Kiʻekiʻe anei kou mau platelets? E kamaʻilio kākou e pili ana i ka Thrombocytosis!

Ua ʻike ʻia hoʻi ʻoe me nā platelets kiʻekiʻe i loko o kou koko? A i ʻole he maʻi kēia i loaʻa i kekahi āu i ʻike ai? He mea maʻamau ke hopohopo iki ke lohe ʻoe i kahi mea e like me kēia. Akā, mai hopohopo, i kēia lā e kamaʻilio mākou e pili ana i kēia maʻi i kapa ʻia ʻo Thrombocytosis ma ke ʻano maʻalahi hiki iā ʻoe ke hoʻomaopopo.

He aha ka thrombocytosis? I ka ʻōlelo maʻalahi…

I ka ʻōlelo maʻalahi, ʻo ka thrombocytosis ka wā he nui loa nā platelets i loko o kou koko. I kēia manawa ke nīnau nei paha ʻoe, "He aha nā platelets?" He nīnau koʻikoʻi loa kēlā!

He ʻano ʻāpana liʻiliʻi nā platelets i loaʻa i loko o ko kākou koko. ʻO kā lākou hana nui ka hoʻōki ʻana i ke kahe ʻana o ke koko ke kahe ke koko, e like me ka wā e loaʻa ai kahi ʻeha. Hana lākou e like me kahi pā liʻiliʻi.

Akā he aha ka mea e hana ai inā piʻi nui ka helu o nā platelets? Hiki i kou koko ke lilo i mānoanoa a pipili. I kekahi mau hihia koʻikoʻi, hiki i kēia mau platelets keu ke hana i nā ʻūpā koko weliweli e hana i loko o nā kīʻaha koko. Hiki i kēia ke hoʻonui i ka pilikia o nā maʻi e like me ka hahau ʻana a i ʻole ka hōʻeha puʻuwai .

Eia nō naʻe, ʻaʻole like ka weliweli o nā hihia āpau o ka Thrombocytosis. ʻO ke koʻikoʻi o ke kūlana, a inā pono ʻoe i ka lāʻau lapaʻau a i ʻole, ma muli o ke kumu.

ʻElua mau ʻano nui o ka thrombocytosis:

ʻAe, ua ʻike nā kauka i ʻelua ʻano nui o kēia maʻi. E kamaʻilio iki kākou e pili ana i kēlā.

1. ʻO ka Thrombocythemia Koʻikoʻi (ET) a i ʻole ka Thrombocytosis Mua

He maʻi koko laha ʻole kēia. Hana ʻia ia i ka wā e hana ai kou iwi iwi - ka hale hana koko i loko o kou mau iwi - i nā platelets he nui loa. E noʻonoʻo e pili ana i ia mea, ʻo ka hapa nui o nā koko koko i loko o ko kākou kino ua hana ʻia i loko o kēia iwi iwi. ʻO ke kanaka me ka thrombocythemia koʻikoʻi, he nui loa ka hana ʻana o nā platelets ma muli o kahi kīnā i loko o kēia kaʻina hana koko.

ʻO kēia kūlana, i kapa ʻia ʻo ET (Essential Thrombocythemia) , ua manaʻo ʻia ʻo ia ka maʻi maʻamau i ka hui koko i kapa ʻia ʻo Myeloproliferative Neoplasm (MPN) .

2. ʻO ka Thrombocytosis Reactive a i ʻole ka Thrombocytosis Lua

ʻO kēia ke ʻano maʻamau o ka Thrombocytosis. ʻO kēia ka wā e hana ai kou kino i nā platelets hou aʻe i ka pane ʻana i kekahi kūlana ʻē aʻe, ka maʻi, ka ʻeha, ke ʻoki ʻana, a i ʻole ka wehe ʻana i ka spleen. I ka ʻōlelo maʻalahi, pane kou kino i kahi mea ʻē aʻe a hoʻonui i kona pae platelet. ʻO kēiaHe manawa pōkole ka thrombocytosis reactive , ʻo ia hoʻi, i ka wā e hoʻoholo ʻia ai ke kumu kumu, hoʻi ka helu platelet i ka maʻamau.

ʻO wai ka mea e loaʻa ana i ka thrombocytosis?

ʻIke pinepine ʻia kēia maʻi i nā poʻe ma luna o 60 mau makahiki. Eia kekahi, ua hōʻike ʻia ua ʻike ʻia kahi ʻano i kapa ʻia ʻo Essential Thrombocythemia (ET) i nā wahine ʻelua ka pinepine ma mua o nā kāne.

He aha nā kumu o ka thrombocytosis?

He ʻokoʻa nō hoʻi nā kumu no nā ʻano ʻelua a mākou i kūkākūkā ai ma mua.

Nā kumu o ka Thrombocythemia Koʻikoʻi (ET)

He maʻi hoʻoilina i loaʻa ka Thrombocythemia Koʻikoʻi (ET) . ʻAʻole ia he mea i hānau ʻia me ʻoe. Hoʻokumu ʻia ia e nā loli, a i ʻole nā ​​mutations, i loko o kekahi mau genes e pili ana i ka hana ʻana o nā platelets. ʻO kēia ke kumu o kou iwi iwi e hana i nā platelets he nui loa.

ʻOi aku ma mua o ka hapalua o ka poʻe me ka Essential Thrombocythemia (ET) he mutation i loko o ka gene JAK2 . He mea maʻamau nō hoʻi nā mutations i loko o nā genes CALR a i ʻole MPL .

ʻAʻole hiki i nā kānaka ʻepekema ke kuhikuhi pololei i ke kumu o kēia mau hoʻololi gene, akā ke hoʻomau nei ka noiʻi ʻana i ia mea.

Nā kumu o ka Thrombocytosis Reactive

Hiki mai kēia ʻano no ka mea hana kou kino i nā platelets hou aʻe i ka pane ʻana i nā kūlana like ʻole. A i ʻole, i kekahi manawa, hiki nō hoʻi no ka mea hōʻiliʻili nā platelets kahiko ma kahi o ka luku ʻia ʻana ma ka wikiwiki maʻamau.

Eia kekahi mau mea e hiki ai ke hana i ka Reactive Thrombocytosis :

• ʻO ka anemia , ʻoi aku hoʻi ka anemia nele i ka hao .
• Nā maʻi koko ʻē aʻe.
• ʻO kekahi mau ʻano maʻi kanesa .
• Nā maʻi, e like me ka maʻi pneumonia .
• Nā kūlana mumū - nā kūlana e hoʻoulu ai i ka mumū i loko o ke kino, e like me ka rheumatoid arthritis.
• ʻEha .
• Ka hāʻule ʻana o nā puʻupaʻa .
• Kekahi mau lāʻau lapaʻau.
• ʻO ke ʻoki kino, ʻoi aku hoʻi ke ʻoki kino o ka ʻōpū.
• Ka wehe ʻana i ka spleen .
• Ka mālama ʻana i ka nele o ka wikamina B12 .

Aia i loko o kēia papa inoa kekahi mau kumu maʻamau. Nui nā kumu ʻē aʻe o ka Reactive Thrombocytosis .

He aha nā hōʻailona o ka thrombocytosis?

I ka manawa pinepine, ʻaʻole ʻike ka poʻe me ka helu platelet kiʻekiʻe i kekahi mau hōʻailona, ​​​​ma ka liʻiliʻi ʻaʻole i nā pae mua. Inā loaʻa iā ʻoe ka Reactive Thrombocytosis , hiki iā ʻoe ke ʻike i nā hōʻailona o ke kūlana olakino i hoʻokumu ʻia.

Eia nō naʻe, i ka wā e kū mai ai nā hōʻailona, ​​pili pinepine lākou i ke kahe koko kūpono ʻole a me ke kāpili ʻana o ke koko i loko o kou kino. E ʻike paha ʻoe i nā hōʻailona e like me:

• ʻEha poʻo .
• ʻEha maʻalahi.
• Manaʻo nāwaliwali, poniuniu, a i ʻole ke poʻo māmā.
• Ke kahe ʻana o ke koko mai ka ihu, ka waha, a me nā ʻāʻī.
• Ke kahe ʻana o ke koko i loko o ka ʻōpū a i ʻole nā ​​​​​​naʻau.

Hiki i kekahi poʻe me ka Thrombocythemia Koʻikoʻi (ET) ke loaʻa i kahi maʻi i kapa ʻia ʻo Erythromelalgia . Hoʻoulu kēia i ka ʻeha, ka pehu, a me ka ʻulaʻula ma nā lima a me nā wāwae. Hiki iā lākou ke ʻike i ka maneʻo a me ke kani ʻana ma nā lima a me nā wāwae.

I nā hihia koʻikoʻi, hiki i ka thrombocytosis ke alakaʻi i nā ʻōpū koko maʻamau ʻole i loko o ka ʻōpū (e.g., Budd-Chari syndrome ) a hoʻonui i ka pilikia o ka hahau ʻana a i ʻole ka hōʻeha puʻuwai .

Pehea e ʻike ʻia ai ka thrombocytosis?

No ka mea, ʻaʻole i hōʻike pinepine ka thrombocytosis i nā hōʻailona, ​​ʻo ka hōʻailona mua āu e loaʻa ai inā hōʻike kahi hoʻāʻo koko maʻamau (e laʻa, Complete Blood Count - CBC ) i ka piʻi ʻana o ka helu platelet.

Ua wehewehe ʻia ka Thrombocytosis ʻo ia ka loaʻa ʻana o nā platelets ma mua o 450,000 i kēlā me kēia microliter o ke koko. Inā kiʻekiʻe kou helu platelet, e kauoha paha kāu kauka i kahi hoʻāʻo koko ʻē aʻe i loko o kekahi mau pule e ʻike ai inā e mau ana ke kiʻekiʻe. ʻO ka piʻi ʻana o ka helu platelet i hoʻokahi manawa a laila hoʻi i ka maʻamau ʻaʻole ia he pilikia maʻamau. Eia nō naʻe, ʻo nā pae kiʻekiʻe mau e hōʻike ana i kahi maʻi olakino.

I ke ʻano o ka reactive thrombocytosis , ʻo ka ʻike ʻana i ke kūlana kumu i hoʻokumu ai (e.g., anemia deficiency hao , maʻi ʻaʻai, maʻi) hiki ke kōkua i nā kauka e ʻike a mālama iā ia. Eia nō naʻe, inā ʻaʻole hiki i ke kauka ke loaʻa i kēlā kumu lua, e hana lākou i nā hoʻokolohua hou aʻe e ʻike inā he Essential Thrombocythemia (ET) kāu.

Hiki i kēia mau hoʻokolohua ke komo pū me:

• Ka hoʻokahe koko peripheral:Nānā kēia e ʻike inā he ʻano ʻē ke ʻano o nā platelets i loko o kou koko.
• Nā hoʻāʻo DNA/genetic: Hiki i kēia ke ʻike i nā hoʻololi genetic e like me JAK2 , kahi i pili pinepine ʻia me ET (Essential Thrombocythemia) .
• Biopsy iwi: Nānā kēia i kou iwi no nā pūnaewele ʻē.

Pehea e mālama ʻia ai ka thrombocytosis?

Inā ʻaʻohe ou hōʻailona, ​​​​pono paha ʻoe i nā nānā maʻamau.

ʻAʻole pono pinepine ka lāʻau lapaʻau no ka reactive thrombocytosis (secondary thrombocytosis). ʻO ka maʻamau, hoʻi nā pae platelet i ka maʻamau ke hoʻopau ʻia ke kūlana i hoʻoulu ai i ka helu platelet kiʻekiʻe (e like me ka ʻeha, ka maʻi, a i ʻole ka hopena i ke ʻoki kino). Eia nō naʻe, inā loaʻa iā ʻoe nā hōʻailona, ​​e mālama kāu kauka i ke kumu kumu.

Inā loaʻa iā ʻoe ka Thrombocythemia Koʻikoʻi (ET) a ke ʻike nei ʻoe i nā hōʻailona, ​​​​hiki i kāu kauka ke ʻōlelo i kekahi mau lāʻau lapaʻau, e like me:

• Ke lawe nei i ka aspirin haʻahaʻa i kēlā me kēia lā: Hiki iā ʻoe ke lawe i ka aspirin i kēlā me kēia lā e pale aku i nā ʻūpā koko. ʻAʻole maʻamau kēia mahele haʻahaʻa e hoʻonāukiuki i ka ʻōpū a i ʻole ke kahe koko. Eia nō naʻe, mai lawe mau i ka aspirin me ka ʻole o ke kamaʻilio ʻana me kāu kauka.
• ʻO ka lawe ʻana i nā lāʻau lapaʻau e hoʻohaʻahaʻa i nā pae platelet: ʻO nā lāʻau lapaʻau e like me Hydroxyurea (inoa inoa: Droxia®, Hydrea®, Siklos®, Mylocel®) a me Anagrelide (inoa inoa: Agrilyn®) e hōʻemi i ka hana ʻana o nā platelets i loko o ka iwi iwi. ʻO Interferon alfa (inoa inoa: Multiferon®) e pale aku i nā platelets maʻamau ʻole mai ka māhele ʻana a me ka hoʻonui ʻana.
• Ke hana ʻana i kahi kaʻina hana e wehe ai i kāu mau platelets: Inā kiʻekiʻe loa kou pae platelet a hiki iā ʻoe ke pilikia i ka loaʻa ʻana o nā clots koko e hoʻoweliweli i ke ola, hiki i kāu kauka ke ʻōlelo i kahi kaʻina hana i kapa ʻia ʻo plateletpheresis . Pili kēia i ka hoʻohana ʻana i kahi mīkini e kānana i nā platelets keu mai kou koko. Eia nō naʻe, i ka hapa nui o nā hihia o ka thrombocytosis , ʻaʻole pono ka plateletpheresis .

Mea nui: Mai hoʻomaka a hoʻōki paha i kekahi o kēia mau lāʻau lapaʻau me ka ʻole o ke aʻo ʻana a ke kauka. Pono e kūkākūkā ʻia nā mea āpau me kāu kauka a hana ʻia ma lalo o kāna alakaʻi.

Hiki ke ho'ōla loa ʻia ka thrombocytosis?

ʻO ka Thrombocythemia Koʻikoʻi (ET)ʻAʻohe lāʻau lapaʻau no ka thrombocytopenia i kēia manawa. Eia nō naʻe, hiki i kāu kauka ke kōkua iā ʻoe e mālama i ke kūlana e hōʻemi i kou pilikia o nā ʻōpū koko. I ke ʻano o ka thrombocytosis reactive (i hoʻokumu ʻia e nā kumu lua), hoʻi pinepine nā pae platelet i ka maʻamau ke mālama ʻia ke kumu kumu.

Hiki ke pale ʻia ka thrombocytosis?

ʻAʻole hiki ke pale ʻia nā kūlana he nui e hoʻoulu ai i ka thrombocytosis, me ka Essential Thrombocythemia (ET) .

He mea hoʻoweliweli anei ke thrombocytosis i ke ola?

ʻAʻole hoʻoweliweli ke kiʻekiʻe o nā platelet i ke ola, akā ʻo nā pilikia e hiki ke hana - e like me nā ʻōpū koko a i ʻole ke kahe koko nui - hiki ke lilo i mea weliweli.

ʻO ka hapa nui o nā kumu o ka thrombocytosis he manawa pōkole wale nō, a ʻaʻole pinepine lākou e alakaʻi i nā ʻūpā koko koʻikoʻi. I ka Thrombocythemia Koʻikoʻi (ET) , ʻoi aku ka kiʻekiʻe o ka pilikia. Eia nō naʻe, e nānā pono kāu kauka iā ʻoe, e kuhikuhi i nā lāʻau lapaʻau e pono ai, a e hana i nā kaʻina hana e pono ai e pale aku i nā ʻūpā koko weliweli. No laila, mai hopohopo.

He aha ka manaʻolana no kekahi me ka thrombocytosis?

Hoʻopau pinepine ʻia ka thrombocytosis reactive ke mālama ʻia ka pilikia kumu. ʻOiai hiki ke piʻi aʻe kou helu platelet no kekahi manawa pōkole (a hiki paha i ka wā lōʻihi ma hope o ka wehe ʻia ʻana o kou spleen), ʻo ka thrombocytosis lua ʻaʻole ia e hoʻoulu i nā ʻōpū koko maʻamau ʻole.

ʻO ka Thrombocythemia Koʻikoʻi (ET) , a i ʻole ka thrombocytosis mua, hiki ke hoʻoulu i ke kahe koko nui a i ʻole nā ​​​​pilikia o ke kāpili ʻana o ke koko. ʻO ka lawe ʻana i ka lāʻau lapaʻau e mālama i kāu mau pae platelet maʻamau hiki ke kōkua i ka pale ʻana i kēia. Eia nō naʻe, ma hope o nā makahiki he nui o ka loaʻa ʻana o ka maʻi, hiki ke loaʻa ka fibrosis o ka iwi marrow (ka ʻōpala o ka iwi marrow). Hiki i kahi poʻe liʻiliʻi me ka Thrombocythemia Koʻikoʻi (ET) ke loaʻa i ka leukemia .

Āhea wau e ʻike ai i kaʻu kauka?

E hahai pono i nā ʻōlelo a kāu kauka e pili ana i ka pinepine o kou hele ʻana no nā hoʻokolohua lapaʻau a inā pono ʻoe e loaʻa nā hoʻāʻo koko e nānā i kāu helu platelet.

Āhea wau e hele ai i ka ʻOihana Pōpilikia (ETU) ?

Inā ʻike ʻoe i nā hōʻailona o ka hahau ʻana a i ʻole ka hōʻeha puʻuwai, e kāhea koke i ka 1990 a i ʻole e hele i ka lumi pilikia haukapila kokoke loa. E makaʻala i kēia mau hōʻailona.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Hiki iā ʻoe ke nīnau i kāu kauka e like me kēia:

• Pono anei au e hopohopo e pili ana i koʻu pae platelet kiʻekiʻe?
• Pono anei au e hana i nā hoʻokolohua hou aʻe e nānā hou i kaʻu pae platelet?
• He aha nā hoʻokolohua e pono ai iaʻu e hana e ʻike ai i ke kumu o ka thrombocytosis?
• He aha nā lāʻau lapaʻau āu e paipai nei?
• He aha nā hoʻololi e hiki iaʻu ke hana i koʻu nohona e mālama ai i kēia kūlana?

Inā hōʻike nā hopena o kāu hoʻāʻo koko ua kiʻekiʻe kou mau platelets, mai hopohopo. Hiki ke kiʻekiʻe kou mau platelets no nā kumu like ʻole. ʻAʻole pono ka nui o kēia mau kumu i ka mālama ʻana. Akā inā kiʻekiʻe mau kou mau pae a loaʻa iā ʻoe nā hōʻailona, ​​​​e hoʻāʻo kāu kauka e ʻimi i ke kumu. ʻO ka nānā pono ʻana a me ka lāʻau lapaʻau e hiki ke pale i nā pilikia koʻikoʻi loa e pili ana me ka thrombocytosis.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

ʻĀ, ua kamaʻilio nui mākou e pili ana i ka Thrombocytosis i kēia lā, ʻeā? Manaʻolana wau ua maopopo iā ʻoe kēia.

ʻO ka mea nui loa, ʻaʻole e hopohopo inā ʻike ʻoe ua kiʻekiʻe kou pae platelet. ʻAʻole weliweli nā hihia a pau o ka Thrombocytosis.

• ʻO ka Reactive Thrombocytosis ke ʻano maʻamau, a hoʻokumu pinepine ʻia e kekahi kumu manawa pōkole. E hoʻomaikaʻi pū kēia ke mālama ʻia kēlā kumu.
• ʻO ka Thrombocythemia Koʻikoʻi (ET) kahi ʻano kakaikahi e pono ai ka mālama ʻana i ka wā lōʻihi.
• E hōʻoia e hana i nā hoʻokolohua a me nā lāʻau lapaʻau kūpono e like me ke kauoha a kāu kauka.
• Mai hoʻowahāwahā i kekahi mau hōʻailona. E ʻimi koke i ke kōkua lapaʻau, ʻoiai inā he kahe koko ʻē kou, he palapū, he ʻeha poʻo nui, he ʻeha umauma, a he paʻakikī paha ka hanu ʻana.
• E kamaʻilio ākea me kāu kauka. E nīnau i nā nīnau a hopohopo paha āu e loaʻa ai.

E hoʻomanaʻo, ʻaʻole ʻoe hoʻokahi. Me ke alakaʻi lapaʻau kūpono a me ke kākoʻo, hiki iā ʻoe ke hoʻokele maikaʻi i kēia kūlana a ola i kahi ola olakino.