It's common for doctors to first prescribe stimulant medications to treat ADHD. However, these medications are not suitable for everyone. Some people can have serious side effects. For others, these medications don't work as well as they should. So if you're looking for other ADHD medication options, you have a few options. Sometimes your doctor will add a stimulant to a medication you're already taking, or they may tell you to take this medication alone without the stimulant.
What are the non-stimulant medications for ADHD?
Simply put, nonstimulant medications for ADHD can be divided into three main categories.
1. ADHD-specific nonstimulants: These are specifically designed to treat ADHD and are approved for that purpose.
2. Blood pressure medications: These medications also help control ADHD symptoms in some people.
3. Antidepressants: These help with ADHD by regulating chemicals in the brain. They are especially helpful for people who have ADHD and other mental health conditions, such as depression and anxiety.
Nonstimulant medications specific to ADHD
Atomoxetine (Strattera) and Viloxazine (Qelbree) are approved for use in children, adolescents, and adults. They work by increasing levels of an important chemical in the brain called norepinephrine. This has been shown to improve attention span and reduce impulsive behavior and hyperactivity .
Although Clonidine ER (Kapvay) and Guanfacine ER (Intuniv) are approved for children ages 6 to 17, doctors also prescribe them to adults. These drugs work by targeting specific areas of the brain. Studies have shown that they reduce distractibility and improve attention, working memory , and impulse control .
What are the advantages of these over stimulant medications?
Unlike stimulant medications, nonstimulant medications generally cause fewer side effects, such as restlessness, insomnia, or loss of appetite. They also do not carry the risk of addiction.
Another important thing is that the effects of stimulant medications can seem to come on suddenly and then go away just as quickly. However, the effects of nonstimulant medications tend to be longer-lasting and smoother .
Let's also be aware of the side effects of nonstimulant medications.
Like any medication, these can have some side effects , so it's important to be aware of this.
| Drug category | Possible side effects |
|---|---|
| Atomoxetine (Strattera) |
|
| Rare but serious risks of Atomoxetine that should be reported to the doctor immediately: | |
| Atomoxetine (serious) |
|
| Clonidine (Kapvay), Guanfacine (Intuniv), Viloxazine (Qelbree) |
|
| Rare but serious risks of these drugs include: | |
| Clonidine, Guanfacine, Viloxazine (severe) |
|
Because these medications can cause drowsiness, it is very important to know exactly how they will affect you before driving or operating heavy machinery .
Blood Pressure Drugs Used for ADHD
Medications commonly used to treat high blood pressure, such as Clonidine (Kapvay) and Guanfacine hcl (Tenex), can also help control ADHD symptoms. They can calm certain areas of the brain.
They also help reduce side effects, especially those caused by stimulant medications, such as insomnia and aggressive behavior. They can be used alone or in combination with stimulant medications.
However, there is some controversy about giving these together with stimulant medications. There have been reports of deaths in children who took both of these medications together. It is not clear whether these deaths were caused by the combination of the two medications, but extreme caution should be exercised when using such combinations.
Your doctor will monitor you regularly. He or she will take steps to reduce your risk by checking your heart rate (ECG) and checking your blood pressure regularly. If the benefits outweigh the risks, your doctor may recommend this treatment.
Side effects of these and who should not take them
The main side effects of these are drowsiness, low blood pressure, headache, and dizziness. Very rarely, irregular heartbeats can occur. These may not be suitable for you if you or someone in your family has a history of low blood pressure or heart disease.
Antidepressants used for ADHD
Several types of antidepressants are used to treat ADHD. These are the best treatments, especially for children or adults who have depression along with ADHD.
These can improve attention, impulse control, hyperactivity, and aggression. But keep in mind, they are not as effective as stimulant or nonstimulant medications in improving attention and concentration.
One advantage of these is that they have a lower risk of addiction. They work by increasing levels of neurotransmitters in the brain, such as `norepinephrine`, `serotonin`, and `dopamine`.
There are several main types used:
- Tricyclic antidepressants: Drugs like `Desipramine` and `Imipramine` belong to this group. Although these are effective, they can cause side effects like dry mouth and constipation.
- Bupropion (Wellbutrin): This is also a very effective medication for ADHD. However, it can cause problems for people with anxiety or seizures.
- MAO inhibitors: These are rarely used because they can have dangerous side effects. They are only considered if no other medications have worked.
Important: The FDA has warned that antidepressants may slightly increase the risk of suicidal thoughts and behavior in children and young people. So if you have any questions or concerns about this, talk to your doctor.
Be aware of these things before taking any nonstimulant medication.
Before you start taking a nonstimulant medication, you should definitely tell your doctor about the following:
- If you are pregnant, trying to become pregnant, or breastfeeding.
- If you are taking medication for any other medical condition (e.g., blood pressure, antidepressants, sedatives).
- If you are using dietary supplements, herbal remedies, or over-the-counter medications.
- If you have any other medical conditions (high or low blood pressure, epilepsy, heart disease, glaucoma, mental health problems, liver disease).
- If you have had an allergic reaction to a medicine in the past.
- If you have a history of drug or alcohol addiction.
Once you and your doctor have decided that nonstimulant medication is right for you, take the medication exactly as prescribed, at the recommended dose . Your doctor may also do things like blood tests from time to time to check if the medication is working properly and if there are any problems.
Take-Home Message
- ADHD is not limited to stimulant medications. There are also a number of nonstimulant options.
- To choose the treatment that's right for you, talk honestly with your doctor about your complete medical history and all other medications you're taking.
- Never stop taking this medication suddenly without medical advice. Doing so may cause problems such as a sudden increase in blood pressure. Stop taking the medication gradually.
- It can take 2-4 weeks or more to feel the full effect of these medications, so be patient and continue taking the treatment.
- Tell your doctor right away if you experience any unusual or severe side effects (especially yellowing of the skin, changes in heart rate, thoughts of suicide).


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