Shin akwai wani a cikin iyalinka, musamman yaro, da ke da matsalar hormonal da aka haifa? Kuna iya sanin matsaloli kamar jinkirin girma, farkon balaga, da kuma zagayowar al'ada mara tsari a cikin mata. Wani yanayi na kwayoyin halitta da ba kasafai ake samunsa ba wanda zai iya haifar da hakan ana kiransa 'Congenital Adrenal Hyperplasia'. Za mu kira shi CAH a takaice. A yau, za mu yi magana a takaice game da wannan da kuma wani sabon magani da aka samu.
A taƙaice dai, menene CAH?
CAH wata cuta ce ta kwayoyin halitta da ke hana glandar adrenal, ƙananan gland guda biyu da ke saman kodan, samar da cortisol, wani hormone da ke da mahimmanci ga rayuwarmu.
Ka yi tunanin jikinmu a matsayin masana'anta. Idan ɗaya daga cikin kayayyakin (cortisol) a wannan masana'anta ya gaza, cibiyar kula da kwakwalwa (pituitary gland) ta rikice kuma ta aika da sigina (ACTH) zuwa ga glandar adrenal don yin aiki tuƙuru. Saboda wannan yawan motsa jiki, kodayake samar da cortisol bai ƙaru ba, maimakon haka yana fara samar da ƙarin hormones na maza da ake kira 'androgens' .
Wannan rashin daidaituwar hormonal na iya haifar da matsaloli da yawa:
- Jariran mata: A lokacin haihuwa, al'aurar waje na iya kama da ta jariri namiji.
- Ga ɓangarorin biyu: matsaloli kamar jinkirin girma, farkon balaga, da rashin haihuwa na iya faruwa daga baya a rayuwa.
Bugu da ƙari, wasu marasa lafiya na CAH suma suna iya samun raguwar samar da wani muhimmin hormone mai suna aldosterone. Ba tare da wannan hormone ba, CAH na iya yin tsanani sosai, wanda zai haifar da girgiza, suma, ko ma mutuwa.
Maganin shekaru 70 da sabuwar fata
Tsawon shekaru da dama, maganin da CAH kawai ke bayarwa shine maye gurbin ƙarancin sinadarin cortisol na hormone na jiki da yawan sinadarin steroid , kamar hydrocortisone. Duk da haka, shan waɗannan magungunan steroid na dogon lokaci na iya haifar da wasu illoli. Mafi yawansu sune ƙaruwar nauyi, hawan jini, raunin ƙashi, da kuma raguwar girma a cikin yara.
Amma yanzu akwai labari mai daɗi! Bayan shekaru 70, FDA ta amince da magani na farko kuma tilo da aka ƙera musamman don CAH, crinecerfont (sunan alama: Crenessity).
Ta yaya wannan sabon magani (Crinecerfont) yake aiki?
Wannan shine mafi mahimmanci. Ba kamar tsohon maganin ba, wannan sabon maganin yana aiki ta wata hanya daban.
'Crinesurfont' ba ya ƙara hormones daga waje. Madadin haka, wannan maganin yana zuwa kai tsaye zuwa cibiyar kula da kwakwalwa (ƙwayar pituitary) kuma yana toshe fitowar siginar da ba a so (ACTH) wacce ke motsa glandar adrenal.
A taƙaice dai, wannan kamar kashe 'maɓallin' tsarin da ba dole ba ne. Wannan yana sarrafa samar da hormones 'androgen' marasa amfani ga jiki.
Babban fa'idar wannan ita ce tunda ana sarrafa matakan androgen, ana iya rage yawan magungunan steroid da ake buƙata don kula da daidaiton hormones sosai . Wannan yana nufin cewa illolin da steroids ke haifarwa suma za a iya rage su sosai.
| Halaye | Tsohon magani (yawan allurai na steroid) | Sabuwar magani (Crinecerfont + ƙarancin allurai na steroid) |
|---|---|---|
| Aiki | Samar da raguwar sinadarin cortisol a waje. | Toshe sakonnin da ba a so (ACTH) daga kwakwalwa da kuma sarrafa samar da sinadarin androgen. |
| Babban maƙasudi | Ana buƙatar allurai masu yawa don sarrafa matakan hormone. | Rage matakan androgen da kuma rage yawan steroids da ake buƙata. |
| Illolin da ke tattare da hakan | Matsaloli na dogon lokaci kamar ƙara nauyi, raguwar girma, da kuma raunin ƙashi. | Akwai yiwuwar rage tasirin da ke tattare da steroid. An bayar da rahoton ƙananan sakamako (ciwon kai, gajiya). |
Waye wannan maganin ya fi dacewa da shi?
A halin yanzu an amince da amfani da 'Crinesurfont' ga marasa lafiya 'yan sama da shekaru 4 na CAH. Ba maye gurbin steroid ba ne, amma ƙari ne ga steroid.Karin magani.
- Ga yara: Tunda yara suna girma, yawan shan steroids na iya yin babban tasiri ga ci gaban su. Saboda haka, wannan maganin, wanda zai iya rage yawan shan steroids, zai iya zama da amfani sosai a gare su. Wannan yana da mahimmanci musamman a lokacin samartaka, lokacin da yake da wahala a sarrafa hormones.
- Ga manya: Wannan maganin zai iya kuma rage wa manya da ke fama da illolin shan steroids na dogon lokaci, ko kuma waɗanda ke da matsala wajen kiyaye matakan hormones masu ƙarfi.
Koyi game da illolin da aminci
A gwaje-gwajen asibiti, an bayar da rahoton ƙananan sakamako na ɗan lokaci kaɗan da wannan maganin.
- Ga manya: gajiya, ciwon kai, jiri, ciwon gaɓɓai.
- Ga yara: ciwon kai, ciwon ciki, gajiya, toshewar hanci.
Abu mafi mahimmanci, yawancin waɗannan alamun ba su da sauƙi, kuma adadin marasa lafiyar da suka daina shan maganin ya yi ƙasa sosai.
Gargaɗi na Musamman: Ku sani game da Rikicin Adrenal!
Lokacin shan wannan maganin, yana da matuƙar muhimmanci a san da wata mummunar cuta da ake kira 'crisis adrenal'. A taƙaice dai, wannan yanayin na iya faruwa idan jiki bai sami adadin da ake buƙata na 'cortisol' ba a lokacin da ake cikin tsananin damuwa (misali, kamuwa da cuta mai tsanani, tiyata, haɗari).
Saboda haka, yi magana da likitanka kuma ka tabbata ka san ainihin adadin maganin steroid da ya kamata ka sha a lokacin gaggawa ("matsalar damuwa") . Haka kuma, ka san alamun 'rikicin adrenal' (misali, amai mai yawa, gudawa, jiri, rashin sani) kuma ka tuna ka je asibiti ko ɗakin gaggawa (ETU) nan da nan idan irin wannan abu ya faru.
Ta yaya zan san ko wannan maganin ya dace da ni/ɗana?
Ya kamata a yanke wannan shawara ne ta hanyar tuntuɓar likitanka, musamman likitan endocrinologist . Likitanka zai yi la'akari da abubuwa da yawa, ciki har da sakamakon gwajin jininka, yawan girma, nauyi, hawan jini, da matakan hormones na yanzu, don tantance ko wannan maganin ya dace da kai.
Wannan ba magani bane ga CAH, amma akwai babban fatan cewa zai taimaka wajen inganta rayuwar marasa lafiya, rage illolin steroid, da kuma sauƙaƙa sarrafa hormones.
Saƙon Ɗauka Gida
- Ma'anar CAHYanayi ne na kwayoyin halitta wanda glandar adrenal ke samar da ƙarancin cortisol da ƙarin hormones na androgen.
- Crinecerfont sabuwar hanyar magani ce da aka ƙirƙiro musamman ga CAH, irinta ta farko cikin shekaru 70.
- Wannan ba magani bane da ke maye gurbin steroids. Magani ne da ake bayarwa ban da steroids kuma yana taimakawa wajen rage yawan steroids da ake buƙata.
- Babban fa'idar ita ce ikon rage illolin steroids na dogon lokaci .
- Tabbatar da tambayar likitanka game da yanayin gaggawa da ake kira 'matsalar adrenal' da kuma "matsalar damuwa" da ya kamata ka sha a wannan lokacin.
- Yana da mahimmanci a tuntuɓi likita wanda ya ƙware a cututtukan hormonal don tantance ko wannan maganin ya dace da kai ko ɗanka.
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