Esi wò ɖɔkta gblɔ na wò be no me dɔdzẽ le ŋuwò la, ɖe nèkpɔ ŋkɔ ‘Taxane’ si woyɔ le wò atikewɔwɔ ƒe ɖoɖoa mea? Ðewohĩ vɔvɔ̃ ɖo wò vie esi nèse ŋkɔ sia. Esɔ be nuwo nava susu me na wò ne èse nya ‘chemotherapy’ kpe ɖe ŋkɔ sia ŋu. Gake mègatsi dzi o. Taxane nye atike si wɔa dɔ ŋutɔ si wozãna le no me dɔdzẽ dada me ƒe 40 kple edzivɔe nye sia. Na míaƒo nu tso eŋu le mɔ bɔbɔe aɖe si gɔme nàte ŋu ase nu.
Nukae nye taxane siawo? Aleke wowɔa dɔe?
Kpuie ko la, taxanes nye atikewɔmɔnu ƒomevi aɖe si xea mɔ na kansa lãmenugbagbeviwo ƒe mama, dzidziɖedzi, kple kaka ɖe ŋutilã bliboa me.
Bu eŋu kpɔ ko, abe alesi ko lãmenugbagbevi siwo le lãmesẽ me le míaƒe ŋutilã me ene la, kansa lãmenugbagbeviwo dzina ɖe edzi to mama me. Lãmenugbagbevi suewo (microtubules) ƒe ɖoɖo aɖe si le woƒe lãmenugbagbeviwo me kpena ɖe lãmenugbagbeviwo ƒe mama ƒe ɖoɖo sia ŋu. Atikewo ƒe taxane hatsotso, alo ne míagblɔe tututu la, ``antimicrotubule agents'', yia tẽe eye woɖoa taɖodzinu na tube system ma tututu. Atike siawo gblẽa mɔ̃ ma ƒe dɔwɔwɔ me eye womewɔa dɔ o. Emegbe kansa lãmenugbagbeviwo mete ŋu mãna o, eye mlɔeba lãmenugbagbevi mawo kuna. Esiae nye gɔmeɖose vevitɔ si le atikewɔwɔ sia me.
Atikewɔwɔ sia ateŋu anye nusi wòle be nàwɔ le wò atikewɔwɔ ƒe ɖoɖoa me, vevietɔ ne no me dɔdzẽ ƒomevi si nye ``(HER2-positive)`` le ŋuwò.
Wozãa taxane atikewo (le kpɔɖeŋu me, `(Docetaxel)` kple `(Paclitaxel)`) le ƒomevi eveawo siaa me:
1. No me dɔdzẽ ƒe gɔmedzedze: Wonaa atike sia hafi wowɔa dɔ nɛ be wòaɖe dɔdzẽa dzi akpɔtɔ eye wòana wòalolo. Wonae hã le amekoko vɔ megbe be kansa la nagatrɔ ava o.
2. No me dɔdzẽ si kaka ɖe teƒe bubuwo: Wozãa atike sia hã tsɔ léa kansa si kaka ɖe ŋutilã ƒe akpa bubuwo nu.
Aleke wonaa Taxane atikewoe?
Fifia wodoa taxane-tikewo ɖe ʋuka me (IV) , si fia be wodoa wo abe dzetsi ene ɖe ʋuka me. Wowɔa esia le kɔdzi alo kansadɔdaƒe.
Ɣeaɖewoɣi la, wonaa taxanes ɖeɖeko (dɔdamɔnu ɖeka). Ɣebubuɣiwo la, wonaa wo kpena ɖe atike bubu siwo wozãna tsɔ daa dɔe ŋu be atikewɔwɔa nawɔ dɔ nyuie wu. Le kpɔɖeŋu me, wonaa wo kpe ɖe atikewo abe Capecitabine, Carboplatin, kple Cyclophosphamide ene ŋu.
Nya nyuiae nye be dzɔdzɔmeŋutinunyalawo le numekuku wɔm fifia le mɔ aɖe si dzi woato ano atike sia abe atikekui ene, si ate ŋu aɖe kɔdzi yiyi dzi akpɔtɔ le etsɔme.
Nukae wòle be nàkpɔ mɔ na ne èle atike wɔm?
Ne wò ɖɔkta nya tso nya me be yeadze taxane zazã gɔme ko la, woawɔ atikewɔwɔ ƒe ɖoɖo aɖe koŋ na wò. Esia lɔ zi nenie wòle be nàva kɔdzi kple ɣeyiɣi didi si wòaxɔ hafi woaxɔ atikeawo ɖe eme.
- Dɔdamɔnuawo ƒe xexlẽme: Esia toa vovo tso ame ɖeka gbɔ yi bubu gbɔ. Enɔ te ɖe atike si ƒomevi wona wò (`(Docetaxel)` alo `(Paclitaxel)`), atike ƒe agbɔsɔsɔme, kple alesi wò ŋutilã wɔa nui ɖe eŋu dzi.
- Le kpɔɖeŋu me, zi geɖe la, wonaa `(Docetaxel)` zi ɖeka le kwasiɖa 3 ɖesiaɖe me . Agbɔsɔsɔ ɖesiaɖe xɔa abe gaƒoƒo ɖeka ene.
- Wodoa paclitaxel enuenu vie wu. Ðewohĩ zi ɖeka le kwasiɖa eve ɖesiaɖe me . Ate ŋu axɔ abe gaƒoƒo eve ene. Nudzɔdzɔ aɖewo hã li siwo me wodoa atike si bɔbɔ wu zi ɖeka le kwasiɖa me na ame aɖewo.
- Agbɔsɔsɔme: Atike agbɔsɔsɔme si woana wò nɔ te ɖe nu geɖe dzi, siwo dometɔ aɖewoe nye wò kansa ƒe ƒomevi kple afisi wòle, wò kpekpeme kple kɔkɔme, kple atike bubu siwo wona wò.
- Ɣeyiɣi didi si woatsɔ ada dɔa: Esia hã nɔ te ɖe alesi atikewɔwɔa kpɔ dzidzedzee kple nenye be wò nugbegblẽ le ame ŋu vevie dzi. Zi geɖe la, wowɔa atike na kansa si mekaka haɖe o la zi etɔ̃ va ɖo ade. Kansa si kaka ate ŋu abia be woawɔ atike nɛ ɣeyiɣi didi wu.
Gake ɖo ŋku edzi be ne èkpɔ nugbegblẽ sesẽwo alo mète ŋu do dzi le atikeawo zazã me o la, wò ɖɔkta ate ŋu atrɔ wò ɖe atike bubu ŋu.
Ðe Taxanes hea nugbegblẽ le ame ŋu vɛa?
Ɛ̃. Nublanuitɔe la, abe atike siwo katã wozãna tsɔ daa dɔe ene la, taxanes ate ŋu ahe nugbegblẽ le ame ŋu vɛ. Esia le alea elabena menye kansa lãmenugbagbeviwo koe atike siawo gblẽa nu le o, ke boŋ lãmenugbagbevi siwo le lãmesẽ me siwo mãna kabakaba hã. Gake zi geɖe la, taxanes ƒe nugbegblẽ le ame ŋu mebɔ kura o eye woate ŋu alɔ̃ ɖe edzi ne wotsɔe sɔ kple atike bubu siwo wozãna tsɔ daa dɔlékuiwoe.
Nusiwo dona tso eme siawo ate ŋu atso suewo dzi va ɖo esiwo nu sẽ ale gbegbe be wòahiã be woaxɔ ame ɖe kɔdzi. Mina míalé ŋku ɖe nusiwo nye nugbegblẽ le ame ŋu siawo ŋu.
| Taxane zazã ƒe nugbegblẽ le ame ŋu | |
|---|---|
| Nusiwo dona tso eme zi geɖe | |
| Ɖeɖiteameŋu | Ðewohĩ ɖeɖi te ŋuwò ŋutɔ ɣeyiɣi akpa gãtɔ. |
| Taɖa ƒe ŋeŋe | Taɖa siwo le ta, kpakple ŋutilã ƒe fu bubuwo ate ŋu age. |
| Lãmetsiwo kple ƒunukpeƒewo ƒe vevesese | Wò ŋutilã ate ŋu ase veve. Ðɔktawo yɔa esia be ``myalgia''. |
| Aɖuɖɔtoe kple ʋuʋudedi | Ðɔktaa ana atike wò be nàtsɔ aɖu esia dzi. |
| Vevesese kple abɔ kple afɔwo ƒe ʋuʋu | Àte ŋu akpɔ ʋuʋudedi, dzobibi, alo vevesese le wò asibidɛwo, afɔkpodziwo, kple asibidɛwo ŋu. Woyɔa esia be ahɔhɔ̃mekawo ƒe dɔléle si le lãme na ame. |
| Nu me ƒe abiwo | Abi suesuesuewo ate ŋu adzɔ le nu me. |
| Dɔlékuiwo xɔxɔ ƒe afɔku si dzina ɖe edzi | Ʋumenugbagbevi ɣiwo dzi ɖeɖe kpɔtɔ (neutropenia) ate ŋu ana nàdze dɔ bɔbɔe. |
| Nu gbegblẽ sesẽ siwo wòle be woagblɔ na ɖɔkta enumake | |
| Aɖuɖɔtoe sesẽ (Diarrhea) . | Aɖuɖɔtoetetedɔ ƒe nɔnɔme si medzudzɔna o. |
| Gbɔdzɔgbɔdzɔ sesẽ le abɔ kple afɔwo ŋu | Asiwo gbɔdzɔ akpa be woalé nane alo afɔ siwo gbɔdzɔ akpa be woate ŋu azɔ. |
| Asrã | Ate ŋu anye dɔlékui aɖe ƒe dzesi le ŋutilãa me. |
| Nukpɔkpɔ trɔna | Nukpɔkpɔ si me kɔ o alo nukpɔkpɔ ƒe bu. |
| Ʋu si dona le ame ŋu si mesɔ o | Ʋu si dona le ŋɔti me alo abi le ametia katã ŋu. |
Zi geɖe la, nugbegblẽ le ame ŋu siawo nu yina le kwasiɖa alo ɣleti ʋɛ aɖewo me ne wodzudzɔ atikewɔwɔ vɔ megbe. Gake nɔnɔme aɖewo li siwo me ahɔhɔ̃mekawo ƒe dɔlélea nu sẽna eye medzona keŋkeŋ le ame aɖewo gome o.
Nu vevitɔe nye be ne èkpɔ dzesi aɖewo siwo mebɔ o la, mègaŋe aɖaba ƒu edzi o eye nàna wò ɖɔkta alo dɔnɔdzikpɔla si le dɔ wɔm na wò la nanya enumake.
Aleke gbegbee atikewɔwɔ sia wɔa dɔe?
Taxane nye atike si wɔa dɔ ŋutɔ, si tae wozãe ɣeyiɣi didi aɖe ɖo.
Le kansa ƒe gɔmedzedze gome la:
Numekukuwo ɖee fia be taxanes nana nyɔnu siwo ŋu no me dɔdzẽ le le eƒe gɔmedzedze eye wowɔa dɔ na wo la, enaa woƒe agbetsitsi dzina ɖe edzi eye wòɖea afɔku si le kansa la ƒe tɔtrɔgbɔ me dzi kpɔtɔna.
Le no me dɔdzẽ si kaka ɖe teƒe bubuwo gome la:
Le nɔnɔme siwo me kansa la kaka ɖo me la, taxane zazã mate ŋu ada kansa la o, gake ate ŋu akpe ɖe ame ŋu ŋutɔ be wòaɖu dɔlélea ƒe ŋgɔyiyi dzi eye wòana wòanɔ agbe didi.
Togbɔ be wozãa atike sia wu na kansa siwo me HER2 le hã la, woate ŋu azãe na kansa ƒomevi aɖe si dada sesẽ wu si woyɔna be Triple-Negative Breast Cancer (TNBC) hã.
Ðe ɣeyiɣi aɖewo li siwo me Taxane zazã mewɔa dɔ oa?
Ẽ, ɣeaɖewoɣi ate ŋui. Menye kansa katãe wɔa nu ɖe taxanes ŋu le mɔ ɖeka nu o. Ðewohĩ kansa aɖewo mawɔ nu ɖe atike sia ŋu tso gɔmedzedzea me ke o. Ɣebubuɣiwo ne dɔdamɔnua wɔ dɔ hena ɣeyiɣi aɖe la, atike la va zu numame na kansa la eye wòte ŋu nɔa te ɖe dɔlékuiwo nu. Emegbe atike la dzudzɔa dɔwɔwɔ.
Nɔnɔme sia bɔ vevietɔ le kansa ``triple-negative'' me. Dzɔdzɔmeŋutinunyalawo menya nusita tututu nusia dzɔna haɖe o.
Le ɣeyiɣi sia me la, wò ɖɔkta ate ŋu atrɔ atike siwo wotsɔ ƒo ƒui alo atrɔ wò ɖe atikewɔwɔmɔnu bubu kura ŋu.
Gbedasi si Wotsɔ Yi Aƒeme
- Taxane nye atikewɔmɔnu si wɔa dɔ ŋutɔ na no me dɔdzẽ. Mègavɔ̃ esia o.
- Wotoa ʋuka si wodona ɖe ʋuka me (IV) dzi naa atikewɔwɔ sia. Ahiã be nàyi kɔdzi le ɖoɖowɔɖi aɖe koŋ dzi.
- Nugbegblẽ le ame ŋu abe ɖa ƒe ŋeŋe, ɖeɖiteameŋu, kple ŋutilã ƒe vevesese ene ate ŋu ado mo ɖa. Esiawo ƒe akpa gãtɔ nu yina ne wonya dzudzɔ atikewɔwɔ ko.
- Ne dzesi sesẽwo abe asrã, aɖuɖɔtoetetedɔ sesẽ, alo gbɔdzɔgbɔdzɔ si gbɔ eme le wò abɔwo kple afɔwo ŋu ene la, na wò ɖɔkta nanya enumake.
- Gome le asiwò be nàdzro nyabiase, vɔvɔ̃, alo ɖikeke ɖesiaɖe si anɔ mewò la me kple wò ɖɔkta gaglãa.
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