Ðe kansa sia si mebɔ o la le viwò suea ŋua? Mina míaƒo nu tso Rhabdoid Tumor ŋu!

Dadawo kple papawo, enye agba gã aɖe na wò dzi eye wònye nusi ŋu màdi gɔ̃ hã be yeabu ne viwò suea va nya be kansa le ye ŋu o. Gake ɣeaɖewoɣi la, ɖeviwo ate ŋu axɔ dɔléle siwo míele mɔ kpɔm na o. Egbea míele nu ƒom tso kansa ƒomevi aɖe si mebɔ kura o, si kaka kabakaba, si dzea ɖeviwo dzi, vevietɔ ɖevi suewo ŋu. Woyɔa esia be Rhabdoid Tumor . Ðewohĩ àse le ɖokuiwò me be ewɔ nuku vie ne èse ŋkɔ sia, gake mina míaɖe eme bɔbɔe.

Nukae nye Rhabdoid Tumor? Kpuie ko la,...

Rhabdoid Tumor nye kansa ƒomevi aɖe si mebɔ o, si le dzidzim ɖe edzi kabakaba . Ðevi suewo kple vidzĩwo mee wòbɔ ɖo wu . Ne wotsɔ nusuekpɔmɔ̃ kpɔ kansa lãmenugbagbevi siawo la, woƒe dzedzeme ɖi rhabdomyoblasts , si nye lãmenugbagbevi ƒomevi aɖe si wɔa lãmekawo. Esia tae woyɔnɛ be "rhabdoid." Kansa sia ate ŋu adze ɖevi ƒe ayikuwo, lãmeka falɛfalɛwo, alo lãmeka siwo le titina (ahɔhɔ̃ kple aklã) me. Nublanuitɔe la, kansa sia ate ŋu akaka kaba ŋutɔ, si wɔnɛ be edada sesẽna.

Ðe Rhabdoid Tumor ƒomevi vovovowo lia?

Ẽ, kansa sia ƒomevi vevi geɖewo li le afisi wòdzɔna le nu. Na míakpɔ nusiwo wonye ɖa.

1. Ayiku me Dɔdzẽ si woyɔna be Rhabdoid (RTK) .

Esia nye rhabdoid tumor of the ayiku le ɖevi me. Woɖea egɔme kpuie ɣeaɖewoɣi be ``(RTK)``.

2. Rhabdoid Dɔdzẽ vɔ̃ɖi siwo le tagbɔ alo ayiku godo

Kansa sia ƒomevi ate ŋu adze ɖevia ƒe lãmeka falɛfalɛwo kple ŋutinu bubuwo, abe aklã, lãkusi, kple ŋutigbalẽ ene me. Wogayɔnɛ be malignant rhabdoid tumors (MRT) . "Malignant" gɔmee nye kansa.

3. Teratoid Rhabdoid Tumors (ATRT) si mebɔ o .

Rhabdoid kansa sia ƒomevi dzɔna le ɖevia ƒe lãmeka siwo le titina, ahɔhɔ̃ kple aklã me. Le kansa sia ƒomevi me la, kansa lãmenugbagbeviwo dzɔna gbã le ɖevia ƒe ahɔhɔ̃ alo aklã me. Kansa siawo (ATRT) ƒe 50% lɔƒo dzɔna le ahɔhɔ̃mekawo (si kpɔa ʋuʋu kple dadasɔ dzi) alo ahɔhɔ̃meka ( si kpɔa nuwo abe gbɔgbɔ kple dzi ƒe tsotso dzi).

Amekae ate ŋu axɔ Rhabdoid Tumors wu?

Vidzĩwo kple ɖevi sue ŋutɔwo koŋue wòdzena le vevietɔ amesiwo xɔ tso ɣleti 11 va ɖo ɣleti 18 . Ame tsitsiwo mexɔa dɔléle sia kura o.

Esia mebɔ o ale gbegbe, numekuku aɖewo gblɔ be edzɔna le ame siwo mede ɖeka le miliɔn ɖeka me o.Wogblɔ be kansa sia dzɔna le agbɔsɔsɔ sue aɖe me. Ema fia be enye nɔnɔme si mebɔ kura o.

Nukatae rhabdoid-dɔdzẽ siawo dona? Nuka gbɔe wòtso?

Zi geɖe la, nusi koŋ gbɔ rhabdoid kansa tsonae nye domenyiŋusẽfianu ƒe tɔtrɔ le SMARCB1 domenyiŋusẽfianu me . Tsɔe be dzɔla sue aɖe le míaƒe ŋutilã me si kpɔa lãmenugbagbeviwo ƒe tsitsi dzi. SMARCB1 domenyiŋusẽfianu sia nye domenyiŋusẽfianu si tea dɔdzẽ nu . Ewɔa protein si kpɔa lãmenugbagbeviwo ƒe tsitsi dzi. Abe ʋukulawo ƒe kpovitɔ ene la, exea mɔ na lãmenugbagbeviwo be womama kaba akpa o. Eyata ne nusi gblẽ, si nye tɔtrɔ aɖe, le SMARCB1 domenyiŋusẽfianu sia me la, dziɖuɖu ma bu eye lãmenugbagbeviwo ma kabakaba akpa, si hea kansa vɛ . Ƒã hafi kansa siawo ate ŋu adze egɔme hã le domenyiŋusẽfianu bubu si tea dɔdzẽ nu si woyɔna be SMARCA4 ƒe tɔtrɔ ta. Togbɔ be ɖevi aɖewo ate ŋu anyi domenyiŋusẽfianu sia si trɔ la ƒe dome tso wo dzilawo gbɔ hã la, zi geɖe la, domenyiŋusẽfianu ƒe tɔtrɔ yeye aɖe si dzɔna ƒome ŋutinya aɖeke manɔmee tae kansa siawo dzɔna . Esia fia be ne ƒomea me tɔ aɖeke mekpɔ tɔtrɔ sia kpɔ o hã la, ɖevia ƒe lãmenugbagbeviwo ate ŋu akpɔ tɔtrɔ sia le vome. Ne wole dɔ wɔm na ɖevia la, woate ŋu awɔ domenyiŋusẽfianu ƒe dodokpɔ atsɔ adi domenyiŋusẽfianu ƒe tɔtrɔ sia.

Nukae nye Rhabdoid Tumor ƒe dzesiwo?

Dzesiawo ate ŋu ato vovo le ɖevia ƒe ƒexɔxɔ kple afisi kansa la le nu . Zi geɖe la, dzesiawo dzea egɔme tso teƒe si kansa la le tsitsim le. Esiawo ate ŋu anye lãmekawo ƒe gbegblẽ, gbɔgbɔ sesẽ, alo ƒunukpeƒetetedɔ le ɖevia ƒe ƒodo me. Esi kansa sia kakana kabakaba ŋutɔ ta la, eƒe dzesiwo ate ŋu adze kaba. Dzesi bubuwo ate ŋu anye:

• Asrã si nɔa ame ŋu enuenu.
• Taɖuame .
• Ʋu si le aɖuɖɔ me ( Hematuria ) .
• Aɖuɖɔtoe kple ʋuʋudedi .
• Lãmetsiŋusẽ ƒe ʋuka siwo vuvu .
• Dzikudodo ɣesiaɣi, dzimaɖitsitsi (Dzikudodo).
• Nuɖuɖu mevivina o .
• Alɔ̃dɔdɔ si mebɔ o.
• Le vidzĩwo gome la, ta ƒe lolome va lolona ɖe edzi.
• Dadasɔ ƒe bu alo azɔlizɔzɔ sesẽ.

Ne dzesi siawo dometɔ ɖeka alo esi wu nenema le viwòa ŋu la, ele vevie ŋutɔ be nàdi atikewɔlawo ƒe aɖaŋuɖoɖo enumake.

Alekee?Aleke wowɔna dea dzesi Rhabdoid Tumor sia?

Ðɔkta si ado viwòa kpɔ la awɔ ŋutilãmedɔ gbã eye wòabia viwòa ƒe dzesiwo wò. Emegbe woaɖe gbe be woawɔ dodokpɔ geɖe atsɔ aɖo kpe dɔlélea dzi. Esiawo ate ŋu anye:

• Ultrasound scan: Esia zãa gbeɖiɖi ƒe ƒutsotsoe siwo ŋu ŋusẽ geɖe le tsɔ wɔa vidzĩa ƒe ŋutinuwo ƒe nɔnɔmetata (sonogram).
• CT scan: Esia zãa X-ray kple kɔmpiuta tsɔ wɔa ɖevia ƒe lãkusi falɛfalɛwo kple ƒuwo ƒe nɔnɔmetata si le akpa etɔ̃ (3D).
• MRI scan: Esia zãa magnet, radio ƒutsotsoewo, kple kɔmpiuta tsɔ wɔa teƒewo abe ɖevia ƒe ahɔhɔ̃ kple aklã ene ƒe nɔnɔmetata tsitotsito.
• Ahɔhɔ̃mekadodokpɔ: Esia doa ɖevia ƒe ahɔhɔ̃, aklã, kple lãmekawo ƒe dɔwɔwɔ kpɔna.
• Lumbar puncture / Spinal tap: Le esia me la, woɖea ahɔhɔ̃metsi (CSF) ƒe kpɔɖeŋu tso ɖevia ƒe aklã me eye wodoa wo kpɔ le nusuekpɔmɔ̃ me be woakpɔe ɖa be kansa lãmenugbagbevi aɖewo li hã.

Gake scan siawo ate ŋu aɖe rhabdoid tumors siwo le abe kansa ƒomevi bubuwo ene afia. Eyata zi geɖe la, ɖɔktawo xɔa lãmenugbagbeviwo ƒe kpɔɖeŋuwo eye woɖea gbe be woagawɔ dodokpɔ bubuwo. Dodokpɔ siawo dometɔ aɖewoe nye:

• Domenyiŋusẽfianu dodokpɔ: Woɖea ɖevia ƒe ʋu alo lãkusi ƒe kpɔɖeŋu aɖe eye wodonɛ kpɔna be domenyiŋusẽfianu `SMARCB1` kple `SMARCA4` ƒe tɔtrɔwo le eme hã.
• Biopsy: Le dɔ sia wɔwɔ me la, ɖɔkta zãa aŋe tsɔ ɖea dɔdzẽa ƒe kpɔɖeŋu sue aɖe. Emegbe dɔléleŋutinunyala aɖe léa ŋku ɖe eŋu le nusuekpɔmɔ̃ me be yeakpɔe ɖa be kansadɔlékui aɖewo li hã. Ne wokpɔ kansa lãmenugbagbeviwo la, woate ŋu aɖe dɔdzẽa ƒe akpa gãtɔ alesi woate ŋui le amekokoa wɔɣi alo le amekoko si woawɔ emegbe me.
• Dɔlélenutsiŋutete ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ: Esia nye dodokpɔ si wowɔna koŋ. Ezãa dɔlékuiwutikewo tsɔ dia dzesi/dɔlékui aɖewo le viwò ƒe lãkusi ƒe kpɔɖeŋu aɖe me. Dzesi siawo ate ŋu akpe ɖe ame ŋu wòanya nenye be rhabdoid kansa alo kansa ƒomevi bubue.

Aleke wodaa Rhabdoid Tumor?

Ðeviwo ƒe kansadɔdala aɖe xɔa ŋgɔ le ɖevi dada me. Ewɔa dɔ kple eŋutinunyala bibi bubuwo ƒe ƒuƒoƒo aɖe tsɔ wɔa atikewɔwɔ ƒe ɖoɖo si asɔ na ɖevia wu. Woate ŋu azã atike vovovo geɖe ɖekae atsɔ ada rhabdoid kansa. Esi wònye be kansa sia kakana kabakaba ta la, numekukuwo ɖee fia be atikewɔmɔnu vovovowo zazã ɖekae ate ŋu awu kansa lãmenugbagbeviwo wu ɖeka ko zazã.

• Amekoko: Ne amekokoa meɖe kansa la ɖa o la, afɔɖeɖe gbãtɔ, ne anya wɔ la, enye be woawɔ amekoko atsɔ aɖe kansa la ƒe akpa gãtɔ alesi woate ŋui, ɖewohĩ wo katã.
• Chemotherapy (Chemo): Esia bia be woana atikewo be woatɔ te kansa lãmenugbagbeviwo ƒe tsitsi. Atike siawo wua kansadɔlékui aɖewo eye woxea mɔ na bubuwo be womama o. Gake atike siawo mete ŋu dea dzesi vovototo si le lãmenugbagbevi nyuiwo kple kansadɔlékuiwo dome o, eyata woate ŋu ahe nugbegblẽ le ame ŋu vɛ.
• Atike siwo wozãna le agbɔsɔsɔ gã me kple lãmenugbagbeviwo dodo na ame: Atike siwo wozãna le agbɔsɔsɔ gã me ate ŋu awu kansadɔlékui geɖe wu. Gake ewua lãmenugbagbevi siwo le lãmesẽ me, abe lãmenugbagbevi siwo wɔa ʋu le ƒumeŋuɖui me ene hã. Be woakpɔ esia gbɔ la, woxɔa ɖevia ƒe ƒumeŋuɖui aɖewo hedzrana ɖo hafi naa atike si ƒe agbɔsɔsɔme sɔ gbɔ. Le atikewɔwɔ vɔ megbe la, wogbugbɔa ƒumeŋuɖui la naa ɖevia be wòaxɔ ɖe lãmenugbagbevi siwo gblẽ la teƒe.
• Kekeli ƒe dɔdamɔnu: Esia zãa X-ray siwo ŋu ŋusẽ geɖe le tsɔ ɖea kansa lãmenugbagbeviwo dzi kpɔtɔna alo tsrɔ̃a wo. Gake esi wònye be keklẽŋusẽdɔdamɔnu ate ŋu akpɔ ŋusẽ ɖe ɖevi ƒe tsitsi kple eƒe ahɔhɔ̃ ƒe tsitsi dzi ta la, wotrɔa asi le agbɔsɔsɔme si woazã ŋu le ɖevia ƒe ƒexɔxɔ kple eƒe lolome nu.
• Dɔdamɔnu dodokpɔwo: Ðɔkta ate ŋu aɖo aɖaŋu hã be woawɔ dɔdamɔnu yeyewo (atike yeye ƒomeviwo, dɔdamɔnu si woɖo taɖodzinu na, alo dɔlélenutsiŋutete ƒe atikewo) atsɔ ada viwò ƒe kansa.

Nukawoe ate ŋu agblẽ le atikewɔwɔa ŋu?

Kansa dada, vevietɔ atikewɔmɔnu, ate ŋu ahe nugbegblẽ le ame ŋu vɛ. Esia le alea elabena atike siwo wozãna tsɔ wua kansa lãmenugbagbeviwo hã wua lãmenugbagbevi siwo le lãmesẽ me. Gake eƒe nugbegblẽ le ame ŋu akpa gãtɔ nu yina ne wodzudzɔ atikewɔwɔ vɔ . Àte ŋu awɔ dɔ kple viwòa ƒe atikewɔlawo ƒe ƒuƒoƒoa akpɔ eƒe nugbegblẽ le ame ŋu siawo gbɔ. Nusiwo wògblẽna le ame ŋu zi geɖe dometɔ aɖewoe nye:

• Taɖa ƒe ʋuʋu `(Alopecia)` .
• Nuɖuɖua mevivina o.
• Miléle.
• Dɔmetɔtrɔ.
• Aɖuɖɔtoe kple ʋuʋudedi.
• Abi siwo le ŋɔti kple nu me.
• Dzoxɔxɔ `(Edema)` .
• Alɔ̃ madɔmadɔ.
• Ðeɖiteameŋu si gbɔ eme .
• Ŋkuɖodzinyawo ƒe kuxiwo.

Ðe woate ŋu axe mɔ ɖe Rhabdoid Tumors nua?

Nublanuitɔe la, domenyiŋusẽfianu ƒe tɔtrɔ gbɔe kansa siawo tsona, eyata mɔ aɖeke meli si dzi woato axe mɔ ɖe wo nu o . Gake ne rhabdoid kansa alo kansa bubuwo le wò ƒomea me kpɔ, eye nèle mɔ kpɔm na vi la, anyo be nàƒo nu tso domenyiŋusẽfianu ŋuti aɖaŋuɖoɖo na wò ɖɔkta ŋu . Domenyiŋusẽfianu ŋuti aɖaŋuɖoɖo ate ŋu akpe ɖe ŋuwò nàse afɔku si le eme be domenyiŋusẽfianu ƒe nɔnɔme aɖe nanɔ viwòa me la gɔme.

Ðe woate ŋu ada Rhabdoid Tumor? Aleke ɖevia ƒe etsɔme anɔ?

Ðɔkta si le viwòa dam ate ŋu ana nyabiase sia ƒe ŋuɖoɖo tututu wò. Gake la,Nublanuitɔe la, ɖevi akpa gãtɔ siwo ŋu rhabdoid dɔdzẽ vɔ̃ɖi le la menɔa agbe wu ƒe ʋɛ aɖewo o. Gake ne wokpɔ dɔlélea le ɖevia ŋu le ƒe 2 xɔxɔ vɔ megbe la , eƒe ŋgɔdonya ate ŋu anyo vie. Alesi kansa sia tsi agbee nɔ te ɖe nu geɖe dzi:

• Ƒe si ɖevia xɔ.
• Afisi kansa la le le ɖevia ƒe ŋutilã me.
• Ne kansa la kaka ɖe ŋutilã ƒe akpa bubuwo hã.
• Aleke gbegbe kansa la ƒe akpa si woɖe le amekoko me.
• Alesi ɖevia awɔ nui le kansa dada me.

Esi wònye be rhabdoid carcinoma vɔ̃ɖi mebɔ o ta la, wotu agbenɔƒe ƒe akɔntabubuwo ɖe dɔnɔ ʋɛ aɖewo ŋutɔ dzi. Eyata ɖevi ƒe agbenɔƒe ŋutɔŋutɔ ate ŋu ato vovo. Numekukuwo ɖee fia be ƒe atɔ̃ ƒe agbetsitsi le ayiku me dɔdzẽ si woyɔna be rhabdoid carcinoma (RTK) me le 20% va ɖo 25% dome . Esia fia be amesiwo ŋu wokpɔ RTK le la dometɔ 20% va ɖo 25% gakpɔtɔ le agbe ƒe atɔ̃ le dɔlélea kpɔkpɔ vɔ megbe. Ƒe atɔ̃ ƒe agbetsitsi ƒe agbɔsɔsɔme na atypical teratoid rhabdoid carcinoma (ATRT) le 32% va ɖo 50% dome.

Enye nusi sɔ be nàse agba gã aɖe eye nàlé blanui ne èse nya sia tɔgbe. Gake ɖo ŋku edzi be menye wò ɖeka koe o.

Nukae wòle be mabia ɖɔktaa?

Enye nusi sɔ be nyabiase geɖe nanɔ asiwò ne èva nya be kansa le viwò ŋu. Nyabiase aɖewo siwo dzi nàɖo ŋkui be nàbia ɣemaɣie nye esi:

• Kansa ka ƒomevie le vinyea ŋu?
• Afikae vinyea ƒe kansa le?
• Dodokpɔ kawoe wòle be woawɔ na vinyea?
• Nukawoe nye vinye ƒe kansa ƒe atikewɔmɔnu siwo woate ŋu azã?
• Mɔnukpɔkpɔ kawoe li be atikewɔwɔ sia nakpɔ dzidzedze?
• Dɔdamɔnu dodokpɔ kawo mee vinyea ate ŋu akpɔ gome le?
• Aleke míawɔ anya ne atikewɔwɔa kpɔ dzidzedze?

Aleke wowɔa kplɔkplɔ ɖo le atikewɔwɔ me kple le atikewɔwɔ vɔ megbe?

Le viwòa ƒe kansa dada katã me la, ahiã be woagawɔ dodokpɔ siwo woazã atsɔ anya dɔlélea dometɔ aɖewo ake. Wozãa dodokpɔ siawo tsɔ dzidzea alesi gbegbe atikewɔwɔa le dɔ wɔm nyuie. Wò atikewɔlawo ƒe ƒuƒoƒoa anɔ te ɖe dodokpɔ siawo me tsonu dzi awɔ dɔ kpli wò atso nya me le afɔɖeɖe siwo nàgaɖe ŋu. Esia ate ŋu alɔ atikewɔwɔa dzi yiyi, tɔtrɔ, alo edzudzɔ. Ne viwòa wu kansa dada nu vɔ la, ahiã be wòatrɔ ava hena dodokpɔ kple dodokpɔ siwo woawɔ atsɔ akplɔe ɖo ɣeaɖewoɣi . Le kplɔkplɔɖoɖo siawo me la, viwòa alé ŋku ɖe eŋu be viwòa ƒe nɔnɔmea nyo ɖe edzi alo ne dɔlélea gadze egɔme hã. Dɔléle sia yometiti ate ŋu anɔ anyi ƒe geɖe le atikewɔwɔ vɔ megbe.

Mlɔeba la, ɖo ŋku edzi... (Take-Home Message)

Míenya be etena ɖe ame dzi ŋutɔ ne èse nya be kansa le viwòa ŋu. Gake ele vevie be nàɖo ŋku edzi be menye wò ɖeka koe o.. Ƒuƒoƒo bliboa si le viwòa dam, siwo dome ɖɔktawo kple dɔnɔdzikpɔlawo hã le, le afisia be yewoakpe ɖe ŋuwò kple wò ƒomea le ɣeyiɣi sesẽ sia me. Atike aɖewo li na rhabdoid dɔdzẽ, eye mɔkpɔkpɔ li na viwòa . Ƒo nu kple viwò ƒe ɖɔkta tso alesi nàge ɖe kansa ƒe kpekpeɖeŋunaha aɖe me na dzilawo alo ƒomewo ŋu. Àte ŋu akpɔ akɔfafa kple dzideƒo geɖe ne ègblɔ wò ŋutinya eye nèse ame bubuwo ƒe nuteƒekpɔkpɔwo.