Ne èwɔe hã la, àte ŋu akpɔ nɔnɔmea gbɔ ɣeyiɣi didi aɖe ne èɖe wò ʋu si sɔ gbɔ la ƒe ɖe ɖa.

Menye kansa ŋutɔe nye afɔku gãtɔ kekeake si tso Polycythemia Vera (PV) gbɔ o, ke boŋ afɔku si le ʋu ƒe sisi me. Ne èle agbe kple PV la, kpɔ egbɔ be yeyi ɖɔkta gbɔ edziedzi. Eye mègaŋlɔ be be yealé be na ye ɖokui kple "nu sueawo" - si nye agbenɔnɔ si me lãmesẽ le. Esiawo kpena ɖe ŋuwò be wò dzitodzito ƒe lãmesẽ bliboa nanɔ anyi, si ate ŋu anɔ vevie wu atikewɔwɔ ɖesiaɖe na Polycythemia Vera.

Gbedasi kae míedi be míatsɔ ayi aƒemee tso ŋutinya sia me?

Enyo, eyata míeƒo nu geɖe tso Polycythemia Vera (PV) ŋu. Nu vevi siwo dzi wòle be woaɖo ŋkui dometɔ aɖewoe nye esi:

• PV nye ʋumenugbagbeviɣidɔ si me ŋutilãa wɔa ʋumenugbagbevi dzĩwo fũ akpa eye wòtsina le mɔ si mesɔ o nu. Enye kansa ƒe ƒuƒoƒo aɖe si woyɔna be `myeloproliferative neoplasm (MPN)` me tɔ.
• Afɔku vevitɔa tso ʋu ƒe sisi kple ʋu ƒe sisi gbɔ, si ate ŋu ahe nɔnɔme sesẽwo abe dzidɔ kple ʋusɔgbɔdɔ ene vɛ.
• Dzesiawo ate ŋu anye ŋutigbalẽ si le ʋuʋum (vevietɔ le tsilele vɔ megbe), kuviawɔwɔ, taɖuame, kple taɖuame.
• Togbɔ be womate ŋu adae keŋkeŋ o hã la, woate ŋu akpɔ egbɔ nyuie ne wodae nyuie, atrɔ agbenɔnɔ, eye wozã atike. Phlebotomy (ʋu ƒe dodo) kple aspirin si ƒe agbɔsɔsɔme le sue ye nye atike vevitɔwo.
• `JAK2` domenyiŋusẽfianu ƒe tɔtrɔ gbɔe esia tsona zi geɖe.
• Ne dzesi siawo dometɔ aɖe le ŋuwò la, kpɔ egbɔ be yeyi ɖɔkta gbɔ hena aɖaŋuɖoɖo. Ne èkpɔe kaba la, enaa mɔnukpɔkpɔ si li be nàƒo asa na kuxiwo ahanɔ agbe si me lãmesẽ le la dzina ɖe edzi.

Mègavɔ̃ o, gake mègabu eŋu nu tsɛe hã o. Lé be na wò lãmesẽ. Ðo dze kple wò ɖɔkta edziedzi, wɔ dodokpɔ kple atike siwo hiã la ɖe game dzi. Ekema àte ŋu anɔ lãmesẽ me ne nɔnɔme sia le ŋuwò gɔ̃ hã!

` Polycythemia Vera, Ʋumenugbagbevi dzĩwo, Ʋu ƒe ʋuʋu, MPN, JAK2, Phlebotomy, Kansa